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Cold Resources,Hot Gains

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ChinAfrica 2024年第3期16卷 22-23页

作者： liu TING 不详

Ice and snow tourism injects new momentum into rural revitalisation and high-quality development in northwest China’s Xinjiang,Local temperatures reached minus 20 degrees Celsius in December 2023 in Altay,Xinjiang Uygur Autonomous Region,but such harsh weather did not hinder well-equipped enthusiasts from skiing in the local Jiangjun Mountain Ski Resort.Since its opening in November,the resort has received an average of more than 4,000 visitors per day,far exceeding that of the same period in previous years.

关键词： Xinjiang northwest weather

Review of deep learning algorithms in molecular simulations and perspective applications on petroleum engineering

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Geoscience Frontiers 2024年第2期15卷 55-67页

作者： Jie liu Tao Zhang Shuyu Sun Physical Science and Engineering Division(PSE) Computational Transport Phenomena LaboratoryKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia

In the last few decades,deep learning(DL)has afforded solutions to macroscopic problems in petroleum engineering,but mechanistic problems at the microscale have not benefited from it.Mechanism studies have been the strong demands for the emerging projects,such as the gas storage and hydrate production,and for some problems encountered in the storage process,which are common found as the chemical interaction between injected gas and mineral,and the formation of hydrate.Emerging advances in DL technology enable solving molecular dynamics(MD)with quantum accuracy.The conventional quantum chemical method is computational expensive,whereas the classical MD method cannot guarantee high accuracy because of its empirical force field parameters.With the help of the DL force field,precision at the quantum chemistry level can be achieved in MD.Moreover,the DL force field promotes the computational speed compared with first-principles calculations.In this review,the basic knowledge of the molecular force field and deep neural network(DNN)is first introduced.Then,three representative opensource packages relevant to the DL force field are introduced.As the most common components in the development of oil and gas reservoirs,water and methane are studied from the aspects of computational efficiency and chemical reaction respectively,providing the foundation of oil and gas researches.However,in the oil and gas problems,the complex molecular topo structures and various element types set a high challenge for the DL techniques in MD.Regarding the computational efficiency,it needs improvement via GPU and parallel accelerations to compete with classical MD.Even with such difficulties,the booming of this technique in the area of petroleum engineering can be predictable.

关键词： Deep neural network Molecular dynamics Force field Petroleum engineering

A Windy and Rainy Shanghai

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China Today 2024年第5期73卷 58-59页

作者： liu FAN 不详

On Suzhou Road in Shanghai,there stood a mercer’s shop.Its shopkeeper was surnamed Yu,but the shop was named Wu’s Silk Shop instead of Yu’s Silk Shop.Yu Jide,the shopkeeper,was born in the town of Yushan,Songjiang ... 详细信息

关键词： Shop Wind administrative

Disease and Economic Burden of Kashin-Beck Disease—China,2021

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China CDC weekly 2024年第2期6卷 40-44页

作者： Silu Cui Wenjun Que Zhe Jiao Qing Deng Xufeng Zhang Yanhong Cao Ning liu Ailin Li Alphonse Sowanou Zhe Li Tuo Wang Yang Li Jun Yu Junrui Pei NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Key Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Kashin-Beck Disease ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Heilongjiang Provincial Key Laboratory of Trace Elements and Human HealthKey Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Endemic Fluorosis ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina

What is already known about this topic?Kashin-Beck disease(KBD)is a chronic and degenerative osteoarthropathy characterized by cartilage degeneration.It is an endemic disease that is highly prevalent among the Chinese population and poses a significant health risk.What is added by this report?This is the first national report on the economic burden of KBD in China.According to the data from 2021,KBD has caused significant disease and economic burdens.The most substantial reduction in healthy life expectancy was observed among patients with degree II severity and those aged 60 years and older,resulting in a total indirect economic burden of 112.74 million Chinese Yuan(CNY).What are the implications for public health practice?The results of this study will contribute to informing the development of tailored prevention and control strategies by the government.These strategies will include targeted policies and recommendations for appropriate healthcare and financial subsidies,which will be based on the demographic characteristics of the endemic areas.

