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Transdermal treatment for malignant melanoma by aptamer-modified tetrahedral framework nucleic acid delivery of vemurafenib

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Chinese Chemical Letters 2024年第4期35卷 260-267页

作者： Dexuan Xiao Tianyu Chen tianxu zhang Sirong Shi Mei zhang Xin Qin Yunkun Liu Longjiang Li Yunfeng Lin State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041China Sichuan Provincial Engineering Research Center of Oral Biomaterials Chengdu 610041China Department of Head and Neck Oncology National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041China

Melanoma is one of the most malignant skin tumors, whose high invasion is generally associated with BRAF gene mutation. Although new chemotherapeutic drugs, such as vemurafenib, have been developed to inhibit the growth of melanoma, these drugs are usually administered intravenously or orally, resulting in toxic side effects on major tissues and organs. Tetrahedral framework nucleic acids(tFNAs) are a novel type of DNA nanostructures with excellent biocompatibility and versatility which have been proven to penetrate through skin barrier with ease. In this study, we prepared t FNAs with vemurafenib and connected DNA aptamer AS1411 at the apex of t FNAs(AS1411-tFNAs/vemurafenib). On one hand, AS1411-tFNAs/vemurafenib could kill melanoma cells by blocking the mutated BRAF gene in vitro. Compared with free vemurafenib, AS1411-tFNAs/vemurafenib had no obvious toxicity to normal cells. On the other hand,AS1411-tFNAs could transfer vemurafenib to cross through the skin barrier and permeate into tumor tissues. In vivo, transdermal delivery of AS1411-t FNAs/vemurafenib could inhibit the growth of human A375melanoma, whose inhibiting effect was stronger than intravenous administration of vemurafenib. These results demonstrated the application prospects of tFNAs combined with chemotherapeutic drugs in skin tumors.

关键词： Melanoma Vemurafenib DNA nanostructure Transdermal treatment Side effect

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空位有序双钙钛矿A2BX6的弹性和热电性质的第一性原理研究

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物理化学学报 2024年第1期40卷 46-47页

作者： Muhammad Faizan 赵国琪张天旭王啸宇贺欣张立军吉林大学材料科学与工程学院长春130012

卤化物钙钛矿在热电应用中表现出了巨大的潜力。准确了解卤化物钙钛矿的热电传输性质对于进一步提高热电设备的应用效率至关重要。本研究采用了Perdew-Burke-Ernzerhof(PBE)和修正的Becke Johnson(mBJ)交换关联泛函探究了卤化物双钙钛矿... 详细信息

卤化物钙钛矿在热电应用中表现出了巨大的潜力。准确了解卤化物钙钛矿的热电传输性质对于进一步提高热电设备的应用效率至关重要。本研究采用了Perdew-Burke-Ernzerhof(PBE)和修正的Becke Johnson(mBJ)交换关联泛函探究了卤化物双钙钛矿Rb_(2)SnI6、Rb_(2)PdI6和Cs_(2)PtI6的弹性和热电性质。通过对这些材料的力学稳定性、有效质量、塞贝克系数、功率因子和热电品质因数的研究,我们发现,这三种化合物都是力学稳定的,并且具有可塑性。这些化合物是窄带隙半导体,具有简并的带边结构,结合低的载流子有效质量使得它们具有热电应用潜力。Cs_(2)PtI6在空穴掺杂在500 K温度下可以达到0.76 mV·K^(−1)的高塞贝克系数。由于高塞贝克系数和最大功率因子,Rb_(2)SnI6、Rb_(2)PdI6和Cs_(2)PtI6在p型掺杂下具有高的热电品质因数,分别为0.91、0.96和0.98。总体而言,我们的研究为卤化物钙钛矿的热电性能提供了新的见解,为这些化合物的实验合成提供了有价值的参考。

关键词：电子结构有效质量 Seebeck系数热电品质因数卤化物双钙钛矿

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Epigenetic modification associated with climate regulates betulin biosynthesis in birch

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Journal of Forestry Research 2023年第1期34卷 21-35页

