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伴有t(16;17)染色体异常的APL样白血病1例报告并文献复习

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中华血液学杂志 2024年第9期45卷 856-860页

作者：王倩吕天鑫艾昊吕晓东尹青松郑州大学附属肿瘤医院(河南省肿瘤医院) 郑州450008

变异型急性早幼粒细胞白血病(APL)及APL样白血病均是APL中的少见类型,其中t(16;17)染色体异常更为罕见。本文报道1例伴有t(16;17)染色体异常及骨骼、淋巴结及中枢神经系统侵犯的APL样白血病患者,经过多周期化疗后获得完全缓解,随后进行... 详细信息

变异型急性早幼粒细胞白血病(APL)及APL样白血病均是APL中的少见类型,其中t(16;17)染色体异常更为罕见。本文报道1例伴有t(16;17)染色体异常及骨骼、淋巴结及中枢神经系统侵犯的APL样白血病患者,经过多周期化疗后获得完全缓解,随后进行造血干细胞移植,并进行文献复习。

关键词：染色体异常造血干细胞移植白血病患者中枢神经系统侵犯 APL 变异型文献复习

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支链氨基酸转移酶1与恶性肿瘤

国际肿瘤学杂志 2019年第1期46卷 36-39页

作者：吕天鑫张兵雷宋永平郑州大学附属肿瘤医院血液科 450008

支链氨基酸转移酶1(BCAT1)作为催化支链氨基酸代谢的关键酶,参与多种生物合成的通路。研究发现BCAT1在白血病、胶质瘤、鼻咽癌、胃癌、乳腺癌等恶性肿瘤中高表达,与肿瘤细胞的增殖、侵袭及转移密切相关,在肿瘤的发生发展中扮演重要角色... 详细信息

支链氨基酸转移酶1(BCAT1)作为催化支链氨基酸代谢的关键酶,参与多种生物合成的通路。研究发现BCAT1在白血病、胶质瘤、鼻咽癌、胃癌、乳腺癌等恶性肿瘤中高表达,与肿瘤细胞的增殖、侵袭及转移密切相关,在肿瘤的发生发展中扮演重要角色,可作为恶性肿瘤新的治疗靶点。

关键词：肿瘤支链氨基酸转移酶1 支链氨基酸

Uncertainty and parameter ranking analysis on summer thermal characteristics of the hydronic thermal barrier for low-energy buildings

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Building Simulation 2023年第1期16卷 27-49页

作者： Sarula Chen Yang Yang tianxin Chang Engineering Research Center of Building Energy Efficiency Control and Evaluation(Ministry of Education) Anhui Jianzhu UniversityHefei 230601China School of Architecture and Urban Planning Anhui Jianzhu UniversityHefei 230601China College of Architecture and Art Hefei University of TechnologyHefei 230601China Anhui Academy of Territory Space Planning and Ecology Anhui Jianzhu UniversityHefei 230601China

The hydronic thermal barrier(HTB)makes the building envelope gradually regarded as a multifunctional element,which is an opportunity to transform thermal insulation solutions from high to zero-carbon ***,inappropriate design,construction,and operation control may lead to issues like low efficiency and high investment,and even the opposite technical *** this paper,a comprehensive uncertainty and variable ranking analysis is numerically conducted to explore the influence mechanism of twelve risk variables on three types and five thermal performance indexes under summer *** uncertainty analysis results showed that the correct application of HTB could significantly reduce the heat gain that needs to be handled by the traditional air-conditioning system and even have the technical effect of auxiliary cooling if the variables are appropriately *** comprehensive influences of water temperature,room temperature,charging duration,and thermal conductivity of the HTB layer were in the first 1/3 *** them,the first two variables were identified as the two most influential variables,and they had a significant mutual restriction relationship in all other four indexes except for the exterior surface cold *** recommended charging duration was not less than eight hours in practical application,and the HTB layer with a higher thermal conductivity value but less than 3.3 W/(m·℃)was ***,the climate zone was no longer the most influential variable affecting the mean radiant temperature of the interior surface due to the combined effects of HTB and static thermal insulation *** addition,pipe spacing should preferably be selected between 100 and 250 mm to help form a continuous thermal buffer zone inside the building envelope.

关键词： uncertainty analysis parameter ranking hydronic thermal barrier thermal characteristics numerical simulation

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可干预因素与关节运动损伤的因果关系

中国组织工程研究 2025年第9期29卷 1953-1962页

作者：董婷婷陈天鑫李妍张晟张磊中国中医科学院望京医院骨关节四科北京市100102

背景:生活方式、代谢特征及营养摄入等干预因素与关节运动损伤的因果关系逐渐得到临床研究的重视,然而可干预因素与关节运动损伤的因果关系尚不明确。目的:运用孟德尔随机化的方法,探讨可干预因素与关节运动损伤的因果关系,为运动损伤... 详细信息

