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Chinese Chemical Letters 2007年第5期18卷 548-550页

作者： Yu Wang Wen Yuan Gao tie jun zhang Yuan Qiang Guo College of Pharmaceuticals and Biotechnology Tianjin University Tianjin 300072 China Tianjin Institute of Pharmaceutical Research Tianjin 300193 China Department of Pharmaceutical Sciences Nankai University Tianjin 300071 China

A novel phenylpropanoid glycosides 1, named parispolyside E and a novel derivation of phenolic glycoside 2, named parispolyside G, as well as two known flavonoid glycosides were isolated from the rhizome of Paris poly... 详细信息

关键词： Paris polyphylla var. yunnanensis Phenylpropanoid glycosides Phenolic glycoside Parispolyside F Parispolyside G

A new macrolide and glycosides from the stem of Sargentodoxa cuneata

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Chinese Chemical Letters 2009年第11期20卷 1339-1341页

作者： Zhi Xian Chen Dai Lin Liu Wen Yuan Gao tie jun zhang School of Pharmaceutical Science and Technology 7ianjin University Tianjin 300072 China pharrnacognosy Laboratory Wujing Medical College lianjin 300162 China Tianjin Institute of Pharmaceutical Research Tianjin 300072 China

A new macrolide glycoside, cuneataside F was isolated from the n-butanol extract of the stem of Sargentodoxa cuneata. The structure was elucidated on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectrosco... 详细信息

关键词： Sargentodoxa cuneata Sargentodoxaceae Glycosides Cuneataside F

A novel alkenoic acid ester and a new benzophenone from Ranunculus ternatus

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Chinese Chemical Letters 2007年第11期18卷 1364-1366页

作者： Ying Xiong Ke Zhong Deng Wen Yuan Gao Yuan Qiang Guo tie jun zhang School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 China Jiangxi University of Traditional Chinese Medicine Nanchang 330006 China Department of Pharmaceutical Sciences Nankai University 7ianjin 300071 China Tianjin Institute of Pharmaceutical Research Tianjin 300193 China

A novel alkenoic acid ester, （E）-4-hydroxy-dodec-2-enedioic acid-12-O-methyl ester and a new benzophenone, ethyl （S）-3-[2- （3,4-dihydroxybenzoyl）-4,5-dihydroxyphenyl]-2-hydroxypropanoate, together with a known compound, （E）-4-hydroxy-dodec-2- enedioic acids were isolated from the roots of Ranunculus ternatus. Their structures were elucidated by spectroscopic methods.

关键词： Ranunculus ternatus Alkenoic acid ester Benzophenone

Two new α,β-unsaturated butyrolactone derivatives from Pleione bulbocodioides

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Chinese Chemical Letters 2007年第9期18卷 1075-1077页

作者： Xin Qiao Liu Wen Yuan Gao Yuan Qiang Guo tie jun zhang Lu Lu Yan School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 China Department of Pharmaceutical Sciences Nankai University Tianjin 300071 China Tianjin Institute of Pharmaceutical Research Tianjin 300193 China

Two new α,β-unsaturated butyrolactone derivatives, 4-(4″-hydroxybenzyl)-3-(3′-hydroxy-phenethyl)furan-2(5H)-one (1) and 3-(3′-hydroxyphenethyl)furan-2(5H)-one (2), together with one known phenolic compound (3), were isolated from the tubers of Pleione bulbocodioides (Franch.) Rolfe. Their structures were elucidated by analysis of spectroscopic data.

关键词： Pleione bulbocodioides α,β-Unsaturated butyrolactone Phenolic compound

A new triterpenoid from Alisma orientalis

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Chinese Chemical Letters 2008年第4期19卷 438-440页

作者： Xue Yan Hu Yuan Qiang Guo Wen Yuan Gao Hai Xia Chen tie jun zhang School of Pharmaceutical Science and Technology Tianjin UniversityTianjin 300072China Department of Pharmaceutical Sciences Nankai UniversityTianjin 300071China Tianjin Institute of Pharmaceutical Research Tianjin 300193China

A new triterpenoid,named 11,25-aahydro-alisol E was isolated from the rhizomes of Alisma orientalis together with nine known *** structures were elucidated by spectroscopic *** compounds showed weak anti-tumor activit... 详细信息

关键词： Alisma orientalis Triterpcnoid 11,25-Anhydroalisol F

A new phenanthro [2,3-b] furan from Pleione bulbocodioides

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Chinese Chemical Letters 2007年第9期18卷 1089-1091页

作者： Xin Qiao Liu Wen Yuan Gao Yuan Qiang Guo tie jun zhang Lu Lu Yan School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 China School of Chemical and Environmental Engineering Hubei University of Technology Wuhan 430068 China Department of Pharmaceutical Sciences Nankai University Tianjin 300071 China Tianjin Institute of Pharmaceutical Research Tianjin 300193 China

A novel phenanthro [2,3-b] furan 1, named (3-hydroxy-9-(4′-hydroxy-3′-methoxyphenyl)-11-methoxy-5,6,9,10-tetrahydrophenanthro [2,3-b] furan-10-yl) methyl acetate, and two known phenolic compounds were isolated from ... 详细信息

关键词： Pleione bulbocodioides Phenanthro [2,3-b] furan Phenolic compounds Cytotoxity

Rapid Analysis and Identification of Absorbed Components and Their Metabolites of Yuanhu Zhitong Dropping Pill in Rat Plasma and Brain Tissue Using UPLC-Q-TOF/MS with Multivariate Statistical Analysis

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Chinese Herbal Medicines 2016年第2期8卷 154-163页

作者： Hong-bing zhang tie-jun zhang jun Xu Xi-min zhang Ya-zhuo Li Chang-xiao Liu School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical Research Gansu Longshenrongfa Pharmaceutical Co. Ltd.

