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Through-polymer,via technology-enabled,flexible,lightweight,and integrated devices for implantable neural probes

Microsystems & Nanoengineering 2024年第2期10卷 279-291页

作者： Cunkai Zhou Ye Tian Gen Li Yifei Ye Lusha Gao Jiazhi Li Ziwei Liu haoyang Su Yunxiao Lu Meng Li Zh.tao Zhou Xiaoling Wei Lunming Qin tiger h.tao Liuyang Sun College of Electronics and Information Engineering Shanghai University of Electric PowerShanghaiChina 2020 X-Lab Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghaiChina School of Graduate Study University of Chinese Academy of SciencesBeijingChina State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghaiChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina School of Physical Science and Technology ShanghaiTech UniversityShanghaiChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina Neuroxess Co. Ltd.(Jiangxi)NanchangJiangxiChina Guangdong Institute of Intelligence Science and Technology HengqinZhuhaiGuangdongChina Tianqiao and Chrissy Chen Institute for Translational Research ShanghaiChina

In implantable electrophysiological recording systems,the headstage typically comprises neural probes that interface with brain tissue and integrated circuit chips for signal processing.While advancements in MEMS and CMOS technology have significantly improved these components,their interconnection still relies on conventional printed circuit boards and sophisticated adapters.This conventional approach adds considerable weight and volume to the package,especially for high channel count systems.To address this issue,we developed a through-polymer via(TPV)method inspired by the through-silicon via(TSV)technique in advanced three-dimensional packaging.This innovation enables the vertical integration of flexible probes,amplifier chips,and PCBs,realizing a flexible,lightweight,and integrated device(FLID).The total weight of the FLIDis only 25%that of its conventional counterparts relying on adapters,which significantly increased the activity levels of animals wearing the FLIDs to nearly match the levels of control animals without implants.Furthermore,by incorporating a platinum-iridium alloy as the top layer material for electrical contact,the FLID realizes exceptional electrical performance,enabling in vivo measurements of both local field potentials and individual neuron action potentials.These findings showcase the potential of FLIDs in scaling up implantable neural recording systems and mark a significant advancement in the field of neurotechnology.

关键词： alloy neural recording

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Long-term flexible penetrating neural interfaces:materials, structures, and implantation

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Science China(Information Sciences) 2021年第12期64卷 5-22页

作者： Chi GU Jianjuan JIANG tiger h.tao Xiaoling WEI Liuyang SUN State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences University of Chinese Academy of Sciences School of Physical Science and Technology Shanghai Tech University Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Science 52020 X-Lab Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences Shanghai Research Center for Brain Science and Brain-Inspired Intelligence Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences

Penetrating neural interface, which collects the neural electrophysiological signal and serves as a key component in brain-computer interface, has drawn great attention recently. The instability of chronic recording is the main challenge for the conventional neural interface. Novel neural probes with improved long-term performance have been developed based on advanced materials and engineered structures. here, we review these emergent innovations contributing to chronic stable recording from the perspectives of materials,structures, and implantation methods. These advances make possible further developments in neuroscience research related to neural decoding, neural circuit mechanism analysis, and neurological disease treatment.

关键词： neural interface long-term flexible minimally invasive biocompatibility

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A silk-based self-adaptive flexible opto-electro neural probe

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Microsystems & Nanoengineering 2022年第6期8卷 85-96页

作者： Yu Zhou Chi Gu Jizhi Liang Bohan Zhang huiran Yang Zh.tao Zhou Meng Li Liuyang Sun tiger h.tao Xiaoling Wei State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences200050 ShanghaiChina School of Graduate Study University of Chinese Academy of Sciences100049 BeijingChina School of Physical Science and Technology ShanghaiTech University200031 ShanghaiChina 2020 X-Lab Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences200050 ShanghaiChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences100049 BeijingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences200031 ShanghaiChina Neuroxess Co. Ltd.(Jiangxi)330029 NanchangJiangxiChina Guangdong Institute of Intelligence Science and Technology Hengqin519031 ZhuhaiGuangdongChina Tianqiao and Chrissy Chen Institute for Translational Research ShanghaiChina

