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非酒精性脂肪性肝病中miRNA的功能及临床研究进展

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国际检验医学杂志 2024年第15期45卷 1883-1886页

作者：徐芸杨天文(综述) 左新(审校) 重庆市第六人民医院消化内科重庆400060

非酒精性脂肪性肝病(NAFLD)目前已成为导致慢性肝病的最重要病因,其致病机制十分复杂。微小核糖核酸(miRNA)是分布十分广泛的非编码RNA,miRNA在包括NAFLD在内的多种慢性肝病的致病及进展中发挥着重要的调控作用,甚至可能作为肝脏疾病的... 详细信息

非酒精性脂肪性肝病(NAFLD)目前已成为导致慢性肝病的最重要病因,其致病机制十分复杂。微小核糖核酸(miRNA)是分布十分广泛的非编码RNA,miRNA在包括NAFLD在内的多种慢性肝病的致病及进展中发挥着重要的调控作用,甚至可能作为肝脏疾病的诊断指标甚至治疗靶点。作为无创生物学指标,大量的研究数据显示miRNA在NAFLD的诊断及预后中有重要临床价值。该文针对miRNA在NAFLD中的致病机制及临床诊疗价值的相关研究进展做一综述。

关键词：非酒精性脂肪性肝病微小核糖核酸预后

Effect of Feeding Strategies on Molecular Responses of Biotransformation Genes in Crassostrea gigas Exposed to Cadmium

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Journal of Ocean University of China 2019年第4期18卷 883-888页

作者： SUN Ming LIU Guangbin LIN Hong ZHANG tianwen GUO Wen Marine Biology Institute of Shandong Province Qingdao 266104 China College of Food Science and Engineering Ocean University of China Qingdao 266003 China

Heavy metals, including cadmium (Cd), are widespread pollutants of great environmental concern because of their ac- cumulation and toxicity. Environmental conditions can affect the accumulation and elimination of Cd in organisms. The aim of this study is to understand the respective responses of metallothioneins (MTs), P-glycoprotein (P-gp), and heat shock protein 70 (hsp70) genes in the mantle and digestive gland of the oyster Crassostrea gigas exposed to 10 g L 1 Cd for 28 days, followed by a depura- tion period of 35 days under different feeding strategies. The MT expression in the digestive gland was higher than in mantle, and was induced in a fluctuating pattern throughout the time of the whole experiment when the oyster was exposed to Cd. The results indicated an enhanced MT activity is required for Cd detoxification. Expression levels of P-gp in the mantle of Cd-exposed oysters fed with algae increased in the first two weeks of the accumulation phase. Then the induction weakened, but the expression still in- creased significantly compared with the control group fed without algae. The P-gp levels in the digestive gland were under-regulated during both the contamination and decontamination periods except in the group fed with Dicrateria inornata at day 0.083. The in- duction of P-gp is possibly related to the important role of pumping Cd out of the cell, while a major implication of P-gp expression inhibition would be a disruption of the protein synthesis. Hsp70 expression exhibited an overall decreasing trend. The highest relative hsp70 inhibition occurred during day 42 to day 63, with approximately 4-fold and 10-fold lower hsp70 levels as compared to the *** feeding with no algae in the mantle and digestive gland, respectively. The induction of hsp70 may be explained by the re- folding of protein in presence of Cd, followed by the inhibition of hsp70 when the protein synthesis was disrupted.

关键词： cadmium metallothionein P-glycoprotein heat shock protein 70 Crassostrea gigas feeding strategies

Study on Alfalfa Yield Improved by New Rare Earth Materials for Agriculture

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Journal of Rare Earths 2004年第z1期22卷 269-270页

作者： Fan tianwen Abudukahar Cui Yingguo Peng Jianzhang Wang Jiachen Grassland Working Station of Yili Yining 835000 China Grassland Working Station of Yili Yining 835000 China Grassland Working Station of Urumqi Urumqi 830000 China Grassland Working Station of Chapuchaer County Yili 835300 China Beijing General Research Institure for Nonferrous Metals Beijing 100088 China

New rare earth(RE) materials for agriculture including RE entire nutrition agent, amino acid chelated RE fertilizer, RE phosphate were used to alfalfa production in Grassland Working Station of Yili, Xinjiang Province, and repetition was 3 with 7 *** result shows that by using new RE materials, the average treatment height of alfalfa increases by 12.5% compared with traditional cultural, and the yield increases from 21.8% to 41.6% compared with that of traditional *** results show that the new materials have significant good effect on alfalfa production.

