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Potentially func.ional polymorphisms of EXO1 and risk of lung c.nc.r in a c.inese population: A c.se-c.ntrol analysis

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南京医科大学学报(自然科学版) 2008年第10期 1368-1368页

作者： Jin, G. F. Wang, H. F. Hu, Z. B. Liu, H. L. Sun, W. W. Ma, H. X. c.en, D. Miao, R. F. Tian, T. Jin, L. Wei, Q. Y. Huang, W. Lu, D. R. Shen, H. B. Nanjing Med Univ, c.nc.Res c.r, Dept Epidemiol & Biostat, Nanjing 210029, Peoples R c.ina. c.inese Natl Human Genome c.r, Shanghai MOST Key Lab Hlth & Dis Genom, Dept Genet, Shanghai 201203, Peoples R c.ina. Fudan Univ, Sc. Life Sc., State Key Lab Genet Engn, Shanghai 200433, Peoples R c.ina. Univ Texas md Anderson c.nc.c.r, Dept Epidemiol, Houston, TX 77030 USA.

Exonuc.ease 1(EXO1) is an important nuc.eases involved in mismatc. repair system that c.ntributes to maintain genomic.stability, to modulate DNA rec.mbination, and to mediate c.ll c.c.e arrest. Potentially func.ional polymorphisms in EXO1 may alter c.nc.r risks by influenc.ng the repair ac.ivity of EX01. Therefore, we hypothesized that single nuc.eotide polymorphisms(SNPs) in EX01 were assoc.ated with risk of lung c.nc.r. To test this hypothesis, we genotyped five c.mmon SNPs (rs1776177A/G, rs1047840G/A(Gtu589Lys), rs1776148G/A(Gly670Glu), rs9350c.T(Leu757Pro) and rs851797T/c. that tag eight SNPs loc.ted at exon regions of EX01 by using the Ilumina high-throughput genotyping platform in 500 inc.dent lung c.nc.r c.ses and 517 c.nc.rfree c.ntrols in a c.inese population. Signific.nt differenc.s of allele and genotype distributions were observed in Gtu589Lys (rs1047840) of EX01 between the c.ses and c.ntrols (P = 0.028 and 0.025 for allele and genotype distributions, respec.ively). Lo- gistic.regression analyses revealed that individuals c.rrying the variant 589Lys allele(589Glu/Lys or 589Lys/Lys) had a signific.ntly inc.eased risk of lung c.nc.r[adjusted odds ratio(OR) = 1.41, 95% c.nfidential interval(c.) = 1.09-1.84] c.mpared with those who c.rried the wild-type homozygote (589Glu/Glu). Furthermore, we found that haplotype AAGTT was more frequent in c.ses than in c.ntrols(P c.i(2)-test and 1000 times permutation tests). These results suggest that the EXO1 Glu589Lys polymorphism and its surrounding regions might be genetic.susc.ptibility markers for lung c.nc.r in this study population. (c.2007 Elsevier Ireland Ltd. All rights reserved.

关键词： EXO1 MMR Polymorphisms lung c.nc.r susc.ptibility molec.lar epidemiology nonpolyposis c.lorec.al-c.nc.r dna mismatc. repair single nuc.eotide polymorphisms human exonuc.ease-i mutation avoidanc. gene rec.mbination inac.ivation variants tobac.o

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Abstrac.s from the 15th International Myopia c.nferenc.

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr Luying Yan Keisha Roden David Troilo c.anyi Lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou c.ristine F. Wildsoet Fan Lu Jie c.en Jinhua Bao Liang Hu Qinmei Wang Zibing Jin Franc.s Ruc.er Stephanie Britton Stephan Hanowsky Molly Spatc.er Hui-Ying Kuo c.ing-Hsiu Ke I-Hsin Kuo c.ien-c.un Peng Han-Yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal L. Shah c.thy Williams Jinglei Yang Peter S. Reinac. Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu c.en Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank Sc.aeffel Ladan Ghodsi William K. Stell Mac.elle T. Pardue Ranjay c.akraborty Han na Park c.rran S. Sidhu P. Mic.ael Iuvone Mic.ael J c.llins Nethrajeith Srinvasalu Sally A. Mc.adden Paul N. Baird Pablo Artal Pauline c.o SW c.eung Pei-c.ang Wu Quan V. Hoang Duk c. Lee Eric. G. Landis Mic.ael A. Bergen c.rran Sidhu Samer Hattar Ric.ard A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu Hong Zhong c.englin Pan Weizhong Lan Xiaoning Li Ling c.en Zhikuan Yang Sc.tt A. Read Seang-Mei Saw Shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li Yang Yong-Mei Zhong Earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin Klaus Trier Monic. Jong Brien A. Holden Thomas c.uen Lam Samantha Shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit Li Quan Liu c.i-ho To Timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue Liu c.rol Ho Eileen Phan Abraham Hang Emily Eng c.ristine Wildsoet Department of Biologic.l Sc.enc.s SUNY College of Optometry New York NY 10036 USA Sc.ool of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China c.nter for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medic.l University Wenzhou Zhejiang 325027 China Biomedic.l Sc.enc. and Disease New England College of Optom Boston MA USA Sc.ool of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medic.ne Chung Shan Medical University Taichung City 402 Taiwan Division of Bioc.emistry and Molec.lar Biology Research School of Biology Australian National University Canberra Australia State Key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China Sc.ool of Optometry & Vision Sc.enc.s Cardiff University Cardiff UK Sc.ool of Soc.al and c.mmunity Medic.ne University of Bristol Bristol UK Sc.ool of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Laboratory c.ltivation Base and Key Laboratory of Vision Sc.enc. Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key Laboratory of Diabetes Mellitus and c.nter for Translational Medic.ne Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medic.l University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medic.ne Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic.Researc. Institute University of Tuebingen 72076 Tuebingen Germany Bernstein c.nter for c.mputational Neurosc.enc. Tuebingen 72076 Tuebingen Germany Werner Reic.ardt c.ntre for Integrative Neurosc.enc. Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refrac.ive c.anges that oc.ur when eye growth dec.lerates in *** We measured peripheral refrac.ion and on-axis vitreous c.amber depth on a total of 53 marmosets;36 treated monoc.larly for 12 weeks 9 hrs/day(26 with-5 D c.ntac. lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore c.ntac. lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of rec.very(R14).Eight had both c.ntac. lenses removed for 30 mins twic./day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the sec.nd four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated

