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Visualized Degradation of CO_(2)-Based Unsaturated Polyesters toward Structure-Controlled and High-Value-Added Fluorophores

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CCS Chemistry 2022年第1期4卷 237-249页

作者： Bo Song tianwen Bai Dongming Liu Rong Hu Dan Lu Anjun Qin Jun Ling Ben Zhong Tang State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesSCUT-HKUST Joint Research InstituteAIE InstituteCenter for Aggregation-Induced EmissionSouth China University of Technology(SCUT)Guangzhou 510640 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027 Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and ReconstructionInstitute for Advanced Studyand Department of Chemical and Biological EngineeringThe Hong Kong University of Science&Technology(HKUST)Clear Water BayKowloonHong Kong 999077

In comparing with traditional polymer degradation toward unknown or unvalued products(i.e.,downcycling),new methods to degrade polymers into monomers or high-value-added materials(i.e.,upcycling)are preferable for sustainable *** this work,CO_(2)-based linear and cross-linked unsaturated polyesters,that is,poly(alkynoate)s,were successfully degraded by benzamidine into diols and high-value-added pyrimidone or imidazolone derivatives through controlled reaction *** degradation process could be visualized under UV light via gradually increased luminescent intensity of the reaction mixtures and fluorescence patterns could be generated through microcontact printing of the stamp on the thin films of poly(alkynoate)***,the pyrimidone derivatives could be applied in bioimaging and inhibiting bacteria,and the imidazolone derivatives could be used for the detection and recovery of gold(III)ions from electronic waste and serve as the fluorescent sensor to detect in situ-generated amines from food ***,this work presents a visualized and high value productselective degradation to solve the end-of-life issue of polymers.

关键词： visualized degradation N-heterocyclic compounds aggregation-induced emission microcontact printing gold enrichment

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旁靠双浮体系统耦合运动时域分析

中国造船 2023年第3期64卷 80-89页

作者：陈天文范菊上海交通大学船舶海洋与建筑工程学院上海200240

旁靠外输是海洋工程领域常见的作业形式,而浮体之间存在狭窄的间隙会产生复杂的水动力相互干扰。应用三维频域势流理论和阻尼盖模型,对旁靠双浮体系统进行频域计算,然后基于间接时域法开展该旁靠系统运动的时域模拟。研究结果表明,阻尼... 详细信息

旁靠外输是海洋工程领域常见的作业形式,而浮体之间存在狭窄的间隙会产生复杂的水动力相互干扰。应用三维频域势流理论和阻尼盖模型,对旁靠双浮体系统进行频域计算,然后基于间接时域法开展该旁靠系统运动的时域模拟。研究结果表明,阻尼盖模型能有效抑制水动力系数异常的共振幅值和改善时延函数的振荡特性。当波峰频率接近间隙水动力峰值频率时形成间隙共振,对时域运动计算结果影响较大。在横浪条件下,旁靠系统会产生较大的横向相对位移,加装防撞系统可在一定程度上控制该相对位移。

关键词：间隙共振阻尼盖法旁靠外输系统间接时域法水动力相互干扰

Protein kinases in cardiovascular diseases

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Chinese Medical Journal 2022年第5期135卷 557-570页

作者： Jiawen Chen Yafei Li Chong Du tianwen Wei Tiankai Shan Liansheng Wang Department of Cardiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing Medical UniversityNanjingJiangsu 210029China

Cardiovascular disease(CVD)remains the leading cause of death ***,exploring the mechanism of CVDs and critical regulatory factors is of great significance for promoting heart repair,reversing cardiac remodeling,and reducing adverse cardiovascular ***,significant progress has been made in understanding the function of protein kinases and their interactions with other regulatory proteins in myocardial *** kinases are positioned as critical regulators at the intersection of multiple signals and coordinate nearly every aspect of myocardial responses,regulating contractility,metabolism,transcription,and cellular ***,reconstructing the disrupted protein kinases regulatory network will help reverse pathological progress and stimulate cardiac *** review summarizes recent researches concerning the function of protein kinases in CVDs,discusses their promising clinical applications,and explores potential targets for future treatments.

关键词： Protein kinases Signal transduction Cardiovascular diseases Phosphorylation

Numerical Analysis of Bond-slip Behavior between Strengthened FRP and Concrete using a Layered Composite Plate Element

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Numerical Analysis of Bond-slip Behavior between Strengthene...

