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An ε-domination based two-archive 2 algorithm for many-objective optimization

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Journal of Systems Engineering and Electronics 2022年第1期33卷 156-169页

作者： wu tianwei AN Siguang HAN Jianqiang SHENTU Nanying College of Mechanical and Electrical Engineering China Jiliang UniversityHangzhou 310018China Key Laboratory of Intelligent Manufacturing Quality Big Data Tracing and Analysis of Zhejiang Province China Jilang UniversityHangzhou 310018China

The two-archive 2 algorithm(Two_Arch2) is a manyobjective evolutionary algorithm for balancing the convergence,diversity,and complexity using diversity archive(DA) and convergence archive(CA).However,the individuals in DA are selected based on the traditional Pareto dominance which decreases the selection pressure in the high-dimensional *** traditional algorithm even cannot converge due to the weak selection ***,Two_Arch2 adopts DA as the output of the algorithm which is hard to maintain diversity and coverage of the final solutions synchronously and increase the complexity of the *** increase the evolutionary pressure of the algorithm and improve distribution and convergence of the final solutions,an ε-domination based Two_Arch2 algorithm(ε-Two_Arch2) for many-objective problems(MaOPs) is proposed in this *** ε-Two_Arch2,to decrease the computational complexity and speed up the convergence,a novel evolutionary framework with a fast update strategy is proposed;to increase the selection pressure,ε-domination is assigned to update the individuals in DA;to guarantee the uniform distribution of the solution,a boundary protection strategy based on I_(ε+) indicator is designated as two steps selection strategies to update individuals in *** evaluate the performance of the proposed algorithm,a series of benchmark functions with different numbers of objectives is *** results demonstrate that the proposed method is competitive with the state-of-the-art multi-objective evolutionary algorithms and the efficiency of the algorithm is significantly improved compared with Two_Arch2.

关键词： many-objective optimization ε-domination boundary protection strategy two-archive algorithm

Understanding the mechanisms of brain functions from the angle of synchronization and complex network

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Frontiers of physics 2022年第3期17卷 165-187页

作者： tianwei wu Xinhua Zhang Zonghua Liu School of Physics and Electronic Science East China Normal UniversityShanghai 200241China Jinhua Middle School Shanghai 200333China

The human brain is the most complicated and fascinated system and executes various important brain functions, but its underlying mechanism is a long-standing problem. In recent years, based on the progress of complex network science, much attention has been paid to this problem and many important results have been achieved, thus it is the time to make a summary to help further studies. For this purpose, we here make a brief but comprehensive review on those results from the aspect of brain networks, i.e., from the angle of synchronization and complex network. First, we briefly discuss the main features of human brain and its cognitive functions through synchronization. Then, we discuss how to construct both the anatomical and functional brain networks, including the pathological brain networks such as epilepsy and Alzheimer’s diseases. Next, we discuss the approaches of studying brain networks. After that, we discuss the current progress of understanding the mechanisms of brain functions, including the aspects of chimera state, remote synchronization, explosive synchronization, intelligence quotient, and remote propagation. Finally, we make a brief discussion on the envision of future study.

关键词： brain functions complex network synchronization chimera state remote synchronization explosive synchronization intelligence quotient remote propagation

microRNA-122与非酒精性脂肪性肝病研究进展

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实用肝脏病杂志 2024年第5期27卷 646-649页

作者：贾双珍吴天威吴捷首都医科大学附属北京儿童医院消化科/国家儿童医学中心北京市100045

非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)作为一种代谢性肝脏病变,其主要病理学表现为肝细胞内过量脂肪积聚[1,2]。NAFLD可由单纯性脂肪肝逐步演化为非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH),继... 详细信息

非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)作为一种代谢性肝脏病变,其主要病理学表现为肝细胞内过量脂肪积聚[1,2]。NAFLD可由单纯性脂肪肝逐步演化为非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH),继而导致肝脏纤维化,甚至肝硬化,这一进展显著增加了NAFLD患者发展为终末期肝病的风险[3]。近20年来,NAFLD发病率显著上升,尤其在西方,患病比例达到人口的三分之一[4]。NAFLD的发生与超重、肥胖、胰岛素抵抗和高脂血症紧密关联,并增加了心血管、内分泌和消化系统疾病的发生风险[5]。微小RNA(microRNA,miRNA)是一类在进化上高度保守、内源性的单链非编码RNA分子。

