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Medical Review 2023年第3期3卷 205-208页

作者： chengyuan Hong Zhusheng Liu tianxiang chen Aiguo Wu Cixi Institute of Biomedical Engineering International Cooperation Base of Biomedical Materials Technology and ApplicationCAS Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of Sciences(CAS)Ningbo Key Laboratory of Biomedical Imaging Probe Materials and TechnologyNingbo 315201Zhejiang ProvinceChina Department of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingboZhejiang ProvinceChina

With the evolution of nanomedicine,the past decades witnessed diversified nanomaterials as marvelous antitumor tools ushering in a new era of tumor diagnosis and treatment.Among them,two-dimensional layered nano-material as an emerging class of nanomaterials has one dimension less than 100 nm,showing a high specific area and the thinnest sheet-like structure(Liu S,Pan X,Liu H.Twodimensional nanomaterials for photothermal therapy.Angew Chem Int Ed 2020;59:5890–900).The discovery of graphene drove the exploration of various new two-dimensional layered nanomaterials for tumor diagnosis and treatment including graphene-based nanomaterials,black phosphorus(BP),transition metal dichalcogenides(TMDs),layered double hydroxides(LDHs),and bismuth oxyhalides(BiOX,X=F,Cl,Br,I)(Ma H,Xue MQ.Recent advances in the photothermal applications of two-dimensional nanomaterial:photothermal therapy and beyond.J Mater Chem 2021;9:17569).On the one hand,they exhibit strong near-infrared(NIR)absorption and the capacity of optimizing corresponding properties by adjusting the crystal structure.On the other hand,they own unique strengths such as fantastic physicochemical properties(graphene-based nanomaterials),high loading capacity(BP),distinct phase-dependent optical properties(TMDs),a specific chemical response to the tumor microenvironment(LDHs),and large X-ray attenuation coefficient(BiOX).Herein,we briefly introduce three typical two-dimensional layered nanomaterials,their prospects and future research priorities in tumor diagnosis and treatment are concluded.

关键词： tumor diagnosis tumor treatment two-dimensional layered nanomaterials

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Identification of transcriptional isoforms associated with survival in cancer patient

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Journal of Genetics and Genomics 2019年第9期46卷 413-421页

作者： Zefang Tang tianxiang chen Xianwen Ren Zemin Zhang School of Life Sciences and BIOPIC Peking UniversityBeijing100871China Beijing Advanced Innovation Centre for Genomics Peking-Tsinghua Centre for Life SciencesPeking UniversityBeijing100871China

The Cancer Genome Atlas(TCGA) project produced RNA-Seq data for tens of thousands of cancer and non-cancer samples with clinical survival information,providing an unprecedented opportunity for analyzing prognostic genes and their isoforms.In this study,we performed the first large-scale identification of transcriptional isoforms that are specifically associated with patient prognosis,even without gene-level association.These specific isoforms are defined as Transcripts Associated with Patient Prognosis(TAPPs).Although a group of TAPPs are the principal isoforms of their genes with intact functional protein domains,another group of TAPPs lack important protein domains found in their canonical gene isoforms.This dichotomy in the distribution of protein domains may indicate different patterns of TAPPs association with cancer.TAPPs in protein-coding genes,especially those with altered protein domains,are rich in known cancer driver genes.We further identified multiple types of cancer recurrent TAPPs,such as DCAF17-201,providing a new approach for the detection of cancer-associated events.In order to make the wide research community to study prognostic isoforms,we developed a portal named GESUR(http://***/),which illustrates the detailed prognostic characteristics of TAPPs and other isoforms.Overall,our integrated analysis of gene expression and clinical parameters provides a new perspective for understanding the applications of different gene isoforms in tumor progression.

关键词： Prognostic isoform Gene expression Survival analysis

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On-line Monitoring of Insulation Dielectric Loss Factor Based on Balance Principle

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电力系统自动化 2013年第21期37卷 180-183页

作者： tianxiang chen Zhenhua SHAO Shaozhen QIN Hong TIAN Xiamen University of Technology Xiamen 361024 China Singapore Power Grid Singapore 238164 Singapore

This paper proposes a new on-line measuring method for tan δ of insulation based on passive current sensors. The new method avoids the difficulties encountered during producing sensors with high precision for ratio error and phase displacement error, thus it is cost-effective and of high accuracy. Combining a phase difference algorithm with the computer technology, the method is suitable for micro-controller unit (MCU). The practicability of the method is validated by field tests, thus its anti-interference ability is confirmed.