The combination of optogenetics and electrophysiological recording enables high-precision bidirectional interactions between neural interfaces and neural circuits,which provides a promising approach for the study of progressive neurophysiological phenomena.Opto-electrophysiological neural probes with sufficient flexibility and biocompatibility are desirable to match the low mechanical stiffness of brain tissue for chronic reliable performance.however,lack of rigidity poses challenges for the accurate implantation of flexible neural probes with less invasiveness.herein,we report a hybrid probe(Silk-Optrode)consisting of a silk protein optical fiber and multiple flexible microelectrode arrays.The Silk-Optrode can be accurately inserted into the brain and perform synchronized optogenetic stimulation and multichannel recording in freely behaving animals.Silk plays an important role due to its high transparency,excellent biocompatibility,and mechanical controllability.Through the hydration of the silk optical fiber,the Silk-Optrode probe enables itself to actively adapt to the environment after implantation and reduce its own mechanical stiffness to implant into the brain with high fidelity while maintaining mechanical compliance with the surrounding tissue.The probes with 128 recording channels can detect high-yield well-isolated single units while performing intracranial light stimulation with low optical losses,surpassing previous work of a similar type.Two months of post-surgery results suggested that as-reported Silk-Optrode probes exhibit better implant-neural interfaces with less immunoreactive glial responses and tissue lesions.

关键词： neural recording implantation

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A mosquito mouthpart-like bionic neural probe

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Microsystems & Nanoengineering 2023年第4期9卷 77-90页

作者： Yu Zhou huiran Yang Xueying Wang heng Yang Ke Sun Zh.tao Zhou Liuyang Sun Jianlong Zhao tiger h.tao Xiaoling Wei State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences200050 ShanghaiChina School of Graduate Study University of Chinese Academy of Sciences100049 BeijingChina 2020 X-Lab Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences200050 ShanghaiChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences100049 BeijingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences200031 ShanghaiChina Neuroxess Co. Ltd.(Jiangxi)330029 NanchangJiangxiChina Guangdong Institute of Intelligence Science and Technology Hengqin519031 ZhuhaiGuangdongChina Tianqiao and Chrissy Chen Institute for Translational Research ShanghaiChina

Advancements in microscale electrode technology have revolutionized the field of neuroscience and clinicalapplications by offering high temporal and spatial resolution of recording and stimulation. Flexible neural probes, withtheir mechanical compliance to brain tissue, have been shown to be superior to rigid devices in terms of stability andlongevity in chronic recordings. Shuttle devices are commonly used to assist flexible probe implantation;however, theprotective membrane of the brain still makes penetration difficult. hidden damage to brain vessels duringimplantation is a significant risk. Inspired by the anatomy of the mosquito mouthparts, we present a biomimeticneuroprobe system that integrates high-sensitivity sensors with a high-fidelity multichannel flexible electrode array.This customizable system achieves distributed and minimally invasive implantation across brain regions. Mostimportantly, the system’s nonvisual monitoring capability provides an early warning detection for intracranial softtissues, such as vessels, reducing the potential for injury during implantation. The neural probe system demonstratesexceptional sensitivity and adaptability to environmental stimuli, as well as outstanding performance in postoperativeand chronic recordings. These findings suggest that our biomimetic neural-probe device offers promising potential forfuture applications in neuroscience and brain-machine interfaces.

关键词： neural implantation recording

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Connections Between Induction Generator Effect and Open-loop Modal Proximity to Cause Sub-synchronous Oscillations in Series-compensated Power System

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 963-973页

作者： Wenjuan Du Yang Wang h.F.Wang tao Zhao Tim Littler College of Electrical Engineering Sichuan UniversityChengduChina School of Electrical Engineering the Queen’s University of BelfastBelfastUK IEEE

The induction generator effect(IGE)and the openloop modal proximity(OLMP)are two different reasons why subsynchronous oscillations(SSOs)in a series-compensated power system(SCPS)may occur.The IGE attributes the growing SSOs to negative resistance,while the OLMP explains the SSO mechanism from the standpoint of modal conditions.In this paper,we investigate the connections between the IGE and the OLMP through equivalent RLC circuit and open-loop modal analysis.Our investigation is conducted for two types of seriescompensated power systems where either a synchronous generator or a DFIG is connected at the sending end.The investigation reveals the conditions,in which the IGE and the OLMP may jointly cause the growing SSOs,i.e.,both the IGE and the OLMP can explain why the growing SSOs occur.Furthermore,the investigation indicates that the IGE and the OLMP may be totally irrelevant and lead to growing SSOs separately.This implies that it is possible that in a SCPS,the growing SSOs are only due to the IGE,and the OLMP is non-existent,and vice versa.hence,when the growing SSOs occurs in a SCPS,examination based on both the IGE and the OLMP should be carefully conducted in order to find if the oscillatory instability is due to the IGE,or the OLMP,or both of them.

