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Comprehensive overview of genotype distribution and prevalence of human papillomavirus in cervical lesions

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Gynecology and Obstetrics Clinical Medicine 2024年第1期4卷 37-47页

作者： Yuhong Ye Terrel Jones tiannan wang Xianxu Zeng Yang Liu Chengquan Zhao Department of Pathology the First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Department of Pathology Magee-Womens HospitalUniversity of Pittsburgh Medical CenterPittsburghPennsylvaniaUSA Department of Pathology University of Southern CaliforniaLos AngelesCaliforniaUSA Department of Pathology The Third Affliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Departments of Medicine and Bioengineering University of PittsburghPittsburghPennsylvaniaUSA Department of Bioengineering University of Illinois Urbana-ChampaignUrbanaIllinoisUSA

Acrosscervical squamousandgl and ular lesions,a spectrum of human papillomavirus(HPV)genotypes has been *** review aims to provide a comprehensive summary detailing the distribution and profile of HPV genotypes detected in cervical lesions,leveraging insights from histological and cytological ***-risk HPV(HR-HPV)genotypes exhibit varying degrees of oncogenic potential,with HPV16 and HPV18 identified as the most prevalent and oncogenic *** of HR-HPVgenotypes varies among different degrees of the cervical lesions and varies between squamous andglandular ***16 is predominantly associated with severe lesions(precancers and carcinomas),while HPV18 demonstrates a significantly higher prevalence in endocervical as compared with squamous *** distribution of HR-HPV in severe squamous lesions is complex,involving many HR-HPV genotypes in addition to HPV16,while the distribution of HR-HPV genotypes in endocervical glandular lesions is mainly limited in HPV18 and *** datasets from China have identified the three mostcommon HR-HPVgenotypes in this population as stratified by diagnostic category:HPV52,HPV16,HPV58 in histologically negative cases and cervical intraepithelial neoplasia 1(CIN1);HPV16,HPV52,HPV58 in CIN2/3;HPV16,HPV58,HPV52 or HPV18 in squamous cell carcinoma(SCC);HPV16,HPV18 and HPV52 in endocervical adenocarcinoma in situ(AIS),invasiveadenocarcinoma,as well asmixedsquamous and glandular ***33 is the fourth most common HPVtype in CIN2/3and SCC,whileHPV45occursmore commonly in AIS and adenocarcinoma,compared with squamous *** prevalence and distribution of multiple HR-HPV coinfections vary across different cervical *** clinical significance and pathogenesis of these multiple HR-HPV infections remain uncertain,although recent two large studies demonstrate that multiple HR-HPV infections are not associated with cumulatively higher risk of high-grade cervical squamous lesiondeve

关键词： cervical lesions prevalence

装甲车辆大功率电驱动系统传导干扰预测模型构建方法

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兵工学报 2024年第9期45卷 3004-3016页

作者：熊瑛李小健范知友李楠王彪王天楠中国北方车辆研究所电磁兼容试验室北京100072

装甲车辆动力系统大功率电驱动系统中开关模组的高速切换将产生一系列高压瞬态脉冲及宽频谐波干扰,对高度电气化的整车系统构成严峻威胁。针对大功率电驱动系统产生的传导干扰缺乏数字化检测及分析问题,提出一种系统级的传导干扰预测模... 详细信息

装甲车辆动力系统大功率电驱动系统中开关模组的高速切换将产生一系列高压瞬态脉冲及宽频谐波干扰,对高度电气化的整车系统构成严峻威胁。针对大功率电驱动系统产生的传导干扰缺乏数字化检测及分析问题,提出一种系统级的传导干扰预测模型构建方法。对电驱动系统各电气部件例如高压电池组、逆变器、负载电机分别独立建模;基于多导体传输线方法,将各模型通过表征系统寄生效应的传输线进行级联,进而构成完整的分布式系统级传导干扰预测模型。通过测试台架对新提出的模型进行精度测试对比验证。对比验证结果表明,新构建的模型在10 kHz~100 MHz频段范围内仿真精度优于8 dB,可为电驱动装甲车辆的电磁兼容正向设计提供有效支撑,具备创新性及实用性。

关键词：装甲车辆传导干扰电驱动系统开关模组三相同步电机模型构建

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AMT控制器电磁发射干扰特性研究

现代电子技术 2024年第6期47卷 75-78页

作者：王彪王天楠张莹中国北方车辆研究所北京100071

基于GJB 151B—2013中对军用设备和分系统的电磁发射要求,以某型号AMT控制器为研究对象,进行AMT控制器电磁发射干扰特性分析,开展CE102电源线传导发射试验和RE102电场辐射发射试验。试验结果表明:试验用AMT控制器的电源线传导发射和电... 详细信息

