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ConvNeXt-UperNet-Based Deep Learning Model for Road Extraction from High-Resolution Remote Sensing Images

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Computers, Materials & Continua 2024年第8期80卷 1907-1925页

作者： Jing Wang Chen Zhang tianwen Lin Geographic Information and Tourism College Chuzhou UniversityChuzhou239000China Anhui Province Key Laboratory of Physical Geographic Environment Chuzhou UniversityChuzhou239000China

When existing deep learning models are used for road extraction tasks from high-resolution images,they are easily affected by noise factors such as tree and building occlusion and complex backgrounds,resulting in incomplete road extraction and low *** propose the introduction of spatial and channel attention modules to the convolutional neural network ***,ConvNeXt is used as the backbone network,which cooperates with the perceptual analysis network UPerNet,retains the detection head of the semantic segmentation,and builds a new model ConvNeXt-UPerNet to suppress noise *** on the open-source DeepGlobe and CHN6-CUG datasets and introducing the DiceLoss on the basis of CrossEntropyLoss solves the problem of positive and negative sample *** results show that the new network model can achieve the following performance on the DeepGlobe dataset:79.40%for precision(Pre),97.93% for accuracy(Acc),69.28% for intersection over union(IoU),and 83.56% for mean intersection over union(MIoU).On the CHN6-CUG dataset,the model achieves the respective values of 78.17%for Pre,97.63%for Acc,65.4% for IoU,and 81.46% for *** with other network models,the fused ConvNeXt-UPerNet model can extract road information better when faced with the influence of noise contained in high-resolution remote sensing *** also achieves multiscale image feature information with unified perception,ultimately improving the generalization ability of deep learning technology in extracting complex roads from high-resolution remote sensing images.

关键词： Deep learning semantic segmentation remote sensing imagery road extraction

In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

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Neural Regeneration Research 2024年第10期19卷 2240-2248页

作者： Meng Yuan Yao Tang tianwen Huang Lining Ke En Huang Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Human Anatomy School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Scientific Research Center School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian ProvinceChina

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment.

关键词： astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 transdifferentiation

FIBTNet:Building Change Detection for Remote Sensing Images Using Feature Interactive Bi-Temporal Network

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Computers, Materials & Continua 2024年第9期80卷 4621-4641页

作者： Jing Wang tianwen Lin Chen Zhang Jun Peng School of Geographic Information and Tourism Chuzhou UniversityChuzhou239000China Anhui Province Key Laboratory of Physical Geographic Environment Chuzhou UniversityChuzhou239000China

In this paper,a feature interactive bi-temporal change detection network(FIBTNet)is designed to solve the problem of pseudo change in remote sensing image building change *** network improves the accuracy of change detection through bi-temporal feature *** designs a bi-temporal feature exchange architecture(EXA)and a bi-temporal difference extraction architecture(DFA).EXA improves the feature exchange ability of the model encoding process through multiple space,channel or hybrid feature exchange methods,while DFA uses the change residual(CR)module to improve the ability of the model decoding process to extract different features at multiple ***,at the junction of encoder and decoder,channel exchange is combined with the CR module to achieve an adaptive channel exchange,which further improves the decision-making performance of model feature *** results on the LEVIR-CD and S2Looking datasets demonstrate that iCDNet achieves superior F1 scores,Intersection over Union(IoU),and Recall compared to mainstream building change detectionmodels,confirming its effectiveness and superiority in the field of remote sensing image change detection.

关键词： Change detection change residual module feature exchange mechanism feature fusion

Combined Effect of Temperature and Cadmium on Molecular Responses of Hsp70 and P-gp Genes in Crassostrea gigas

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Journal of Ocean University of China 2024年第4期23卷 1115-1120页

作者： HU Fanguang SUN Ming LIU Guangbin JING Yuanyuan CHEN Qun ZHANG tianwen Marine Science Research Institute of Shandong Province Qingdao 266104China

To evaluate the combined effect of temperature and cadmium on the molecular responses of heat shock protein 70(hsp70)and P-glycoprotein(P-gp)in mantle,digestive gland and gills of Crassostrea gigas,oysters were exposed to combinations of five temperature levels(10,15,20,25,and 30℃)and 10μg L^(-1)cadmium for 21 *** were sampled for mRNA quantification by qPCR,and the results showed that the P-gp gene expression changed significantly after treatment at different temperatures and different treatment *** P-gp gene expression was the highest in the digestive *** with the control group,the P-gp gene expression in cadmium treatment groups at all the different temperatures were significantly higher than the control *** control oysters(kept at 10℃during the whole experiment without cadmium)expressed low levels of hsp70,but the groups treated with cadmium displayed somewhat higher *** present study demonstrated hsp70 and P-gp played an important role in the detoxification of Cd in ***,and confirmed temperature should be considered for the assessment of Cd-induced toxicity in oysters.