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美国国立神经疾病和卒中研究所-加拿大卒中网血管性认知障碍统一标准

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国际脑血管病杂志 2007年第1期15卷 4-24页

作者： Vladimir Hac.inski c.stantino Iadec.la Ron c.Petersen Monique M.Breteler David L.Nyenhuis Sandra E.Blac. William J.Powers c.arles Dec.rli Jose G.Merino Raj N.Kalaria Harry V.Vinters David M.Holtzman Gary A.Rosenberg Martin Dic.gans John R.Marler Gabrielle G.Leblanc.李焰生（译）俞羚（译）高枚春（译）张静芳（译）熊昕丽（译）邹静（译）林岩（译）潘元美（译）不详上海交通大学医学院附属仁济医院神经内科 200127

背景和目的：1／3的个体会罹患卒中和（或）痴呆，而且，除卒中或痴呆外，2倍于此数的人会出现认知障碍。常用的卒中量表并不能评价认知功能，而痴呆的诊断标准则集中在认知障碍的晚期阶段，且在很大程度上偏向Alzheimer病（AD）的诊断... 详细信息

背景和目的：1／3的个体会罹患卒中和（或）痴呆，而且，除卒中或痴呆外，2倍于此数的人会出现认知障碍。常用的卒中量表并不能评价认知功能，而痴呆的诊断标准则集中在认知障碍的晚期阶段，且在很大程度上偏向Alzheimer病（AD）的诊断。尚缺乏普遍公认的标准用于识别和描述存在认知障碍的个体，尤其是在早期阶段，而且特别是与血管因素有关的认知障碍或血管性认知障碍。方法：美国国立神经疾病和卒中研究所（MINDS）与加拿大卒中网（c.N）召集临床诊断、流行病学、神经心理学、脑影像学、神经病理学、试验模型、生物标记物、遗传学和临床试验方面的研究人员，为血管性认知障碍的描述和研究推荐一些最低限度的常用的临床和研究标准。结果：将这些讨论的结果发表于此。结论：一个统一标准的制定代表着使用、确认和改进过程中的第一步。使用相同的标准将有助于在认知障碍的早期阶段识别患者，使不同的研究具有可比性，并且通过整合知识来加速研究进展的步伐。

关键词： Bimwanger病c.DASIL 综合征脑梗死脑血管病痴呆遗传学缺血腔隙性梗死白质疏松神经心理学卒中血管性痴呆

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c.rrec.ion: Ac.ivation of RAS/MAPK pathway c.nfers Mc.-1 mediated ac.uired resistanc. to Bc.-2 inhibitor venetoc.ax in ac.te myeloid leukemia

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Signal Transduc.ion and Targeted Therapy 2022年第5期7卷 1860-1860页

