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Effects of water saturation and loading rate on direct shear tests of andesite

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第2期14卷 653-662页

作者： tianshu bao Kimihiro Hashiba Katsunori Fukui Department of Systems Innovation The University of TokyoTokyo113-8656Japan

For estimating the long-term stability of underground framework,it is vital to learn the mechanical and rheological characteristics of rock in multiple water saturation ***,the majority of previous studies explored the rheological properties of rock in air-dried and water saturated conditions,as well as the water effects on compressive and tensile *** this study,andesite was subjected to direct shear tests under five water saturation conditions,which were controlled by varying the wetting and drying *** tests were conducted at alternating displacement rates under three vertical *** results reveal that the shear strength decreases exponentially as water saturation increases,and that the increase in shear strength with a tenfold increase in displacement rate is nearly constant for each of the vertical *** on the findings of the shear tests in this study and the compression and tension tests in previous studies,the influences of both water saturation and loading rate on the Hoek-Brown failure criterion for the andesite was *** results indicate that the brittleness index of the andesite,which is defined as the ratio of uniaxial compressive strength to tensile strength,is independent of both water saturation and loading rate and that the influences of the water saturation dependence and the loading rate dependence of the failure criterion can be converted between each other.

关键词： Direct shear test Water saturation Loading rate dependence Failure criterion

三维适形放疗治疗原发性肝癌患者疗效及发生放射性肝损伤影响因素分析

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实用肝脏病杂志 2024年第1期27卷 105-108页

作者：包天舒杜野牧姚善文冯鹤云南京医科大学附属淮安第一医院介入放射科江苏省淮安市223300 南京医科大学附属淮安第一医院肝胆胰外科江苏省淮安市223300 南京医科大学附属淮安第一医院影像中心江苏省淮安市223300

目的分析采用三维适形放疗(3DCRT)治疗原发性肝癌(PLC)患者的疗效和放射性肝损伤(RILI)发生的影响因素。方法2019年4月~2022年4月我院诊治的PLC患者85例,均接受3DCRT治疗。按照实体瘤疗效评价标准考核疗效,根据报道的标准诊断RILI。应用... 详细信息

目的分析采用三维适形放疗(3DCRT)治疗原发性肝癌(PLC)患者的疗效和放射性肝损伤(RILI)发生的影响因素。方法2019年4月~2022年4月我院诊治的PLC患者85例,均接受3DCRT治疗。按照实体瘤疗效评价标准考核疗效,根据报道的标准诊断RILI。应用Logistic回归模型分析影响PLC患者接受3D-CRT治疗疗效和RILI发生的因素。结果经3D-CRT治疗,本组获得客观缓解50例(58.8%);客观缓解组TNMⅣ期和Child-Pugh B级占比分别为36.0%和14.0%,均显著低于非客观缓解组的60.0%和48.6%(P<0.05),而单次剂量为3~4 Gy和总剂量为50~60 Gy占比分别为52.0%和68.0%,均显著高于非客观缓解组的28.6%和45.7%(P<0.05);本组发生RILI者15例(17.7%);RILI组TNMⅣ期和Child-Pugh B级、单次剂量为3~4 Gy和总剂量50~60 Gy占比分别为80.0%、93.0%、73.3%和86.7%,均显著高于无RILI组(分别为38.6%、14.3%、35.7%和52.9%,P<0.05);多因素Logistic回归分析发现,TNM分期、Child-Pugh分级、单次剂量和总剂量均为影响3DCRT治疗的疗效和发生RILI的因素(OR=5.078、4.988、4.600、4.850、4.963、5.043、5.150、4.740,P<0.05)。结论PLC患者接受3DCRT治疗的疗效和RILI的发生受TNM分期、Child-Pugh分级、单次剂量和总剂量的影响,临床在制定放疗计划时,要充分考虑以上敏感因素,以保证提高疗效并显著降低RILI的发生。

关键词：原发性肝癌三维适形放疗放射性肝损伤治疗影响因素

Efficacy and safety of transvaginal mesh repair in a cohort with a minimum of 10-year follow-up

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Science China(Life Sciences) 2024年第5期67卷 1061-1068页

