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Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder

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General Psychiatry 2024年第2期37卷 265-273页

作者： Jie Wang Wenfeng Zhao Huang Wang Haixia leng Qing Xue Mao Peng Baoquan Min Xiukun Jin Liucen Tan Keming Gao Hongxing Wang Songjiang Hospital and Songjiang Research Institute Shanghai Key Laboratory of Emotions and Affective DisordersShanghai Jiao Tong University School of MedicineShanghaiChina Institute of Neuroscience and Brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyangHubeiChina Division of Neuropsychiatry and Psychosomatics Department of NeurologyXuanwu Hospital of Capital Medical UniversityBeijingChina Electroconvulsive Therapy University Hospitals Cleveland Medical CenterClevelandOhioUSA Department of Psychiatry Case Western Reserve University School of MedicineClevelandOhioUSA Institute of Sleep and Consciousness Disorders Center of EpilepsyBeijing Institute for Brain DisordersCapital Medical UniversityBeijingChina Institute of Special Medical Sciences School of Forensic MedicineShanxi Medical UniversityTaiyuanShanxiChina

Background Although 15 mA transcranial alternating current stimulation(tACS)has a therapeutic effect on depression,the activations of brain structures in humans accounting for this tACS configuration remain largely *** To investigate which intracranial brain structures are engaged in the tACS at 77.5 Hz and 15 mA,delivered via the forehead and the mastoid electrodes in the human *** Actual human head models were built using the magnetic resonance imagings of eight outpatient volunteers with drug-naïve,first-episode major depressive disorder and then used to perform the electric field distributions with SimNIBS *** The electric field distributions of the sagittal,coronal and axial planes showed that the bilateral frontal lobes,bilateral temporal lobes,hippocampus,cingulate,hypothalamus,thalamus,amygdala,cerebellum and brainstem were visibly stimulated by the 15 mA tACS *** Brain-wide activation,including the cortex,subcortical structures,cerebellum and brainstem,is involved in the 15 mA tACS intervention for first-episode major depressive *** results indicate that the simultaneous involvement of multiple brain regions is a possible mechanism for its effectiveness in reducing depressive symptoms.

关键词： stimulation involvement activation

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Independent dual beams generated by array element division in integrated optical phased arrays

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Chinese Optics Letters 2024年第7期22卷 35-41页

作者： Guihan Wu Yu Xin Lemeng leng Xiang Ji Shichong Yang Kaifei Tang Quan Luo Hongsheng Luo Jinshan Su Wei Jiang College of Engineering and Applied Sciences Nanjing UniversityNanjing 210023China National Laboratory of Solid-State Microstructures Nanjing 210093China Key Laboratory of Intelligent Optical Sensing and Manipulation Ministry of EducationNanjing UniversityNanjing 210023China Jiangsu Key Laboratory of Artificial Functional Materials Nanjing UniversityNanjing 210023China Key Laboratory of Vibration Signal Capture and Intelligent Processing Yili Normal UniversityIli 835000China

Optical phased arrays(OPAs)have broad application prospects due to their advanced capability in beamforming and *** this work,we achieve independent dual beams in the far field by dividing the array elements of the OPA,with the maximum scanning range reaching 100°.Based on the working principle of OPAs,theoretical considerations of such multibeam generation are presented.A phase data allocation approach for OPAs in the presence of fabrication-induced random phase variation is *** of large ensembles of OPAs with various levels of random residual phase errors have been conducted to help analyze the *** approach can help OPAs realize multi-beams for light detection and ranging(LiDAR).