关键词：介质损耗因数平衡原则在线监测绝缘相位误差高精确度电流传感器位移传感器

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改进黑猩猩算法的光伏发电功率短期预测

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电力系统及其自动化学报 2024年第2期36卷 135-143页

作者：谢国民陈天香辽宁工程技术大学电气与控制工程学院葫芦岛125105

针对晴空、非晴空条件下光伏出力预测精度不高等问题,提出一种改进K均值(K-means++)算法和黑猩猩优化算法CHOA(chimpanzee optimization algorithm)相结合,优化最小二乘支持向量机LSSVM(least squares support vector machine)的模型,进行光伏功率预测。首先,利用密度聚类和混合评价函数改进K-means++对原始数据进行自适应类别划分。其次,通过相关性分析和随机森林特征提取构建模型的输入特征集。最后,根据特征集建立基于DK-PCHOA-LSSVM的短期光伏发电预测模型。结合实际算例,结果表明:该模型在恶劣天气下预测精度明显优于其他模型,验证了其有效性和优越性。

关键词：光伏功率短期预测自适应聚类最小二乘支持向量机黑猩猩优化算法极端天气

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Cramer-Rao lower bound-based observable degree analysis

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Science China(Information Sciences) 2019年第5期62卷 29-31页

作者： Quanbo GE tianxiang chen Hongli HE Zhentao HU School of Automation Hangzhou Dianzi University Chinese Flight Test Establishment College of Computer and Information Engineering Henan University

Dear editor,Controllability and observability are basic concepts in modern control theory that are based on Kalman filtering (KF)[1, 2]. In particular, observability is closely related to state estimation ability [2–4]. The indicator called observable degree(OD) has been used to quantitatively measure the degree of observability [5–7]. However, limited by

关键词： ODA Cramer-Rao lower bound-based observable degree analysis

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Controllable synthesis of layered black bismuth oxidechloride nanosheets and their applications in internal tumor ablation

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Regenerative Biomaterials 2022年第1期9卷 501-510页

作者： Qianlan Fang Yu Xu Lijia Luo Chuang Liu Zihou Li Jie Lin tianxiang chen Aiguo Wu Cixi Institute of Biomedical Engineering International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Science(CAS)Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringCASNingbo 315201P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000P.R.China

The recently emerging bismuth oxyhalide(BiOX)nanomaterials are promising indirect band gap photosensitizer for ultraviolet(UV)light-triggered phototherapy due to their unique layered nanosheet structure.However,the low absorption and poor photothermal conversion efficiency have always impeded their further applications in cancer clinical therapy.Herein,BiOCl rich in oxygen vacancies has been reported to have fullspectrum absorption properties,making it possible to achieve photothermal property under near-infrared laser.Under 808nm irradiation,the photothermal conversion efficiency of black BiOCl nanosheets(BBNs)is up to 40%.BBNs@PEG can effectively clear primary subcutaneous tumors and prevent recurrence,achieving good synergistic treatment effect.These results not only broke the limitation of UV on the BiOCl material and provided a good template for other semiconductor materials,but also represent a promising approach to fabricate BBN@PEG a novel,potent and multifunctional theranostic platform for precise photothermal therapy and prognostic evaluation.

关键词： black bismuth oxidechloride nanosheet photothemal therapy tumor photothermal conversion efficiency

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个人信息权的弱势主体法理批判

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法治现代化研究 2024年第1期8卷 97-109页

作者：陈天翔浙江大学光华法学院

法律和企业相关隐私政策须要以弱势群体而非消费者为叙事,关注其作为弱势权利主体的个人信息保护。既有法律对个人信息的保护忽视了弱势主体,他们难以有效地行使个人信息权利。依据情境一致理论的启发,分析个人信息权需要立足于信息关... 详细信息

法律和企业相关隐私政策须要以弱势群体而非消费者为叙事,关注其作为弱势权利主体的个人信息保护。既有法律对个人信息的保护忽视了弱势主体,他们难以有效地行使个人信息权利。依据情境一致理论的启发,分析个人信息权需要立足于信息关系中信息主体双方的情境要素以表达权利主体的角色及弱势要素。在我国个人信息保护法的语境下,进一步完善目的和同意原则需要反映弱势主体的真实期望,相关权利的实现需要企业的技术助推。

关键词：弱势群体个人信息权情境一致目的同意技术助推

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In-orbit performance of LE onboard Insight-HXMT in the first 5 years

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Radiation Detection Technology and Methods 2023年第1期7卷 25-33页

作者： Xiaobo Li Yong chen Liming Song Weiwei Cui Wei Li Juan Wang Shuang-Nan Zhang Fangjun Lu Yupeng Xu Haisheng Zhao Mingyu Ge Youli Tuo Yusa Wang tianxiang chen Dawei Han Jia Huo Yanji Yang Maoshun Li Ziliang Zhang Yuxuan Zhu Xiaofan Zhao Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Science19B Yuquan RoadShijingshan DistrictBeijing 100049China

