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Validity and reliability of the Ocular Motor Nerve Palsy Scale

Neural Regeneration Research 2018年第10期13卷 1851-1856页

作者： Ling-Yun Zhou Chang Su tie-juan liu Xue-Mei Li Ocular Motility Disorder Treatment & Rehabilitation Center Department of AcupunctureFirst Affiliated Hospital of Harbin Medical University

Objective and accurate assessment of the degree of ocular motor nerve palsy is helpful not only in the evaluation of prognosis, but also for the screening of treatment methods. However, there is currently no comprehensive measure of its severity. In this study, we designed the Ocular Motor Nerve Palsy Scale and investigated its validity and reliability. Six experts were invited to grade and evaluate the scale. The study recruited 106 patients with a definite diagnosis of unilateral isolated ocular motor nerve palsy. Three physicians evaluated the patients using the scale. One of the three physicians evaluated the patients again after 24 hours. The content validity index（CVI） and factor analysis were used to analyze the scale＇s construct validity. The intraclass correlation coefficient and Cronbach＇s alpha were used to evaluate the inter-rater and test-retest reliability and the internal consistency. The CVI results（I-CVI = 1.0, S-CVI = 0.9, Pc = 0.016, K＊ = 1） indicated good content validity. Factor analysis extracted two common factors that accounted for 85.2% of the variance. Furthermore, the load value of each component was above 0.8, indicating good construct validity. The Ocular Motor Nerve Palsy Scale was found to be highly reliable, with an inter-rater reliability intraclass correlation coefficient of 0.965（P 0.01）, a test-retest reliability intraclass correlation coefficient of 0.976（P 0.01）, and Cronbach＇s alpha values of 0.63–0.70. In conclusion, the Ocular Motor Nerve Palsy Scale with good validity and reliability can be used to quantify the severity of ocular motor nerve palsy. This study was registered at Chinese Clinical Trial Registry（registration number： Chi CTR-OOC-17010702）.

关键词： nerve regeneration Ocular Motor Nerve Palsy Scale oculomotor nerve paralysis abducens nerve paralysis trochlear nerve paralysis validity reliability internal consistency diplopia eyeball movement disorder ptosis neural regeneration

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Adult reference values of the computerized diplopia test

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International Journal of Ophthalmology(English edition) 2016年第11期9卷 1646-1650页

作者： Ling-Yun Zhou tie-juan liu Xue-Mei Li Ocular Motility Disorder Treatment Centre the First Affiliated Hospital of Harbin Medical University

AIM： To estimate the adult reference values for measured deviations by a computerized diplopia test and testify the ***： Totally 391 participants were recruited and taken the computerized diplopia test. The plots and amplitude of deviations were recorded. The differences in different gender, age and visual acuity groups were analyzed respectively. Of 30 subjects were enrolled to testify the interobserver reliability. Another 46 subjects（including 26 normal subjects and 20 patients） were taken the test and theirs deviations were recorded to testify the validity of the reference ***： The max horizontal and vertical deviations were 2.55° and 0.76° with normal corrected visual acuity while 3.88° and 1.46° for subjects with poor corrected vision. The differences between age groups was insignificant（Z =3.615, 4.758; P =0.461, 0.313 for horizontal and vertical respectively）. The max horizontal deviation of female was smaller than male（Z =-2.177; P =0.029）,but the difference in max vertical deviation was insignificant（Z =-1.296; P =0.195）. The mean difference between observers were both-0.1°, with 95% confidence limits（CI） of-1.4° and 1.6° in max horizontal deviations while-2.1° and 1.8° in max vertical deviation. The mean deviation of 26 normal subjects was 1.02° ±0.84° for horizontal and 0.47° ±0.30° for vertical which both within the range of reference values. The mean deviation of 20 patients was 13.51°±11.69° for horizontal and 8.34°±8.58°for vertical which both beyond the reference ***： The max amplitude of horizontal and vertical deviation is pointed as the numerical parameters of computerized diplopia test. The reference values are different between normal corrected visual acuity and poor corrected vision. These values may useful for evaluating patients with diplopia in veriety conditions during clinical practice.