Objective To establish an effective approach for rapid and comprehensive analysis on the absorbed and metabolic components in rats after ig administration of Yuanhu Zhitong Dropping Pill（YHZT）. Methods Based on the combination of UPLC-Q-TOF/MS and multivariate statistical analysis, the absorbed prototype constituents and their metabolites in rat plasma were rapidly analyzed and identified, and the components absorbed into brain were further identified by comparing the extracted ion chromatograms（EICs） of control and brain tissue samples of dosed rats. Results A total of 38 YHZT-related xenobiotic compounds were detected and identified as the potential bioactive constituents in rat plasma, including 24 absorbed prototype constituents and 14 metabolites. In particular, of all prototype constituents, 14 were also detected in rat brain tissue, indicating that they could penetrate the blood-brain barrier and enter into brain. Conclusion An effective method is established and applied to analyze the potential bioactive constituents in YHZT, which provides a pathway to further investigate the pharmacological pattern and mechanism of YHZT.

关键词： metabolites multivariate statistical analysis prototype constituents UPLC-Q-TOF/MS Yuanhu Zhitong Dropping Pill

Advances in Studies on Pharmacological Functions of Ligustilide and their Mechanisms

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Chinese Herbal Medicines 2012年第1期4卷 26-32页

作者： Jin-ying YANG[a] Hu-hu CHEN[a] Jiang WU[b] Su-xiao GONG[b] Chang-qing CHEN[b] tie-jun zhang[b] Min-jie WANG[c] Tianjin University of Traditional Chinese Medicine Tianjin 300193 China

The article reviewed the research progress of ligustilide in recent years and elaborated its pharmacological functions and mechanisms in detail, especially in ischemic brain injury. Its mechanism includes reducing cerebral infarct volumes and improving neurobehavioral deficits, anti-oxidant and anti-apoptosis, antithrombotic activity, calcium channel blockers function, and effect on erythropoietin. Other pharmacological effects of ligustilide including inhibiting vascular smooth muscle cell proliferation, anti-inflammatory and analgesic effects, effects on LPS-induced endotoxic shock, inhibiting constriction effect, suppression of the central nervous system, and ameliorating the memory impairment induced by scopolamine and so on, are also introduced. Ligustilide has potential pharmacological value, which provides a reference for its further research and development.

关键词： cerebral infarct ischemic brain injury ligustilide neurobehavioral deficit pharmacological function and mechanism

Inhibitory effect of extracts of Ginkgo biloba leaveson VEGF-induced hyperpermeability of bovine coronary endothelial cells in vitro

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Acta Pharmacologica Sinica 2004年第10期 66-71页

作者： Yan QIU, Yao-cheng RUI, tie-jun LI, Li zhang, Peng-yuan YANG Department of Pharmacology, School of Pharmacy, Second Medical Military University, Shanghai 200433, China

AIM: To study whether extract of Ginkgo biloba (EGb) can protect against atherosclerosis. METHODS: Confluent monolayers of bovine coronary endothelial cells (BCECs), bovine coronary smooth muscle cells (BCSMCs), and cocultures of the two were incubated with medium containing VEGF and/or EGb, and flux of 125I-labeled oxidized low density lipoprotein (ox-LDL) across the monolayers was measured. RESULTS: Incubation with VEGF significantly increased the permeability of BCEC monolayers to 125I-ox-LDL in a time- and concentration-dependent manner, but had no effect on permeability of BCSMCs or endothelial cells-smooth muscle cells cocultures. EGb significantly inhibited the VEGF-induced hyperpermeability of BCECs. CONCLUSION: VEGF was important in the formation and development of atherosclerosis. The inhibition of VEGF-induced permeability by EGb suggests that extracts of Ginkgo biloba leaves may have important clinical applications in the treatment of cardiovascular diseases.

关键词： Ginkgo biloba vascular endothelium coronary vessals vascular endothelial growth factor capillary permeability iodine radioisotopes LDL lipoproteins

Anti-mutagenicity of Swertiamarin and Its Metabolite in Incubated System of Human Intestinal Flora

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Chinese Herbal Medicines 2017年第1期9卷 92-95页

作者： Cheng-wang Tian Ya-ting Cheng tie-jun zhang Xiu-wei Yang Tianjin Institute of Pharmaceutical Research Tianjin 300193 China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin 300193 China National ＆ Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine Tianjin 300193 China School of Science Tianjin University Tianjin 300072 China The State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing 100083 China

Objective To study the biotransformation regulation and pharmacological effect of swertiamarin and its metabolite in incubated system of human intestinal flora. Methods Incubated system of human intestinal flora was utilized to research the intestinal metabolism of swertiamarin. Furthermore, mutagenic test and anti-mutagenic test were carried out to research the activity relationship of swertiamarin and its metabolite. Results Gentianine was found in the metabolites of swertiamarin. The pharmacological experiment indicated that swertiamarin and its metabolite both had good anti-mutagenic effect. Conclusion Swertiamarin is partly metabolized to gentianine after oral administration. They show similar anti-mutagenicity effects.

关键词： anti-mutagenicity biotransformation human intestinal flora swertiamarin