检索结果-南通市图书馆

Fluorescein angiography of retinal vascular involution after intravitreal injection of ranibizumab for retinopathy of prematurity

引用

International Journal of Ophthalmology(English edition) 2019年第1期12卷 79-82页

作者： Yong Cheng tie-gang liu Wei-Yi Li Ming-Wei Zhao Jian-Hong Liang Department of Ophthalmology Peking University People's Hospital Eye diseases and Optometry Institute Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases College of Optometry Peking University Health Science Center Clinical College of Ophthalmology Tianjin Medical University Tianjin Eye Hospital Tianjin Key Laboratory of Ophthalmology and Visual Science Tianjin Eye Institute Department of Ophthalmology Beijing Capital International Airport Hospital Eye Hospital China Academy of Chinese Medical Sciences College of Optometry Peking University Health Science Center

AIM: To describe the involution patterns of vessel growth of retina through fluorescein angiography(FA) of children, who had been under treatment up to 1 y previously intravitreal ranibizumab(IVR) as monotherapy for retinopathy of prematurity(ROP). METHODS: This is a retrospective study. The medical information and FA of 17 children(34 eyes) whose area of avascular retina from the ora serrata was more than two disc diameters(DD) were analyzed. RESULTS: Among 34 eyes, all were the presence of finger-shaped vessels and arteriolar-venular shunts(100%,34/34 eyes). Popcorn abnormalities were found in most of the eyes(94.1%, 32/34 eyes). Furthermore, in many cases(23.5%, 8/34 eyes), there were leakage persisting in the region of the junction between avascular and vascular retina. In contrast, just 2 eyes(5.9%) showed damage of retinal capillary bed and 3 eyes(8.8%) showed large area of retinal pigment epithelium(RPE) atrophy. CONCLUSION: Although IVR can be very effective in ROP, we should remain cautious as infants may remain avascular peripheral retinas and abnormal vessel. FA allows accurate visualization of vessel abnormalities in eyes with ROP, which will be helpful to affect assessment of disease activity and therapeutic effect.

关键词： retinopathy of prematurity fluorescein angiography anti-VEGF ranibizumab

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于极限学习机算法的学困生预测研究

引用

现代教育技术 2018年第4期28卷 34-40页

作者：李刚生高铁刚刘旭于海波中国海洋大学教育系山东青岛266100 沈阳师范大学教育技术学院辽宁沈阳110034 中国海洋大学工程学院山东青岛266100 中国海洋大学计算机基础部山东青岛266100

高校学困生预测方法的研究正越来越受到研究者的关注,但目前还没有一种成熟有效的学困生预测方法。针对该问题,文章提出了一种大数据环境下基于极限学习机的学困生预测方法,并以中国海洋大学2011级学生的学籍信息、心理测试得分、第一... 详细信息

高校学困生预测方法的研究正越来越受到研究者的关注,但目前还没有一种成熟有效的学困生预测方法。针对该问题,文章提出了一种大数据环境下基于极限学习机的学困生预测方法,并以中国海洋大学2011级学生的学籍信息、心理测试得分、第一学期考试成绩为输入变量,以学生的学困情况为输出变量,进行了极限学习机的训练;同时,以2012级学生数据作为测试集输入极限学习机进行测试。测试结果表明,约有46%的学困生被准确预测,7%的非学困生被误判,此预测结果验证了文章所采用方法的有效性。

关键词：学困生预测极限学习机

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

引用

Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li Zhang Zheng gang Zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Correlations of the expression of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

引用

World Journal of Gastrointestinal Oncology 2025年第1期17卷 207-213页

作者： Rong-gang Luan Ming-Da liu Zi-Feng Deng Cong-Lan Lu Mei-Ling Yu Ming-Yu Zhang Rong liu Ran An You-Liang Yao Dong-Bei Guo Yong-Xing Zhang Lei Zhao Department of Gastrointestinal Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102Fujian ProvinceChina Trauma Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina Department of Orthopaedics Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ***,reduced expression results in a loss of this capacity to facilitate cyclin E *** ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical *** To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBXW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon *** Expression levels of Cx43,SCFFBXW7,p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their *** Positive rate of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%*** expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node ***43 and SCFFBXW7(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCFFBXW7 and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(P<0.05),and expressions of the above proteins were positively correlated in colon *** Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCFFBXW7,thereby influencing the ubiquitination and degradation of cyclin E1.