关键词： computerized diplopia test referencevalues amplitude of deviations

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Efficacy of intraorbital electroacupuncture for diabetic abducens nerve palsy： study protocol for a prospective single-center randomized controlled trial

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Neural Regeneration Research 2017年第5期12卷 826-830页

作者： Ling-yun Zhou Xue-mei Li tie-juan liu Xiao-jie Ji Ming Zhao Chang Su Ji-chao liu Jiang-yun Sun Ocular Motility Disorder Treatment & Rehabilitation Center Department of Acupuncture the First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang Province China

Abducens nerve palsy（ANP） is commonly seen in patients with diabetes mellitus. The validity of acupuncture as a traditional Chinese medicine method in peripheral nerve repair is well established. However, its efficacy in randomized controlled trials remains unclear. Herein, we designed a protocol for a prospective, single-center, randomized controlled trial to investigate the effect of intraorbital electroacupuncture on diabetic ANP. We plan to recruit 60 patients with diabetic ANP, and randomly divide them into treatment and control groups. Patients in both groups will continue their glucose-lowering therapy. A neural nutrition drug will be given to both groups for six weeks. The treatment group will also receive intraorbital electroacupuncture therapy. We will assess efficacy of treatment, eyeball movement, diplopia deviation and the levels of fasting blood-glucose and glycosylated hemoglobin before treatment at 2, 4, and 6 weeks after treatment. The efficacy and recurrence will be investigated during follow-up（1 month after intervention）. This protocol was registered at Chinese Clinical Trial Registry on 16 January 2015（Chi CTR-IPR-15005836）. This study was approved by the Ethics Committee of First Affiliated Hospital of Harbin Medical University of China（approval number： 201452）. All protocols will be in accordance with Declaration of Helsinki, formulated by the World Medical Association. Written informed consent will be provided by participants. We envisage that the results of this clinical trial will provide evidence for promoting clinical use of this new therapy for management of ANP.

关键词： nerve regeneration sixth cranial nerve peripheral nerve injury electroacupuncture diabetes mellitus eyeball movement diplopia rehabilitation ocular motility disorder intervention randomized controlled trail neural regeneration

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A new interpretation and quantitative method for diplopia test： 304 cases of ocular motor nerve palsy for clinical test and verify

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International Journal of Ophthalmology(English edition) 2017年第11期10卷 1768-1770页

作者： Ling-Yun Zhou tie-juan liu Xue-Mei Li Chang Su Xiao-Jie Ji Ming Zhao Ocular Motility Disorder Treatment & Rehabilitation Center Acupuncture Department the First Affiliated Hospital of Harbin Medical University Harbin 150001 HeilongjiangProvince China

We introduce a new interpretation and quantitative method for computerized diplopia test. By comparing this new method to the Hess screen test, we validate its applicability among 304 patients with ocular motor nerve palsy. This new method shows great assistant value as the Hess screen test in making accurate diagnosis and quantitative evaluation the severity of diplopia. Furthermore, it is more convenient and suitable for daily clinical use.

关键词： diplopia test interpreting and scoring method Hess charts ocular motor nerve palsy max angle of diplopia

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Synthesis of faveolate open-structured Ru-N/C cathode catalyst with high bifunctional activity for rechargeable quasi-solid-state Li-O_(2)batteries

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Nano Research 2025年第1期18卷 351-361页

作者： tie liu School of Chemistry and Chemical Engineering Heze UniversityHeze 274015China

The constituents and geometric design of cathodic electrocatalyst to achieve high activity and durability are effective but challenging for the development of high-performance Li-O_(2)*** study employs a mild solution precipitation method followed by thermolysis to construct a faveolate open-structured Ru-N/C matrix with a loosely braided network morphology as a bifunctional *** details prove that this hybrid structure is composed of ultrafine Ru globular nanoparticles(ca.2 nm)coated with an N-enriched carbon film and exhibits a valuable beehive through-hole character for rapid mass transport during oxygen redox *** synergistic effect of open-structured and reticular network matrix with metal-N4 coordination induces asymmetric charge distributions with moderate adsorption/desorption behaviour with oxygen ***,this particular Ru-N/C matrix cathode provides a promising Li_(2)O_(2)accommodation space and exhibits superior electrochemical performance in terms of a positive discharge plateau and low charge ***,the assembled batteries also present a high discharge capacity and a long cycle life(exceeding 283 cycles).The density functional theory(DFT)calculations also corroborate the assertion that the Ru-N/C catalyst exhibits robust electronic coupling transfer and superior bifunctional *** such,our work demonstrates that this type of open-structured Ru-N/C matrix is promising for fabricating high-performance quasi solid-state Li-O_(2)batteries.

