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Effects of orientation on the fatigue crack growth behaviors of the ZK60 magnesium alloy in air and PBS

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Journal of Magnesium and Alloys 2024年第1期12卷 281-294页

作者： Jiaqi Hu Zheng Liu Zuoliang Ning hong Gao School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Chemical Process Safety and Equipment Technology Tianjin 300072China

Strong anisotropic corrosion and mechanical properties caused by specimen orientations greatly limit the applications of wrought magnesium alloys.To investigate the influences of specimen orientation,the corrosion tests and(corrosion)fatigue crack growth tests were conducted.The rolled and transverse surfaces of the materials show distinct corrosion rate differences in the stable corrosion stage,but the truth is the opposite for the initial stage of corrosion.In air,specimen orientations have a significant influence on the plastic deformation mechanisms near the crack tip,which results in different fatigue fracture surfaces and cracking paths.Compared with R-T specimens,N-T specimens show a slower fatigue crack growth(FCG)rate in air,which can be attributed to crack closure effects and deformation twinning near the crack tip.The corrosion environment will not significantly change the main plastic deformation mechanisms for the same type of specimen.However,the FCG rate in phosphate buffer saline(PBS)is one order of magnitude higher than that in air,which is caused by the combined effects of hydrogen-induced cracking and anodic dissolution.Owing to the similar corrosion rates at crack tips,the specimens with different orientations display close FCG rates in PBS.

关键词： Magnesium alloy Orientation Corrosion Fatigue crack growth

Hydrogel loaded with bone marrow stromal cell-derived exosomes promotes bone regeneration by inhibiting inflammatory responses and angiogenesis

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World Journal of Stem Cells 2024年第5期16卷 499-511页

作者： Shuai Zhang Chuan Lu Sheng Zheng Guang hong Division for International Collaborative and Innovative Dentistry Tohoku University Graduate School of DentistrySendai 980-8575MiyagiJapan School of Stomatology Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Bone healing is a complex process involving early inflammatory immune regu-lation,angiogenesis,osteogenic differentiation,and biomineralization.Fracture repair poses challenges for orthopedic surgeons,necessitating the search for efficient healing methods.AIM To investigate the underlying mechanism by which hydrogel-loaded exosomes derived from bone marrow mesenchymal stem cells(BMSCs)facilitate the process of fracture healing.METHODS Hydrogels and loaded BMSC-derived exosome(BMSC-exo)gels were charac-terized to validate their properties.In vitro evaluations were conducted to assess the impact of hydrogels on various stages of the healing process.Hydrogels could recruit macrophages and inhibit inflammatory responses,enhance of human umbilical vein endothelial cell angiogenesis,and promote the osteogenic differen-tiation of primary cranial osteoblasts.Furthermore,the effect of hydrogel on fracture healing was confirmed using a mouse fracture model.RESULTS The hydrogel effectively attenuated the inflammatory response during the initial repair stage and subsequently facilitated vascular migration,promoted the formation of large vessels,and enabled functional vascularization during bone repair.These effects were further validated in fracture models.CONCLUSION We successfully fabricated a hydrogel loaded with BMSC-exo that modulates macrophage polarization and angiogenesis to influence bone regeneration.

关键词： Hydrogel Bone marrow mesenchymal stem cells Macrophage polarization Angiogenesis Bone regeneration

CD209 signaling pathway as a biomarker for cisplatin chemotherapy response in small cell lung cancer

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Genes & Diseases 2024年第3期11卷 11-14页

作者： Anqi Lin hong Yang Jian Zhang Peng Luo Department of Oncology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510282China The First Clinical Medical School Southern Medical UniversityGuangzhouGuangdong 510515China

One of the bottlenecks in the clinical treatment of small cell lung cancer(SCLC)is its susceptibility to multidrug resistance.While SCLC is sensitive to platinum-based chemotherapy at the initial stage of treatment,it can rapidly become drug-resistant,allowing tumor growth to accelerate.A significant decrease in drug sensitivity after recurrence and multidrug resistance can seriously interfere with the effectiveness of treatment,making sensitivity maintenance one of the urgent challenges to be solved.Therefore,discovering prognostic markers for cisplatin chemotherapy and understanding the mechanisms of cisplatin resistance have great practical significance for improving the outcomes of sCLC patients.

