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Periodontal treatment and microbiome-targeted therapy in management of periodontitis-related nonalcoholic fatty liver disease with oral and gut dysbiosis

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World Journal of Gastroenterology 2023年第6期29卷 967-996页

作者： Ryutaro Kuraji Takahiko Shiba tien S dong Yukihiro Numabe Yvonne L Kapila Department of Periodontology The Nippon Dental University School of Life Dentistry at TokyoTokyo 102-0071Japan Department of Orofacial Sciences University of California San FranciscoSan FranciscoCA 94143United States Department of Oral Medicine Infectionand ImmunityHarvard School of Dental MedicineBostonMA 02115United States Department of Periodontology Tokyo Medical and Dental UniversityTokyo 113-8549Japan The Vatche and Tamar Manoukian Division of Digestive Diseases University of California Los AngelesDepartment of MedicineUniversity of California David Geffen School of MedicineLos AngelesCA 90095United States Department of Periodontology The Nippon Dental University School of Life Dentistry at TokyoTokyo 102-8159Japan Sections of Biosystems and Function and Periodontics Professor and Associate Dean of ResearchFelix and Mildred Yip Endowed Chair in DentistryUniversity of California Los AngelesLos AngelesCA 90095United States

A growing body of evidence from multiple areas proposes that periodontal disease,accompanied by oral inflammation and pathological changes in the microbiome,induces gut dysbiosis and is involved in the pathogenesis of nonalcoholic fatty liver disease(NAFLD).A subgroup of NAFLD patients have a severely progressive form,namely nonalcoholic steatohepatitis(NASH),which is characterized by histological findings that include inflammatory cell infiltration and *** has a high risk of further progression to cirrhosis and hepatocellular *** oral microbiota may serve as an endogenous reservoir for gut microbiota,and transport of oral bacteria through the gastro-intestinal tract can set up a gut microbiome *** dysbiosis increases the production of potential hepatotoxins,including lipopolysaccharide,ethanol,and other volatile organic compounds such as acetone,phenol and ***,gut dysbiosis increases intestinal permeability by disrupting tight junctions in the intestinal wall,leading to enhanced translocation of these hepatotoxins and enteric bacteria into the liver through the portal *** particular,many animal studies support that oral administration of Porphyromonas gingivalis,a typical periodontopathic bacterium,induces disturbances in glycolipid metabolism and inflammation in the liver with gut ***,also known as the hepatic phenotype of metabolic syndrome,is strongly associated with metabolic complications,such as obesity and *** disease also has a bidirectional relationship with metabolic syndrome,and both diseases may induce oral and gut microbiome dysbiosis with insulin resistance and systemic chronic inflammation *** this review,we will describe the link between periodontal disease and NAFLD with a focus on basic,epidemiological,and clinical studies,and discuss potential mechanisms linking the two diseases and possible therapeutic approaches focused on the *** conc

关键词： Periodontal disease Nonalcoholic fatty liver disease Microbiota Dysbiosis Metabolic syndrome Probiotics

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Impact of sustained virologic response on chronic kidney disease progression in hepatitis C

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World Journal of Hepatology 2017年第36期9卷 1352-1360页

作者： Elizabeth S Aby tien S dong Jenna Kawamoto Joseph R Pisegna Jihane N Benhammou Division of Gastroenterology Hepatology and Parenteral Nutrition Department of Medicine VA Greater Los Angeles Healthcare System the Vatche and Tamar Manoukian Division of Digestive Diseases UCLA Los Angeles Department of Medicine University of California David Geffen School of Medicine