基于GJB 151B—2013中对军用设备和分系统的电磁发射要求,以某型号AMT控制器为研究对象,进行AMT控制器电磁发射干扰特性分析,开展CE102电源线传导发射试验和RE102电场辐射发射试验。试验结果表明:试验用AMT控制器的电源线传导发射和电场辐射发射均满足GJB 151B—2013的电磁发射要求,电源正线和电源负线的电磁传导发射情况基本一致,均存在以50 Hz为基波的多次谐波干扰,在50 Hz处安全裕度最小,约为10 dBμV;经屏蔽处理后的AMT控制器在垂直极化和水平极化两种天线状态下的电磁辐射情况基本一致。为进一步提高AMT控制器电磁发射干扰的安全裕度,既要在电源线端口处采取以50 Hz为基波的多次谐波干扰抑制措施,同时还要对AMT控制器上的孔缝、接口以及线缆进一步采取屏蔽防护措施。

关键词： AMT控制器电磁发射谐波干扰 CE102试验 RE102试验干扰抑制

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调查研究的哲学方法论探析

辽宁师范大学学报（社会科学版） 2024年第2期47卷 73-78页

作者：王天楠辽宁师范大学马克思主义学院辽宁大连116081

调查研究是以马克思主义的世界观和方法论为指导,坚持实践本体论,并将实践作为对象、目的、方法、动力和检验标准,内涵了“六个必须坚持”的重要工作方法。调查研究要揭示的是事物普遍联系的根本内容和变化发展的内在动力,蕴含了“大兴... 详细信息

调查研究是以马克思主义的世界观和方法论为指导,坚持实践本体论,并将实践作为对象、目的、方法、动力和检验标准,内涵了“六个必须坚持”的重要工作方法。调查研究要揭示的是事物普遍联系的根本内容和变化发展的内在动力,蕴含了“大兴”与“常兴”、结果与过程、形式与内容、“上意”与“下情”、百家与专家等辩证关系,并且用辩证思维方法处理调研与检查、质性与量化、规模与效率、布置与突袭、态度与方法等关系,是唯物辩证法与历史唯物主义在实际工作中的应用。

关键词：调查研究哲学方法论实践

地面装备电源变换系统高低压线缆串扰仿真研究

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强激光与粒子束 2024年第4期36卷 166-172页

作者：熊瑛李小健王彪张莹杜晓琳聂秀丽王天楠中国北方车辆研究所电磁兼容试验室北京100072

电源变换系统中功率器件如MOSFET和IGBT开关管的高速切换将产生高幅值和宽频段的电磁干扰,是电动车辆最为常见也无法避免的电磁干扰源。同时,互连线缆是机电设备传递信号和能量的载体,是实现设备功能不可或缺的组成部分,线缆的天线效应... 详细信息

电源变换系统中功率器件如MOSFET和IGBT开关管的高速切换将产生高幅值和宽频段的电磁干扰,是电动车辆最为常见也无法避免的电磁干扰源。同时,互连线缆是机电设备传递信号和能量的载体,是实现设备功能不可或缺的组成部分,线缆的天线效应使其成为设备产生电磁干扰的主要途径,是系统电磁兼容问题的主要根源之一。为了分析高压电源变换系统对低压控制系统的电磁耦合,以某典型地面装备电源变换系统IGBT开关管产生的脉冲宽度调制波(PWM波)作为电磁干扰源,以实装线缆作为分析对象,构建高低压线缆串扰模型,仿真分析不同线缆对地距离、线缆间距条件下单线、屏蔽线、双绞线等多类低压线缆的近端串扰电压,得出低压线缆的抗干扰性,为系统线缆的布线提供指导。

关键词：线缆电磁兼容电源变换系统线缆串扰共模干扰

中心切割二维液相色谱-串联质谱法测定卷烟主流烟气中4种芳香胺类化合物的含量

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理化检验（化学分册） 2024年第4期60卷 349-357页

作者：王天南戚大伟汪阳忠陈敏陶立奇费婷吴达陆捷上海烟草集团有限责任公司技术中心上海201315

提出了中心切割二维液相色谱-串联质谱法(2DLC-MS/MS)测定卷烟主流烟气中1-氨基萘(1-NA)、2-氨基萘(2-NA)、3-氨基联苯(3-ABP)和4-氨基联苯(4-ABP)等4种芳香胺类化合物含量的方法。用剑桥滤片捕集20支卷烟烟气粒相物,加入200μL 1 mg·L... 详细信息

提出了中心切割二维液相色谱-串联质谱法(2DLC-MS/MS)测定卷烟主流烟气中1-氨基萘(1-NA)、2-氨基萘(2-NA)、3-氨基联苯(3-ABP)和4-氨基联苯(4-ABP)等4种芳香胺类化合物含量的方法。用剑桥滤片捕集20支卷烟烟气粒相物,加入200μL 1 mg·L^(-1)混合内标溶液和20 mL 5%(质量分数)盐酸溶液,超声萃取30 min。分取10 mL,加入1 mL 50%(质量分数)氢氧化钠溶液调节溶液酸度至pH 7,再加入2 mL二氯甲烷,涡旋振荡15 min,有机相经0.2μm聚四氟乙烯滤膜过滤。第一维液相色谱法采用强阳离子交换(SCX)色谱柱对目标物进行分离除杂,通过补偿泵在线稀释、中和有机相,目标物被保留于捕集柱,随后目标物被洗脱至第二维反相(RP)色谱系统,分离后在质谱检测器的多反应监测(MRM)模式下,采用内标法定量分析。结果表明:1-NA和2-NA标准曲线的线性范围为0.50~50.0μg·L^(-1),3-ABP和4-ABP标准曲线的线性范围为0.25~50.0μg·L^(-1),检出限(3S/N)为0.002~0.008 ng·支^(-1);4种目标物在3个加标浓度水平下的回收率为86.0%~97.4%,日间精密度与日内精密度试验所得测定值的相对标准偏差均小于8.0%。对市售烤烟型和混合型卷烟样品进行分析,所得混合型卷烟烟气芳香胺类化合物的测定值与盒标焦油量呈正相关,而烤烟型卷烟无明显线性关系。