关键词： cisplatin chemotherapy lung

A survey of decision making in adversarial games

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Science China(Information Sciences) 2024年第4期67卷 85-112页

作者： Xiuxian LI Min MENG Yiguang hong Jie CHEN College of Electronics and Information Engineering Tongji University Shanghai Research Institute for Intelligent Autonomous Systems

In many practical applications, such as poker, chess, drug interdiction, cybersecurity, and national defense, players often have adversarial stances, i.e., the selfish actions of each player inevitably or intentionally inflict loss or wreak havoc on other players. Therefore, adversarial games are important in realworld applications. However, only special adversarial games, such as Bayesian games, are reviewed in the literature. In this respect, this study aims to provide a systematic survey of three main game models widely employed in adversarial games, i.e., zero-sum normal-form and extensive-form games, Stackelberg(security) games, and zero-sum differential games, from an array of perspectives, including basic knowledge of game models,(approximate) equilibrium concepts, problem classifications, research frontiers,(approximate) optimal strategy-seeking techniques, prevailing algorithms, and practical applications. Finally, promising future research directions are also discussed for relevant adversarial games.

关键词： adversarial games zero-sum games Stackelberg games differential games Nash equilibrium correlated equilibrium regret

Effects of different concentrations of nicotinamide on hematopoietic stem cells cultured in vitro

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World Journal of Stem Cells 2024年第2期16卷 163-175页

作者： Yan Ren Yan-Ni Cui hong-Wei Wang The Second Clinical Medical College Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology The Second Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology Key Laboratory of Molecular Diagnosis and Treatment of Blood Diseases in Shanxi ProvinceTaiyuan 030001Shanxi ProvinceChina

BACKGROUND In vitro expansion to increase numbers of hematopoietic stem cells(HSCs)in cord blood could improve clinical efficacy of this vital resource.Nicotinamide(NAM)can promote HSC expansion ex vivo,but its effect on hematopoietic stem and progenitor cells(HSPCs,CD34^(+)CD38)and functional subtypes of HSCs-shortterm repopulating HSCs(ST-HSCs,CD34^(+)CD38CD45RACD49f^(+))and long-term repopulating HSCs(LT-HSCs,CD34^(+)CD38CD45RACD49f^(+)CD90^(+))is not yet known.As a sirtuin 1(SIRT1)inhibitor,NAM participates in regulating cell adhesion,polarity,migration,proliferation,and differentiation.However,SIRT1 exhibits dual effects by promoting or inhibiting differentiation in different tissues or cells.We propose that the concentration of NAM may influence proliferation,differentiation,and SIRT1 signaling of HSCs.AIM To evaluate the effects and underlying mechanisms of action of different concentrations of NAM on HSC proliferation and differentiation.METHODS CD34^(+)cells were purified from umbilical cord blood using MacsCD34 beads,and cultured for 10-12 d in a serum-free medium supplemented with cytokines,with different concentrations of NAM added according to experimental requirements.Flow cytometry was used to detect phenotype,cell cycle distribution,and apoptosis of the cultured cells.Real-time polymerase chain reaction was used to detect the transcription levels of target genes encoding stemness-related factors,che mokines,components of hypoxia pathways,and antioxidant enzymes.Dichloro-dihydro-fluorescein diacetate probes were used to evaluate intracellular production of reactive oxygen species(ROS).Determination of the effect of different culture conditions on the balance of cytokine by cytometric bead array.RESULTS Compared with the control group,the proportion and expansion folds of HSPCs(CD34^(+)CD38)incubated with 5 mmol/L or 10 mmol/L NAM were significantly increased(all P<0.05).The ST-HSCs ratio and fold expansion of the 5 mmol/L NAM group were significantly higher than those of the control and 10 mmol/L N

