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Hemin-induced increase in saponin content contributes to the alleviation of osmotic and cold stress damage to Conyza blinii in a heme oxygenase 1-dependent manner

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第8期22卷 682-694页

作者： tianrun zheng Junyi ZHAN Ming YANG Maojia WANG Wenjun SUN Zhi SHAN Hui CHEN College of Life Science Sichuan Agricultural UniversityYa'an 625014China College of Life Science Nanjing Agricultural UniversityNanjing 210095China Chongqing Academy of Chinese Materia Medica Chongqing 400065China

Hemin can improve the stress resistance of plants through the heme oxygenase system.Additionally,substances contained in plants,such as secondary metabolites,can improve stress resistance.However,few studies have explored the effects of hemin on secondary metabolite content.Therefore,the effects of hemin on saponin synthesis and the mechanism of plant injury relief by hemin in Conyza blinii were investigated in this study.Hemin treatment promoted plant growth and increased the antioxidant enzyme activity and saponin content of C.blinii under osmotic stress and cold stress.Further study showed that hemin could provide sufficient precursors for saponin synthesis by improving the photosynthetic capacity of C.blinii and increasing the gene expression of key enzymes in the saponin synthesis pathway,thus increasing the saponin content.Moreover,the promotion effect of hemin on saponin synthesis is dependent on heme oxygenase-1 and can be reversed by the inhibitor Zn-protoporphyrin-IX(ZnPPIX).This study revealed that hemin can increase the saponin content of C.blinii and alleviate the damage caused by abiotic stress,and it also broadened the understanding of the relationship between hemin and secondary metabolites in plant abiotic stress relief.

关键词： Hemin Saponin Conyza blinii Heme oxygenase Abiotic stress

Roles of hydroxyl and oxygen vacancy of CeO;·xH;O in Pd-catalyzed ethanol electro-oxidation

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Science China Chemistry 2022年

作者： Zhenyu Li Jiefei Li Zexuan zheng Kunhong Jiang tianrun zheng Dongmin Wang Hang Wei Zhiming Shi Xiaotian Li Haibin Chu College of Chemistry and Chemical Engineering Inner Mongolia Engineering and Technology Research Center for Catalytic Conversion and Utilization of Carbon Resource Molecules Inner Mongolia University College of Materials Science and Engineering Jilin University College of Chemistry Jilin University State Key Laboratory of Luminescence and Applications Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences

In the field of noble metal-catalyzed alcohol electro-oxidation reaction（AOR）, huge attention is paid on the composition, size,facet, and structure of the metals, while the support engineering should also be emphasized. CeO;has been widely used as an unique support in AOR, primarily due to its abundant oxygen vacancies（Ov）. Herein, we report CeO;·xH;O nanoparticles with both massive hydroxyl groups（OH） and Ovremarkably enhance the catalytic activity and stability of Pd toward ethanol oxidation reaction（EOR）. The CO striping experiments and density functional theory（DFT） calculations suggest that OH and Ov on CeO;·xH;O surface bring about a large downshift of Pd d-band center and a significant weakening of CO absorption on Pd.Moreover, OH and Ovalso play synergic roles in the removal of toxic intermediates. Consequently, the important roles of OH and Ovof CeO;·xH;O are confirmed in Pd-catalyzed EOR. The facile CeO;·xH;O-enhanced strategy can contribute to the catalyst design for other energy conversion reactions.

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On-surface synthesis and characterization of polyynic carbon chains

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National Science Review 2024年第3期11卷 192-199页

作者： Wenze Gao Wei zheng Luye Sun Faming Kang zheng Zhou Wei Xu Interdisciplinary Materials Research Center School of Materials Science and Engineering Tongji University

Carbyne, an elusive sp-hybridized linear carbon allotrope, has fascinated chemists and physicists for decades. Due to its high chemical reactivity and extreme instability, carbyne was much less explored in contrast to the sp2-hybridized carbon allotropes such as graphene. Herein, we report the on-surface synthesis of polyynic carbon chains by demetallization of organometallic polyynes on the Au（111） surface;the longest one observed consists of ～60 alkyne units（120 carbon atoms）. The polyynic structure of carbon chains with alternating triple and single bonds was unambiguously revealed by bond-resolved atomic force microscopy. Moreover, an atomically precise polyyne, C14, was successfully produced via tip-induced dehalogenation and ring-opening of the decachloroanthracene molecule(C14Cl10) on a bilayer NaCl/Au（111） surface at 4.7 K, and a band gap of 5.8 eV was measured by scanning tunnelling spectroscopy,in a good agreement with the theoretical HOMO–LUMO gap（5.48 eV）.