Purpose The low-energy X-ray telescope(LE)is a main instrument of the Insight-HXMT mission and consists of 96 swept charge devices covering the 1–10 keV energy band.The energy gain and resolution are continuously calibrated by analyzing Cassiopeia A(Cas A)and blank sky data,while the effective areas are also calibrated with the observations of the Crab Nebula.In this paper,we present the evolution of the in-orbit performances of LE in the first 5 years since launch.Methods The Insight-HXMT data analysis software package(HXMTDAS)is utilized to extract the spectra of Cas A,blank sky,and Crab Nebula using different good time interval selections.We fit a model with a power-law continuum and several Gaussian lines to different ranges of Cas A and blank sky spectra to get peak energies of their lines through xspec.After updating the energy gain calibration in CALibration DataBase(CALDB),we rerun the Cas A data to obtain the energy resolution.An empirical function is used to modify the simulated effective areas so that the background-subtracted spectrum of the Crab Nebula can best match the standard model of the Crab Nebula.Results The energy gain,resolution,and effective areas are calibrated every month.The corresponding calibration results are duly updated in CALDB,which can be downloaded and used for the analysis of Insight-HXMT data.Simultaneous observations with NuSTAR and NICER can also be used to verify our derived results.Conclusion LE is a well-calibrated X-ray telescope working in 1–10 keV band.The uncertainty of LE gain is less than 20eV in 2–9 keV band,and the uncertainty of LE resolution is less than 15eV.The systematic errors of LE,compared to the model of the Crab Nebula,are lower than 1.5%in 1–10 keV.

关键词： X-ray Calibration SCD In-orbit performance

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A facile fabrication route for binary transition metal oxide-based Janus nanoparticles for cancer theranostic applications

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Nano Research 2018年第10期11卷 5735-5750页

作者： M. Zubair Iqbal Wenzhi Ren Madiha Saeed tianxiang chen Xuehua Ma Xu Yu Jichao Zhang Lili Zhang Aiguo Li Aiguo Wu iang Province & Division of Functional Materials and Nano devices Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo 315201 China ShanghaiSynchrotron Radiation Facility Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai201204 China

Janus nanoparticles （JNPs） have multiple configurations for molecular imaging, targeting, and therapeutic effects on cancers; these properties have made these particles attractive for biomedical applications. Nonetheless, smart strategies for the controlled synthesis in a liquid phase and exploration of the appropriate applications of JNPs remain a challenge. In this study, a unique liquid-phase method was applied to fabricate Mn3O4-TiO2/ZnO/Fe3O4 multifunctional binary transition metal oxide-based JNPs, using the concept of epitaxial growth and lattice mismatch among synthesized materials. Transmission electron microscopy and scanning transmission electron microscopy results revealed that the created materials are embedded in the form of dimers with good dispersion and homogeneous growth in a nonpolar solvent. Pluronic F-127-coated MnBO4- TiO2 JNPs were utilized as a contrast agent in T1-weighted magnetic resonance imaging （MRI） and in photodynamic therapy （PDT） for cancers in vitro and in vivo. In vivo T1-weighted MRI of the heart, liver, and kidneys in mice after intravenous injection of the nanoparticles revealed high sensitivity and biocompatibility of as-synthesized Mn3O4--TiO2 JNPs. Results of synchrotron X-ray fluorescence microscopy mapping showed the stability of the nanocomposites and efficiency of penetration into the cytoplasm and perinuclear area. Inorganic TiO2 photosensitizers showed promising tumor ablation performance in PDT in vitro and in vivo at low intensity of UV irradiation （5.6 mW.cm-2） because of their ultrasmall size and photodegradable stability. These results reveal that multifunctional Mn3O4-TiO2 JNPs enhance a T1-weighted MRI contrast and have excellent properties for PDT and therefore, may be a novel agent for cancer theranostics.

关键词： Janus nanostructures manganese oxide magnetic resonance imaging photodynarnic therapy breast cancer

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10 kV线路下方森林火灾成因分析及试验研究

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消防科学与技术 2024年第2期43卷 271-277页

作者：杨博闻陈天翔魏玉文曾潮旭成都理工大学核技术与自动化工程学院四川成都610059 国网四川省电力公司简阳分公司四川成都641400

近年来,国内外因树线故障导致森林火灾的事故频发,因外在社会因素引发森林火灾,从而导致输配电线路跳闸的事故也层出不穷。本文针对10 kV配电线路下方森林火灾事故,从社会因素引发森林火灾和树线故障引发森林火灾两个角度出发,考虑了纯... 详细信息

近年来,国内外因树线故障导致森林火灾的事故频发,因外在社会因素引发森林火灾,从而导致输配电线路跳闸的事故也层出不穷。本文针对10 kV配电线路下方森林火灾事故,从社会因素引发森林火灾和树线故障引发森林火灾两个角度出发,考虑了纯火焰、树线放电及放电后引发火灾等多种极端环境对导线表面痕迹的影响,通过配电网故障模拟真型试验平台,对极端环境下导线表面形貌变化进行试验研究,得到了火烧痕迹、树线放电一次痕迹以及二次痕迹。基于宏观法、显微法和图像特征提取法分析了各类痕迹的特征,并找到了鉴别树线放电一次痕迹的方法。研究结果表明:放电痕迹一方面是树线电弧直接侵蚀导线,另一方面是电弧间接转移炭渣至导线表面形成炭黑痕迹;树线故障初期未引发森林火灾时,导线表面仅有一次放电痕迹,相同条件下,松树放电使导线质量变化最明显,可增重0.59 g;树线故障末期引发森林火灾后,火烧痕迹会覆盖放电痕迹形成二次痕迹,擦拭表面痕迹后发现,一、二次痕迹灰度曲面相似且分形维数之差小于0.03。

关键词：电气森林火灾树线故障火烧痕迹放电痕迹分形维数

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