护理学专业本科生外科实习岗位胜任能力里程碑评价体系的构建与思考

第十一届南方计算力学学术会议（SCCM-11）

作者： Xiaodan Teng tianwen Wu Jie Xu College of Civil Engineering and Architecture Guangxi University Guangxi Key Laboratory of Disaster Prevention and Engineering Safety Guangxi University

Bond-slip behavior between FRP and concrete is analyzed by developing a new layered composite plate element for modelling FRP-strengthened concrete slabs. The new 8-node, 48-DOF composite layered rectangular plate element with the bond-slip effect is introduced. To include the bond-slip effect, a zero-thickness bond element is used to connect the concrete and FRP and model the debonding between them. The layered composite plate element is developed based on the Mindlin-Reissner plate theory. Timoshenko’s composite beam functions and the plane displacement interpolation function for a quadrilateral isoparametric element with drilling degrees of freedom are employed, with both geometric and material nonlinearities included in the finite element model.

关键词： Bond slip FRP concrete layered composite plate element

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中华医学教育杂志 2024年第6期44卷 421-425页

作者：黄天雯邓丽君刘圆圆张伟玲黄晓敏李娜中山大学附属第一医院骨科-显微外科医学部广东省骨科学重点实验室广州510080

目的构建护理学专业本科生外科实习岗位胜任能力里程碑评价体系。方法2022年5至10月,通过文献回顾拟定评价体系初稿,再采用德尔菲法进行2轮函询,通过专家积极系数、专家权威系数、专家意见协调程度和集中程度进行评价,其中专家积极系数... 详细信息

目的构建护理学专业本科生外科实习岗位胜任能力里程碑评价体系。方法2022年5至10月,通过文献回顾拟定评价体系初稿,再采用德尔菲法进行2轮函询,通过专家积极系数、专家权威系数、专家意见协调程度和集中程度进行评价,其中专家积极系数用问卷回收率表示,专家权威系数(Cr)使用专家熟悉程度和判断依据的均值表示,专家意见协调程度和集中程度分别用肯德尔和谐系数(Kendall's W)和变异系数(CV)表示,最终确定评价体系。结果遴选来自北京、上海、四川、湖北、广东的三级甲等综合性教学医院的18名专家进行函询。2轮专家函询的专家权威系数均为0.90,专家积极系数均为1.0,肯德尔和谐系数分别为0.194和0.474。最终构建的护理学专业本科生外科实习岗位胜任能力里程碑评价体系包括6项一级指标、28项二级指标。结论本研究构建的护理学专业本科生外科实习岗位胜任能力里程碑评价体系具有权威性,评价体系具有良好的信度和效度,科学可靠,可操作性强,可以为全面客观评价护理学专业本科生外科实习的综合能力提供参考。

关键词：护理学德尔菲法外科护理本科生实习岗位胜任力评价体系

A Four-color Matching Method Combining Neural Networks with Genetic Algorithm

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High Technology Letters 2003年第4期9卷 39-43页

作者：苏小红 Wang Yadong ZHANG tianwen School of Computer Science and Technology Harbin Institute of Technology Harbin 150001 P.R.China

A brief review of color matching technology and its application of printing RGB images by CMY or CMYK ink jet printers is presented, followed by an explanation to the conventional approaches that are commonly used in color matching. Then, a four color matching method combining neural network with genetic algorithm is proposed. The initial weights and thresholds of the BP neural network for RGB to CMY color conversion are optimized by the new genetic algorithm based on evolutionarily stable strategy. The fourth component K is generated by using GCR (Gray Component Replacement) concept. Simulation experiments show that it is well behaved in both accuracy and generalization performance.