关键词： polyyne scanning probe microscopy carbon allotrope on-surface synthesis organometallic polyyne

Plate tectonics in the Archean:Observations versus interpretations

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Science China Earth Sciences 2024年第1期67卷 1-30页

作者： YongFei zheng School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Key Laboratory of Crust-Mantle Materials and Environment Chinese Academy of SciencesHefei 230026China Center of Excellence for Comparative Planetology Chinese Academy of SciencesHefei 230026China

Plate tectonics theory,established in the 1960s,has been successful in explaining many geological phenomena,processes and events that occurred in the Phanerozoic.However,the theory has often struggled to provide a coherent framework in interpreting geological records in continental interior and Precambrian period.In dealing with the relationship between plate tectonics and continental geology,continental interior tectonics was often separated from continental margin tectonics in the inheritance and development of their structure and composition.This separation led to the illusion that the plate tectonics theory is not applicable to Precambrian geology,particularly in explaining the fundamental geological characteristics of Archean cratons.Although this illusion does not mean that the Archean continental crust did not originate from a regime of plate tectonics,it led to the development of alternative tectonic models,often involving vertical movements under a regime of stagnant lid tectonics,including not only endogenous processes such as gravitational sagduction,mantle plumes and heat pipes but also exogenous processes such as bolide impacts.These vertical processes were not unique to the Archean but persisted into the Phanerozoic.They result from mantle poloidal convection at different depths,not specific to any particular period.Upgrading the plate tectonics theory from the traditional kinematic model in the 20th century to a holistic kinematic-dynamic model in the 21st century and systematically examining the vertical transport of matter and energy at plate margins,it is evident that plate tectonics can explain the common geological characteristics of Archean cratons,such as lithological associations,structural patterns and metamorphic evolution.By deciphering the structure and composition of convergent plate margins as well as their dynamics,the formation and evolution of continental crust since the Archean can be divided into ancient plate tectonics in the Precambrian and modern plate tectonics in the Phanero

关键词： Plate tectonics Archean geology Continental origin Crustal reworking Plate interior Plate margin

Orthogonal Combinatorial Raman Codes Enable Rapid High-Throughput-Out Library Screening of Cell-Targeting Ligands

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Research 2024年第1期2023卷 199-208页

作者： Yuchen Tang Xingxing zheng Tingjuan Gao China Key Laboratory of Pesticide and Chemical Biology of Ministry of Education College of ChemistryCentral China Normal UniversityWuhan 430079China

High-throughput assays play an important role in the fields of drug discovery,genetic analysis,and clinical diagnostics.Although super-capacity coding strategies may facilitate labeling and detecting large numbers of targets in a single assay,practically,the constructed large-capacity codes have to be decoded with complicated procedures or are lack of survivability under the required reaction conditions.This challenge results in either inaccurate or insufficient decoding outputs.Here,we identified chemical-resistant Raman compounds to build a combinatorial coding system for the high-throughput screening of cell-targeting ligands from a focused 8-mer cyclic peptide library.The accurate in situ decoding results proved the signal,synthetic,and functional orthogonality for this Raman coding strategy.The orthogonal Raman codes allowed for a rapid identification of 63 positive hits at one time,evidencing a high-throughput-out capability in the screening process.We anticipate this orthogonal Raman coding strategy being generalized to enable efficient high-throughput-out screening of more useful ligands for cell targeting and drug discovery.

关键词： enable throughput allowed

Recent advances in cancer-associated fibroblast:Biomarkers,signaling pathways,and therapeutic opportunities

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Chinese Medical Journal 2024年第6期137卷 638-650页

作者： Donger Zhou Lei zheng Department of Hepatobiliary-Pancreatic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Sidney Kimmel Comprehensive Cancer Center The Skip Viragh Pancreatic Cancer Center for Clinical Research and Careand The Bloomberg-Kimmel Institute for Immunotherapy at Johns Hopkins University School of MedicineBaltimoreMD 21287USA

Anti-cancer therapies usually focus on tumor cells,but non-tumor stromal components in the tumor microenvironment also play vital roles in tumor initiation and progression,which may be the prognostic factors and potential therapeutic targets.Cancer-associated fibroblasts(CAFs)are the essential component in the tumor environment,exhibiting high heterogeneity in their cell origin and phenotype with diverse functions that influence tumor angiogenesis,immune systems,and metabolism.Single-cell RNA sequencing and genetically engineered mouse models have increased our understanding of CAF diversity,and many subtypes have been defined.However,the precise functions of these subtypes need to be studied and validated.Studies of signaling pathways and epigenetic changes in CAFs facilitate understanding of the phenotypes of CAFs and the crosstalk between tumor cells and CAFs to provide potential therapeutic targets.Some clinical trials,including phase III trials targeting CAFs,have been performed recently.However,few of these trials have generated promising results,which indicates that the complexity of CAFs in the tumor microenvironment remains largely unknown,and in-depth investigations of CAFs should be performed.This review summarizes the research on CAFs,focusing on the heterogeneity of their phenotypes and functions,specific signaling pathways,and the therapeutic strategies involving CAFs.Additionally,we briefly discuss the current technologies commonly used in CAF studies and describe the challenges and future perspectives of CAF research.