作者： Jiang Wang Bowei Chen Shahid Ali tianxu zhang Yu Wang He zhang Lishan Wang Yonglan zhang Linan Xie Tingbo Jiang Jing Yin Heike W.Sederoff Gaurav Zinta Ronald R.Sederoff Yuhua Li Qingzhu zhang State Key Laboratory of Tree Genetics and Breeding Northeast Forestry UniversityHarbin 150040People’s Republic of China College of Life Sciences Northeast Forestry UniversityHarbin 150040People’s Republic of China Forest Biotechnology Group Department of Forestry and Environmental ResourcesNorth Carolina State UniversityRaleighNC 27695USA Biotechnology Division CSIR-Institute of Himalayan Bioresource TechnologyPalampur 176061India

The Betula genus contains pentacyclic triterpenoid betulin known for its environmental adaptation and medicinal ***,the mechanisms underlying betulin biosynthesis responding to climate change remain *** this study,the role of epigenetic modification(DNA methylation) in betulin biosynthesis was examined and how climatic factors influence ***-genome bisulfite sequencing was performed for greenhouse-grown Chinese white birch(Betula platyphylla Sukaczev) treated with DNA methylation inhibitor zebularine(ZEB) and a natural birch population in Northeast *** treatment significantly affected the CHH methylation level of transposable elements and betulin content in a hormesis dose-dependent *** methylation and expression of bHLH9,a key transcriptional factor controlling betulin biosynthesis,were also consistently affected by ZEB treatment as a hormetic *** the natural population,there was a positive correlation between promoter methylation of bHLH9 and summer precipitation,while winter temperature was negatively *** climate-dependent methylation of bHLH9 regulates the expression of downstream genes involved in betulin *** study highlights the role of environmental signals to induce epigenetic changes that result in betulin production,possibly helping to develop resilient plants to combat ongoing climate change and enhance secondary metabolite production.

关键词： Epigenetics DNA methylation Betulin bHLH9 transcription factor Hormesis Climate change Secondary metabolite

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Uncovering of the formation of rare earth texture and pseudo fiber bimodal microstructure in the high ductility Mg-2Gd-0.4Zr alloy during extrusion

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Journal of Materials Science & Technology 2024年第5期172卷 166-184页

作者： tianxu Zheng Yaobo Hu Chao zhang Tianshuo Zhao Bin Jiang Fusheng Pan Aitao Tang College of Materials Science and Engineering Chongqing UniversityChongqing400044China National Engineering Research Center for Magnesium Alloys Chongqing400044China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai200240China

The aim of this research was to elucidate the underlying mechanism involved in the formation of rare earth(RE)texture and pseudo fiber bimodal microstructure in the high ductility Mg-2Gd-0.4Zr *** microstructure and texture evolution during the extrusion process were analyzed using various tech-niques,including optical microscopy(OM),scanning electron microscopy(SEM),electron backscatter diffraction(EBSD),and electron probe microanalysis(EPMA).The findings revealed that the RE texture in the extruded Mg-2Gd-0.4Zr alloy emerged during the dynamic recrystallization(DRX)process and was further strengthened during the subsequent static recrystallization and grain growth *** nu-cleation and growth of grains in the streamline region of Zr particles were delayed in comparison to other regions due to the pinning effect of Zr particles,ultimately resulting in the formation of pseudofiber bi-modal microstructure in the extruded Mg-2Gd-0.4Zr alloy.

关键词： Magnesium alloys Ductility Rare earth texture Bimodal microstructure

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Multi-layer hierarchical cellulose nanofibers/carbon nanotubes/vinasse activated carbon composite materials for supercapacitors and electromagnetic interference shielding

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Nano Research 2024年第3期17卷 904-912页

作者： tianxu Wang Chuanyin Xiong Yongkang zhang Bo Wang Qing Xiong Mengjie Zhao Yonghao Ni College of Bioresources Chemical&Materials Engineering Shaanxi University of Science and TechnologyXi’an 710021China Department of Chemical and biomedical Engineering The University of MaineOronoME 04469USA University of New Brunswick Limerick Pulp&Paper CtrFrederictonNB E3B 5A3Canada

