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MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer

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Journal of Pharmaceutical Analysis 2024年第6期14卷 863-877页

作者： Haowei Zhang Qixin Li Xiaolong Guo Hong Wu Chenhao Hu Gaixia Liu tianyu yu Xiake Hu Quanpeng Qiu Gang Guo Junjun She Yinnan Chen Department of General Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Center for Gut Microbiome Research Med-X InstituteThe First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Department of High Talent The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China

Chemotherapy resistance plays a pivotal role in the prognosis and therapeutic failure of patients with colorectal cancer(CRC).Cisplatin(DDP)-resistant cells exhibit an inherent ability to evade the toxic chemotherapeutic drug effects which are characterized by the activation of slow-cycle programs and DNA *** the elements that lead to DDP resistance,O^(6)-methylguanine(O^(6)-MG)-DNA-methyltransferase(MGMT),a DNA-repair enzyme,performs a quintessential *** this study,we clarify the significant involvement of MGMT in conferring DDP resistance in CRC,elucidating the underlying mechanism of the regulatory actions of MGMT.A notable upregulation of MGMT in DDP-resistant cancer cells was found in our study,and MGMT repression amplifies the sensitivity of these cells to DDP treatment in vitro and in ***,in cancer cells,MGMT overexpression abolishes their sensitivity to DDP ***,the interaction between MGMT and cyclin dependent kinase 1(CDK1)inducing slow-cycling cells is attainted via the promotion of ubiquitination degradation of ***,to achieve nonhomologous end joining,MGMT interacts with XRCC6 to resist chemotherapy *** transcriptome data from samples of 88 patients with CRC suggest that MGMT expression is co-related with the Wnt signaling pathway activation,and several Wnt inhibitors can repress drug-resistant *** summary,our results point out that MGMT is a potential therapeutic target and predictive marker of chemoresistance in CRC.

关键词： Colorectal cancer MGMT Chemotherapy resistance Slow-cycling cells Nonhomologous end joining Wnt pathway

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资本主义“技术性失业”的政治经济学阐释——从机器到智能机器

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哲学动态 2024年第8期 16-26页

作者：于天宇吉林大学马克思主义学院

资本主义“技术性失业”问题在智能机器时代表现得尤为严峻,呈现出智能机器逐渐替代人力的趋势。任何形式的机器本质上都是人类活动的产物,都是人类本质力量的对象化的体现。因机器的发展和完善而产生的“技术性失业”,其原因显然不在... 详细信息

资本主义“技术性失业”问题在智能机器时代表现得尤为严峻,呈现出智能机器逐渐替代人力的趋势。任何形式的机器本质上都是人类活动的产物,都是人类本质力量的对象化的体现。因机器的发展和完善而产生的“技术性失业”,其原因显然不在于机器本身,而在于支配机器的资本逻辑。因此,马克思对机器产生“过剩人口”及其“技术性失业”的社会历史效应的政治经济学批判,既是对机器作为资本增殖手段的历史洞见,更是智能时代解决“技术性失业”、解放“无用阶级”的重要思想资源。智能机器在服务资本增殖的过程中,将始于机器时代的“技术性失业”推进到全新的阶段并造成了人的再次异化。只有真正打破人类本质力量的对象化产物被资本控制和支配的逻辑,使之真正服务于社会财富的充裕和自由时间的充足,才能够从社会形制的现实中认识“技术性失业”产生的政治前提,从历史发展的逻辑中发掘机器的价值与生命的意义,从“人-机”互构方式的建构中推进人类社会的持续繁荣。

关键词：技术性失业资本权力无用阶级自由劳动

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3D打印制备金属盐掺杂熔石英玻璃

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硅酸盐学报 2024年第5期52卷 1562-1569页

作者：彭可付华龙于天宇吴攀姚佳慧陈明君哈尔滨工业大学机器人技术与系统国家重点实验室哈尔滨150001 哈尔滨工业大学机电工程学院哈尔滨150001

增材制造技术在制造复杂形状零件方面具有显着的优势,然而熔石英玻璃的3D打印技术仍有待开发。基于液晶显示3D打印成型技术,研究了脱脂、金属掺杂、烧结等工艺,并制备了致密透明的熔石英玻璃样件,研究掺杂Cr^(^(3+))、Co^(^(2+))2种金... 详细信息

增材制造技术在制造复杂形状零件方面具有显着的优势,然而熔石英玻璃的3D打印技术仍有待开发。基于液晶显示3D打印成型技术,研究了脱脂、金属掺杂、烧结等工艺,并制备了致密透明的熔石英玻璃样件,研究掺杂Cr^(^(3+))、Co^(^(2+))2种金属离子的熔石英玻璃致密化和光学吸收特性。研究发现掺杂含Cr^(^(3+))、Co^(^(2+))2种金属离子的熔石英玻璃具有独特的光学吸收性能,掺杂熔石英玻璃能保持无定型结构,可对特定波段光谱进行过滤,掺杂Cr^(^(3+))的绿色熔石英玻璃对波长471nm的蓝光和波长660 nm的红光过滤明显;掺杂Co^(^(2+))的蓝色熔石英玻璃对波长597 nm的黄光和波长662 nm的红光过滤明显,在集成复杂光学元件结构应用方面拥有一定的潜力。

