检索结果-南通市图书馆

PRESSURE COMPENSATION METHOD OF UNDERWATER HYDRAULIC SYSTEM WITH HYDRAULIC POWER UNIT BEING UNDER ATMOSPHERIC CIRCUMSTANCE AND PRESSURE COMPENSATED VALVE

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2005年第3期18卷 419-423页

作者： Wang Qingfeng Li Yanmin zhong tianyu Xu Guohua State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

Based on the analysis of the-state-of-the-art of pressure compensation of underwater hydraulic systems （UHSs）, a new method of pressure compensation of UHSs, whose hydraulic power unit is in the atmospheric circumstance, is proposed. And a pilot-operated relief valve with pressure compensation is realized. The pressure compensation precision is guaranteed by direct detection. Its dynamic performance and stability are improved by a dynamic feedback. Theoretical study, simulation and experiment show that the pilot-operated relief valve with pressure compensation has a fine property of tracking underwater ambient pressure and meet the requirement of underwater ambient pressure compensation.

关键词： Underwater hydraulic system (UHS) Pressure compensation Underwater ambient pressure (UAP) Pressure relief valve

冷冻干燥法制备高强度果胶-二氧化硅复合气凝胶及其对花青素的递送

在线全文

学校读者我要写书评

暂无评论

食品科技 2024年第8期49卷 255-262页

作者：李艾潼钟添宇毛子鋆韩旭杰杨晨汪建明天津科技大学食品科学与工程学院天津300457

二氧化硅气凝胶是一种新型的介孔纳米材料,应用广泛。在食品工业中,气凝胶主要作为包装、活性物质包埋递送及油凝胶的制备前体,主要通过其吸附性质达成。然而二氧化硅气凝胶结构主要由硅骨架构成,强度较低。因此,研究通过制备复合气凝... 详细信息

二氧化硅气凝胶是一种新型的介孔纳米材料,应用广泛。在食品工业中,气凝胶主要作为包装、活性物质包埋递送及油凝胶的制备前体,主要通过其吸附性质达成。然而二氧化硅气凝胶结构主要由硅骨架构成,强度较低。因此,研究通过制备复合气凝胶来提高其性能。研究结果表明,适量添加果胶制备二氧化硅气凝胶(果胶含量10%)可使孔隙率最高达到95.3%,与二氧化硅复合改善了复合气凝胶的热稳定性。抗压结果表明,12.5%果胶添加量的气凝胶在100 g压力下形变量仅为80.6%,印证了果胶可以有效调节气凝胶的强度。吸附实验证明,添加果胶后对水蒸气的吸附程度增强,而对玉米油的吸附程度减弱,持油量增加。最后以花青素为模型,建立复合气凝胶对营养素的递送体系,复合气凝胶对花青素的控释有明显的效果,能够更好帮助营养素消化。该研究为复合气凝胶进一步在食品工业中的应用提供一定的理论依据。

关键词：二氧化硅气凝胶果胶吸附性花青素

Screening cytokine/chemokine profiles in serum and organs from an endotoxic shock mouse model by LiquiChip

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2017年第11期60卷 1242-1250页

作者： jinghua liu juan wang haihua luo zhijie li tianyu zhong jing tang yong jiang guangdong provincial key laboratory of protemicsstate key laboratory of organ failure researchsouthern medical universityGuangzhou 510515China

Studying the cytokine profiles in animal models or patients with sepsis provides an experimental basis for the identification of diagnostic biomarkers and therapeutic targets. In this study, we used a liquid protein chip （LiquiChip）, also known as flexible multi-analyte profiling technology, to perform quantitative analyses of several cytokines and chemokines （e.g., IL-II3, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, TNF-ct, IFN-7, granulocyte-macrophage colony-stimulating factor, keratinocyte chemoattractant, monocyte chemoattractant protein, monokine induced by gamma interferon, IFN-7-inducible protein 10, and macrophage inflammatory protein 1 alpha）. The levels of these cytokines and chemokines were determined both in the blood and in tissues, including the lung, liver, heart, kidney, spleen, brain, stomach, intestine and muscle, of mice challenged with LPS, Our data showed variable production levels of LPS-induced cytokines in different mouse organs, and the cytokine in the blood did not correlate with those in the organs. We also showed that the levels of most cytokines peaked within 1 to 6 h and decreased rapidly afterward. A variety of inflammatory cytokines might be related to the damage in different organs during septic shock. Our data also suggest that the spleen might be an important target organ in the development of systemic inflammatory response syndrome and sepsis.