AIM To determine how sustained virological response at 12 wk(SVR12) with direct acting antivirals(DAAs) for the treatment of hepatitis C virus(HCV) infection affects chronic kidney disease(CKD) progression. METHODS A retrospective analysis was performed in patients aged ≥ 18 years treated for HCV with DAAs at the VA Greater Los Angeles Healthcare System from 2014-2016. The treatment group was compared to patients with HCV from 2011-2013 who did not undergo HCV treatment, prior to the introduction of DAAs; the control group was matched to the study group in terms of age, gender, and ethnicity. Analysis of variance and co-variance was performed to compare means between SVR12 subgroups adjusting for *** Five hundred and twenty-three patients were evaluated. When comparing the rate of change in estimated glomerular filtration rate(e GFR) one-year after HCV treatment to one-year before treatment, patients who achieved SVR12 had a decline in GFR of 3.1 m L/min ± 0.75 m L/min per 1.73 m^2 compared to a decline in e GFR of 11.0 m L/min ± 2.81 m L/min per 1.73 m^2 in patients who did not achieve SVR12(P = 0.002). There were no significant clinical differences between patients who achieved SVR12 compared to those who did not in terms of cirrhosis, treatment course, treatment experience, CKD stage prior to treatment, diuretic use or other co-morbidities. The decline in e GFR in those with untreated HCV over 2 years was 2.8 m L/min ± 1.0 m L/min per 1.73 m^2, which was not significantly different from the e GFR decline noted in HCV-treated patients who achieved SVR12(P = 0.43).CONCLUSION Patients who achieve SVR12 have a lesser decline in renal function, but viral eradication in itself may not be associated improvement in renal disease progression.

关键词： Hepatitis C Direct-acting antivirals Chronic kidney disease End stage renal disease Sustained virological response

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Controllers Design for the Multi-Shuttle and Multi-Station Transportation System

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Open Journal of Applied Sciences 2021年第8期11卷 946-965页

作者： tien dong Ha Minh tien Trinh Tran Thanh Cong Vu Tuong Quan Vo Faculty of Mechanical Engineering Ho Chi Minh City University of Technology VNU-HCM Viet Nam

Nowadays, the Multi-Shuttle and Multi-Station Transportation System (MMTS) is one of the most interesting research topics in many fields of industries. It is an effective solution to reduce unexpected accidents that occur during transportation as well as increase productivity in manufacturing. The aim of this paper is to introduce the controller design for the MMTS which is built in our BK-Recme BioMech Lab at Ho Chi Minh City University of Technology (VNU-HCM), Viet Nam. Based on the design of this system, the control algorithms will be conducted to check the operation of the whole system. To evaluate the feasibility and effectiveness of this model, we design a series of random instances for different quantities of nodes as well as the different quantities of shuttles. Our system includes 4 stations and 6 shuttles which are assembled in the serial chain system. However, the number of stations and number of shuttles can be expanded to any desired ones which are based on the requirement of the industries. In this paper, we mainly focus on the controller design of this system to make it operate in an effective way that the goods will be transported and delivered to the target station as fast as possible. In order to solve the large-scale instances and realistic transport problems, we propose three algorithms for three progresses as shuttles calling, path reading and shuttles communicating. The shuttles calling is to decide which shuttle should be called to the start-node. Path reading to determine the shortest way to go from start-node to end-node. Finally, shuttles co

关键词： Multi-Station Multi-Shuttle Transportation Shuttle Calling RFID Communicating Start-Node End-Node

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Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis

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Liver Research 2021年第4期5卷 224-231页

作者： Camellia Dalai John M Azizian Harry Trieu Anand Rajan Formosa C Chen tien dong Simon W Beaven James H.Tabibian UCLA-Olive View Internal Medicine Residency Program Department of MedicineOlive View-UCLA Medical CenterSylmarCAUSA Keck School of Medicine University of Southern CaliforniaLos AngelesCAUSA Department of Surgery David Geffen School of Medicine at UCLALos AngelesCAUSA Vatche and Tamar Manoukian Division of Digestive Diseases David Geffen School of Medicine at UCLALos AngelesCAUSA Division of Gastroenterology Department of MedicineOlive View-UCLA Medical CenterSylmarCAUSA

