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Low-dose metformin treatment in the subacute phase improves the locomotor function of a mouse model of spinal cord injury

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Neural Regeneration Research 2021年第11期16卷 2234-2242页

作者： Wen-Ye Song Han Ding tiffany dunn Jun-Ling Gao Javier Allende Labastida Caitlin Schlagal Guang-Zhi Ning Shi-Qing Feng Ping Wu Department of Neuroscience Cell Biology&AnatomyUniversity of Texas Medical Branch at GalvestonGalvestonTXUSA Department of Orthopedics Tianjin Medical University General HospitalTianjinChina

Metformin,a first-line drug for type-2 diabetes,has been shown to improve locomotor recovery after spinal cord ***,there are studies reporting no beneficial ***,we found that high dose of metformin(200 mg/kg,intraperitoneal)and acute phase administration(immediately after injury)led to increased mortality and limited locomotor function ***,we used a lower dose(100 mg/kg,i.p.)metformin in mice,and compared the effect of immediate administration after spinal cord injury(acute phase)with that of administration at 3 days post-injury(subacute phase).Our data showed that metformin treatment starting at the subacute phase significantly improved mouse locomotor function evaluated by Basso Mouse Scale(BMS)*** studies also revealed significant inhibitions of microglia/macrophage activation and astrogliosis at the lesion ***,metformin treatment at the subacute phase reduced neutrophil *** changes were in parallel with the increased survival rate of spinal neurons in animals treated with *** findings suggest that low-dose metformin treatment for subacute spinal cord injury can effectively improve the functional recovery possibly through anti-inflammation and *** study was approved by the Institute Animal Care and Use Committee at the University of Texas Medical Branch(approval No.1008041C)in 2010.

关键词： inflammation locomotor function metformin microglia mortality neuroprotection spinal cord injury subacute administration

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