Developing porous self-supporting electrodes with excellent conductivity,good mechanical properties,and high electrochemical activity is crucial for constructing electrode materials with lightweight,ultra-thin,flexible,and high capacitance *** this work,we prepared a cellulose nanofibers(CNFs)/carbon nanotubes(CNTs)/vinasse activated carbon(VAC)(CCV)composite material with a multi-layer hierarchical conductive structure through simple vacuum filtration and *** this composite material,the self-assembly of CNF provides the main skeleton structure of a multi-layer hierarchical *** provides a fast path for the rapid transfer of electrons and is beneficial for the loss of electromagnetic *** provides sufficient double layer *** synergistic effect of the above three endows CCV composite materials with excellent energy storage performance and electromagnetic interference(EMI)shielding *** addition,we endowed the CCV composite with a certain shape and performance by introducing a vitrimer polymer with a dynamic cross-linked network *** summary,thanks to the synergistic effect of various components in the multi-layer hierarchical structure,CCV composite materials exhibit excellent integration performance,especially stable energy storage performance and EMI shielding *** significant properties make CCV composite materials have great application prospects in the fields of energy storage and intelligent EMI shielding.

关键词： self-supporting electrodes multi-layer hierarchical structure supercapacitors electromagnetic interference shielding

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Research on a novel restoration algorithm of turbulence-degraded images with alternant iterations

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Journal of Systems Engineering and Electronics 2006年第3期17卷 477-482页

作者： Liu Chunsheng Hong Hanyu zhang tianxu Inst. for Pattern Recognition and AI State Key Laboratory of Image Processing and Intelligent Control Huazhong Univ. of Science and Technology Wuhan 430074 P. R. China

A new restoration algorithm based on double loops and alternant iterations is proposed to restore the object image effectively from a few frames of turbulence-degraded images, Based on the double loops, the iterative relations for estimating the turbulent point spread function PSF and object image alternately are derived. The restoration experiments have been made on computers, showing that the proposed algorithm can obtain the optimal estimations of the object and the point spread function, with the feasibility and practicality of the proposed algorithm being convincing.

关键词： turbulence-degraded image image restoration double loops alternant iterations.

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New multi-DSP parallel computing architecture for real-time image processing

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Journal of Systems Engineering and Electronics 2006年第4期17卷 883-889页

作者： Hu Junhong zhang tianxu Jiang Haoyang Dept. of Electronics and Information Engineering Central China Normal Univ.Wuhan 430079P.R. China Inst. for Pattern Recognition and Artificial Intelligence Huazhong Univ. of Science and Technology Wuhan 430074 P.R. China

The flexibility of traditional image processing system is limited because those system are designed for specific applications. In this paper, a new TMS320C64x-based multi-DSP parallel computing architecture is presented. It has many promising characteristics such as powerful computing capability, broad I/O bandwidth, topology flexibility, and expansibility. The parallel system performance is evaluated by practical experiment.

关键词： parallel computing image processing real-time computer architecture

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Titanium mesh for bone augmentation in oral implantology: current application and progress

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International Journal of Oral Science 2020年第4期12卷 275-286页

作者： Yu Xie Songhang Li tianxu zhang Chao Wang Xiaoxiao Cai State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of Head and Department of Implant Dentistry West China Hospital of StomatologySichuan UniversityChengduChina College of Stomatology Chongqing Medical UniversityChongqingChina Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijingChina

Guided bone regeneration(GBR)is an effective and simple method for bone augmentation,which is often used to reconstruct the alveolar ridge when the bone defect occurs in the implant *** mesh has expanded the indications of GBR technology due to its excellent mechanical properties and biocompatibility,so that the GBR technology can be used to repair alveolar ridges with larger bone defects,and can obtain excellent and stable bone augmentation ***,GBR with titanium mesh has various clinical applications,including different clinical *** graft materials,titanium mesh covering methods,and titanium mesh fixing methods are also ***,the research of GBR with titanium mesh has led to multifarious progresses in digitalization and material *** article reviews the properties of titanium mesh and the difference of titanium mesh with other barrier membranes;the current clinical application of titanium mesh in bone augmentation;common complications and management and prevention methods in the application of titanium mesh;and research progress of titanium mesh in digitization and material *** to provide a reference for further improvement of titanium mesh in clinical application and related research of titanium mesh.