Background and aims:Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance *** aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography(ERCP)-confirmed choledocholithiasis and accordingly developed predictive machine learning models(MLMs).Methods:Clinical data of consecutive patients undergoing first-ever ERCP for suspected chol-edocholithiasis from 2015 to 2019 were abstracted from a prospectively-maintained *** logistic regression was used to identify predictors of ERCP-confirmed *** were then trained to predict ERCP-confirmed choledocholithiasis using pre-ERCP ultrasound(US)imaging only as well as using all available noninvasive imaging(US,computed tomography,and/or magnetic reso-nance cholangiopancreatography).The diagnostic performance of American Society for Gastrointestinal Endoscopy(ASGE)“high-likelihood”criteria was compared to ***:We identified 270 patients(mean age 46 years,62.2%female,73.7%Hispanic/Latino,59%with noninvasive imaging positive for choledocholithiasis)with native papilla who underwent ERCP for suspected choledocholithiasis,of whom 230(85.2%)were found to have ERCP-confirmed *** regression identified choledocholithiasis on noninvasive imaging(odds ratio(OR)¼3.045,P¼0.004)and common bile duct(CBD)diameter on noninvasive imaging(OR¼1.157,P¼0.011)as predictors of ERCP-confirmed *** the various MLMs trained,the random forest-based MLM performed best;sensitivity was 61.4%and 77.3%and specificity was 100%and 75.0%,using US-only and using all available imaging,*** high-likelihood criteria demonstrated sensitivity of 90.9%and specificity of 25.0%;using cut-points achieving this specificity,MLMs achieved sensitivity up to 97.7%.Conclusions:MLMs using age,sex,race/ethnicity,presence of diabetes,fever,body mass index(BMI),total bilirubin,maximum CBD di

关键词： Machine learning models(MLMs) Endoscopic retrograde cholangiopancreatography(ERCP) Noninvasive imaging Bile duct disorders Common bile duct stones Gallstones

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Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c

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World Journal of Hepatology 2018年第9期10卷 612-621页

作者： tien S dong Elizabeth S Aby Jihane N Benhammou Jenna Kawamoto Steven-Huy Han Folasade P May Joseph R Pisegna the Vatche and Tamar Manoukian Division of Digestive Diseases University of California Los AngelesDepartment of MedicineUniversity of California David Geffen School of MedicineLos AngelesCA 90095United States Division of Gastroenterology Hepatology and Parenteral NutritionDepartment of MedicineVA Greater Los Angeles Healthcare SystemLos AngelesCA 90073United States the Pfleger Liver Institute Department of SurgeryUniversity of California David Geffen School of MedicineLos AngelesCA 90095United States VA Health Services Research and Development Center for the Study of Healthcare Innovation Center for the Study of Healthcare Innovation Implementation and Policy(CSHIIP)Los AngelesCA 90073United States Jonsson Comprehensive Cancer Center Los AngelesCA 90095United States

AIM To determine whether successful treatment with direc-tacting antivirals(DAA) is associated with improvements in hemoglobin A1 c(HbA1 c) and if type 2 diabetes mellitus(T2 DM) or metabolic syndrome affects sustained virologic response(SVR).METHODS We performed a retrospective analysis of all hepatitis C virus(HCV) patients at the VA Greater Los Angeles Healthcare System treated with varying DAA therapy between 2014-2016. Separate multivariable logistic regression was performed to determine predictors of HbA1 c decrease ≥ 0.5 after DAA treatment and predictors of SVR 12-wk post treatment(SVR12).RESULTS A total of 1068 patients were treated with DAA therapy between 2014-2016. The presence of T2 DM or metabolic syndrome did not adversely affect SVR12. 106 patients had both HCV and T2 DM. Within that cohort,patients who achieved SVR12 had lower mean HbA1 c pre treatment(7.35 vs 8.60,P = 0.02),and lower mean HbA1 c post-treatment compared to non-responders(6.55 vs 8.61,P = 0.01). The mean reduction in HbA1 c after treatment was greater for those who achieved SVR12 than for non-responders(0.79 vs 0.01,P = 0.03). In adjusted models,patients that achieved SVR12 were more likely to have a HbA1 c decrease of ≥ 0.5 than those that did not achieve SVR12(adjusted OR = 7.24,95%CI: 1.22-42.94). CONCLUSION In HCV patients with T2 DM,successful treatment with DAA was associated with a significant reduction in HbA1 c suggesting that DAA may have a role in improving insulin sensitivity. Furthermore,the presence of T2 DM or metabolic syndrome does not adversely affect SVR12 rates in patients treated with DAA.