关键词：非酒精性脂肪性肝病微小RNA-122 进展

肿瘤患者免疫治疗相关胃肠道反应预防及管理的证据总结

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上海护理 2024年第7期24卷 49-56页

作者：胡丽莎彭淑华祝玲吴恬玮李屏彭红华孝感市中心医院湖北孝感432000

目的检索、评价并总结肿瘤患者免疫治疗相关胃肠道反应的预防及管理最佳证据,为临床提供参考。方法在国内外相关网站及数据库(UpToDate计算机决策支持系统、BMJ最佳临床实践、澳大利亚JBI网站、美国国立临床诊疗指南数据库、国际指南协... 详细信息

目的检索、评价并总结肿瘤患者免疫治疗相关胃肠道反应的预防及管理最佳证据,为临床提供参考。方法在国内外相关网站及数据库(UpToDate计算机决策支持系统、BMJ最佳临床实践、澳大利亚JBI网站、美国国立临床诊疗指南数据库、国际指南协作网、苏格兰院际指南网、世界肿瘤学网络、美国国家癌症综合网络、医脉通指南网,英国国家卫生与临床优化研究所、美国医疗保健与研究质量局、加拿大安大略注册护士协会、多国癌症支持治疗协会、美国临床肿瘤学会、癌症免疫治疗协会等网站,以及Cochrane Library、Embase、CHINAL、Web of Science、OVID、PubMed、SinoMed、知网、万方、维普数据库等数据库)中,系统检索关于肿瘤患者免疫治疗胃肠道反应预防及管理的临床指南、最佳临床实践信息册、推荐实践、证据总结、专家共识、系统评价及相关原始研究。检索时限为建库2022年9月1日。由2名研究者独立进行文献质量评价和资料提取,在结合临床专业人员判断的基础上进行证据总结。结果共纳入17篇文献,包括6篇指南、1篇证据总结、3篇专家共识、3篇系统评价、1篇随机对照试验及3篇队列研究,围绕肿瘤患者免疫治疗相关胃肠道反应的预防及管理,汇总了胃肠道评估、危险因素、基线筛查、诊断检查、药物治疗、胃肠道护理、健康教育7个方面的23条最佳证据。结论该研究总结了肿瘤患者免疫治疗胃肠道反应预防及管理的最佳证据,为医护人员临床实践提供循证依据。

关键词：肿瘤免疫治疗胃肠道反应预防证据总结循证护理

Broadband continuous supersymmetric transformation:a new paradigm for transformation optics

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eLight 2022年第1期2卷 203-212页

作者： Jieun Yim Nitish Chandra Xilin Feng Zihe Gao Shuang wu tianwei wu Haoqi Zhao Natalia M.Litchinitser Liang Feng Department of Materials Science and Engineering University of PennsylvaniaPhiladelphiaPA 19104USA Department of Electrical and Computer Engineering Duke UniversityDurhamNC 27708USA Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA 19104USA.

Transformation optics has formulated a versatile framework to mold the flow of light and tailor its spatial characteristics at *** its huge success in bringing scientific fiction(such as invisibility cloaking)into reality,the coordinate transformation often yields extreme material parameters unfeasible even with ***,we demonstrate a new transformation paradigm based upon the invariance of the eigenspectra of the Hamiltonian of a physical system,enabled by *** creating a gradient-index metamaterial to control the local index variation in a family of isospectral optical potentials,we demonstrate broadband continuous supersymmetric transformation in optics,on a silicon chip,to simultaneously transform the transverse spatial characteristics of multiple optical states for arbitrary steering and switching of light *** a novel synergy of symmetry physics and metamaterials,our work provides an adaptable strategy to conveniently tame the flow of light with full exploitation of its spatial degree of freedom.

关键词： Supersymmetry Transformation optics Metamaterials Integrated photonics

Inactivation Mechanisms of Escherichia Coli in Drinking Water Using Reactive Species Generated from a Surface Discharge

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高电压技术 2013年第9期39卷 2119-2124页

作者： LI Jie SHANG Kefeng WANG Tiecheng LU Na WANG tianwei wu Yan Institute of Electrostatics and Special Power Dalian University of Technology Dalian 116024 China

Bacterial and chemical contaminations of drinking water imperil the health of people.A reactive species injection method is presented for sterilizing drinking *** produce reactive species,a gas phase surface discharge reactor(SDR)is designed:a spiral stainless steel wire attached on the inside wall of a quartz glass tube is used as the high voltage electrode,and the drinking water is the ground *** performance and mechanisms of the method in inactivating of Escherichia coli(***)are *** results show that 500 mL ***-contaminated drinking water(108CFU/mL)is completely sterilized within 4 *** on the scanning electron microscope(SEM)analysis,there were plasma-induced cell structure damages of the *** in the sterilized water,and the damage resulted in the leakage of protein,which was proved by chemical ***,the heating effect concomitantly generated by discharge plasma does not influence *** inactivation,and the contribution of direct ultraviolet(UV)irradiation could be neglected *** ozone generated by SDR and the hydroxyl radicals(·OH)subsequently generated in drinking water play the decisive roles in *** inactivation because these reactive species cause the cell rupture.

