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A STIR nucleic acid drug delivery system for stirring phenotypic switch of microglia in Parkinson’s disease treatments

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Nano Research 2023年第5期16卷 7216-7226页

作者： Yanyue Wu Wenli Wang Xinyu Qiu Zhiguo Lu Weihong Ji Jie Shen Huan Peng Ruichen Zhao Jingwen Wang tianlu zhang Jun Yang Xin zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Neuroinflammation is one of the three important pathological features in neurodegenerative diseases including Parkinson’s disease(PD).The regulation of neuroinflammation can reduce the severity of neurological damage to alleviate diseases.Numerous studies have shown that the phenotype switch of microglia is tightly associated with the nuclear factorκB(NF-κB)-mediated inflammatory pathway.Therefore,the small interfering RNA(siRNA)therapy for downregulating the expression of NF-κB,provides a promising therapeutic strategy for Parkinson’s disease treatments.Considering the brain delivery challenges of siRNA,a sequential targeting inflammation regulation(STIR)delivery system based on poly(amino acid)s is developed to improve the therapeutic effects of Parkinson’s disease treatments.The STIR system sequentially targets the blood–brain barrier and the microglia to enhance the effective concentration of siRNA in the targeted microglia.The results demonstrate that the STIR nanoparticles can transform microglial phenotypes and regulate brain inflammation,thus achieving neuronal recovery and abnormal aggregation ofα-synuclein protein(α-syn)reduction in the treatment of Parkinson’s disease.Herein,this STIR delivery system provides a promising therapeutic platform in PD treatments and has great potential for other neurodegenerative diseases’therapies.

关键词： sequential targeting inflammation regulation phenotypic switch of microglia targeted drug delivery siRNA-based gene therapy responsive release Parkinson’s disease

Development of bioactive materials for glioblastoma therapy

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Bioactive Materials 2016年第1期1卷 29-38页

作者： Jun Yang Yan Li tianlu zhang Xin zhang National Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China

Glioblastoma is the most common and deadly human brain cancers.Unique barriers hinder the drug delivering pathway due to the individual position of glioblastoma,including blood-brain barrier and blood-brain tumor barrier.Numerous bioactive materials have been exploited and applied as the transvascular delivery carriers of therapeutic drugs.They promote site-specific accumulation and long term release of the encapsulated drugs at the tumor sites and reduce side effects with systemic delivery.And the delivery systems exhibit a certain extent of anti-glioblastoma effect and extend the median survival time.However,few of them step into the clinical trials.In this review,we will investigate the recent studies of bioactive materials for glioblastoma chemotherapy,including the inorganic materials,lipids and polymers.These bioactive materials construct diverse delivery vehicles to trigger tumor sites in brain intravenously.Herein,we exploit their functionality in drug delivery and discuss the deficiency for the featured tumors,to provide guidance for establishing optimized therapeutic drug formulation for anti-glioblastoma therapy and pave the way for clinical application.

关键词： Glioblastoma Bioactive material Blood-brain barrier Blood-brain tumor barrier Chemotherapy

Synthesis and characterization of novel biocompatible nanocapsules encapsulated lily fragrance

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Chinese Chemical Letters 2019年第3期30卷 739-742页

作者： Weihong Ji tianlu zhang Zhiguo Lu Jie Shen Zuobing Xiao Xin zhang State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai Research Institute of Fragrance and Flavor Industry School of Perfume and Aroma Technology Shanghai Institute of Technology

Fragranced products are wildly used in our daily life. However, their storage, application and quality are severely influenced by their strong volatility. In order to overcome these natural defects of fragrances,fragrance encapsulation approaches have been developed recently. In this study, a mild, simple and lowcost method of fragrance encapsulation was invented. Liposomes composed of soya lecithin/DSPEPEG2000/PLGA were prepared to encapsulate lily fragrance(LF). And these nanosized fragrance products was named LF-NPs. The hydrodynamic diameters of LF-NPs were approximately 100 nm and their encapsulation efficiency was up to 21.9%. Besides, LF-NPs could also prolong the release time of lily fragrance. Finally, the cytotoxicity tests indicated that LF-NPs offered biocompatibility. Therefore, LF-NPs were expected to have application prospects.