关键词： endotoxin septic shock cytokine chemokine

在线全文

学校读者我要写书评

暂无评论

IRF3在乳腺癌中的研究进展

山东第一医科大学（山东省医学科学院）学报 2024年第5期45卷 315-320页

作者：许中满吴思铭王晓玲钟田雨张文娟赣南医科大学第一临床医学院江西赣州341000 赣南医科大学第一附属医院检验科江西赣州341000 赣南医科大学第一附属医院精准医学中心江西赣州341000 赣南医科大学儿童白血病免疫治疗药物开发赣州市重点实验室江西赣州341000

乳腺癌作为全球女性健康的重大挑战,其研究的重要性和紧迫性日益凸显。干扰素调节因子3(interferon regulatory factor 3,IRF3)属于人类干扰素调节因子(interferon regulatory factors,IRFs)家族的一员,是一个关键的转录因子。IRF3在天... 详细信息

乳腺癌作为全球女性健康的重大挑战,其研究的重要性和紧迫性日益凸显。干扰素调节因子3(interferon regulatory factor 3,IRF3)属于人类干扰素调节因子(interferon regulatory factors,IRFs)家族的一员,是一个关键的转录因子。IRF3在天然免疫应答的信号传递过程中起着重要的调节作用。近年来研究揭示了IRF3在肿瘤免疫学领域的关键作用,特别是在乳腺癌中。IRF3不仅调节乳腺癌细胞的生长和凋亡,而且通过诱导Ⅰ型干扰素(type Ⅰ interferons,IFN-Ⅰ)及其他重要细胞因子的产生,对肿瘤细胞的行为产生影响。然而,在乳腺癌中,IRF3的激活受到多种机制的抑制,这包括阻断IRF3依赖的细胞凋亡途径和通过调节微RNA表达来抑制干扰素基因刺激因子(stimulator of interferon genes,STING)等。在特定情况下,IRF3还可能促进乳腺癌发生及复发。本综述全面探讨了IRF3的基本特征、参与的信号通路、在乳腺癌发展中的作用及当前研究的最新进展,并总结了基于IRF3作用机制的潜在治疗方法。

关键词：干扰素调节因子3 乳腺癌 Ⅰ型干扰素免疫治疗

SEI/dead Li-turning capacity loss for high-performance anode-free solid-state lithium batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第9期96卷 145-152页

作者： Qianwen Yin tianyu Li Hongzhang Zhang Guiming zhong Xiaofei Yang Xianfeng Li Division of Energy Storage Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Long-Duration and Large-Scale Energy Storage Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Laboratory of Advanced Spectro-Electrochemistry and Lithium-Ion Batteries Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Anode-free solid-state lithium metal batteries(AF-SSLBs)have the potential to deliver higher energy density and improved safety beyond lithium-metal ***,the unclear mechanism for the fast capacity decay in AF-SSLBs,either determined by dead Li or solid electrolyte interface(SEI),limits the proposal of effective strategies to prolong cycling *** clarify the underlying mechanism,herein,the evolution of SEI and dead Li is quantitatively analyzed by a solid-state nuclear magnetic resonance(ss-NMR)technology in a typical LiPF6-based polymer *** results show that the initial capacity loss is attributed to the formation of SEI,while the dead Li dominates the following capacity loss and the growth rate is 0.141 mA h cm^(−2)cycle−*** reduce the active Li loss,the combination of inorganic-rich SEI and self-healing electrostatic shield effect is proposed to improve the reversibility of Li deposition/dissolution behavior,which reduces the capacity loss rate for the initial SEI and following dead Li generation by 2.3 and 20.1 folds,*** a result,the initial Coulombic efficiency(ICE)and stable CE increase by 15.1%and 15.3%in Li-Cu cells,which guides the rational design of high-performance AF-SSLBs.

关键词： Solid-state lithium batteries Solid-state NMR Anode-free SEI Dead Li

亚麻籽胶-魔芋胶复合凝胶体系的制备及特性研究

在线全文

学校读者我要写书评

暂无评论

天津科技大学学报 2024年第2期39卷 8-15页

作者：杨振东李文博程婕钟添宇杨晨汪建明天津科技大学食品科学与工程学院天津300457

亚麻籽胶(flaxseed gum,FG)的凝胶性较弱,魔芋胶(konjac glucomannan,KGM)有较高的黏度和良好的持水性,可提高所形成亚麻籽胶-魔芋胶复合凝胶体系(flaxseed gum-konjac glucomannan system,FKG)的特性。以亚麻籽胶和魔芋胶为原料,研究... 详细信息

亚麻籽胶(flaxseed gum,FG)的凝胶性较弱,魔芋胶(konjac glucomannan,KGM)有较高的黏度和良好的持水性,可提高所形成亚麻籽胶-魔芋胶复合凝胶体系(flaxseed gum-konjac glucomannan system,FKG)的特性。以亚麻籽胶和魔芋胶为原料,研究不同比例下FKG的形成过程及其特性。结果表明:随着魔芋胶添加比例逐渐增大,FKG的凝胶强度和凝胶性能逐渐增强,并在亚麻籽胶与魔芋胶的质量比为6∶4时达到最大,且FKG的硬度、咀嚼性、胶着性和弹性均优于其他比例样品,相较于亚麻籽胶分别提升了10.00倍、6.25倍、5.29倍和1.61倍;其表观黏度和剪切应力表现出较强的协同增效作用;Zeta电位绝对值为13.85 mV,稳定性相对较高;通过红外光谱3425.13 cm^(-1)附近的羟基伸缩振动峰观察到FG与KGM之间可能产生了分子间氢键;扫描电子显微镜结果证实,FKG具有较为致密的空间网状结构,说明亚麻籽胶经过与魔芋胶复合后有效改善了凝胶特性,为进一步推进亚麻籽胶的研究与应用提供了基础。

