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浅谈校园网络安全防范

计算机光盘软件与应用 2011年第1期14卷 84-84页

作者：黄钰淇满天星王大伟吉林大学计算机科学与技术学院长春130012

随着国家校园网工程的逐步推进，越来越多的学校已经逐步建立并完善了自己的校园网络，并应用于教学和管理中，校园网络安全问题也日益突显，因此，如何加强和维护校园网络安全是摆在校园网络管理人员面前的重大课题。本文从校园网络安... 详细信息

随着国家校园网工程的逐步推进，越来越多的学校已经逐步建立并完善了自己的校园网络，并应用于教学和管理中，校园网络安全问题也日益突显，因此，如何加强和维护校园网络安全是摆在校园网络管理人员面前的重大课题。本文从校园网络安全概述、现状及主要防范措施几个方面来阐述校园网络安全防范。

关键词：校园网络网络安全防范措施

Antigenic characterization of SARS-CoV-2 Omicron subvariants XBB.1.5,BQ.1,BQ.1.1,BF.7 and BA.2.75.2

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1372-1374页

作者： Airu Zhu Peilan Wei Miao man Xuesong Liu tianxing Ji Jiantao Chen Canjie Chen Jiandong Huo Yanqun Wang Jincun Zhao State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina University Hospital and Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and TechnologyMacao SARChina Clinical Laboratory Medicine Department The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Guangzhou laboratory BioislandGuangzhouChina Shanghai Institute for Advanced Immunochemical Studies School of Life Science and TechnologyShanghaiTech UniversityShanghaiChina

Dear Editor,Recently,a number of new Omicron subvariants related to BA.4/5 and BA.2.75 have emerged and shown remarkable antibody evasion capacities,in particular BF.7,BQ.1,BQ.1.1,BA.2.75.2,XBB and XBB.1.5.1 Unsurprisingly,these new subvariants are quickly gaining prevalence *** fact,some of them have outcompeted BA.5 in the USA according to CDC’s national genomic surveillance data in which,as of 6th February 2023,XBB.1.5,BQ.1.1,BQ.1,XBB and BF.7 have achieved a dominance of 66.4%,19.9%,7.3%,2.3%and 0.5%in the USA,as compared to 0.5%for *** this report,using plasma samples collected from individuals following different vaccination strategies and COVID-19 convalescent donors,we performed pseudoviral neutralization assays to confirm severe reductions in neutralization titers against BF.7,BQ.1,BQ.1.1,BA.2.75.2,XBB and XBB.1.5 in comparison to other Omicron *** and XBB.1.5 were shown to be remarkably resistant to plasma neutralization in all tested *** comparing the differential neutralization profiles,we found that a heterologous booster with an aerosolized vaccine following 2 doses of inactivated vaccine seemed to be superior to other vaccination strategies.

关键词： doses vaccination fir

Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma

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Cancer Biology & Medicine 2023年第3期20卷 196-217页

作者： tianxing Zhou Quan man Xueyang Li Yongjie Xie Xupeng Hou Hailong Wang Jingrui Yan Xueqing Wei Weiwei Bai Ziyun Liu Jing Liu Jihui Hao Department of Pancreatic Cancer Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Hepatopancreatobiliary Surgery Tongliao City HospitalTongliao 028000China Department of Breast Oncoplastic Surgery Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerKey Laboratory of Breast Cancer Prevention and TherapyTianjin Medical UniversityMinistry of EducationTianjin 300060China Department of Cancer Cell Biology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerKey Laboratory of Breast Cancer Prevention and TherapyTianjin Medical UniversityMinistry of EducationTianjin 300060China Department of Diagnostic and Therapeutic Ultrasonography Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerKey Laboratory of Breast Cancer Prevention and TherapyTianjin Medical UniversityMinistry of EducationTianjin 300060China