作者： Zhibo Zhang Jianbin Guo Weijie Tian Ye Zhang Yuelun Zhang tianshu Sun Jiali Duan Xinmiao bao Yuan Wang Yang Ye Qianqian Gao Honghui Shi Abraham Nick Morse Juan Chen Lan Zhu Departmentof Obstetrics and Gynecology Peking Union MedicalCollege HospitalChinese Academyof Medical Sciences&Peking Union MedicalCollegeNational Clinical Research Center for Obstetricand Gynecologic DiseasesBeijing 100730China Department of Gynecology Guizhou Provincial People’s HospitalMedical College of Guizhou UniversityGuiyang 550002China Department of Obstetrics and Gynecology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Medical Doctor Program Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Pathology Peking Union Medical College HospitalBeijing 100730China Tufts University School of Medicine Boston MA 02111USA

Although transvaginal mesh(TVM)repair is no longer used in some countries,long-term outcomes after TVM surgery are of great importance ***,reports with follow-up>10 years are ***,this study aimed to report outcomes in a prospective cohort with at least 10 years of *** with stageⅢ–Ⅳsymptomatic prolapse were approached consecutively from 2008 to 2013 at one tertiary *** main outcome measure was symptomatic *** outcomes included anatomic failure,recurrence,patient satisfaction,complications,and *** Kaplan-Meier curve was used to estimate the cumulative failure *** the 121 patients enrolled in the study,103(85.1%)completed a median follow-up of 11 *** estimated probability rates of symptomatic and anatomic failure were 17.6%and 8.8%in 11 years,*** estimated incidence of symptomatic failure increased by 8.2%between 5 and 11 years;however,the corresponding rate for anatomic failure was 3.7%.The most common complication was vaginal mesh exposure,and its estimated probability increased from 19.3%to 28.4%from 5 to 11 years,*** trimming resolved 80.0%of vaginal *** patients did not report decreased overall *** with vaginal mesh exposure requiring>3 office procedures or mesh removal in the operating room(5.8%by 11 years)had lower satisfaction rates(P<0.01)and were defined as having severe mesh *** rates of postoperative pain,reoperation,and Patient Global Impression of Improvement≥2 were 2.5%,3.3%,and 94.2%,*** results of this study implied that TVM treatment gradually increased the symptomatic failure rate but provided durable anatomical support of the vaginal *** mesh exposure was common in women who were largely not sexually active;however,80%of the cases could be managed in the outpatient clinic,which did not affect patient satisfaction.

关键词： complication efficacy long-term follow-up pelvic organ prolapse safety transvaginal mesh

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羰基合成从丁醛到戊醛的工艺分析

化工进展 2013年第S1期32卷 42-47页

作者：包天舒中国石油化工股份有限公司北京化工研究院北京100013

通过分析和借鉴工业化生产丁醛的工艺,即戴维和三菱化学的工艺流程,讨论了由混合丁烯生产戊醛的工艺中,低压羰基合成反应工段反应溶剂的选择、烯烃的循环利用和反应器的形式,均相产物分离工段分离顺序和分离方式,最终提出了一套可行的... 详细信息

通过分析和借鉴工业化生产丁醛的工艺,即戴维和三菱化学的工艺流程,讨论了由混合丁烯生产戊醛的工艺中,低压羰基合成反应工段反应溶剂的选择、烯烃的循环利用和反应器的形式,均相产物分离工段分离顺序和分离方式,最终提出了一套可行的由混合丁烯生产戊醛的工艺,并采用ASPEN Plus V7.0软件进行了工艺流程模拟。

关键词：低压羰基合成工艺丁醛丙烯丁烯戊醛

In-situ generation of gold nanoparticles on MnO_2 nanosheets for the enhanced oxidative degradation of basic dye(Methylene Blue)

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Journal of Environmental Sciences 2018年第3期30卷 236-245页

作者： Xueqin bao Zhen Qin tianshu Zhou Jingjing Deng School of Ecological and Environmental Sciences East China Normal University

In this work,the gold nanoparticles（Au-NPs）were in-situ generated on the surface of MnO2nanosheets to form MnO2/Au-NPs nanocomposite in a simple and cost-effective *** experiments were carried out to optimize the oxidation of basic dye（Methylene Blue（MB））,including the molar ratio of MnO2to chloroauric acid（HAu Cl4）,the p H of the solution and the effect of initial *** the optimal condition,the highest degradation efficiency for MB achieved to 98.9%within 60 min,which was obviously better than commercial MnO2powders（4.3%）and MnO2nanosheets（74.2%）.The enhanced oxidative degradation might attribute to the in-situ generation of ultra-small and highly-dispersed Au-NPs which enlarged the synergistic effect and/or interfacial effect between MnO2nanosheets and Au-NPs and facilitated the uptake of electrons by MnO2from MB during the oxidation,thus validating the application of MnO2/Au-NPs nanocomposite for direct removal of organic dyes from wastewater in a simple and convenient fashion.