关键词： prevention degeneration burden

Response of SiC Schottky Barrier Diode to Swift Heavy Ion Irradiation

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IMP & HIRFL Annual Report 2019年第1期 107-107页

作者： Yan Xiaoyu liu Jie liu tianqi Hu Peipei Zhao Peixiong Ai Wensi Sun Youmei 不详

Due to the lager bandgap,higher breakdown electric field,higher thermal conductivity and lager saturated electron drift velocity of silicon carbide(SiC),the SiC power devices have many advantages like high-voltage ope... 详细信息

关键词： breakdown Schottky lager

Spatial continuous modeling of early Cenozoic carbon cycle and climate

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National Science Review 2024年第4期11卷 30-32页

作者： Yonggang liu Jian Zhang Haoyue Zuo Zhilin He Jiaqi Guo Qifan Lin Haonan Yu Jiawenjing Lan Jing Han Zhihong Song Zihan Yin Liang Zhao Yongyun Hu Zhengtang Guo Laboratory for Climate and Ocean-Atmosphere Studies Department of Atmospheric and Oceanic Sciences School of Physics Peking University Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of Sciences State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences

The partial pressure of atmospheric CO2（pCO2） is determined by the carbon cycle that involves climate, biogeochemistry, and plate tectonics. In this cycle,atmospheric CO2is converted into organic carbon and carbonates by biological activities and silicate weathering, and buried as sediments. The sediments on the ocean floor are subducted into the Earth’s interior, and subsequently converted back into CO2and outgassed into the atmosphere.

关键词： ATMOSPHERIC CO2

First-line camrelizumab(a PD-1 inhibitor)plus apatinib(an VEGFR-2 inhibitor)and chemotherapy for advanced gastric cancer(SPACE):a phase 1 study

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1760-1767页

作者： Xiaofeng Chen Hao Xu Xiaobing Chen Tongpeng Xu Yitong Tian Deqiang Wang Fen Guo Kangxin Wang Guangfu Jin Xiao Li Rong Wang Fengyuan Li Yongbin Ding Jie Tang Yueyu Fang Jing Zhao Liang liu Ling Ma Lijuan Meng Zhiguo Hou Rongrong Zheng Yang liu Ni Guan Bei Zhang Shuang Tong Shiqing Chen Xing Li Yongqian Shu Department of Oncology The First Affiliated Hospital with Nanjing Medical UniversityNanjingChina Gusu School Nanjing medical UniversitySuzhouChina Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingChina Department of General surgery The First Affiliated Hospital with Nanjing Medical UniversityNanjingChina Department of Oncology Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhouChina Henan Engineering Research Center of Precision Therapy of Gastrointestinal Cancer&Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer ZhengzhouChina Department of Oncology Digestive Disease Institute&Cancer Institute of Jiangsu UniversityAffiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Oncology Suzhou Hospital of Nanjing Medical UniversitySuzhouChina Department of Oncology Nanjing PuKou People’s HospitalNanjingChina Department of Epidemiology School of Public HealthNanjing Medical UniversityNanjingChina Department of Pathology The First Affiliated Hospital with Nanjing Medical UniversityNanjingChina Department of general surgery Jurong Branch hospital of Jiangsu Province People HospitalJurongChina Department of Medical Oncology Liyang People’s HospitalLiyangChina Department of radiology Nanjing PuKou People’s HospitalNanjingChina Jiangsu Hengrui Pharmaceuticals ShanghaiChina Department of Medical Affairs 3D Medicines Inc.ShanghaiChina Shanghai OrigiMed Co. Ltd.ShanghaiChina