关键词： Hepatitis C virus Hemoglobin A1c Diabetes mellitus Direct-acting antivirals Metabolic syndrome

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A new species Lobophora tsengii ***.(Dictyotales;Phaeophyceae)from Bach Long Vy(Bailongwei)Island,Vietnam

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Journal of Oceanology and Limnology 2021年第6期39卷 2363-2369页

作者： Zhongmin SUN Minh dong DAO Quoc Toan TRAN Duc tien DAM Department of Marine Organism Taxonomy and Phylogeny Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China Graduate University of Science and Technology Vietnam Academy of Science and Technology(VAST)Hanoi 100000Vietnam Institute of Natural Products Chemistry Vietnam Academy of Science and Technology(VAST)Cau GiayHanoi 100000Vietnam Institute of Marine Environment and Resources(IMER) Vietnam Academy of Science and Technology(VAST)Haiphong 180000Vietnam Haiphong University of Medicine and Pharmacy Haiphong 180000Vietnam

A new species Lobophora tsengii is described from Bach Long Vy(Bailongwei)Island,Haiphong Province,*** plants inhabit the subtidal zone and have predominantly erect fan-shaped thalli that attach to the substrate by a basal *** thallus is commonly composed of a single layer of large medullary cells with four layers of cortical cells on either side of the *** newly collected specimens from the island are morphologically similar to those from Hainan Island,China,but differ from the New Caledonian ones in having thicker *** molecular phylogenetic analyses based on concatenated rbcL and cox3 s equences,the specimens from the island were 100%identical to those from Hainan Island,China,and they formed a clade separating from other Lobophora ***,based on analyses of numerous cox3 s equences,our specimens were also distinguished from the closely related taxa occurring in New Caledonia,Kenya,and West *** the morphological and molecular analyses,we conclude that our specimens represent a new species of Lobophora,which is apparently endemic to the Beibu Gulf(Gulf of Tonkin)and adjacent waters.

关键词： Bach Long Vy(Bailongwei)Island cox3 Lobophora molecular phylogeny morphology rbcL

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An Analytical Approach for Nonlinear Buckling Analysis of Torsionally Loaded Sandwich Carbon Nanotube Reinforced Cylindrical Shells with Auxetic Core

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Advances in Applied Mathematics and Mechanics 2023年第2期15卷 468-484页

作者： Dang Thuy dong Nguyen Thi Phuong Vu Hoai Nam Le Ngoc Ly Nguyen Van tien Vu Minh Duc Tran Quang Minh Vu Tho Hung Nguyen Thi Huong Giang Faculty of Civil Engineering University of Transport TechnologyHanoi 100000Vietnam Graduate School of Advanced Science and Engineering Hiroshima University1-4-1 KagamiyamaHigashi-HiroshimaHiroshima 739-8527Japan Faculty of Fundamental Science for Engineering University of Transport TechnologyHanoi 100000Vietnam

The main aim of this paper is to present an analytical approach on the postbuckling for torsionally loaded sandwich carbon nanotube(CNT)reinforced cylindrical shells with the auxetic *** considered shells consist of three layers,external and internal CNT reinforced layers,and the auxetic lattice core made by isotropic *** homogenization model for honeycomb auxetic lattice core is utilized,and the equilibrium equations are formulated based on the nonlinear Donnell’s thin shell theory with von Karman geometrical *** three terms of deflection are considered,the Airy’s stress function and Galerkin’s method are utilized,the explicit expression of critical buckling of torsionally loaded shells and load-deflection expression of postbuckling states are *** effects of two carbon nanotube reinforced layers,the auxetic core layer,the volume fraction of carbon nanotube on the torsional buckling behavior are examined and remarked.

关键词： Nonlinear postbuckling carbon nanotube reinforced composite cylindrical shell torsion auxetic core

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Monkeypox:A comprehensive review of a multifaceted virus

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Infectious Medicine 2023年第2期2卷 74-88页

作者： Randa Elsheikh Abdelrahman M.Makram Tamilarasy Vasanthakumaran Shubham Tomar Khizer Shamim Nguyen dong Tranh Sara S.Elsheikh Nguyen Thanh Van Nguyen tien Huy Deanery of Biomedical Sciences at Edinburgh Medical School University of EdinburghEdinburgh EH105HFUnited Kingdom Online Research Club(http://***) Nagasaki 852-8523Japan School of Public Health Imperial College LondonLondon SW72BXUnited Kingdom Global Clinical Scholars Research Training Harvard Medical SchoolBostonMA 02115USA Tata Memorial Hospital Varanasi 400012India DataQ Health Karachi 75100Pakistan Department of Infection Control Binh Dinh Provincial General HospitalBinh Dinh 55000Vietnam Faculty of Medicine Zagazig UniversityZagazig 44519Egypt School of Tropical Medicine and Global Health Nagasaki UniversityNagasaki 852-8523Japan