关键词： temperature cadmium P-gp hsp70 Crassostrea gigas

Nickel-Catalyzed Regioselective Hydrosilylation of Conjugated Dienes

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Chinese Journal of Chemistry 2024年第1期42卷 13-19,I0004页

作者： Xiaoyu Wu Wei Liu Liqun Yang Yue Wang tianwen Liu Yao Yuan Yan Lu Zhaoguo Zhang Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs School of Chemistry and Chemical EngineeringShanghai JiaoTong University800 Dongchuan RoadShanghai 200240China Joseph Black Building The University of EdinburghDavid Brewster RoadEdinburghEH9 3FJUK

With the increasing demand for homoallylic silanes and allylic silanes,the highly efficient and regioselective hydrosilylations of conjugated dienes are urgently ***,we developed a Ni-catalyzed regiodivergent hydrosilylation of aromatic conjugated dienes by adjusting the temperature and *** low temperature(-30℃),an eternal-ligand-free system(Ni/t-BuOk)can efficiently facilitate the 3,4-anti-Markovnikov hydrosilylation to provide homoallylic silanes via electrophilic activation process;under room temperature(25℃),a ligand-controlled system(Ni/t-BuOk/PPh3)can eventuate the 3,4-Markovnikov hydrosilylation to produce allylic silanes via Chalk-Harrod *** systems are compatible with various conjugated dienes and primary silanes in excellent yields andregioselectivities.

关键词： Nickel-catalyzed Regioselective hydrosilylation Conjugated dienes Electrophilic activation Homoallylic silanes

Preclinical evaluation of cyclophosphamide and fludarabine combined with CD19 CAR-T in the treatment of B-cell hematologic malignancies in vivo

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Oncology Research 2024年第6期32卷 1109-1118页

作者： ZHIGANG XIA MENGYAO TIAN YUCAI CHENG WENFANG YI ZEFAN DU tianwen LI YUCHEN WEN LINDI LI YONG LIU CHUN CHEN Pediatric Hematology Laboratory Division of Hematology/OncologyDepartment of PediatricsThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China

Background:Chimeric antigen receptor T(CAR-T)cell therapy has achieved marked therapeutic success in ameliorating hematological ***,there is an extant void in the clinical guidelines concerning the most effective chemotherapy regimen prior to chimeric antigen receptor T(CAR-T)cell therapy,as well as the optimal timing for CAR-T cell infusion *** and Methods:We employed cell-derived tumor xenograft(CDX)murine models to delineate the optimal pre-conditioning chemotherapy regimen and timing for CAR-T cell ***,transcriptome sequencing was implemented to identify the therapeutic targets and elucidate the underlying mechanisms governing the treatment ***:Our preclinical in vivo evaluation determined that a combination of cyclophosphamide and fludarabine,followed by the infusion of CD19 CAR-T cells five days subsequent to the chemotherapy,exerts the most efficacious therapeutic effect in B-cell hematological ***,RNA-seq data indicated that the therapeutic efficacy predominantly perturbs tumor cell metabolism,primarily through the inhibition of key mitochondrial targets,such as C-Jun Kinase enzyme(C-JUN).Conclusion:In summary,the present study offers critical clinical guidance and serves as an authoritative reference for the deployment of CD19 CAR-T cell therapy in the treatment of B-cell hematological malignancies.

关键词： CD19 CAR-T B-cell hematologic malignancies Metabolism In vivo

Analysis of large datasets for identifying molecular targets in intestinal polyps and metabolic disorders

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BIOCELL 2024年第3期48卷 415-429页

作者： SHAN OU YUN XU QINGLAN LIU tianwen YANG WEI CHEN XIU YUAN XIN ZUO PENG SHI JIE YAO Department of Gastroenterology The First Affiliated Hospital of Chongqing Medical and Pharmaceutical CollegeChongqingChina