关键词：饮用水消毒大肠杆菌表面放电型活性物种机制灭活放电等离子体扫描电子显微镜

芍药甘草汤对急性期神经根型颈椎病大鼠炎症因子水平的影响

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亚太传统医药 2018年第12期14卷 9-13页

作者：吴大伟何坚福建中医药大学福建福州350000

目的:探讨不同剂量芍药甘草汤对急性期神经根型颈椎病大鼠神经炎症损伤的作用及可能的作用机制。方法:将60只雄性SPrague-Dawley大鼠随机分为假手术组(n=12)和手术组(n=48)。手术组以椎管插线法制备大鼠神经根型颈椎病模型,符合纳入标准... 详细信息

目的:探讨不同剂量芍药甘草汤对急性期神经根型颈椎病大鼠神经炎症损伤的作用及可能的作用机制。方法:将60只雄性SPrague-Dawley大鼠随机分为假手术组(n=12)和手术组(n=48)。手术组以椎管插线法制备大鼠神经根型颈椎病模型,符合纳入标准的48只大鼠随机分为4组:模型组,芍药甘草汤高、中、低剂量组(n=12)。芍药甘草汤组大鼠经高、中、低剂量芍药甘草汤灌胃治疗,共7d。造模后1d、7d行小动物磁共振扫描观察神经根局部炎性水肿情况;造模后1d、3d、7d采用Basso、Beattie、Bresnahan(BBB)颈脊髓损伤评定量表进行模型相关评定;干预7d后进行造模节段脊髓HE染色及尼氏染色,观察脊髓前角脊神经炎症及神经元病理变化;采用酶联免疫吸附法检测大鼠外周血液中TNF-α、IL-33、IL-6水平。结果:假手术组BBB评分在正常范围内,造模后各组大鼠运动评定均提示运动功能缺损,实验发现,芍药甘草汤组及模型组大鼠BBB评分均较术后升高,且芍药甘草汤组与模型组比较差异具有统计学意义(P0.05);中、高剂量组与低剂量组大鼠炎症因子水平比较差异具有统计学意义(P0.05)。结论:芍药甘草汤能有效改善神经根型颈椎病大鼠的感觉、运动功能,可能与减轻神经根局部炎症水肿,抑制局部IL-6、IL-33及TNF-α相关炎症因子的表达有关。

关键词：神经根型颈椎病芍药甘草汤脊髓前角神经元炎症因子

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5G通信技术与大数据融合技术研究

通信电源技术 2021年第21期38卷 110-112页

作者：吴天威中国联合网络通信有限公司哈尔滨软件研究院黑龙江哈尔滨150040

在整个国家的发展中,5G通信相关的网络与设备是国内重要的基础设施,支撑着整个国家进行智能化、数字化以及网络化的转型和发展。在整个第四次工业革命中,5G通信技术的发展同时带动了人工智能、大数据以及云计算等前沿技术的研发,能够更... 详细信息

在整个国家的发展中,5G通信相关的网络与设备是国内重要的基础设施,支撑着整个国家进行智能化、数字化以及网络化的转型和发展。在整个第四次工业革命中,5G通信技术的发展同时带动了人工智能、大数据以及云计算等前沿技术的研发,能够更好地为各行各业提供信息化服务。目前,整个5G规模化的应用与推广正在进行,为行业发展赋能,阐述5G关键技术,同时叙述5G与大数据技术深度融合的相关特点。

关键词： 5G通信数据融合规模化大数据

内分泌干扰物壬基酚与辛基酚的污染现状与毒性的研究进展

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环境化学 2017年第5期36卷 951-959页

作者：吴天伟孙艺崔蓉张宝旭北京大学公共卫生学院北京100191

壬基酚与辛基酚是典型的内分泌干扰物,应用广泛,且具有较强的亲脂性与生物蓄积性,可通过食物链进入生物体并导致各种生物毒性作用.全面了解这些毒性作用,有助于临床上相关疾病的预防与治疗.本文对近年来壬基酚与辛基酚的污染现状与毒性... 详细信息

壬基酚与辛基酚是典型的内分泌干扰物,应用广泛,且具有较强的亲脂性与生物蓄积性,可通过食物链进入生物体并导致各种生物毒性作用.全面了解这些毒性作用,有助于临床上相关疾病的预防与治疗.本文对近年来壬基酚与辛基酚的污染现状与毒性的研究进展进行了综述,对二者未来的研究方向进行了展望.

关键词：壬基酚辛基酚污染现状毒性