关键词： Nanocapsules Encapsulation Fragrance Biocompatibility Simple operation

Zwitterionic comb-like lipid polymers encapsulating linalool for increasing the fragrance retention time

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Chinese Chemical Letters 2021年第1期32卷 573-576页

作者： tianlu zhang Zhiguo Lu Xiangyu Wang Jie Shen Jianze Wang Yunwei Niu Zuobing Xiao Xin zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Shanghai Research Institute of Fragrance and Flavor Industry Shanghai 200232China School of Perfume and Aroma Technology Shanghai Institute of TechnologyShanghai 200233China

Fragrances are widely used in cosmetics,apparel and detergents.However,the rapid evaporation of the aro ma shortens the useful life of the aromatic product.Therefore,improving the fragrance retention time of aromatic products and prolonging the service life of aromatic products are the key scientific problems that need to be solved in current aromatic products.In this study,zwitterionic comb-like lipid polymers were synthesized to encapsulate the fragrance molecule linalool.The results showed that the zwitterionic comb lipid molecules were capable of encapsulating more linalool than linear lipid molecules.At the same time,the zwitterionic comb-like lipid molecules also limited the slow release rate of the aroma,thereby increasing the fragrance retention time of the nano-fragrance.

关键词： Linalool Zwitterionic comb-like lipid polymers Nano-fragrance Fragrance retention time Slow release

Mesoporous silica nanospheres with the ability of photo-driven releasing sandela 803 for the application to wallpaper

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Chinese Chemical Letters 2019年第3期30卷 747-749页

作者： Weihong Ji tianlu zhang Zhiguo Lu Jie Shen Jing Hu Yunwei Niu Zuobing Xiao Xin zhang State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai Research Institute of Fragrance and Flavor Industry School of Perfume and Aroma Technology Shanghai Institute of Technology

Fragrances are widely used in our daily life and have made great contributions to creating a clean and fresh healthy air environment. However, the rapid volatilization severely influences their storage,application and quality. Therefore, it is necessary and urgent to develop approaches to controllably release the odorants as demanded. In this study, photo-driven mesoporous silica nanospheres loaded with sandela 803 was designed, prepared and named as S803@MS-S. S803@MS-S possessed ordered mesoporous, large specific surface area and pore volume. After adsorption of sandela 803, the S803@MSS was added into wallpaper to prepare fragrant wallpaper S803@MS-S-W. And this wallpaper exhibited excellent sustained and controlled release performances stimulated by light.

关键词： Mesoporous silica nanospheres Sandela 803 Photo-driven release Wallpaper Azobenzene derivatives

Preparation of hollow mesoporous silica nanorods for encapsulating and slowly releasing eugenol

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Chinese Chemical Letters 2020年第12期31卷 3135-3138页

作者： tianlu zhang Zhiguo Lu Luyao zhang Yan Li Jun Yang Jie Shen Jianze Wang Yunwei Niu Zuobing Xiao Lei Chen Xin zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Department of Obstetrics and Gynecology Navy General Hospital of People Liberation ArmyBeijing 100048China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Shanghai Research Institute of Fragrance and Flavor Industry Shanghai 200232China School of Perfume and Aroma Technology Shanghai Institute of TechnologyShanghai 200233China

Fragrances are widely used in many aspects of our lives.They cannot only make people happy,but also treat many diseases.However,excessively fast evaporation rate is one of the main obstacles to the use of spices.In this study,mesoporous silica nanorods(MSNRs)and hollow mesoporous silica nanorods(HMSNRs)were prepared to encapsulate eugenol.These two nano-fragrances were named eugenol@MSNRs and eugenol@HMSNRs,respectively.The morphologies,size,interior structures and pore performances of MSNRs and HMSNRs.Besides,the performances of encapsulation and fragrance release of eugenol@MSNRs and eugenol@HMSNRs were compared and analyzed.The results showed that eugenol@HMSNRs encapsulated more fragrance and were faster to encapsulate compared with eugenol@MSNRs.Both the release rates of eugenol from eugenol@MSNRs and eugenol@HMSNRs were slow.But the eugenol was released from eugenol@MSNRs more slowly.