关键词： Induction generator effect open-loop modal proximity series compensation sub-synchronous oscillations

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h?lder continuous weak solutions of the 2D Boussinesq equation with thermal diffusion

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Science China Mathematics 2024年第8期67卷 1777-1806页

作者： Tianwen Luo tao tao Liqun Zhang Yau Mathematical Sciences Center Tsinghua University School of Mathematics Shandong University Institute of Mathematics Academy of Mathematics and Systems ScienceChinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences

We show the existence of h?lder continuous periodic weak solutions of the 2D Boussinesq equation with thermal diffusion which satisfy the prescribed kinetic energy. More precisely, for any smooth e(t):[0, 1]→■ and ... 详细信息

关键词： 2D Boussinesq equation with thermal diffusion hölder continuous periodic weak solutions prescribed kinetic energy

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Net effect of air pollution controls on health risk in the Beijing-Tianjin-hebei region during the 2022 winter Olympics and Paralympics

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Journal of Environmental Sciences 2024年第1期135卷 560-569页

作者： Changqing Lin Peter K.K.Louie Alexis K.h.Lau Jimmy C.h.Fung Zibing Yuan Minghui tao Xuguo Zhang Md.Shakhaoat hossain Chengcai Li Xiang Qian Lao Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong KongChina Environmental Protection Department Hong Kong Government SARHong KongChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina School of Environment and Energy South China University of TechnologyGuangzhou 510006China hubei Key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public health and Informatics Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Jockey Club School of Public health and Primary Care The Chinese University of Hong KongHong KongChina

Due to the non-linearity in ozone(O_(3))formation,reducing the emission of nitrogen oxides(NO_(x))may increase O_(3) concentration.Given the counteractive O_(3) response to NO_(x) reduction,overall impact of air pollution controls can be ambiguous when the assessments focus on the changes in pollutant concentrations.In this study,a risk-based method was used to gauge the net effect of air pollution controls on mortality risk in the Beijing–Tianjin–hebei(BTh)region during the 2022 Winter Olympics and Paralympics(WOP).This mega-event presents a unique opportunity to investigate the efficacy of deep cuts in pollutant emissions.Results show that O_(3) concentrations greatly increased as nitrogen dioxide(NO_(2))concentrations decreased in the BTh.Due to the active photochemical formations,O_(3) became the dominant pollutant that affected human health during the WOP.Despite the substantial O_(3) increases,the health benefits of NO_(2) reductions overwhelmed the adverse health effects of O_(3) increases in most regions of the BTh(at 81 out of 112 stations).After considering the impacts of particulate matter,the integrated health risk of air pollution mixtures declined almost everywhere in the BTh.Our results underscore the great necessity of changing the assessment paradigm of pollution control from using concentration-based methods to using risk-based methods.Together with the carbon neutrality policy,stringent control of NO_(x)emission from combustion sources is a promising way to achieve synergistic control solutions for air pollution and climate change.

关键词： Ozone Nitrogen dioxide health risk Carbon neutrality Mega-events

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Associations of daily sedentary behavior,physical activity,and sleep with irritable bowel syndrome:A prospective analysis of 362,193 participants

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Journal of Sport and health Science 2024年第1期13卷 72-80页

作者： Xu Gao Sifan Tian Ninghao huang Gang Sun tao huang Department of Occupational and Environmental health Sciences School of Public HealthPeking UniversityBeijing 100191China Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Gastroenterology and hepatology First Medical Center of People's Liberation Army General HospitalBeijing 100853China