背景:生活方式、代谢特征及营养摄入等干预因素与关节运动损伤的因果关系逐渐得到临床研究的重视,然而可干预因素与关节运动损伤的因果关系尚不明确。目的:运用孟德尔随机化的方法,探讨可干预因素与关节运动损伤的因果关系,为运动损伤预防提供依据。方法:从公开数据库获取可干预因素和关节运动损伤的GWAS数据集,运用逆方差加权法、MR-Egger法、加权中位数法探讨生活方式、代谢特征、营养摄入与关节运动损伤的因果关系。敏感性分析方面,采用Cochran’s Q检验、MR-Egger回归、留一法和MR-PRESSO,以验证结果的稳定性和可靠性。结果与结论:①生活方式方面,咖啡(OR=0.29,95%CI:0.10-0.79,P=0.016)、茶消耗量(OR=0.41,95%CI=0.19-0.85,P=0.017)与足踝关节运动损伤风险下降,咖啡消耗量(OR=3.31,95%CI=1.02-10.73,P=0.046)与肩关节运动损伤风险上升具有潜在因果关系;从未吸烟(OR=0.78,95%CI=0.70-0.87,P=1.49×10^(-5))与足踝关节运动损伤风险下降具有显著因果关系。②代谢特征方面,钙水平(OR=0.88,95%CI=0.79-0.98,P=0.017)与手腕关节运动损伤风险下降具有潜在因果关系。③营养摄入方面,维生素A摄入(OR=1.08,95%CI:1.02-1.13,P=0.007)与膝关节运动损伤风险增加具有潜在因果关系。④敏感性分析方面,Cochran’s Q检验显示存在异质性(P0.05),留一法显示逐个剔除单核苷酸多态性后,结果具有稳定性。⑤此研究初步揭示生活方式、代谢特征及营养摄入等可干预因素对关节运动损伤风险的影响,为关节运动损伤的预防提供研究证据与研究方向。

关键词：孟德尔随机化关节运动损伤可干预因素生活方式代谢特征营养摄入因果关系敏感性分析

Structural uncertainty quantification of Reynolds-Averaged Navier–Stokes closures for various shock-wave/boundary layer interaction flows

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Chinese Journal of Aeronautics 2024年第3期37卷 34-48页

作者： Fanzhi ZENG tianxin ZHANG Denggao TANG Jinping LI Chao YAN School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China School of Aeronautical Engineering Air Force Engineering UniversityXi’an 710038China

Accurate prediction of Shock-Wave/Boundary Layer Interaction(SWBLI)flows has been a persistent challenge for linear eddy viscosity models.A major limitation lies in the isotropic representation of the Reynolds stress,as assumed under the Boussinesq *** studies have shown promise in improving the prediction capability for incompressible separation flows by perturbing the Reynolds-stress anisotropy ***,it remains uncertain whether this approach is effective for SWBLI flows,which involve compressibility and *** address this issue,this study systematically quantifies the structural uncertainty of the anisotropy for oblique SWBLI *** eigenspace perturbation method is applied to perturb the anisotropy tensor predicted by the Menter Shear–Stress Transport(SST)model and reveal the impacts of anisotropy on the prediction of quantities of interest,such as separation and reattachment positions,wall static pressure,skin friction,and heat *** results demonstrate the potential and reveal the challenges of eigenspace perturbation in improving the SST ***,a detailed analysis of turbulent characteristics is performed to identify the source of *** findings indicate that eigenspace perturbation primarily affects turbulent shear stress,while the prediction error of the SST model is more related to turbulent kinetic energy.

关键词： Shock-wave/boundary layer interaction(SWBLI) Turbulence models Uncertainty analysis Eigenspace perturbation Anisotropy

Molecularly Imprinted Polymer Thin Film Based Surface Plasmon Resonance Sensor to Detect Hemoglobin

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Chemical Research in Chinese Universities 2014年第1期30卷 42-48页

作者： WANG Yang ZHANG Qingwen REN Yamin JING Lijing WEI tianxin Key Laboratory of Cluster Science Ministry of Education Beijing Institute of Technology Beijing 100081 P. R. China

Molecularly imprinted polymer（MIP） films for hemoglobin detection were prepared onto the Au/Cr coated surface plasmon resonance（SPR） sensor chips by the in situ electropolymerization of 3-aminophenylboronic acid（3-APBA）.The formation of the films and rebinding processes of hemoglobin were monitored by in situ electrochemical-SPR（EC-SPR） spectroscopy,with allowed real-time observation of the simultaneous changes in electrochemical and optical properties of the *** electron microscopy（SEM） and atomic force microscopy（AFM）were used to characterize the surface morphologies of the MIP *** effects of pH,ion strength,different metal ions on rebinding Hb,the specific binding and the selective recognition were *** results obtained with the molecular imprinted SPR chips indicate a good adsorption of Hb in a range of 0.0005-5 mg/mL in 0.05 mol/L sodium phosphate buffer at pH=7.0.A linear calibration curve（R2=0.94） of the SPR sensor for Hb detection was obtained in a range of 0.05-5 mg/*** detection limit for hemoglobin by this method was 0.000435 mg/mL（S/N=3）.Interference studies indicate that the MIP films have a good selectivity compared with the referenced *** stability of the sensor was also *** indicate that the SPR sensor chip keeps 87.6％ of its original response after 14 d of storage under dry and ambient conditions.