Objective:Pancreatic ductal adenocarcinoma(PDAC)is an aggressive ***8^(+)T cells,cancer stem cells(CSCs),and tumor budding(TB)have been significantly correlated with the outcome of patients with PDAC,but the correlations have been independently *** addition,no integrated immune-CSC-TB profile for predicting survival in patients with PDAC has been ***:Multiplexed immunofluorescence and artificial intelligence(AI)-based comprehensive analyses were used for quantification and spatial distribution analysis of CD8^(+)T cells,CD133^(+)CSCs,and *** vivo humanized patient-derived xenograft(PDX)models were *** analysis,calibration curve,time-dependent receiver operating characteristic curve,and decision curve analyses were performed using R ***:The established‘anti-/pro-tumor’models showed that the CD8^(+)T cell/TB,CD8^(+)T cell/CD133^(+)CSC,TB-adjacent CD8^(+)T cell,and CD133^(+)CSC-adjacent CD8^(+)T cell indices were positively associated with survival of patients with *** findings were validated using PDX-transplanted humanized mouse *** integrated nomogram-based immune-CSC-TB profile that included the CD8^(+)T cell/TB and CD8^(+)T cell/CD133^(+)CSC indices was established and shown to be superior to the tumor-nodemetastasis stage model in predicting survival of patients with ***:‘Anti-/pro-tumor’models and the spatial relationship among CD8^(+)T cells,CSCs,and TB within the tumor microenvironment were *** strategies to predict the prognosis of patients with PDAC were established using AI-based comprehensive analysis and machine learning *** nomogram-based immune-CSC-TB profile can provide accurate prognosis prediction for patients with PDAC.

关键词： Artificial intelligence CD8 CSCs tumor budding PDAC nomogram

Long-chain acyl-CoA synthetase regulates systemic lipid homeostasis via glycosylation-dependent lipoprotein production

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Life Metabolism 2024年第2期3卷 38-54页

作者： Jie Li Yue Dong tianxing Zhou He Tian Xiahe Huang Yong Q.Zhang Yingchun Wang Sin man Lam Guanghou Shui State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Lipidall Technologies Company Limited ChangzhouJiangsu 213000China

Interorgan lipid transport is crucial for organism development and the maintenance of physiological ***,we demonstrate that Drosophila long-chain acyl-CoA synthetase(dAcsl),which catalyzes the conversion of fatty acids into acyl-coenzyme As(acyl-CoAs),plays a critical role in regulating systemic lipid *** deficiency in the fat body led to the ectopic accumulation of neutral lipids in the gut,along with significantly reduced lipoprotein contents in both the fat body and *** aberrant phenotypes were rescued by fat body-specific overexpression of apolipophorin.A multi-omics investigation comprising lipidomics,metabolomics,and proteomics in conjunction with genetic screening revealed that glycosylation processes were suppressed in dAcsl knockdown *** of CG9035,human ortholog of which is implicated in the congenital disorder of glycosylation,ame-liorated gut lipid accumulation in *** lipoprotein glycosylation led to accelerated proteasome-related degradation and induced ER stress in dAcsl knockdown flies,impairing lipoprotein release into the circulation which compromised interorgan lipid transport between the fat body and the *** of ubiquitin-proteasome-dependent degradation alleviated the phenotype of gut ectopic fat accumulation in dAcsl knockdown ***,we verified that ACSL4,the human homolog of dAcsl,also regulated lipoprotein levels in HepG2 cells,indicating that the role of dAcsl in modulating lipoprotein secretion and systemic lipid homeostasis is possibly conserved in humans.

关键词： lipid homeostasis apolipoprotein glycosylation lipidomics metabolomics proteomics

A robust,integrated platform for comprehensive analyses of acylcoenzyme As and acyl-carnitines revealed chain length-dependent disparity in fatty acyl metabolic fates across Drosophila development

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Science Bulletin 2020年第21期65卷 1840-1848,M0004页

作者： Sin man Lam tianxing Zhou Jie Li Shaohua Zhang Gek Huey Chua Bowen Li Guanghou Shui State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China LipidALL Technologies Company Limited Changzhou 213022China University of Chinese Academy of Sciences Beijing 100049China