关键词： Hematopoietic stem cells Nicotinamide Concentration Proliferation Differentiation Sirtuin 1

A systematic evaluation of computational methods for predicting translated non-canonical ORFs from ribosome profiling data

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Journal of Genetics and Genomics 2024年第1期51卷 105-108页

作者： Tianyu Lei Yue Chang Chao Yao hong Zhang College of Ecology Lanzhou UniversityLanzhouGansu 730000China Cuiying Honors College Lanzhou UniversityLanzhouGansu 730000China

Ribosome profiling(Ribo-Seg)enables genome-wide survey of translational activities at nucleotide resolution by enriching and sequencing ribosome-protected fragments(RPFs)in the cell(Ingolia et al.,2009).Based on the characteristic distribution of RPFs in Ribo-Seq,such as enrichment in open reading frames(ORFs)and three-nucleotide periodicity,many computational methods have been developed to detect translated ORFs from Ribo-Seq data(Wang et al.,2020a).

关键词： translated enable canonical

Evaluating human exposure to antibiotic resistance genes

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Biosafety and Health 2024年第2期6卷 98-100页

作者： Zhenchao Zhou hong Chen College of Environmental and Resource Sciences Zhejiang UniversityHangzhou 310058China International Cooperation Base of Environmental Pollution and Ecological Health Science and Technology Agency of ZhejiangZhejiang UniversityHangzhou 310058China

Antibiotic resistance is an escalating global concern,leading to millions of annual fatalities.Antibiotic resistance genes(ARGs)present in bacteria equip them to withstand the effects of antibiotics.Intra-and interspecific ARGs transmission through horizontal gene transfer further exacerbates resistance dissemination.The presence of ARGs in the environment heightens the probability of human exposure via direct inhalation,ingestion,or contact with polluted air,food,or water,posing substantial biosafety and health hazards.Consequently,ARGs represent a critical focal point in public health and environmental safety and are classified as emerging contaminants.This perspective underscores the necessity to assess ARG exposure within the One Health framework and to accord greater attention to the mitigation strategies and tactics associated with ARGs.

关键词： Antibiotic resistance genes Human exposure Biosafety

Insights into postural orthostatic tachycardia syndrome after COVID-19 in pediatric patients

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World Journal of Pediatrics 2024年第3期20卷 201-207页

作者： Ya-Xi Cui Jun-Bao Du hong-Fang Jin Department of Pediatrics Peking University First HospitalNo.1 Xi-an Men StreetWest DistrictBeijing 100034China State Key Laboratory of Vascular Homeostasis and Remodeling Peking UniversityBeijing 100191China

The pandemic caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)profoundly threatened human health globally and greatly impacted the world economy[1].While most patients recovered,some suff... 详细信息

关键词： acute patients tachycardia

Construction of Optimal Mixed-Level Uniform Designs

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Journal of Systems Science & Complexity 2024年第2期37卷 841-862页

作者： CHATTERJEE Kashinath LIU Min-Qian QIN hong YANG Liuqing Department of Population Health Sciences Division of Biostatistics and Data ScienceAugusta UniversityGA 30912USA NITFID LPMC&KLMDASRSchool of Statistics and Data ScienceNankai UniversityTianjin 300071China School of Statistics and Mathematics Zhongnan University of Economics and LawWuhan 430073China

The theory of uniform design has received increasing interest because of its wide application in the field of computer experiments.The generalized discrete discrepancy is proposed to evaluate the uniformity of the mixed-level factorial design.In this paper,the authors give a lower bound of the generalized discrete discrepancy and provide some construction methods of optimal mixed-level uniform designs which can achieve this lower bound.These methods are all deterministic construction methods which can avoid the complexity of stochastic algorithms.Both saturated mixed-level uniform designs and supersaturated mixed-level uniform designs can be obtained with these methods.Moreover,the resulting designs are also χ^(2)-optimal and minimum moment aberration designs.

关键词： Generalized discrete discrepancy Hadamard matrix mixed-level design orthogonal array supersaturated design