关键词： Surface plasmon resonance Molecularly imprinted polymer Hemoglobin 3-Aminophenylboronic acid

A three-equation transition model with mechanical considerations

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Chinese Journal of Aeronautics 2022年第11期35卷 178-190页

作者： tianxin ZHANG Jianqiang CHEN Yatian ZHAO Zaijie LIU Chao YAN School of Aeronautic Science and Engineering Beihang UniversityBeijing 100083China Computational Aerodynamics Institute China Aerodynamics Research&Development CenterMianyang 621000China School of Aeronautics and Astronautics Central South UniversityChangsha 410083China

A three-equation transition model based on the transition V-model is proposed for subsonic flows in this study. Considering the mechanical approximation of the generation process of the pre-transitional vorticities, the value of laminar Reynolds shear stress related to the mean shear deformation was calculated in the original transition V-model. Then a new transition model, named V-SA model, was proposed, which considered the phenomenological process of transition and presented great results for flows with and without pressure gradient. It is well-known that the baseline Shear Stress Transport(SST) turbulence model shows excellent performance of accuracy and robustness in plentiful flow cases, but it is important to predict boundary layer transition. The current model(V-SST) successfully couples the V-model to the SST turbulence model by introducing the effective turbulent viscosity and additional correction terms into the transport equations. A thorough evaluation of its ability to predict transition features is performed versus the well-documented flat plate of ERCOFTAC, including T3A and T3B without pressure gradient, T3L2 and T3L3 with semi-circular leading edge, the three-dimensional 6:1 prolate-spheroid under two angles of attack, and the NLR-7301 airfoil under different Mach numbers. Numerical results show that the current model has an attractive and superior performance in the simulation of boundary layer transition processes.

关键词： Laminar kinetic energy Mechanical consideration Shear stress transport turbulence model Transition model V-model

Performance Evaluation Method for Automated Driving System in Logical Scenario

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Automotive Innovation 2022年第3期5卷 299-310页

作者： Peixing Zhang Bing Zhu Jian Zhao tianxin Fan Yuhang Sun State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchunChina

With the continuous improvement of automated driving technology,how to evaluate the performance of an automated driving system is attracting more and more ***,with the creation of scenario-based test methods,the traditional evaluation index based on a single test can no longer meet the requirements of high-level safety verification for automated driving system,and the performance evaluation of such a system in logical scenarios will be the *** on the scenario-based test method and Turing test theory,a performance evaluation method for an automated driving system in the whole parameter space of a logical scenario is *** logical scenario parameter space is partitioned according to the risk degree of concrete scenario,and the evaluation process in different zones are ***,the anthropo-morphic index in the safe zone and the collision-avoidance index in the danger zone are defined by comparing test results of human driving and ideal vehicle *** front vehicle low-speed and cut-out scenarios as examples,two automated driving algorithms are tested in the virtual environment,and the test results are evaluated both by the proposed method and by human *** results show that the results of the proposed method are consistent with the subjective feelings of humans;additionally,it can be applied to scenario-based tests and the verification process of an automated driving system.

关键词： Automated driving system Logical scenario Performance evaluation Anthropomorphic index

Effects of Nitrogen Doping on Microstructures and Irradiation Resistance of Ti-Zr-Nb-V-Mo Refractory High-Entropy Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 1007-1018页

作者： Huanzhi Zhang tianxin Li Qianqian Wang Zhenbo Zhu Hefei Huang Yiping Lu Engineering Research Center of High Entropy Alloy Materials(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian116024China Shanghai Institute of Applied Physics Chinese Academy of Sciences(CAS)Shanghai201800China

Interstitial strengthening with nitrogen(N)is one of the effective ways to improve the mechanical properties of HEAs,but the effects of N on the microstructures and mechanical properties of the irradiated HEAs have not been studied ***,the microstructures and mechanical properties of N-free and N-doped Ti_(2)ZrNbV_(0.5)Mo_(0.2)HEAs before and after He irradiation were *** results showed that the solid solution strengthening caused by interstitial N improved the yield strength at room temperature and 1023 K without significantly reducing plasticity.N doping significantly promoted the growth,aggregation and wider spatial distribution of He bubbles by enhancing the mobility of He atoms/He-vacancy complexes,with the average size of He bubbles increasing from 10.4 nm in N-free HEA to 31.0 nm in N-doped *** addition,N-doped HEA showed a much higher irradiation hardness increment and hardening fraction than N-free *** to conventional materials doped with N,the introduction of N into Ti_(2)ZrNbV_(0.5)Mo_(0.2)HEA had adverse effects on its resistance to He bubble growth and irradiation *** results of this study indicated that N doping may not improve the irradiation resistance of HEAs.

关键词： High-entropy alloys Nitrogen doping Mechanical properties Helium bubbles Irradiation resistance