Acyl-coenzyme A thioesters(acyl-CoAs)denote a key class of intermediary metabolites that lies at the hub of major metabolic *** great diversity in polarity between short-and long-chain acylCoAs makes it technically challenging to cover an inclusive range of acyl-CoAs within a single *** of acyl-carnitines,which function to convey fatty acyls into mitochondria matrix forβ-oxidation,indicate the efficiency of mitochondrial import and utilization of corresponding ***,we report a robust,integrated platform to allow simultaneous quantitation of endogenous acyl-CoAs and *** this method,we monitored changes in intermediary lipid profiles across Drosophila development under control(ND)and high-fat diet(HFD).We observed specific accumulations of medium-chain(C8-C12)and long-chain(≥C16)acyl-carnitines distinct to L3 larval and pupal stages,*** observations suggested development-specific,chain length-dependent disparity in metabolic fates of acyl-CoAs across Drosophila development,which was validated by deploying the same platform to monitor isotope incorporation introduced from labelled 12:0 and 16:0 fatty acids into extra-and intra-mitochondrial acyl-CoA *** found that pupal mitochondria preferentially import and oxidise C12:0-CoAs(accumulated as C12:0-carnitines in L3 stage)over C16:*** oxidation of medium-chain acyl-CoAs limits mitochondrial utilization of long-chain acyl-CoAs(C16-C18),leading to pupal-specific accumulation of long-chain acyl-carnitines mediated by enhanced CPT1-6 A *** skewed C16:0-CoAs towards catabolism over anabolism in pupa,thereby adversely affecting overall *** developed platform emphasizes the importance of integrating biological knowledge in the design of pathway-oriented platforms to derive maximal physiological insights from analysis of complex biological systems.

关键词： Acyl-coenzyme As Acyl-carnitines Fatty acids Drosophila High-fat diet β-Oxidation

晚清小说创作中的自我禁抑现象——以禁抑诲淫和迷信为中心的考察

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中国文学研究 2022年第3期 81-88页

作者：张天星台州学院人文学院浙江台州317000

自觉遏制诲淫和迷信是晚清小说创作中的普遍现象。狭邪小说作家采用避而不写、简洁含蓄两种方式处理性描写;改良小说作家要求儿女之情关乎国家社会,在创作中采取有情无欲的方式摒弃性欲描写;清末反迷信潮流兴起,作家普遍采取拒绝迷信素... 详细信息

自觉遏制诲淫和迷信是晚清小说创作中的普遍现象。狭邪小说作家采用避而不写、简洁含蓄两种方式处理性描写;改良小说作家要求儿女之情关乎国家社会,在创作中采取有情无欲的方式摒弃性欲描写;清末反迷信潮流兴起,作家普遍采取拒绝迷信素材和涉及迷信立即解释这两种方式禁抑迷信描写。晚清小说家自我禁抑淫秽和迷信是作家的创作目的、审美追求、禁毁活动、禁毁舆论等交织作用的产物,这种自我禁抑现象从深层次折射出晚清小说与时代风气、官方和民间规诫碰撞和融合的发展历史。

关键词：晚清小说创作自我禁抑性描写迷信

火烧迹地土千年健对麻栎化感作用及其机理研究

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北方园艺 2016年第13期 77-81页

作者：李天星楚雄师范学院化学与生命科学学院云南楚雄675000

为探索火灾后化感作用对森林植被自然恢复的影响机制,选取滇中地区针阔混交林火烧迹地优势物种麻栎和土千年健,研究了土千年健水浸液对麻栎种子及其幼苗的化感作用和作用机理。结果表明:土千年健水浸液对麻栎种子萌发、麻栎幼苗主根长... 详细信息