关键词： Eugenol Hollow mesoporous silica nanorods Mesoporous silica nanorods Nano-fragrance Slow release of fragrance

Preparation of mesoporous silica nanoparticle with tunable pore diameters for encapsulating and slowly releasing eugenol

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Chinese Chemical Letters 2021年第5期32卷 1755-1758页

作者： tianlu zhang Zhiguo Lu Jianze Wang Jie Shen Qiulian Hao Yan Li Jun Yang Yunwei Niu Zuobing Xiao Lei Chen Xin zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Department of Obstetrics and Gynecology Navy General Hospital of People Liberation ArmyBeijing 100048China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Shanghai Research Institute of Fragrance and Flavor Industry Shanghai 200232China School of Perfume and Aroma Technology Shanghai Institute of TechnologyShanghai 200233China

Fragrances are frequently added to a variety of products,including food,cosmetics and health products.However,the high volatility and instability of essence limit its application in some fields.In this study,mesoporous silica nanoparticles(MSNs) were prepared to encapsulate eugenol,which could reduce the volatilization of the fragrance molecules.A facile approach was presented to synthesize MSNs with three different pore diameters for encapsulating eugenol.In addition,the properties of MSNs including mean particle size,morphology,encapsulating efficiency and release tendency were charac terized.Results showed that the larger the pore diameters of MSNs,the more aromatic molecules were adsorbed.Furthermore,the release mechanism was described as the smaller the pore diameters of MSNs,the slower the release of eugenol.

关键词： Eugenol Mesoporous silica nanoparticles Nano-fragrance Slow release of fragrance

Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition

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Bioactive Materials 2020年第4期5卷 1127-1137页

作者： Zhiguo Lu Jianze Wang Lina Qu Guanghan Kan tianlu zhang Jie Shen Yan Li Jun Yang Yunwei Niu Zuobing Xiao Yinghui Li Xin zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190PR China State Key Laboratory of Space Medicine Fundamentals and Application China Astronaut Research and Training CenterBeijing100094China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049PR China Shanghai Research Institute of Fragrance and Flavor Industry Shanghai200232PR China School of Perfume and Aroma Technology Shanghai Institute of TechnologyShanghai200233PR China

Astronauts are under high stress for a long time because of the microgravity condition,which leads to anxiety,affects their learning and memory abilities,and seriously impairs the health of astronauts.Aromatherapy can improve the physical and mental health of astronauts in a way that moisturizes them softly and silently.However,the strong volatility of fragrances and inconvenience of aroma treatment greatly limit their application in the field of spaceflight.In this study,reactive mesoporous silica nanoparticles were prepared to encapsulate and slowly release limonene.The limonene loaded nanoparticles were named limonene@mesoporous silica nanoparticles-cyanuric chloride(LE@MSNs-CYC).LE@MSNs-CYC were then applied to wallpaper to improve the convenience of aromatherapy.LE@MSNs-CYC could chemically react with the wallpaper,thus firmly adsorbed on the wallpaper.In the following,the mice were treated with hindlimb unloading(HU)to simulate a microgravity environment.The results showed that 28-day HU led to an increase in the level of anxiety and declines in learning,memory,and physical health in mice.LE@MSNs-CYC showed significant relief effects on anxiety,learning,memory,and physical health of HU treated mice.Subsequently,the molecular mechanisms were explored by hypothalamic-pituitary-adrenal axis related hormones,immune-related cytokines,learning,and memory-related neurotransmitters and proteins.

关键词： Reactive mesoporous silica nanoparticles Slow release of limonene Simulated microgravity condition Improvement of physical health Improvement of mental health

Cationic and temperature-sensitive liposomes loaded with eugenol for the application to silk

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Chinese Chemical Letters 2020年第12期31卷 3139-3142页

作者： Zhiguo Lu Xiangyu Wang tianlu zhang Luyao zhang Jun Yang Yan Li Jie Shen Jianze Wang Yunwei Niu Zuobing Xiao Guiying Liu Xin zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Department of Pediatrics Capital Medical University Affiliated Beijing Anzhen HospitalBeijing 100029China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Shanghai Research Institute of Fragrance and Flavor Industry Shanghai 200232China School of Perfume and Aroma Technology Shanghai Institute of TechnologyShanghai 200233China

Silk has been widely used in the clothing industry due to their soft and smooth features,good biocompatibility,good heat dissipation,warmth and ultraviolet resistance.The application of fragrance to silk can significantly improve the performance of silk.However,there are two key scientific problems that need to be solved:slowing down the release rate of fragrances and increasing the scent lasting time of silk.In this study,cationic and temperature-sensitive liposomes were designed and prepared to encapsulate eugenol.These fragrance-loaded liposomes significantly slowed down the release rate of the fragrance and controlled the release rate of the fragrance in a thermo-sensitive manner.The liposomes adhered to the silk through electrostatic adsorption interaction.The positive charge on the fragranceloaded liposomes neutralized much negative charge on silk and thereby increasing the adhesion efficiency.

关键词： Eugenol Silk Cationic and temperature-sensitive liposomes Slow release of fragrance Controlled release of fragrance