Background:The interrelation between intestinal polyps,metabolic syndrome(MetS),and colorectal cancer(CRC)is a critical area of *** research focuses on pinpointing potential molecular targets to understand the link between intestinal polyp formation,metabolic irregularities,and CRC ***:We examined clinical samples from patients with intestinal polyps coexisting with MetS and compared them with samples from patients with standard intestinal *** sequencing and public database analysis were employed to identify significant pathways and *** targets were then validated through immunohistochemistry(IHC).Following the RNA interference of key target expression,a series of experiments,including the cell counting kit-8 assay,colony formation,wound healing,and Transwell assays,were ***:Comparative analysis revealed 75 up-regulated and 61 down-regulated differentially expressed genes(DEGs)in the MetS polyp group *** *** encyclopedia of genes and genomes(KEGG)pathway enrichment suggested these DEGs were primarily associated with cell cycle and *** with comparative toxicogenomics database(CTD)and the cancer genome atlas(TCGA)databases highlighted 44 key CRC-related *** interaction networks indicated connections of purkinje cell protein 4(PCP4),olfactomedin 1(OLFM1),fibronectin 1(FN1),and transforming growth factor beta 3(TGF-β3)with the mitogen-activated protein kinase(MAPK)*** correlation studies suggested higher risk associations with FN1,PCP4,and TGF-β3,while OLFM1 was identified as a lower risk *** analysis revealed a decrease in OLFM1 in MetS-associated intestinal *** interference with OLFM1 in polyp epithelial cells,there was a significant enhancement in cell proliferation,colony formation,and cell migration and invasion ***:Our study highlights a significant decrease in OLFM1 expression in MetS-associated intestinal

关键词： Colorectal cancer Metabolic syndrome Intestinal polyp OLFM1 Exosome

法律权衡方法的形式理性——基于偏好聚合的分析

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逻辑学研究 2024年第2期17卷 32-55页

作者：许天问浙江大学光华法学院浙江大学数字法治实验室

如何克服个案验证的局限,在一般性层面上准确、有效地评判权衡方法的方法论效用,是法律权衡理论面临的重要问题。社会选择理论在讨论集体决策时使用的“偏好聚合”视角,可从形式理性的面向为解答该问题提供线索。实例研究首先表明,法律... 详细信息

如何克服个案验证的局限,在一般性层面上准确、有效地评判权衡方法的方法论效用,是法律权衡理论面临的重要问题。社会选择理论在讨论集体决策时使用的“偏好聚合”视角,可从形式理性的面向为解答该问题提供线索。实例研究首先表明,法律权衡与集体决策共享偏好聚合的数学形式,二者的运作皆表现为从复数个体偏好向整体偏好的过渡。以此为桥梁,社会选择理论对集体决策悖论的分析,显示了形式理性同样对权衡方法是必要的。依据偏好聚合的数学形式,社会选择理论为集体决策方法定义的形式理性条件及验证手段,则可转化为检验法律权衡方法的形式理性与方法论效用的一般性方案。作为试验,该方案被运用至阿列克西提出的法律权衡方法“权重公式”,发现了权重公式在形式理性上的重要特征与方法论局限。

关键词：法律权衡形式理性方法论效用偏好聚合权重公式

行政借道社会:基层治理创新中的政府调适行为研究--基于Z省S区的经验案例分析

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西南大学学报（社会科学版） 2024年第3期50卷 66-79页

作者：刘天文华中师范大学中国农村研究院湖北武汉430079

在一个现代化快速转型的国家,政府调适能力是保证基层治理体制稳定运行的必然要求。近年来,随着基层治理体系规范化的不断推进,基层问责的强化以及创新压力的增大,基层治理正面临体制刚性化的转型困境,基层行政体制内部的调适空间也在... 详细信息

在一个现代化快速转型的国家,政府调适能力是保证基层治理体制稳定运行的必然要求。近年来,随着基层治理体系规范化的不断推进,基层问责的强化以及创新压力的增大,基层治理正面临体制刚性化的转型困境,基层行政体制内部的调适空间也在逐渐缩小。为了化解科层体制压力、再造自主行政空间,基层政府会主动突破行政科层体系边界与社会组织展开“策略性合作”,通过“行政借道社会”强化自身的调适能力。“行政借道社会”是基层政府做出的一种新型外部调适行为,其不仅超越了以往的“策略主义”“共谋”“避责”“工作机制创新”等的理论解释框架,还深化了政社关系中的嵌入性视角,是重新认识基层治理体制保持弹性和适应性的重要切入点。为此,应该积极透过“行政借道社会”的复杂实践过程与机制的阐释分析,拓展基层政府调适能力下体制弹性与适应性维持的中国经验和理论命题,同时为当前实现基层治理现代化提供方法论启示。

关键词：基层政府体制刚性化调适行为政社互动借道机制嵌入理论治理现代化