关键词：熔石英玻璃液晶显示成型 3D打印金属盐掺杂

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数字资本主义交往异化的政治经济学批判

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河北大学学报(哲学社会科学版) 2024年第4期49卷 50-60页

作者：于天宇秦铭吉林大学马克思主义学院

资本逻辑与数字技术的联合进一步激化了数字资本主义社会中主体间交往的异化问题，呈现出交往主体虚拟化、交往形式碎片化以及交往关系表象化等新表现。这是资本主义生产方式将主体间的交往过程纳入资本增殖过程的现实后果，在一定程度... 详细信息

资本逻辑与数字技术的联合进一步激化了数字资本主义社会中主体间交往的异化问题，呈现出交往主体虚拟化、交往形式碎片化以及交往关系表象化等新表现。这是资本主义生产方式将主体间的交往过程纳入资本增殖过程的现实后果，在一定程度上造成了人与人之间的交往被数据与数据之间的交往所掩盖，人在资本的宰制下进一步被工具化。对此，数字社会主义构建的数据“共享原则”为破除数字资本主义交往异化提供了一种理想范式，但其在实践层面存在着不可忽视的局限性。因此，我们仍然需要回到马克思的政治经济学原理中，探寻破除资本统治、维护数字技术良性发展、解决数字资本主义交往异化的根本性法则。

关键词：交往异化数字资本主义资本主义生产方式数字社会主义

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Experimental and numerical study of deposition mechanisms for cold spray additive manufacturing process

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Chinese Journal of Aeronautics 2022年第2期35卷 276-290页

作者： tianyu yu Mingjun CHEN Zhuoru WU State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150001China School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China Department of Mechanical Engineering Iowa State UniversityAmes 50011USA

Cold spray is an attractive and rapidly developing process for additive manufacturing with high efficiency and precision,repairing and coating,especially in aircraft and aerospace *** spray additive manufacturing deposits micro-particles with large plastic deformation below their melting point,eliminating heat effect zone which could deteriorate the quality of repairing *** particle deposition in cold spray is a complex process which involves high strain rate,high contact pressure and high *** we develop,utilize and validate a thermomechanical model to provide a definitive way to predict deposition mechanics and surface deformation evolution for particle deposition process in cold spray additive *** a single particle and dual particles models were developed to investigate the contact interaction between particle/substrate and particle/*** combinations of particle/substrate materials(Cu/Cu,Al/Al,steel/steel,and nickel/nickel)and process parameters were considered in this *** experimental study was conducted to validate simulation results,providing useful information for understanding the limitations and challenges associated with cold spray additive *** framework provides insights into improving the quality and precision of stress/strain formation,particle interactions and particle deposition in cold spray additive manufacturing process.

关键词： Additive manufacturing Cold spray Finite element analysis Residual stresses Surface morphology

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Effects of pore structure and distribution on strength of porous Cu-Sn-Ti alumina composites

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Chinese Journal of Aeronautics 2017年第6期30卷 2004-2023页

作者： Biao ZHAO tianyu yu Wenfeng DING Xianying LI College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics Department of Aerospace Engineering Iowa State University

Porous Cu-Sn-Ti alumina composites were fabricated by sintering Cu-Sn-Ti alloy powders, graphite particles, and alumina hollow particles agent. The effects of the pore structure and distribution on the composites strength were evaluated. Different pore distributions were modeled by using finite element analysis to investigate the tensile strength of the composites. Furthermore, a fractal analysis-based box-covering algorithm was used on the Cu-Sn-Ti alumina composites topology graphs to better investigate the pore structure and distribution. Results obtained show that different sizes and concentrations of alumina hollow particles could result in different porosities from20% to 50%. A larger pore size and a higher pore concentration reduce the strength, but provide more space for chip formation as a bonding material of a grinding wheel. The body-centered pore structure of the composites shows the highest stress under a tension load. The original composites topology graphs have been transformed to ordered distributed pore graphs based on the total pore area conservation. The information dimension magnitude difference between the original topology graphs and the ordered distributed circulars graphs is found to be linear with the Cu-Sn-Ti alumina composites strength. A larger difference renders a lower flexural strength, which indicates that uniform ordered distributed pores could benefit the composites strength.

关键词： Finite element analysis(FEA) Metal-matrix composites(MMCs) Microstructurat analysis Pore structure Strength

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Reduction of Sensitivity to Sintering Temperature for Nd-Fe-B Magnets through Zr and Nb Additions

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Journal of Materials Science & Technology 2009年第5期25卷 629-632页

作者： Mi Yan Xigui Cui Lianqing yu tianyu Ma State Key Laboratory of Silicon Materials Department of Materials Science and Engineering Zhejiang University Hangzhou 310027 China

To reduce the sensitivity of grain growth to sintering temperature for improving property consistency of sintered Nd-Fe-B magnets, combined additions of Zr and Nb were investigated. It was found that when Zr content was increased to 0.07 at. pct, abnormal grain growth was effectively hindered even when the sintering temperature reached 1100℃. With combined additions of 0.07 at. pct Zr and 0.07 at. pct Nb, the sensitivity of grain growth to sintering temperature was greatly reduced consistency than the magnets containing no Zr and also improved. The magnets sintered at 1100℃ showed higher property Nb. In addition, the magnetic properties of magnets were also improved.