关键词： optical phased arrays beamforming phase error calibration array element division.D01:10.3788/COL202422.071301

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β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture

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Bone Research 2024年第2期12卷 302-313页

作者： Jie Huang Tong Wu Yi-Rong Jiang Xuan-Qi Zheng Huan Wang Hao Liu Hong Wang Hui-Jie leng Dong-Wei Fan Wan-Qiong Yuan Chun-Li Song Department of Orthopedics Peking University Third Hospital100191 BeijingChina Beijing Key Laboratory of Spinal Disease 100191 BeijingChina Engineering Research Center of Bone and Joint Precision Medicine 100191 BeijingChina

The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone *** found that fractures lead to increased sympathetic tone,enhanced osteoclast resorption,decreased osteoblast formation,and thus hastened systemic bone loss in ovariectomized(OVX)***,the combined administration of parathyroid hormone(PTH)and theβ-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX *** effect of this treatment is superior to that of treatment with PTH or propranolol *** vitro,the sympathetic neurotransmitter norepinephrine(NE)suppressed PTH-induced osteoblast differentiation and mineralization,which was rescued by ***,NE decreased the PTH-induced expression of Runx2 but enhanced the expression of Rankl and the effect of PTH-stimulated osteoblasts on osteoclastic differentiation,whereas these effects were reversed by ***,PTH increased the expression of the circadian clock gene Bmal1,which was inhibited by NE-βAR ***1 knockdown blocked the rescue effect of propranolol on the NE-induced decrease in PTHstimulated osteoblast *** together,these results suggest that propranolol enhances the anabolic effect of PTH in preventing systemic bone loss following osteoporotic fracture by blocking the negative effects of sympathetic signaling on PTH anabolism.

关键词： blocker metabolism inhibited

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电碳市场背景下典型环境权益产品衔接互认机制及关键技术

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中国电机工程学报 2024年第7期44卷 2558-2577,I0005页

作者：尚楠陈政冷媛南方电网能源发展研究院有限责任公司广东省广州市510663

“碳达峰、碳中和”目标下,我国电力市场、碳市场、绿证市场等在产品属性、价格形成、治理监管等方面的联系日益密切,推动电碳市场背景下典型环境权益产品的联通互认,是推动实现不同市场体系之间充分融合、协同发展的关键桥梁和有力抓... 详细信息

“碳达峰、碳中和”目标下,我国电力市场、碳市场、绿证市场等在产品属性、价格形成、治理监管等方面的联系日益密切,推动电碳市场背景下典型环境权益产品的联通互认,是推动实现不同市场体系之间充分融合、协同发展的关键桥梁和有力抓手。目前,国内电碳环境权益产品尚未形成规范统一的概念定义,暂未出现电碳环境权益产品衔接互认的成熟案例,亦较为缺少密切相关的政策与市场机制设计。该文通过归纳分析国内外主流电碳环境权益产品特点及衔接互认经验,结合我国电力市场、碳市场等市场建设发展现状,剖析当前绿色电力证书、绿色电力消费、非水可再生能源(电力)消纳量、碳排放权、自愿减排量(Chinese certified emission reduction,CCER)等不同类型环境权益产品衔接互认过程中存在的碳排放量核算不准确、减排量重复认证、CCER申领范围不清晰等问题。该文在分析论述已有方案的同时,研究提出一种电碳市场背景下的不同类型环境权益产品的衔接互认体系,包括绿色电力消费与碳排放量的衔接、绿证或非水可再生能源(电力)消纳量与碳排放量的衔接、绿证与CCER的衔接等,并阐述支撑电碳环境权益产品衔接的4大类关键技术,为推动电、碳、绿证等多市场体系之间的协同发展提供决策参考。

关键词：电碳市场环境权益产品衔接互认机制碳排放量绿色电力消费碳排放因子

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天文/惯性组合系统中重力扰动补偿方法

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系统工程与电子技术 2024年第4期46卷 1357-1363页

作者：冷悦钟胜华中科技大学人工智能与自动化学院湖北武汉430074 多谱信息智能处理技术全国重点实验室湖北武汉430074 华中光电技术研究所武汉光电国家研究中心湖北武汉430223

针对重力扰动引起惯性水平基准姿态测量误差进而导致天文/惯性组合导航系统定位精度下降的问题,提出天文/惯性组合系统中的重力扰动补偿方法。首先,基于导航误差模型分析了影响天文/惯性组合导航系统定位精度的主要因素。其次,推导了重... 详细信息