关键词： MnO2/Au-NPs nanocomposite In-situ generation Dye degradation Synergistic effect and inteffacial effect Enhanced oxidative degradation

MsxC基因在斑马鱼肌间刺和大侧肌发育中的作用

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上海海洋大学学报 2022年第2期31卷 328-335页

作者：庞天抒车金远范纯新鲍宝龙上海海洋大学水产种质资源发掘与利用教育部重点实验室上海201306 上海海洋大学水产科学国家级实验教学示范中心上海201306

肌间刺存在于有些真骨鱼类的肌间隔中,作为Hox基因家族成员,MsxC(muscle segment homeobox C)基因的表达模式与唇䱻肌间刺形成有一定的相关性。为了进一步探究MsxC基因在肌间刺形成中的作用,利用CRISPR/Cas9基因编辑技术,建立斑马鱼MsxC... 详细信息

肌间刺存在于有些真骨鱼类的肌间隔中,作为Hox基因家族成员,MsxC(muscle segment homeobox C)基因的表达模式与唇䱻肌间刺形成有一定的相关性。为了进一步探究MsxC基因在肌间刺形成中的作用,利用CRISPR/Cas9基因编辑技术,建立斑马鱼MsxC基因纯合突变体(MsxC^(^(-/-)))。结果表明:与野生型斑马鱼相比,MsxC^(-/-)斑马鱼尾部的髓弓小骨和脉弓小骨平均缩短15%以上,差异极显著,而躯干部的肌间刺长度则无明显差异;MsxC^(-/-)斑马鱼大侧肌肌隔周围白肌细胞分布疏松,且排列混乱,越靠近尾部差异越明显;MsxC^(-/-)突变体红肌面积增大,越靠近尾部,红肌面积增大越明显,尾部红肌面积增大2.22%(P<0.01),而躯干靠前部位面积增大0.97%(P<0.05)。这表明,MsxC基因的缺失既影响了肌间刺的形成,同时也影响了大侧肌的发育。

关键词：斑马鱼 MsxC 肌间刺大侧肌 CRISPR/Cas9

基于单位生命周期费用最小的继电保护装置更换策略

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电力系统自动化 2013年第5期37卷 44-48,60页

作者：薛安成王睿琛王宝毕天姝黄少锋新能源电力系统国家重点实验室华北电力大学北京市102206 云南电力调度控制中心云南省昆明市650011

从可靠性经济的角度对继电保护装置的最小维修模型进行建模,并基于该模型计算最优更换周期。采用泊松分布拟合和Cramer-von Mises拟合优度检验确定继电保护装置的故障特性,采用对数正态分布拟合保护装置修复特性,从而构建最小维修模型;... 详细信息

从可靠性经济的角度对继电保护装置的最小维修模型进行建模,并基于该模型计算最优更换周期。采用泊松分布拟合和Cramer-von Mises拟合优度检验确定继电保护装置的故障特性,采用对数正态分布拟合保护装置修复特性,从而构建最小维修模型;将单位生命周期费用应用于继电保护可靠性评估,制定以单位生命周期费用最小为目标的继电保护装置更换策略。依据现场保护装置的实际运行数据并考虑保护双重化的影响,对最优更换周期进行求解,验证了该策略的可行性。

关键词：继电保护装置最小维修模型单位生命周期费用最优更换周期

基于中性粒细胞胞外诱捕网研究隔药灸减轻克罗恩病大鼠结肠炎症的效应机制

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Journal of Acupuncture and Tuina Science 2024年第3期22卷 173-183页

作者：路驰徐静陆嫄吴璐一包春辉马喆钟蕊王照钦孙可鑫郑寒丹翁志军黄艳吴焕淦杨燕萍(译) Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Research Institute of Acupuncture and Meridian Shanghai 200030China 不详

目的:从中性粒细胞胞外诱捕网(NETs)参与克罗恩病(CD)进展的角度,阐释隔药灸减轻CD大鼠肠道炎症的效应机制。方法:将大鼠随机分为正常组、模型组、隔药灸组和美沙拉嗪组。除正常组外,其余大鼠采用2,4,6-三硝基苯磺酸制备CD模型。正常组... 详细信息