关键词： Colon cancer Cx43 SCFFBXW7 Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CsI(Tl)闪烁探测器读出电路设计

引用

核电子学与探测技术 2016年第11期36卷 1138-1141页

作者：李元东葛良全张开琪侯铁钢邱腾刘毅孙坤盛磊成都理工大学地学核技术四川省重点实验室成都610051

介绍了配置于新型γ能谱仪的CsI(Tl)闪烁探测器的读出电路设计。输入缓冲级采用折叠嵌位电路,改善了系统频率特性并提高了输入阻抗;放大级采用自举电路,改善了系统动态性能并提高了开环增益;输出级采用电流源负载电路,改善了输出信号的... 详细信息

介绍了配置于新型γ能谱仪的CsI(Tl)闪烁探测器的读出电路设计。输入缓冲级采用折叠嵌位电路,改善了系统频率特性并提高了输入阻抗;放大级采用自举电路,改善了系统动态性能并提高了开环增益;输出级采用电流源负载电路,改善了输出信号的线性度并增强了系统的稳定性。实验表明:读出电路噪声为51.08 f C+1.97 f C/p F,时间漂移为0.112%,探头对137Cs源γ射线的输出信号信噪比可达23:1,能量分辨率可达4.98%。

关键词： CsI(Tl)探测器读出电路能谱响应输出波形能量分辨率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lower work function of thermoelectric material by ordered arrays

引用

Science China Chemistry 2016年第10期59卷 1264-1269页

作者： gang liu Zhenjie Xue Guiying Xu Cong Yan tie Wang Laboratory of Special Ceramics and Powder Metallurgy University of Science and Technology Beijing Beijing 100083 China Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

In this paper, PbTe nanocubes are assembled on Bi_(0.5)Sb_(1.5)Te_3 substrates with both ordered and disordered structures through a straightforward method to form a P-N section. The work function of such semiconductor system is then measured by the ultraviolet photoelectron spectroscopy. This results show that the work function of orderly arrayed PbTe deposition is much lower than the disordered assemblies. Such change of the work function provides the possibility to tune it in a P-N section system. The change of the work function is attributed to the less surface roughness and easier electron escaping in the ordered structures.

关键词： work function PbTe nanocubes Bi0.5Sb1.5Te3 P-N sections

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Editorial for rare metals, special issue on photocatalysis

引用

Rare Metals 2019年第5期38卷 359-360页

作者： tie-Rui Zhang gang liu Yong-Fa Zhu Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Department of Chemistry Tsinghua UniversityBeijing 100084China

Burning of fuels is an irreversible entropy increasing process,requiring additional energies derived from the environment to let the process *** theory,photon energy delivered from the sun could fix the huge energy demand in a clean and sustainable *** is such an ideal approach to reconvert inert molecules directly into fuels and other chemical feedstocks using photon energy without any other energy inputs.

关键词： irreversible entropy Editorial photocatalysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of Nitrogen Flow Ratio on the Microstructure, Composition, and Mechanical Properties of DC Magnetron Sputtered Zr-B-O-N Films