针对重力扰动引起惯性水平基准姿态测量误差进而导致天文/惯性组合导航系统定位精度下降的问题,提出天文/惯性组合系统中的重力扰动补偿方法。首先,基于导航误差模型分析了影响天文/惯性组合导航系统定位精度的主要因素。其次,推导了重力扰动、惯性水平基准姿态测量误差与天文导航定位误差之间的传播机理。然后,研究了重力扰动建模与修正方法,并将重力扰动补偿方法应用于惯性水平基准的导航解算回路中,实现重力扰动的有效补偿。跑车试验结果表明,所提重力扰动补偿方法可以将天文/惯性组合导航系统中定位误差的振荡幅值由1.6 n mile降低至0.5 n mile。

关键词：天文导航系统惯性导航系统组合导航系统重力扰动

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Diagnostic Method for Beam Position Monitor Based on Clustering by Fast Search and Find of Density Peaks

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Journal of Shanghai Jiaotong university(Science) 2024年第3期29卷 457-462页

作者：姜瑞涛杨星邓又铭冷用斌 Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China

Beam position monitors(BPMs)are important to monitor the beam moving *** the beam's normal motion is an important mission for Shanghai Synchrotron Radiation *** diagnostic analysis is an important way to accomplish this *** paper develops a new method based on clustering analysis to diagnose the healthy of BPMs with basic running data,i.e.,the β oscillation of X and Y directions and noise *** analysis results showed that all beam position monitors(140 BPMs)can be classified into three groups:normal group,worse performance group,and fault group,*** addition,the abnormal BPMs(including worse performance)could be *** new method showed its ability to handle faulty BPMs and it could instruct daily *** the other hand,it will be a useful supplement for data analysis in accelerator physics.

关键词： synchrotron radiation beam position monitor(BPM) βoscillation beam position monitor noise beam position monitor troubleshooting

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General anesthetic agents induce neurotoxicity through oligodendrocytes in the developing brain

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Zoological Research 2024年第3期45卷 691-703页

作者： Wen-Xin Hang Yan-Chang Yang Yu-Han Hu Fu-Quan Fang Lang Wang Xing-Hua Qian Patrick M.McQuillan Hui Xiong Jian-Hang leng Zhi-Yong Hu Department of Anesthesiology First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Department of Cell Biology Yale UniversityNew HavenCT 06520USA Department of Neurology of the First Affiliated Hospital Interdisciplinary Institute of Neuroscience and TechnologySchool of Brain Science and Brain MedicineZhejiang University School of MedicineHangzhouZhejiang 310027China Department of Anesthesiology Jiaxing Maternity and Childcare Health HospitalJiaxingZhejiang 314009China Department of Anesthesiology Penn State Hershey Medical CentrePenn State College of MedicineHersheyPA 17033USA Department of Central Laboratory Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang 310006China

General anesthetic agents can impact brain function through interactions with neurons and their effects on glial *** perform essential roles in the central nervous system,including myelin sheath formation,axonal metabolism,and neuroplasticity *** are particularly vulnerable to the effects of general anesthetic agents resulting in impaired proliferation,differentiation,and *** are increasingly interested in the effects of general anesthetic agents on *** agents not only act on the surface receptors of oligodendrocytes to elicit neuroinflammation through modulation of signaling pathways,but also disrupt metabolic processes and alter the expression of genes involved in oligodendrocyte development and *** this review,we summarize the effects of general anesthetic agents on *** anticipate that future research will continue to explore these effects and develop strategies to decrease the incidence of adverse reactions associated with the use of general anesthetic agents.

关键词： Oligodendrocytes General anesthetic agents Neurotoxicity Central nervous system Perioperative neurocognitive disorders

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High-precision X-ray polarimeter based on channel-cut crystals

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Nuclear Science and Techniques 2024年第3期35卷 30-39页

作者： Shang-Yu Si Zhong-Liang Li Wen-Hong Jia Lian Xue Hong-Xin Luo Jian-Cai Xu Bai-Fei Shen Lin-Gang Zhang Liang-Liang Ji Yu-Xin leng Ren-Zhong Tai Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800China

We report on using synthetic silicon for a high-precision X-ray polarimeter comprising a polarizer and an analyzer,each based on a monolithic channel-cut crystal used at multiple Brewster reflections with a Bragg angle very close to 45°.Experiments were performed at the BL09B bending magnet beamline of the Shanghai Synchrotron Radiation Facility using a Si(800)crystal at an X-ray energy of 12.914 keV.A polarization purity of 8.4×10^(-9)was *** result is encouraging,as the measured polarization purity is the best-reported value for the bending magnet ***,this is the firstly systematic study on the hard X-ray polarimeter in China,which is crucial for exploring new physics,such as verifying vacuum birefringence.