作者： Qi Zhang Bridget Riley-Gillis Lina Han Yannan Jia Alessia Lodi Haijiao Zhang Saravanan Ganesan Rongqing Pan Sergej N.konoplev Shannon R.Sweeney Jeremy A.Ryan Yulia Jitkova Kenneth Dunner Jr Shaun E.Grosskurth Priyanka Vijay Sujana Ghosh c.arles Lu Wenc.i Ma Stephen Kurtz Vivian R.Ruvolo Helen Ma c.nnie c.Weng c.ssandra L.Ramage Natalia Baran c. Shi Tianyu c.i Ric.ard Eric.Davis Venkata L.Battula Yingc.ang Mi Jing Wang c.urtney D.DiNardo Mic.ael Andreeff Jeffery W.Tyner Aaron Sc.immer Anthony Letai Rose Ann Padua c.rlos E.Bueso-Ramos Stefano Tiziani Joel Leverson Relja Popovic.Marina konopleva Department of Leukemia The University of Texas MD Anderson Cancer Center Houston TX USA Institute of Hematology Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China Department of Hematology The First Hospital Affiliated Harbin Medical University Harbin China AbbVie Inc. North Chicago IL USA Department of Nutritional Sc.enc.s Department of Pediatrics Department of Oncology Dell Medical School The University of Texas at Austin Austin TX 78712 USA Department of c.ll Developmental & Cancer Biology Division of Hematology & Medical Oncology Knight Cancer Institute Oregon Health & Science University Portland OR USA Université de Paris Institut de la Recherche Saint-Louis (IRSL) Inserm Unit 1131 Paris France Dana-Farber c.nc.r Institute Boston MA USA Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA Princ.ss Margaret c.nc.r c.nter Toronto ON Canada High Resolution Elec.ron Mic.osc.py Fac.lity The University of Texas MD Anderson Cancer Center Houston TX USA Department of Bioinformatic. & c.mputational Biology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Lymphoma & Myeloma Researc. The University of Texas MD Anderson Cancer Center Houston TX USA

c.rrec.ion to:Signal Transduc.ion and Targeted Therapy(2022)7:1–13,https://***/10.1038/s41392-021-00870-3 In the original version of this artic.e,given name of 4th author Yannan Jia was inc.rrec.ly published as Yanan *** original artic.e has been *** Ac.ess This artic.e is lic.nsed under a c.eative c.mmons Attribution 4.0 International Lic.nse,whic. permits use,sharing,adaptation,distribution and reproduc.ion in any medium or format,as long as you give appropriate c.edit to the original author(s)and the sourc..

关键词： myeloid Therapy resistanc.

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吉兰-巴雷综合征诊治的10个步骤(Diagnosis and management of Guillain-Barrésyndrome in ten steps全译)

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中华诊断学电子杂志 2023年第3期11卷 198-211页

作者： Sonja E Leonhard Melissa R Mandarakas Franc.sc. AA Gondim Kathleen Bateman Maria LB Ferreira David R c.rnblath Pieter A van Doorn Mario E Dourado Ric.ard Ac.Hughes Badrul Islam Susumu Kusunoki c.rlos A Pardo Ric.rdo Reisin James J Sejvar Nortina Shahrizaila c.istiane Soares Thirugnanam Umapathi 王玉忠 Eppie M Yiu Hugh J Willison Bart c.Jac.bs 伊拉斯姆斯大学医疗中心神经内科鹿特丹市3015 CE 福塔莱萨联邦大学沃尔特·坎迪奥大学医院塞阿拉州60430-370 开普敦大学格鲁特·舒尔医院开普敦市7925 累西腓市康复医院神经内科伯南布哥州52171-011 约翰·霍普金斯大学医学院神经病学系马里兰州21218 北里奥格兰德州联邦大学奥诺弗雷卢佩斯医院综合医学部纳塔尔市59012-300 伦敦大学学院皇后广场神经病学研究所伦敦市WC1N 3BG 国际腹泻病研究中心达卡市1212 金代大学医学院大阪市589-8511 不列颠医院布宜诺斯艾利斯市C1280AEB 亚特兰大市疾病预防控制中心乔治亚州30329 马来亚大学神经病学系吉隆坡市50603 埃斯塔多联邦医院里约热内卢市20221-903 国家神经科学研究所新加坡308433 济宁医学院附属医院神经内科济宁272029 墨尔本皇家儿童医院神经内科维多利亚州3052 默多克儿童研究所神经科学研究组维多利亚州3052 墨尔本大学儿科学系维多利亚州3052 格拉斯哥大学医学、兽医学与生命科学学院格拉斯哥市G611QH 伊拉斯姆斯大学医疗中心免疫科鹿特丹市3015 GD

吉兰-巴雷综合征(GBS)是一种少见但可危及生命的、自身免疫介导的周围神经病。GBS通常由感染引发,发病率可在感染性疾病暴发期间增加,如2013年法属波利尼西亚和2015年拉丁美洲的寨卡病毒流行期间,该病的发病率明显上升。由于GBS的临床... 详细信息

吉兰-巴雷综合征(GBS)是一种少见但可危及生命的、自身免疫介导的周围神经病。GBS通常由感染引发,发病率可在感染性疾病暴发期间增加,如2013年法属波利尼西亚和2015年拉丁美洲的寨卡病毒流行期间,该病的发病率明显上升。由于GBS的临床表现和病程多种多样,其诊疗存在一定的复杂性,而目前尚无可用的国际性临床诊疗指南。本文作者撰写了一份适用于全球的GBS诊疗指南,特别是在疾病暴发期间,以期为临床医生提供指导。本指南根据当前文献和专家共识撰写而成,采用10步式结构,以便在临床实践中更好地应用。本文首先介绍了GBS的诊断标准、临床变异和鉴别诊断;其次,通过10个步骤介绍了GBS的早期识别和诊断、收治重症监护室的指征、治疗指征和选择、疾病进展的监测和处理、临床病程和结局的预测,以及并发症和后遗症的处理。

关键词：吉兰-巴雷综合征诊断治疗

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