引用

Journal of Materials Science & Technology 2012年第11期28卷 981-991页

作者： tie-gang Wang Yanmei liu Tengfei Zhang Doo-In Kim KwanKHo Kim

Nanocrystalline ZrB2 film and nanocomposite Zr-B-O-N films were prepared by non-reactive as well as re- active magnetron sputtering techniques, respectively. By means of X-ray diffraction analysis, electron probe microanalysis, X-ray photoelectron spectroscopy, and scanning electron microscopy, the influence of nitrogen flow ratio on the film microstructure and characteristics were investigated systematically, including the depo- sition rate, chemical compositions, phase constituents, grain size, chemical bonding, as well as cross-sectional morphologies. Meanwhile, the hardness and adhesion of above films were also evaluated by micro-indentation method and a scratch tester. With increasing the nitrogen flow ratio, the deposition rate of above films de- creased approximately linearly, whereas the contents of N and O in the films increased gradually and tended to saturation. Moreover, the film microstructure was also altered gradually from a fine columnar microstructure to a featureless glass-structure. As the nitrogen flow ratio was 11.7%, the Zr-B-O-N film possessed an typical nanocomposite structure and presented good mechanical properties. During the process of reactive sputtering of metal borides, the introduction of nitrogen can show a pronounced suppression of columnar grain growth and strong nanocomposite structure forming ability.

关键词： Films DC magnetron sputtering Nanocomposite Microhardness Adhesion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prevalence of Helicobacter pylori infection in Chinese military personnel:A cross-sectional,multicenter-based study

引用

World Journal of Gastroenterology 2025年第3期31卷 42-49页

作者： Han-Chen Min Chun-Yan Zhang Fang-Yu Wang Xiao-Hui Yu Shan-Hong Tang Hong-Wu Zhu Ya-gang Zhao Ji-Luo liu Jian Wang Jing-Han Guo Xiao-Mei Zhang Yun-Sheng Yang Chinese People’s Liberation Army Medical School Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology and Hepatology The First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Sixth Healthcare Department The Second Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Gastroenterology General Hospital of Western Theater CommandChengdu 610011Sichuan ProvinceChina Department of Gastroenterology General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina Department of Epidemiology Naval Medical UniversityShanghai 200433China School of Medicine Nankai UniversityTianjin 300071China National Clinical Research Center for Geriatric Diseases Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Helicobacter pylori(***)infection is a prevalent disease encountered in military internal medicine and recognized as the main cause of dyspepsia,gastritis,and peptic ulcer,which are common diseases in military *** guidelines in China state all patients with evidence of active infection with *** are offered ***,the prevalence of *** infection and its regional distribution in the military population remain unclear,which hinders effective prevention and treatment *** the prevalence of *** infection in the military population will aid in the development of customized strategies to better manage this infectious *** To investigate the prevalence of *** infection in the Chinese military population in different geographic *** This multicenter,retrospective study included 22421 individuals from five tertiary hospitals located in north,east,southwest,and northwest cities of *** infection was identified using the urea breath test,which had been performed between January 2020 and December *** Of the 22421 military service members,7416(33.1%)were urea breath *** highest prevalence of *** was in the 30-39 years age group for military personnel,with an infection rate of 34.9%.The majority of infected subjects were younger than 40-years-old,accounting for 70.4%of the infected *** individuals serviced in Lanzhou and Chengdu showed a higher infection prevalence than those in Beijing,Nanjing,and Guangzhou,with prevalence rates of 44.3%,37.9%,29.0%,31.1%,and 32.3%,*** *** infection remains a common infectious disease among military personnel in China and has a relatively high prevalence rate in northwest China.

关键词： Helicobacter pylori Prevalence Military personnel Urea breath test Multicenter study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Serum inflammatory factor and cytokines in AECOPD

引用

Asian Pacific Journal of Tropical Medicine 2014年第12期7卷 1005-1008页

作者： tie-gang Jia Jian-Qing Zhao Jian-Hua liu Department of Respiratory Medicine First Affiliated Hospital of Hebei North University

Objective:To explore the serum levels of IL-32,*** and CRP in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:A total of 50 patients with AECOPD and 45 cases with acute asthma attack admitted from October 2013 to August 2014 were selected,and the serum levels of *** and CRP were determined and compaed by using Double antibody sandwich Enzyme linked immunosorbent assay,immunofluorescence double antibody sandwich assay and immunoturbidimetry ***:Serum levels of *** and CRP were significantly higher in AECOPD group than acute asthma attack group(Ptients was increased more ***:Serum levels of IL-32 and MMP-9 were negatively correlated with lung function,and the worse the lung function *** more significant the increase is.

关键词： MMP-9 IL-32 PCT CRP Serum AHTMA AECOPD PF

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：