关键词：卷烟烟气芳香胺类化合物中心切割二维液相色谱-串联质谱法

Advances in diagnosis,clinical management and molecular characterization of ovarian Brenner tumors

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Gynecology and Obstetrics Clinical Medicine 2023年第1期3卷 18-21页

作者： Valentina Zanfagnin Tiffany Lee Chengquan Zhao tiannan wang Department of Pathology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA90033USA Department of Pathology Magee-Womens HospitalUniversity of Pittsburgh Medical CenterPittsburghPA15213USA

Brenner tumors is a very uncommon ovarian epithelial neoplasm,morphologically resembling the transitional cell neoplasm of urinary *** is further classified into three subtypes as a disease spectrum based on histological examination and tumorigenesis:benign Brenner tumors,borderline Brenner tumors(BBTs),and malignant Brenner tumors(MBTs).The etiology of these tumors is not well understood,and literature is limited due to the rarity of this entity,but recent advances,particularly in molecular alterations,have *** scope of this review is to provide an update on the clinical,histopathological,and most recently,molecular characterizations of ovarian Brenner tumors.

关键词： Brenner clinical diagnosis

Internet of Things Intrusion Detection System Based on Convolutional Neural Network

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计算机、材料和连续体（英文） 2023年第4期75卷 2119-2135页

作者： Jie Yin Yuxuan Shi Wen Deng Chang Yin tiannan wang Yuchen Song Tianyao Li Yicheng Li Department of Computer Information and Cyber Security Jiangsu Police InstituteNanjingChina Engineering Research Center of Electronic Data Forensics Analysis NanjingChina Key Laboratory of Digital Forensics Department of Public Security of Jiangsu ProvinceNanjingChina

In recent years, the Internet of Things (IoT) technology has developedby leaps and bounds. However, the large and heterogeneous networkstructure of IoT brings high management costs. In particular, the low costof IoT devices exposes them to more serious security concerns. First, aconvolutional neural network intrusion detection system for IoT devices isproposed. After cleaning and preprocessing the NSL-KDD dataset, this paperuses feature engineering methods to select appropriate features. Then, basedon the combination of DCNN and machine learning, this paper designs acloud-based loss function, which adopts a regularization method to preventoverfitting. The model consists of one input layer, two convolutional layers,two pooling layers and three fully connected layers and one output ***, a framework that can fully consider the user’s privacy protection isproposed. The framework can only exchange model parameters or intermediateresults without exchanging local individuals or sample data. This paperfurther builds a global model based on virtual fusion data, so as to achievea balance between data privacy protection and data sharing computing. Theperformance indicators such as accuracy, precision, recall, F1 score, and AUCof the model are verified by simulation. The results show that the model ishelpful in solving the problem that the IoT intrusion detection system cannotachieve high precision and low cost at the same time.

关键词： Internet of things intrusion detection system convolutional neural network federated learning

Current understanding of glucose transporter 4 expression and functional mechanisms

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World Journal of Biological Chemistry 2020年第3期11卷 76-98页

作者： tiannan wang Jing wang Xinge Hu Xian-Ju Huang Guo-Xun Chen Department of Nutrition The University of TennesseeKnoxvilleTN 37996United States College of Pharmacy South-Central University for NationalitiesWuhan 430074Hubei ProvinceChina

Glucose is used aerobically and anaerobically to generate energy for *** transporters(GLUTs)are transmembrane proteins that transport glucose across the cell *** promotes glucose utilization in part through promoting glucose entry into the skeletal and adipose *** has been thought to be achieved through insulin-induced GLUT4 translocation from intracellular compartments to the cell membrane,which increases the overall rate of glucose flux into a *** insulin-induced GLUT4 translocation has been investigated ***,significant progress has been made in our understanding of GLUT4 expression and ***,we summarized the methods and reagents used to determine the expression levels of Slc2a4 mRNA and GLUT4 protein,and GLUT4 translocation in the skeletal muscle,adipose tissues,heart and ***,a variety of methods such real-time polymerase chain reaction,immunohistochemistry,fluorescence microscopy,fusion proteins,stable cell line and transgenic animals have been used to answer particular questions related to GLUT4 system and insulin *** seems that insulininduced GLUT4 translocation can be observed in the heart and brain in addition to the skeletal muscle and *** other than insulin can induce GLUT4 ***,more studies of GLUT4 are warranted in the future to advance of our understanding of glucose homeostasis.

关键词： Glucose transporter 4 Insulin Skeletal muscle Adipocytes Brain Heart Antibodies