关键词： rare earth materials for agriculture alfalfa yield

一种基于迁移学习和长短期记忆神经网络的降水预报方法

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暴雨灾害 2024年第1期43卷 45-53页

作者：黄天文焦飞伍志方广东省肇庆市气象局肇庆526040 肇庆学院肇庆526061 广东省气象台广州510640

为给智能网格强降水预报提供客观参考,提出了一种基于迁移学习和长短期记忆神经网络(LSTM)的降水预报方法。迁移学习是一种机器学习方法,可将源域学习到的知识迁移到目标域中以应用;LSTM是一种可以处理序列数据中的长期依赖关系的深度... 详细信息

为给智能网格强降水预报提供客观参考,提出了一种基于迁移学习和长短期记忆神经网络(LSTM)的降水预报方法。迁移学习是一种机器学习方法,可将源域学习到的知识迁移到目标域中以应用;LSTM是一种可以处理序列数据中的长期依赖关系的深度学习模型。基于2009—2022年广东省肇庆市6个国家气象观测站逐小时雨量、气温、气压、相对湿度、风向和风速的观测资料,以肇庆高要国家气象观测站作为目标域,其它5个国家气象观测站作为源域,利用迁移学习方法对目标域有缺失值的观测资料进行订正,使目标域形成完整的训练样本;然后,利用深度学习方法,对目标域分别建立单变量LSTM日雨量预报模型和多变量LSTM小时雨量预报模型;最后,对目标域2022年日雨量与小时雨量进行预报,与对应实况对比。结果表明:(1)单变量LSTM预报方法在1—2月、6月、10—12月的24 h晴雨预报准确率在80%以上,多变量LSTM预报方法在3月、6月、8月、12月的1 h晴雨预报准确率在80%以上。(2)单变量LSTM预报方法仅6月能预报出24 h雨量在50 mm以上的强降水,多变量LSTM预报方法在3月、5月、6—8月能预报出1 h雨量在20 mm以上的强降水,其中3月和6月的小时雨量预报TS评分高于25%。

关键词：降水预报时间序列迁移学习 LSTM 深度学习

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GSDMD介导的肝细胞焦亡在急性肝衰竭中的致病机制

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海南医学院学报 2024年第9期30卷 700-706页

作者：关海梅曾阳玲王恬雯谢宝华李国宝毛德文广西中医药大学研究生院广西南宁530001 广西中医药大学第一附属医院肝病科广西南宁530023

消皮素D(gasdermin D,GSDMD)是一种广泛表达的蛋白质,可以被肝细胞内的炎性因子激活。一旦被激活,GSDMD的N末端域(GSDMD-N)将形成孔道,导致细胞膜破裂和胞浆泄漏,最终导致细胞死亡。细胞焦亡是GSDMD介导的最具特征的致炎性裂解细胞死亡... 详细信息

消皮素D(gasdermin D,GSDMD)是一种广泛表达的蛋白质,可以被肝细胞内的炎性因子激活。一旦被激活,GSDMD的N末端域(GSDMD-N)将形成孔道,导致细胞膜破裂和胞浆泄漏,最终导致细胞死亡。细胞焦亡是GSDMD介导的最具特征的致炎性裂解细胞死亡模式。最近研究发现,GSDMD被激活可扩大炎症反应,诱导肝细胞焦亡,进而加快急性肝衰竭的进展。本文着重探讨了GSDMD介导的肝细胞焦亡在急性肝衰竭中的致病机制及潜在的治疗靶点,以期为寻找有效治疗急性肝衰竭的潜在干预靶点提供新思路。

关键词： GSDMD 细胞焦亡急性肝衰竭潜在靶点

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井工煤矿全波形反演的初始模型构建探究

中国煤炭 2024年第2期50卷 90-100页

作者：梁旭徐裴白喜成李志勇孙瑞雪聂天文陕西小保当矿业有限公司陕西省榆林市719399 北京中矿大地地球探测工程技术有限公司北京市海淀区100083

为提高全波形反演在井工煤矿工作面的运算效果,探究了三维程函方程求解时间场的方法,由透射初至走时反演刻画出初始模型,通过建立含断层的复杂地质模型理论计算正反演来验证算法可靠性。依据小保当二号煤矿工作面实际数据,通过折射横纵... 详细信息

为提高全波形反演在井工煤矿工作面的运算效果,探究了三维程函方程求解时间场的方法,由透射初至走时反演刻画出初始模型,通过建立含断层的复杂地质模型理论计算正反演来验证算法可靠性。依据小保当二号煤矿工作面实际数据,通过折射横纵波有效信息,初步刻画煤岩分界,改进初始模型,提升全波形反演梯度结果,研究成果可用于煤矿工作面的高精度探测,建立更优全波形反演系统。

关键词：井工煤矿全波形反演模型构建高精度探测程函方程射线追踪梯度计算最小二乘法

Robust Solution for Boundary Layer Height Detections with Coherent Doppler Wind Lidar

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Advances in Atmospheric Sciences 2021年第11期38卷 1920-1928页