关键词： ruthenium nitride nitrogen-doped carbon electrocatalyst Li-O_(2)battery

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Effects of Intraorbital Electroacupuncture on Diabetic Abducens Nerve Palsy

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Chinese Medical Journal 2017年第14期130卷 1741-1742页

作者： Ling-Yun Zhou tie-juan liu Xue-Mei Li Chang Su Jin Zhou Ocular Motility Disorder Treatment Centre The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Hematology The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China

Diabetic abducens nerve palsy main symptoms include ocular motility disorders and *** disease is mainly caused by severe vascular *** is a serious impact on patient＇s quality of life and mental ***,there is no effective means of intervention for eye movement disorders and diplopia,the patients could only expect for neural self-repair.[1] Our team invented intraorbital electroacupuncture （IEA） therapy to repair abducens nerve affected by *** the meantime,we applied it into clinical practice and achieved great success.

关键词： Acupuncture Diabetic Abducens Nerve Palsy Diplopia Deviation Eyeball Movement

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Intraorbital Electroacupuncture Therapy for Thyroid-associated Ophthalmopathy

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Chinese Medical Journal 2017年第15期130卷 1884-1885页

作者： Ling-Yun Zhou Chang Su Xue-Mei Li tie-juan liu Ming Zhao Department of Acupuncture and Moxibustion The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China

To the Editor：Intraorbital electroacupuncture （IEA） therapy is highly effective in treating ocular motility disorders,but it has only rarely been used to treat thyroid-associated ophthalmopathy （TAO）.Herein,we report one successful case.A 54-year-old Chinese man was diagnosed with hyperthyroidism 4 years ago and received I[3] ***,the result was *** had to keep taking antithyroid drugs （ATDs）.His palpebral edema gradually worsened and he developed visual impairment during the ATD *** therapy was administered to relieve his ***,his condition worsened after a reduction in the glucocorticoid dosage.

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Rehabilitation of Abducens Nerve Palsy after Cholesteatoma Resection at Cerebellopontine Angle by Intraorbital Electroacupuncture

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Chinese Medical Journal 2017年第13期130卷 1625-1626页

作者： Ling-Yun Zhou Xue-Mei Li tie-juan liu Xiao-Jie Ji Ming Zhao Chang Su Harbin Med Univ Affiliated Hosp 1 Dept Acupuncture & Moxibust 199 Dongdazhi St Harbin 150001 Heilongjiang Peoples R China

To the Editor： A 20-year-old man reported with a complaint of diplopia for 10 days after a resection of cholesteatoma at left cerebellopontine angle （CPA）. One and half months before the surgery, the patient suddenly had a shock and unbearable pain on his left cheek with no obvious incentives. The patient did not have facial hypoesthesia, hearing loss, diplopia, and other symptoms such as nausea and vomiting. Two weeks later, the pain became deteriorated, was induced easily by touching or washing face,

关键词： Abducens Nerve Palsy Cholesteatoma Resection Cerebellopontine Angle

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Sora文生视频大模型对学术期刊出版的机遇、挑战及应对

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 79-88页

作者：刘娟新疆师范大学期刊社新疆乌鲁木齐830017

随着Sora文生视频大模型的迅猛发展,学术期刊出版正在经历深刻的变革与重塑。Sora技术的多模态特征与智能化能力,一方面促进学术信息的动态整合与开放获取,推动传统出版模式向协同创新与知识共享的新范式转型;另一方面,赋予著作权归属... 详细信息

随着Sora文生视频大模型的迅猛发展,学术期刊出版正在经历深刻的变革与重塑。Sora技术的多模态特征与智能化能力,一方面促进学术信息的动态整合与开放获取,推动传统出版模式向协同创新与知识共享的新范式转型;另一方面,赋予著作权归属和著作权风险治理等新的价值意蕴。面对Sora文生视频大模型对学术期刊出版带来的机遇和挑战,学术期刊应构建跨学科协作网络、重塑基于价值的学术评价标准、创新人才培养机制,强化全球学术出版治理。文本通过系统分析大语言模型、文生视频大模型驱动下的新兴学术生态,旨在为学术界提供理论视角和实践样态,实现知识生产的原创性与伦理性,推动学术出版在新技术环境中的学术治理现代化及可持续高质量发展。

关键词： Sora 学术期刊出版技术伦理学术伦理学术生态系统

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Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

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Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang juan Wang Zongjian liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

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