In May 2022,the world witnessed the re-emergence of the zoonotic disease *** this was not the first epidemic of this disease,what differentiated the outbreak was the rapid global spread and increase of cases,which led the WHO to declare monkeypox a global health *** the disease spreads mainly through inadequately cooked meat of various rodent species,this virus also shows droplet,respiratory,sexual,and even vertical *** further multiplies in lymphoproliferative organs and presents with a classical smallpox-like rash,fever,headache,and muscle *** is confirmed with a polymerase-chain-reaction test and is managed largely supportively with possible usage of some antivirals and ***,some pre-exposure and postexposure prophylactic vaccines have been *** paper aims to conduct an in-depth review of the historical epidemics,transmission,pathophysiology,clinical presentation,and management of the monkeypox disease.

关键词： Monkeypox Orthopoxvirus Outbreak Smallpox

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An improved parallel contrast-aware halftoning

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第12期14卷 918-929页

作者： Ling-yue LIU Wei CHEN tien-tsin WONG Wen-ting ZHENG Wei-dong GENG State Key Lab of CAD & CG Zhejiang University Department of Computer Science and Engineering The Chinese University of Hong Kong

Digital image halftoning is a widely used technique. However, achieving high fidelity tone reproduction and structural preservation with low computational time cost remains a challenging problem. This paper presents a highly parallel algorithm to boost real-time application of serial structure-preserving error diffusion. The contrast-aware halftoning approach is one such technique with superior structure preservation, but it offers only a limited opportunity for graphics processing unit(GPU) acceleration. Our method integrates contrast-aware halftoning into a new parallelizable error-diffusion halftoning framework. To eliminate visually disturbing artifacts resulting from parallelization, we propose a novel multiple quantization model and space-filling curve to maintain tone consistency, blue-noise property, and structure consistency. Our GPU implementation on a commodity personal computer achieves a real-time performance for a moderately sized image. We demonstrate the high quality and performance of the proposed approach with a variety of examples, and provide comparisons with state-of-the-art methods.

关键词：半色调感知平行串行结构实时应用程序图形处理单元空间填充曲线数字图像

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A New Species of Amsassia from the Ordovician of Korea and South China:Paleobiological and Paleogeographical Significance

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Acta Geologica Sinica(English Edition) 2016年第3期90卷 796-806页

作者： Mirinae LEE Heeju PARK Nguyen Viet tien Suk-Joo CHOH Robert J.ELIAS dong-Jin LEE Department of Earth and Environmental Sciences Andong National UniversityAndong36729Republic of Korea Institute of Geological Sciences-Vietnam Academy of Science and Technology(IGS-VAST) Hanoi100000Socialist Republic of Vietnam Department of Earth and Environmental Sciences Korea UniversitySeoul02841Republic of Korea Department of Geological Sciences The University of ManitobaWinnipegR3T 2N2Canada

A new species of the probable calcareous alga Amsassia, A. koreanensis, is recognized from the Duwibong Formation （Middle Ordovician, Darriwilian） of the Taebaeksan Basin in mid-eastern Korea. This is the first report of the genus from the Korean Peninsula, expanding its geographical range to the eastern Sino-Korean Block. The new species also occurs in the Xiazhen Formation （Upper Ordovician, Katian） at Zhuzhai in the South China Block. Amsassia koreanensis is the smallest species of this modular genus, having a maximum module diameter of 0.28 ram. Module increase is by bipartite, tripartite and quadripartite types of longitudinal axial fission, but unlike other species of the genus, quadripartite fission is common. The types of fission are comparable to those in some Tetradiida （now Prismostylales, florideophycean rhodophyte algae）, although the processes of fission are different. The distribution of A. koreanensis further strengthens the biogeographical connection between the Sino-Korean and South China blocks, suggesting that these two paleocontinents were located closer together during the Middle to Late Ordovician than previously speculated.

关键词： Amsassia koreanensis sp. nov. Ordovician Sino-Korean Block South China Block paleobiology paleogeography.

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