关键词：亚麻籽胶魔芋胶复合凝胶凝胶特性凝胶结构

Research progress on the role of extracellular vesicles in neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2023年第1期12卷 296-314页

作者： Zhengzhe Li Xiaoling Wang Xiaoxing Wang Xiaomei Yi Yin Kwan Wong Jiyang Wu Fangfang Xie Die Hu Qi Wang Jigang Wang tianyu zhong The First School of Clinical Medicine Gannan Medical UniversityGanzhou 341000China Laboratory Medicine First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China Department of Nephrology Shenzhen Key Laboratory of Kidney Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People’s HospitalThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Oncology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China

Neurodegenerative diseases,such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease,affect millions of people *** efforts have been put into disease-related research,but few breakthroughs have been made in diagnostic and therapeutic *** vesicles(EVs)are heterogeneous cell-derived membrane structures that arise from the endosomal system or are directly separated from the plasma *** contain many biomolecules,including proteins,nucleic acids,and lipids,which can be transferred between different cells,tissues,or organs,thereby regulating cross-organ communication between cells during normal and pathological ***,EVs have been shown to participate in various aspects of neurodegenerative *** secretion and levels of EVs are closely related to the pathogenesis of neurodegenerative diseases and contribute to disease *** studies have proposed EVs as therapeutic targets or biomarkers for neurodegenerative *** this review,we summarize and discuss the advanced research progress on EVs in the pathological processes of several neurodegenerative ***,we outline the latest research on the roles of EVs in neurodegenerative diseases and their therapeutic potential for the diseases.

关键词： Extracellular vesicle Neurodegenerative disease Central nervous system Neurodegeneration Pathogenesis Biomarker

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

双向电液比例张力绞车的直接自适应鲁棒控制

农业机械学报 2007年第11期38卷 144-148,160页

作者：钟天宇王庆丰姚斌浙江大学流体传动及控制国家重点实验室

设计了基于比例溢流阀调压回路的双向电液比例张力绞车,并进行了理论分析。针对液压系统的不确定性因素以及卷绕机构参数变化对张力控制的影响,提出了直接自适应鲁棒电液张力控制方法,并用张力负载模拟试验系统进行了研究。理论分析与... 详细信息

设计了基于比例溢流阀调压回路的双向电液比例张力绞车,并进行了理论分析。针对液压系统的不确定性因素以及卷绕机构参数变化对张力控制的影响,提出了直接自适应鲁棒电液张力控制方法,并用张力负载模拟试验系统进行了研究。理论分析与试验均表明,对于具有不确定性因素的张力跟踪控制,所设计的电液张力绞车及其控制策略,具有良好的控制性能。

关键词：张力绞车电液系统直接自适应鲁棒控制

Assessing risk of Bombali virus spillover to humans by mutagenesis analysis of viral glycoprotein

在线全文

学校读者我要写书评

暂无评论

hLife 2024年第1期2卷 32-42页

作者： Lincan Li tianyu Gan Ziyue Ma Yi Huang Jin zhong Unit of Viral Hepatitis CAS Key Laboratory of Molecular Virology and ImmunologyShanghai Institute of Immunity and InfectionCenter for Biosafety Mega-ScienceChinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina ShanghaiTech University ShanghaiChina Wuhan National Biosafety Laboratory Center for Biosafety Mega-ScienceChinese Academy of SciencesHubeiChina

Ebolaviruses,such as the highly pathogenic Ebola virus(EBOV),belong to the family Filoviridae and have caused out-breaks of severe and fatal hemorrhagic fever over the past *** virus(BOMV)is a newly discovered ebolavirus from bats with unknown potential to infect *** most ebolaviruses,the interaction between viral glycoprotein(GP)and host receptor Niemann-Pick C1(NPC1)is crucial for viral entry and determines host ***,we analyzed the BOMV GP-mediated virus entry into human cells using our recently developed EBOV transcription-and replication-competent virus-like particle(trVLP)*** demonstrated that while BOMV GP can be efﬁciently incorporated into trVLPs,it is inefﬁcient in mediating trVLP entry into human ***,BOMV GP-mediated virus entry into human cells can be signiﬁcantly enhanced by a few mutations in the NPC1-binding domain of ***,we showed that these mutations increase the binding of BOMV-GP to human *** summary,our results suggested that although wild-type BOMV does not efﬁciently infect human cells,the emergence of mutations in viral GP may boost its ability to spill over to humans,highlighting the importance of monitoring BOMV GP evolution in preventing potential BOMV spillover events.

关键词： Bombali virus glycoprotein entry Ebola virus Niemann-Pick C1