Background:Irritable bowel syndrome(IBS)substantially affects quality of life and requires early prevention.This study aimed to elucidate the relationships between IBS and daily behaviors,including sedentary behavior(SB),physical activity(PA),and sleep.In particular,it seeks to identify healthy behaviors to reduce IBS risk,which previous studies have rarely addressed.Methods:Daily behaviors were retrieved from self-reported data of 362,193 eligible UK Biobank participants.Incident cases were determined by self-report or health care data according to RomeⅣcriteria.Results:A total of 345,388 participants were IBS-free at baseline,during a median follow-up of 8.45 years,19,885 incident IBS cases were recorded.When examined individually,SB and shorter(≤7 h/day)or longer(>7 h/day)sleep duration were each positively associated with increased IBS risk,and PA was associated with lower IBS risk.The isotemporal substitution model suggested that replacing SB with other activities could provide further protective effects against IBS risk.Among people sleeping≤7 h/day,replacing 1 h of SB with equivalent light PA,vigorous PA,or sleep was associated with 8.1%(95%confidence interval(95%CI):0.901-0.937),5.8%(95%CI:0.896-0.991),and 9.2%(95%CI:0.885-0.932)reduced IBS risk,respectively.For people sleeping>7 h/day,light and vigorous PA were associated with a 4.8%(95%CI:0.926-0.978)and a 12.0%(95%CI:0.815-0.949)lower IBS risk,respectively.These benefits were mostly independent of genetic risk for IBS.Conclusion:SB and unhealthy sleep duration are risk factors for IBS.A promising way to mitigate IBS risk for individuals sleeping≤7 h/day and for those sleeping>7 h/day appears to be by replacing SB with adequate sleep or vigorous PA,respectively,regardless of the genetic predisposition of IBS.

关键词： Irritable bowel syndrome Isotemporal substitution model Physical activity Sedentary behavior Sleep

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Subcellular distribution of prohibitin 1 in rat liver during liver regeneration and its cellular implication

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World Journal of hepatology 2024年第1期16卷 65-74页

作者： Qing-Ju Sun tao Liu Department of Clinical Laboratory Navy No.971 HospitalQingdao 266072Shandong ProvinceChina Department of Infectious Diseases Navy No.971 HospitalQingdao 266071Shandong ProvinceChina

BACKGROUND The function of prohibitin 1(Phb1)during liver regeneration(LR)remains relatively unexplored.Our previous research identified downregulation of Phb1 in rat liver mitochondria 24 h after 70%partial hepatectomy(Phx),as determined by subcellular proteomic analysis.AIM To investigate the potential role of Phb1 during LR.METhODS We examined changes in Phb1 mRNA and protein levels,subcellular distribution,and abundance in rat liver during LR following 70%Phx.We also evaluated mitochondrial changes and apoptosis using electron microscopy and flow cytometry.RNA-interference-mediated knockdown of Phb1(PhBi)was performed in BRL-3A cells.RESULTS Compared with sham-operation control groups,Phb1 mRNA and protein levels in 70%Phx test groups were downregulated at 24 h,then upregulated at 72 and 168 h.Phb1 was mainly located in mitochondria,showed a reduced abundance at 24 h,significantly increased at 72 h,and almost recovered to normal at 168 h.Phb1 was also present in nuclei,with continuous increase in abundance observed 72 and 168 h after 70%Phx.The altered ultrastructure and reduced mass of mitochondria during LR had almost completely recovered to normal at 168 h.PhBi in BRL-3A cells resulted in increased S-phase entry,a higher number of apoptotic cells,and disruption of mitochondrial membrane potential.CONCLUSION Phb1 may contribute to maintaining mitochondrial stability and could play a role in regulating cell proliferation and apoptosis of rat liver cells during LR.

关键词： Prohibitin 1 Liver regeneration Subcellular proteomic analysis Mitochondrial stability Cell proliferation

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ANALYSIS OF ThE IMPLICIT-EXPLICIT ULTRA-WEAK DISCONTINUOUS GALERKIN METhOD FOR CONVECTION-DIFFUSION PROBLEMS

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Journal of Computational Mathematics 2024年第1期42卷 1-23页

作者： haijin Wang Anping Xu Qi tao School of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China Beijing Computational Science Research Center Beijing 100193China

In this paper,we first present the optimal error estimates of the semi-discrete ultra-weak discontinuous Galerkin method for solving one-dimensional linear convection-diffusion equations.Then,coupling with a kind of Runge-Kutta type implicit-explicit time discretization which treats the convection term explicitly and the diffusion term implicitly,we analyze the stability and error estimates of the corresponding fully discrete schemes.The fully discrete schemes are proved to be stable if the time-stepτ≤τ0,whereτ0 is a constant independent of the mesh-size h.Furthermore,by the aid of a special projection and a careful estimate for the convection term,the optimal error estimate is also obtained for the third order fully discrete scheme.Numerical experiments are displayed to verify the theoretical results.

关键词： The ultra-weak discontinuous Galerkin method Convection-diffusion Implicitexplicit time discretization Stability Error estimate

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