目的:从中性粒细胞胞外诱捕网(NETs)参与克罗恩病(CD)进展的角度,阐释隔药灸减轻CD大鼠肠道炎症的效应机制。方法:将大鼠随机分为正常组、模型组、隔药灸组和美沙拉嗪组。除正常组外,其余大鼠采用2,4,6-三硝基苯磺酸制备CD模型。正常组和模型组不治疗仅做与其他组相同的固定。隔药灸组予以隔药灸气海和双侧天枢穴。美沙拉嗪组接受美沙拉嗪肠溶片灌胃治疗。比较各组大鼠一般情况,苏木精-伊红染色观察结肠组织病理学变化并评分。采用ABC酶联免疫吸附测定法检测各组大鼠血清中性粒细胞胞外诱捕网DNA(NETs-DNA)、中性粒细胞弹性蛋白酶DNA(NE-DNA)、过氧化物酶DNA(MPO-DNA)浓度,采用免疫荧光和实时定量聚合酶链反应技术观察各组大鼠结肠组织瓜氨酸化组蛋白3(citH3)、MPO和NE蛋白和mRNA的表达。结果:与正常组比较,模型组结肠黏膜溃疡深达肌层,上皮不完整,杯状细胞明显减少,可见大量炎性细胞浸润,结肠黏膜损伤指数(CMDI)评分显著增加(P<0.01),模型组血清NETs-DNA、NE-DNA、MPO-DNA浓度均增加(P<0.05),模型组结肠组织NE、citH3和MPO蛋白和mRNA表达均上调(P<0.01或P<0.05);与模型组相比,隔药灸组和美沙拉嗪组结肠黏膜上皮修复,杯状细胞明显增多,可见少量炎性细胞浸润,CMDI评分明显降低(P<0.01),隔药灸组和美沙拉嗪组血清NETs-DNA、NE-DNA、MPO-DNA浓度均下降(P<0.05),隔药灸组和美沙拉嗪组NE、citH3和MPO蛋白和mRNA表达下调(P<0.01或P<0.05)。结论:隔药灸能降低血清中性粒细胞NETs复合物的浓度,抑制结肠组织中的NETs复合物的蛋白和mRNA表达,可能是隔药灸缓解CD结肠黏膜炎症的机制之一。

关键词：隔药灸疗法药饼灸疗法炎症性肠病克罗恩病中性粒细胞胞外诱捕网

Metabolomics of ginger based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry technology

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Food Quality and Safety 2021年第2期5卷 170-178页

作者：严辉邹冬倩周桂生余函纹李鹏辉王天舒包贝华郭盛段金廒 Jiangsu Collaborative Innovation Center of Chinese Medicine Resource Industrialization/Key Laboratory of Chinese Medicine Resources Recycling Utilization of National Administration of Traditional Chinese Medicine Nanjing University of Chinese MedicineNanjingJiangsuChina.

Objectives:Dried ginger and ginger are the same type of medicine and *** differential components of ginger and dried ginger,dried ginger and ginger charcoal were *** and Methods:The experimental materials were divided into three sample groups:the ginger group,dried ginger group,and ginger charcoal *** ginger group,dried ginger group,and ginger charcoal group were qualitatively analyzed by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass *** data were processed by Marker View *** component analysis and orthogonal partial least-square discriminant analysis were performed with SIMCA 13.0 *** differential components of the ginger and dried ginger groups as well as the dried ginger and ginger charcoal groups with a variable importance in the projection>2(P<0.05)were identified with PeakView 1.2 ***:Ten differential components,including 6-gingerol,8-gingerol,and 10-gingerol,were identified between the ginger group and dried ginger group;13 differential components,including 6-shogaol,10-gingerol,and zingiberone,were identified between the dried ginger group and ginger charcoal ***:The main differential components between the ginger and dried ginger groups and the dried ginger and ginger charcoal groups were gingerols and *** on metabolomics analysis of the chemical composition of ginger’s medicinal materials,effects,and other related factors,it is recommended that 6-gingerol,6-shogaol,and zingiberone should be used as indicative components for the respective quality evaluation of ginger,dried ginger and ginger *** results of this study may provide a basis for the reasonable quality evaluation of ginger medicinal materials.

关键词： Ginger dried ginger ginger charcoal metabolomics quality evaluation