关键词： titanium Titanium mesh

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空心莲子草乙酸乙酯部位体内外抗H9N2亚型禽流感病毒活性的研究

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中国畜牧兽医 2024年第2期51卷 759-769页

作者：廖思雨郑新戴琪许诗怡张天旭张秀桥桂春湖北中医药大学药学院武汉430065

[目的]探究空心莲子草乙酸乙酯部位(ethyl acetate extract from Alternanthera philoxeroides,AETAC)体内外抗H9N2亚型禽流感病毒(H9N2 subtype Avian influenza virus, AIV-H9N2)活性及其作用机制。[方法]利用CCK-8法检测不同浓度AETAC作用不同时间对鸡胚成纤维细胞(DF-1)的抑制作用,通过预防感染、影响复制、阻止吸附及直接杀灭4种方式作用后检测AETAC对DF-1细胞的毒性,选择体外最佳抗AIV-H9N2作用方式。尿囊腔接种不同浓度AETAC确定其对鸡胚的最大安全浓度;将AETAC以3种不同给药方式作用于AIV-H9N2感染后鸡胚,选择体内最佳给药方式。经尿囊腔同时接种AETAC和AIV-H9N2,统计各组鸡胚存活数,测定血凝效价,并观察胚胎的发育情况和鸡胚法氏囊病理组织变化。[结果]在一定范围内,随着AETAC浓度升高或作用时间延长,AETAC对DF-1细胞的抑制率升高。与空白对照组相比,4种抗AIV-H9N2作用方式下,病毒对照组和药物组细胞存活率均显著降低(P<0.05);与病毒对照组相比,AETAC浓度为5~30μg/mL时,4种抗AIV-H9N2作用方式下,药物组细胞存活率均显著升高(P<0.05)。4种作用方式下,DF-1细胞存活率分别为8.15%~64.96%(预防感染)、8.56%~83.83%(影响复制)、1.82%~5.90%(阻止吸附)和6.90%~40.12%(直接杀灭)。AETAC对鸡胚的最大安全浓度为16.41 mg/mL,对感染鸡胚的最佳给药方式为AETAC和病毒混合后接种。以最佳体内作用方式给药后,AETAC中、低浓度组鸡胚存活率为40%~60%,高浓度组鸡胚全部存活,胚胎喙部发育明显,鸡胚法氏囊淋巴滤泡发育完整,滤泡大小和数量正常,充血量少,组织病理状态改善。[结论]AETAC在体内外对AIV-H9N2均具有显著的抑制作用,且主要与影响病毒复制作用方式相关。

关键词：空心莲子草乙酸乙酯部位(AETAC) H9N2亚型禽流感病毒(AIV-H9N2) DF-1细胞鸡胚

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Hard tissue stability after guided bone regeneration: a comparison between digital titanium mesh and resorbable membrane

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International Journal of Oral Science 2021年第4期13卷 389-397页

作者： Songhang Li Junyi Zhao Yu Xie Taoran Tian tianxu zhang Xiaoxiao Cai State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Implant dentistry West China Hospital of StomatologySichuan UniversityChengduChina

Guided bone regeneration(GBR)uses resorbable and non-resorbable membranes as biological *** study compared the differences in hard tissue stability between GBR using evidence-based digital titanium mesh and resorbable collagen membranes during implant placement.A total of 40 patients(65 implant sites)were enrolled and divided into two groups:resorbable membrane and digital titanium mesh *** alveolar bone was analyzed at two-and three-dimensional levels using conebeam computed tomography and by reconstructing and superimposing the hard tissues at four time points:preoperatively,postoperatively,before second-stage surgery,and 1 year after *** use of digital titanium mesh showed less alveolar bone resorption in vertical and horizontal directions two-dimensionally before the second-stage surgery and 1 year after *** volumetric stability,the percentage of resorption after 6 months of healing with resorbable membrane coverage reached 37.5%.However,it was only 23.4%with titanium *** postoperative bone volume was greater at all labial sites with resorbable membrane than with digital titanium mesh,after substantial bone resorption within 1 year of loading,the labial bone thickness at the upper part of implants was thinner with resorbable membrane than with digital titanium ***,digital titanium meshes made according to ideal bone arch contour reduced soft tissue irritation,and the exposure rate was only 10%.Therefore,although both resorbable membrane and digital titanium mesh in GBR were able to successfully reconstruct the bone defect,digital titanium meshes were better at maintaining the hard tissue volume in the osteogenic space.

关键词： titanium stability mesh

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