Patients with advanced gastric cancer typically face a grim prognosis.This phase 1a(dose escalation)and phase 1b(dose expansion)study investigated safety and efficacy of first-line camrelizumab plus apatinib and chemotherapyfor advanced gastric or gastroesophageal junction adenocarcinoma.The primary endpoints included maximum tolerated dose(MTD)in phase 1a and objective response rate(ORR)across phase 1a and 1b.Phase 1a tested three dose regimens of camrelizumab,apatinib,oxaliplatin,and S-1.Dose regimen 1:camrelizumab 200 mg on day 1,apatinib 250 mg every other day,oxaliplatin 100 mg/m^(2) on day 1,and S-140 mg twice a day on days 1-14.Dose regimen 2:same as dose regimen 1,but oxaliplatin 130mg/m.Dose regimen3:same as dose regimen 2,but apatinib 250 mg daily.Thirty-four patients were included(9 in phase 1a,25 in phase 1b).No dose-limiting toxicities occurred so no MTD was identified.Dose 3 was set for the recommended phase 2 doses and administered in phase 1b.The confrmed ORR was 76.5%(95%CI 58.8-89.3).The median progression-free survival was 8.4 months(95%CI 5.9-not evaluable[NE]),and the median overall survival(OS)was not mature(11.6-NE).Ten patients underwent surgery after treatment and the multidisciplinary team evaluation.Among 24 patients without surgery,the median OS was 19.6 months(7.8-NE).Eighteen patients(52.9%)developed grade≥3 treatment-emergent adverse events.Camrelizumab plus apatinib and chemotherapy showed favorable clinical outcomes and manageable safety for untreated advanced gastric cancer(ChiCTR2000034109).

关键词： regimen cancer doses

Observation of the Effectiveness of Rapid Recovery Nursing on Lung Cancer Surgery Patients and Its Impact on Sleep Quality

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Journal of Cancer Therapy 2024年第2期15卷 29-32页

作者： Weiwei Chen Dandan liu Sun Yat-sen University Cancer Center Guangzhou China

Objective: To investigate the nursing effects of rapid recovery care measures on lung cancer surgery patients. Methods: 42 cases of lung cancer surgery patients were divided into control group and study group, with 21 cases in each group. The sleep quality and postoperative recovery indicators were compared between the two groups. Results: The study group showed better results than the control group in terms of PSQI scores, venting time, extubation time, time to getting out of bed, and duration of antibiotic use, with P Conclusion: Rapid recovery nursing has a positive impact on improving sleep quality and promoting postoperative recovery in lung cancer surgery patients.

关键词： Rapid Recovery Nursing Lung Cancer Surgery Sleep Quality

Micropulse transscleral laser therapy for secondary angle-closure glaucoma in nanophthalmos: a case report

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1381-1384页

作者： Ping Yu Bai-Yu Hu Yu He Lin Jing Han-Ying Fan Jing Shu liu-Zhi Zeng Chengdu First People’s Hospital Chengdu 610095Sichuan ProvinceChina Eye School of Chengdu University of TCM Chengdu 610075Sichuan ProvinceChina

Dear Editor,The choice of surgical intervention for nanophthalmos patients with secondary angle-closure glaucoma poses a challenging decision for ophthalmologists.Because nanophthalmos patients who have undergone filtration surgery or other intraocular procedures are more susceptible to severe complications,including choroidal effusion,malignant glaucoma,and explosive choroidal hemorrhage,all of which can lead to vision loss[1].This dilemma is particularly pronounced in patients with shorter axial lengths.Micropulse transscleral laser therapy(M-TLT),also known as micropulse transscleral cyclophotocoagulation(MP-TSCPC),is a nonincisional laser therapy surgery for glaucoma[2].In 2015,Golan and Kurtz[3]were the first to report four patients with secondary angle-closure glaucoma in nanophthalmos with axial lengths ranging between 17 and 19 mm(mean 18 mm)who were successfully treated with M-TLT,and choroidal detachment was observed in all patients(recovery spontaneously in two patients and recovery after systemic steroid treatment in the other two),of which two had a slight decrease in visual acuity.

关键词： glaucoma surgery closure