为探索火灾后化感作用对森林植被自然恢复的影响机制,选取滇中地区针阔混交林火烧迹地优势物种麻栎和土千年健,研究了土千年健水浸液对麻栎种子及其幼苗的化感作用和作用机理。结果表明:土千年健水浸液对麻栎种子萌发、麻栎幼苗主根长度及其鲜样质量和干样质量以及地上部分的高度及鲜样质量和干样质量的影响,呈现出低浓度促进,高浓度抑制的现象;随着土千年健水浸液浓度的增大,麻栎幼苗叶绿素含量逐渐降低,脯氨酸含量、丙二醛含量则逐渐升高,其对麻栎幼苗过氧化物酶活性的抑制作用也逐渐增强。研究发现,土千年健水浸液通过抑制保护酶活性和叶绿素的生成,增加膜脂过氧化伤害,抑制麻栎种子萌发和幼苗生长,从而表现出化感作用,且化感效应随着浓度的增加而增强。该研究为火灾后森林植被的人工恢复提供理论参考。

关键词：火烧迹地化感作用土千年健麻栎

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火烧迹地土千年健对尼泊尔酸模的化感作用

北方园艺 2016年第18期 65-70页

作者：李天星尹秋林楚雄师范学院化学与生命科学学院云南楚雄675000

为探索化感作用对药用植物栽培的影响及火灾后化感作用对森林植被自然恢复的影响机制,选取滇中地区针阔混交林火烧迹地优势物种的2种药用植物尼泊尔酸模和土千年健为研究对象,研究了土千年健水浸液对尼泊尔酸模种子及其幼苗的化感作用... 详细信息

为探索化感作用对药用植物栽培的影响及火灾后化感作用对森林植被自然恢复的影响机制,选取滇中地区针阔混交林火烧迹地优势物种的2种药用植物尼泊尔酸模和土千年健为研究对象,研究了土千年健水浸液对尼泊尔酸模种子及其幼苗的化感作用和作用机理。结果表明:土千年健水浸液对尼泊尔酸模种子萌发、幼苗主根长度及其鲜质量和干质量以及地上部分的高度及其鲜质量和干质量、幼苗叶绿素含量都呈现出低浓度促进、高浓度抑制的现象;随着土千年健水浸液浓度的增大,其对尼泊尔酸模幼苗过氧化物酶活性的抑制作用逐渐增强,但其幼苗脯氨酸含量、丙二醛含量却逐渐升高。研究发现,土千年健水浸液通过抑制保护酶活性和叶绿素的生成,增加膜脂过氧化和逆境伤害,抑制尼泊尔酸模种子萌发和幼苗生长,从而表现出化感作用,且化感效应随着浓度的增加而增强。该研究为药用植物栽培及火灾后森林植被的人工恢复提供参考。

关键词：火烧迹地化感作用土千年健尼泊尔酸模

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元江栲对蒲公英和凤仙花化感作用研究

楚雄师范学院学报 2020年第6期35卷 44-54页

作者：李天星杨实道楚雄师范学院化学与生命科学学院云南楚雄675000

为探索化感作用对药用植物栽培的影响及化感作用对森林植被自然恢复的影响机制,研究了元江栲对蒲公英和凤仙花种子及其幼苗的化感作用。结果表明:随着元江栲水浸液浓度的增大,元江栲水浸液对蒲公英和凤仙花种子萌发、幼苗地上部分的高... 详细信息

为探索化感作用对药用植物栽培的影响及化感作用对森林植被自然恢复的影响机制,研究了元江栲对蒲公英和凤仙花种子及其幼苗的化感作用。结果表明:随着元江栲水浸液浓度的增大,元江栲水浸液对蒲公英和凤仙花种子萌发、幼苗地上部分的高度、幼苗叶绿素含量、幼苗可溶性蛋白及总糖含量的抑制作用逐渐增强,但其幼苗丙二醛含量却逐渐升高。研究发现,元江栲水浸液通过增加膜脂过氧化和逆境伤害,抑制叶绿素的生成,抑制蒲公英和凤仙花种子萌发和幼苗生长,从而表现出化感作用,且化感效应随着元江栲水浸液浓度的增加而增强。研究为药用植物栽培及森林植被的人工恢复提供参考。

关键词：化感作用元江栲蒲公英凤仙花