关键词： Cancer-associated fibroblasts Tumor microenvironment Anti-cancer therapy Targeted therapy

A positive trend in the stability of global offshore wind energy

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Acta Oceanologica Sinica 2024年第1期43卷 123-134页

作者： Chongwei zheng Dalian Naval Academy Dalian 116018China Marine Resources and Environment Research Group on the Maritime Silk Road Dalian 116018China Shandong Provincial Key Laboratory of Ocean Engineering Ocean University of ChinaQingdao 266100China

The recognition on the trend of wind energy stability is still extremely rare,although it is closely related to acquisition efficiency,grid connection,equipment lifetime,and costs of wind energy utilization.Using the 40-year(1979–2018)ERA-Interim data from the European Center for Medium-Range Weather Forecasts,this study presented the spatial-temporal distribution and climatic trend of the stability of global offshore wind energy as well as the abrupt phenomenon of wind energy stability in key regions over the past 40 years with the climatic analysis method and Mann-Kendall(M-K)test.The results show the following 5 points.(1)According to the coefficient of variation(C_(v))of the wind power density,there are six permanent stable zones of global offshore wind energy:the southeast and northeast trade wind zones in the Indian,Pacific and Atlantic oceans,the Southern Hemisphere westerly,and a semi-permanent stable zone(North Indian Ocean).(2)There are six lowvalue zones for both seasonal variability index(S_(v))and monthly variability index(M_(v))globally,with a similar spatial distribution as that of the six permanent stable zones.M_(v) and S_(v) in the Arabian Sea are the highest in the world.(3)After C_(v),M_(v) and S_(v) are comprehensively considered,the six permanent stable zones have an obvious advantage in the stability of wind energy over other sea areas,with C_(v) below 0.8,M_(v) within 1.0,and S_(v) within 0.7 all the year round.(4)The global stability of offshore wind energy shows a positive climatic trend for the past four decades.C_(v),M_(v) and S_(v) have not changed significantly or decreased in most of the global ocean during 1979 to2018.That is,wind energy is flat or more stable,while the monthly and seasonal variabilities tend to shrink/smooth,which is beneficial for wind energy utilization.(5)C_(v) in the low-latitude Pacific and M_(v) and S_(v) in both the North Indian Ocean and the low-latitude Pacific have an obvious abrupt phenomenon at the end of the20th century.

关键词： global oceans wind energy stability spatial-temporal distribution climatic trend

Recent progress in functional modification and crosslinking of bioprosthetic heart valves

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Regenerative Biomaterials 2024年第1期3卷 1-16页

作者： Cheng zheng Li Yang Yunbing Wang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China

Valvular heart disease(VHD),clinically manifested as stenosis and regurgitation of native heart valve,is one of the most prevalent cardiovascular diseases with high mortality.Heart valve replacement surgery has been recognized as golden standard for the treatment of VHD.Owing to the clinical application of transcatheter heart valve replacement technic and the excellent hemodynamic performance of bioprosthetic heart valves(BHVs),implantation of BHVs has been increasing over recent years and gradually became the preferred choice for the treatment of VHD.However,BHVs might fail within 10-15 years due to structural valvular degeneration(SVD),which was greatly associated with drawbacks of glutaraldehyde crosslinked BHVs,including cytotoxicity,calcification,component degradation,mechanical failure,thrombosis and immune response.To prolong the service life of BHVs,much effort has been devoted to overcoming the drawbacks of BHVs and reducing the risk of SVD.In this review,we summarized and analyzed the research and progress on:(i)modification strategies based on glutaraldehyde crosslinked BHVs and(ii)nonglutaraldehyde crosslinking strategies for BHVs.

关键词： bioprosthetic heart valves modification crosslinking anticalcification antithrombosis

Damping Characteristic Analysis and Optimization of Wind-thermal-bundled Power Transmission by LCC-HVDC Systems

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 299-312页

作者： Liwen zheng Shiying Ma the Power System Department China Electric Power Research InstituteBeijing 100192China

With the rapid development of renewable energy,wind-thermal-bundled power transmission by line-commutated converter based high-voltage direct current(LCC-HVDC)systems has been widely developed.The dynamic interaction mechanisms among permanent magnet synchronous generators(PMSGs),synchronous generators(SGs),and LCC-HVDC system become complex.To deal with this issue,a path analysis method(PAM)is proposed to study the dynamic interaction mechanism,and the damping reconstruction is used to analyze the damping characteristic of the system.First,based on the modular modeling,linearized models for the PMSG subsystem,the LCC-HVDC subsystem,and the SG subsystem are established.Second,based on the closed-loop transfer function diagram of the system,the disturbance transfer path and coupling relationship among subsystems are analyzed by the PAM,and the damping characteristic analysis of the SG-dominated oscillation mode is studied based on the damping reconstruction.Compared with the PAM,the small-signal model of the system is obtained and eigenvalue analysis results are presented.Then,the effect of the control parameters on the damping characteristic is analyzed and the conclusions are verified by time-domain simulations.Finally,the penalty functions of the oscillation modes and decay modes are taken as the objective function,and an optimization strategy based on the Monte Carlo method is proposed to solve the parameter optimization problem.Numerical simulation results are presented to validate the effectiveness of the proposed strategy.

关键词： Wind-thermal-bundled power transmission line-commutated converter based high-voltage direct current(LCC-HVDC) path analysis method(PAM) damping characteristic analysis Monte Carlo method