关键词： X-ray polarimeter Vacuum birefringence Synchrotron radiation Channel-cut crystal

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Toughening Mechanism of Large Heat Input Weld Metal for Marine Engineering Extra-Thick Plate

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Journal of Shanghai Jiaotong university(Science) 2024年第2期29卷 349-360页

作者：冷俊杰邸新杰利成宁程尚华 School of Materials Science and Engineering Tianjin UniversityTianjin 300350China Tianjin Key Laboratory of Advanced Joining Technology Tianjin 300350China Penglai Jutao Offshore Engineering Heavy Industry Co.Ltd. Yantai 265600ShandongChina

In order to study the latest designed large heat input welding material of marine engineering extra-thick plate,EH36 steel was joined by using twin-wire submerged arc welding with heat inputs of 85,100 and 115 kJ/cm ***,the microstructure and mechanical properties were evaluated to explore the toughening mechanism of weld *** show that a lot of active inclusions are obtained in the weld metal due to the design idea of low carbon and oxide metallurgy,which contributes to the generation of numerous fine and interlocking acicular *** acicular ferrite volume ratio of weld metal exceeds 60%.Moreover,the impact energy at-40℃ surpasses 115 J and the crack tip opening displacement value at-10℃ is more than 0.2 mm under three heat inputs owing to the role of acicular ferrite,of which 85 kJ/cm is the *** martensite-austenite constituents are minor in size and the microstructure of the weld metal in reheated zone is dominated by small massive equiaxed ferrite,without impairing the *** the heat input increases,the content of acicular ferrite drops and then rises;the impact toughness and fracture toughness first worsen consequently and then stabilize on account of the dramatic expansion of the proeutectoid ferrite size.

关键词： large heat input extra-thick plate weld metal acicular ferrite toughness

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Sustained Release of Branched-Chain Amino Acids from Slow-Digesting Whey Enhances Endurance Running Performance and Improves Skeletal Muscle Protein Synthesis in Mice

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Food Science and Human Wellness 2024年

作者： Juncai leng Tingyi Zhou Yiming Jiang Beibei Wang Shuoming Liu Shiqi Zhang Li Li Wei Zhao State Key Laboratory of Food Science and Resources， School of Food Science and Technology， Jiangnan University Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment & Technology， Jiangnan University

Post-exercise whey protein isolate (WPI) supplement is beneficial for skeletal muscle recovery due to the stimulation of branched chain amino acids (BCAAs). This implies us that intake slow digestion rate of protein to sustain BCAAs releasing rate may facilitate muscle protein synthesis. To examine this hypothesis， we conducted a series of protein supplements including modified slow-digesting whey (SDW)， whey， hydrolyzed whey and casein， orally to mice undergoing endurance running. Our results showed that the SDW gavage constant supplied BCAAs in the serum of mice within 6 hours and significantly enhanced (P < 0.01) endurance exercise capacity， compared to other groups. In addition， the SDW supplementation increased the cross-sectional area of mice gastrocnemius fibers， as well as their muscle and liver glycogen content. It also increased the testosterone/cortisol ratio in serum and IL-6 levels in muscle， while it decreased the TNF-α levels and oxidative stress in muscle. Moreover， it may activate mechanistic target of rapamycin signaling by upregulating mRNA (bcat-1 and pgc-1α) expression. Thus， our findings illustrate that prolonged BCAAs supply duration promotes mice endurance running capacity and skeletal muscle growth， contributing to the advancement of sports nutrition practices.

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