作者： Lu WANG Wei QIANG Haiyun XIA tianwen WEI Jinlong YUAN Pu JIANG School of Earth and Space Science University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology University of Science and Technology of ChinaHefei 230026China

Although coherent Doppler wind lidar(CDWL)is promising in detecting boundary layer height(BLH),differences between BLH results are observed when different CDWL measurements are used as ***,a robust solution for BLH detections with CDWL is proposed and demonstrated:mixed layer height(MLH)is retrieved best from turbulent kinetic energy dissipation rate(TKEDR),while stable boundary layer height(SBLH)and residual layer height(RLH)can be retrieved from carrier-to-noise ratio(CNR).To study the cause of the BLH differences,an intercomparison experiment is designed with two identical CDWLs,where only one is equipped with a stability control *** the experiment,it is found that the CNR could be distorted by instrument instability because the coupling efficiency from free-space to the polarization-maintaining fiber of the telescope is sensitive to the surrounding *** the ML,a bias up to 2.13 km of the MLH from CNR is found,which is caused by the CNR *** contrast,the MLH from TKEDR is robust as long as the accuracy of wind is *** the SBL(RL),the CNR is found capable to retrieve SBLH and RLH simultaneously and *** solution is tested during an observation period over one *** analysis shows that the root-mean-square errors(RMSE)in the MLH,SBLH,and RLH are 0.28 km,0.23 km,and 0.24 km,respectively.

关键词： boundary layer height coherent Doppler wind lidar carrier-to-noise ratio turbulent kinetic energy dissipation rate

Microbial production of L-malate from renewable non-food feedstocks

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Chinese Journal of Chemical Engineering 2021年第2期34卷 105-111页

作者： Youming Jiang Xiaohan Ye tianwen Zheng Weiliang Dong Fengxue Xin Jiangfeng Ma Min Jiang State Key Laboratory of Materials-Oriented Chemical Engineering College of Biotechnology and Pharmaceutical EngineeringNanjing Tech UniversityNanjing 211800China

L-malate is an intermediate of the tricarboxylic acid cycle which is naturally occurred in various microorganisms,and it has been widely applied in polymer,beverage and food,textile,agricultural and pharmaceutical *** by the pursuit of a sustainable economy,microbial production of L-malate has received much attention in last *** this review,we focus on the utilization of wastes and/or byproducts as feedstocks for the microbial production of ***,we present the recent developments on the natural or engineered metabolic pathways that dedicate to the biosynthesis of L-malate,and also provide a comprehensive discussions on developing high-efficient ***,the recent achievements in microbial production of L-malate from various carbon sources were concluded and ***,some abundant non-food feedstocks which have been used for microbial production of other chemicals were reviewed,as they may be potential candidate feedstock for L-malate production in ***,we outlined the major challenges and proposed further improvements for the production of L-malate.

关键词： L-malate Renewable feedstock Microbial fermentation Bioeconomy C4 dicarboxylic acid

大顶苦瓜种质资源的遗传多样性分析与指纹图谱构建

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浙江农业学报 2024年第1期36卷 103-114页

作者：杨天文王静李炯徐彬其程蛟文洪宇曹毅崔竣杰佛山科学技术学院园艺系广东佛山528225 华南农业大学园艺学院广东广州510642

为实现对大顶苦瓜种质的快速精准鉴定,以包含主栽品种在内的26份大顶苦瓜种质为材料,通过筛选高多态性简单重复序列(simple sequence repeat,SSR)核心标记,对其进行聚类分析和指纹图谱构建。结果表明:在苦瓜基因组6种SSR基序单元类型中... 详细信息

为实现对大顶苦瓜种质的快速精准鉴定,以包含主栽品种在内的26份大顶苦瓜种质为材料,通过筛选高多态性简单重复序列(simple sequence repeat,SSR)核心标记,对其进行聚类分析和指纹图谱构建。结果表明:在苦瓜基因组6种SSR基序单元类型中,二核苷酸SSR标记的多态性最好,适用于进一步从中筛选苦瓜SSR核心标记。在遗传相似系数0.80处,40个SSR标记将26份大顶苦瓜种质分为3个类群,第一类群包含18份种质,果形以短圆锥形为主;第二类群包含5份种质,果形以长圆锥形为主;第三类群包含3份种质,其果形与大顶苦瓜相似,但含有非大顶苦瓜种质背景。利用MC05_69594、MC04_50530、MC06_87314和MC10_146038这4个SSR核心标记可对26份大顶苦瓜种质进行有效鉴定,并为每份大顶苦瓜种质建立独特的QR编码指纹图谱,其中,1号大顶和3号大顶疑为相似材料。构建的大顶苦瓜指纹图谱可以为大顶苦瓜种质鉴定与育种利用提供科学依据。

关键词：大顶苦瓜简单重复序列标记遗传多样性种质鉴定指纹图谱

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