关键词： color matching color reproduction back propagation (BP) neural networks genetic algorithm

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具有全色发光的非芳香聚马来酰亚胺

化学进展 2022年第9期34卷 1879-1881页

作者：朱天文袁望章上海交通大学化学化工学院上海200240

有机发光材料由于分子结构多样、发光颜色可调、加工简便等优点受到广泛关注。经典有机发光分子往往含有大的π共轭结构,并由此产生充分的电子离域。然而,此类有机发光分子往往含有稠环或芳杂环结构,具有潜在的细胞毒性;且在调节发光颜... 详细信息

有机发光材料由于分子结构多样、发光颜色可调、加工简便等优点受到广泛关注。经典有机发光分子往往含有大的π共轭结构,并由此产生充分的电子离域。然而,此类有机发光分子往往含有稠环或芳杂环结构,具有潜在的细胞毒性;且在调节发光颜色时往往需要增加分子共轭、改变取代基或引入不同的推拉电子结构,合成步骤较为繁琐。与之相比,不含大型共轭单元而仅含N、O、S、P等杂原子及C=O、C=N、C≡N、C=C等富电子单元的非典型发光化合物结构简单,可通过商购或简单反应获得。且许多非典型发光分子与生物体系密切相关,生物相容性良好,有利于后续应用。

关键词：有机发光材料电子单元发光颜色马来酰亚胺电子离域生物体系简单反应芳杂环

Research on Multidimensional Mutation Strategy Method of Fuzzing Test

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Research on Multidimensional Mutation Strategy Method of Fuz...

SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation

第40届中国控制会议

作者： tianwen Ding Jingqi Fu Renliang Shen School of Mechanical Engineering and Automation Shanghai University

Industrial control network security has become increasingly severe and has been highly *** paper studies the problems of low code coverage and relatively rough mutation strategies in the generation method of industrial control network protocol fuzzing test cases,and proposes a multidimensional mutation strategy-based fuzzing test ***,construct a multidimensional protocol field matrix according to the fields of the industrial control network protocol messages,and generate the corresponding variation factor matrix according to the characteristics of the ***,the agreement field matrix and the mutation factor matrix are processed by the Cartesian product to generate a multidimensional mutation *** strategy is used to guide the mutation of original data and test case ***,this method has undergone a comparative experiment on the Modbus/TCP *** results show that the proposed method not only improves the acceptance rate and coverage rate of test cases that generate malformed data,but also discovers two new "zero-day" vulnerabilities.

关键词： Industrial Control Network Protocol Multidimensional mutation strategy Multidimensional Protocol Field Matrix Variation factor matrix

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1953-1969页

作者： Xiuli Yi Huina Wang Yuqi Yang Hao Wang Hengxiang Zhang Sen Guo Jianru Chen Juan Du Yangzi Tian Jingjing Ma Baolu Zhang Lili Wu Qiong Shi tianwen Gao Weinan Guo Chunying Department of Dermatology Xijing HospitalFourth Military Medical UniversityNo 127 of West Changle RoadXi’anShaanxi 710032China

Melanoma is the most lethal type of skin cancer,originating from the malignant transformation of *** the development of targeted therapy and immunotherapy has gained revolutionary advances in potentiating the therapeutic effect,the prognosis of patients with melanoma is still *** tumor progression,melanoma frequently encounters stress from both endogenous and exogenous sources in tumor ***7 is a nuclear-localized deacetylase of which the activity is highly dependent on intracellular nicotinamide adenine dinucleotide(NAD+),with versatile biological functions in maintaining cell ***,whether SIRT7 regulates tumor cell biology and tumor immunology in melanoma under stressful tumor microenvironment remains ***,we reported that SIRT7 orchestrates melanoma progression by simultaneously promoting tumor cell survival and immune evasion via the activation of unfolded protein *** first identified that SIRT7 expression was the most significantly increased one in sirtuins family upon ***,we proved that the deficiency of SIRT7 potentiated tumor cell death under stress in vitro and suppressed melanoma growth in ***,SIRT7 selectively activated the IRE1α-XBP1 axis to potentiate the pro-survival ERK signal pathway and the secretion of tumorpromoting ***7 directly de-acetylated SMAD4 to antagonize the TGF-β-SMAD4 signal,which relieved the transcriptional repression on IRE1αand induced the activation of the IRE1α-XBP1 ***,SIRT7 up-regulation eradicated anti-tumor immunity by promoting PD-L1 expression via the IRE1α-XBP1 ***,the synergized therapeutic effect of SIRT7 suppression and anti-PD-1 immune checkpoint blockade was also *** together,SIRT7 can be employed as a promising target to restrain tumor growth and increase the effect of melanoma immunotherapy.

关键词： melanoma SIRT7 immunity