关键词： Sintered Nd-Fe-B magnet Magnetic properties Consistency Sintering temperature

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Synthesis of sponge-like TiO_(2) with surface-phase junctions for enhanced visible-light photocatalytic performance

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Chinese Chemical Letters 2021年第5期32卷 1823-1826页

作者： yue Jiang Yao Qin tianyu yu Sijie Lin College of Environmental Science and Engineering The Institute for Translational NanomedicineShanghai East HospitalTongji UniversityShanghai 200092China Key Laboratory of Yangtze River Water Environment Shanghai Institute of Pollution Control and Ecological SecurityTongji UniversityShanghai 200092China Institute for Regenerative Medicine The Institute for Translational NanomedicineShanghai East HospitalTongji University School of MedicineShanghai 200123China

Maximizing adsorption and catalytic active sites and promoting the photo-excited charge separation are two key factors to achieve excellent photocatalytic *** this study,we report a sol-gel synthesis approach to obtain non-metal doped TiO_(2)with sponge-like structure and surface-phase junctions all at *** doping of carbon and nitrogen shifted the activation wavelength to the visible-light region,the innovative use of perchloric acid as a pore-making agent led to the formation of three-dimensional lamellar and porous structure with surface-phase *** surface area with catalytic active sites rendered by the sponge-like structure and surface-phase junctions contributed to the much improved photocatalytic degradation efficiency toward rhodamine B,tetracycline and Disperse Red 60 with excellent reusability and *** improved gen eration and separati on efficie ncy of the photo-induced charge carriers of the as-prepared TiO_(2)were supported by electrochemical impedance measurements and transient photocurrent *** method could also be applied to other photocatalysts to achieve structural alteration and element doping simultaneously.

关键词： Structural alteration Surface-phase junction Photocatalytic degradation Visible light TiO_(2)

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T-PBFT: An EigenTrust-Based Practical Byzantine Fault Tolerance Consensus Algorithm

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China Communications 2019年第12期16卷 111-123页

作者： Sheng Gao tianyu yu Jianming Zhu Wei Cai School of Information Central University of Finance of EconomicsBeijing 100081China Grain Information Processing and Control Key Laboratory of Ministry of Education Henan University of TechnologyZhengzhou 450001China School of Science and Engineering The Chinese University of Hong KongShenzhen 518172China

Blockchain with these characteristics of decentralized structure, transparent and credible, time-series and immutability, has been considering as a promising technology. Consensus algorithm as one of the core techniques of blockchain directly affects the scalability of blockchain systems. Existing probabilistic finality blockchain consensus algorithms such as PoW, PoS, suffer from power consumptions and low efficiency;while absolute finality blockchain consensus algorithms such as PBFT, HoneyBadgerBFT, could not meet the scalability requirement in a largescale network. In this paper, we propose a novel optimized practical Byzantine fault tolerance consensus algorithm based on EigenTrust model, namely T-PBFT, which is a multi-stage consensus algorithm. It evaluates node trust by the transactions between nodes so that the high quality of nodes in the network will be selected to construct a consensus group. To reduce the probability of view change, we propose to replace a single primary node with a primary group. By group signature and mutual supervision, we can enhance the robustness of the primary group further. Finally, we analyze T-PBFT and compare it with the other Byzantine fault tolerant consensus algorithms. Theoretical analysis shows that our T-PBFT can optimize the Byzantine fault-tolerant rate,reduce the probability of view change and communication complexity.

关键词： blockchain consensus protocol Byzantine fault tolerance trust model

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BP neural network based flexural strength prediction of open-porous Cu-SnTi composites

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Progress in Natural Science:Materials International 2018年第3期28卷 315-324页

作者： Biao Zhao tianyu yu Wenfeng Ding Xianying Li Honghua Su College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics Department of Aerospace Engineering Iowa State University

Open-porous Cu-Sn-Ti composites are fabricated by the space holder sintering technique using carbamide particles as space-holder material. Generally, the mechanical properties of open-porous sintered composites,especially the flexural strength affect the machine tools wear significantly. In this paper, a back-propagation(BP)artificial neural network with genetic algorithm(GA) and particle swarm optimization algorithm(PSOA) was then employed to relate the composition parameters(pore size, porosity and concentration of molybdenum disulfide particles) to the flexural strength. Furthermore, a comparison of predicted and experimental results using GA-BP and PSOA-BP models was conducted and good prediction accuracy was obtained. The study showed that PSOA-BP models could achieve better prediction results in aspects of the higher convergence velocity, lower relative errors of the flexure strength utilizing GA-BP models. Finally, the high porosity and desired flexural strength were achieved by optimizing the input parameters of open-porous Cu-Sn-Ti composites.

关键词： Flexural strength BP artificial neural network Training algorithms Metallic porous material Space holder sintering

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