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Nano Research 2024年第4期17卷 2555-2562页

作者： Guangyuan Yan tianlu wang Biwei Zhao Wenjing Gao Tong Wu Liming Ou School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China

Medium-entropy oxides(MEOs)with broad compositional tunability and entropy-driven structural stability,are receiving booming attention as a promising candidate for oxygen evolution reaction(OER)electrocatalysts.Meanwhile,ultrathin two-dimensional(2D)nanostructure offers extremely large specific surface area and is therefore considered to be an ideal catalyst structure.However,it remains a grant challenge to synthesize ultrathin 2D MEOs due to distinct nucleation and growth kinetics of constituent multimetallic elements in 2D anisotropic systems.In this work,an ultrathin 2D MEO(MnFeCoNi)O was successfully synthesized by a facile and low-temperature ionic layer epitaxy method.Benefiting from multi-metal synergistic effects within ultrathin 2D nanostructure,this 2D MEO(MnFeCoNi)O revealed excellent OER electrocatalytic performance with a quite low overpotential of 117 mV at 10 mA·cm^(-2) and an impressive stability for 120 h continuous operation with only 6.9%decay.Especially,the extremely high mass activity(5584.3 A·g^(-1))was three orders of magnitude higher than benchmark RuO_(2)(3.4 A·g^(-1))at the same overpotential of 117 mV.This work opens up a new avenue for developing highly efficient and stable electrocatalysts by creating 2D nanostructured MEOs.

关键词： medium-entropy oxide two-dimensional nanomaterials ionic layer epitaxy oxygen evolution reaction electrocatalysis

Parallel System Based Quantitative Assessment and Self-evolution for Artificial Intelligence of Active Power Corrective Control

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 13-28页

作者： Tianyun Zhang Jun Zhang Feiyue wang Peidong Xu tianlu Gao Haoran Zhang Ruiqi Si School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072HubeiChina State Key Laboratory for Management and Control of Complex System Institute of AutomationChinese Academy of SciencesBeijing 100190China

In artificial intelligence(AI)based-complex power system management and control technology,one of the urgent tasks is to evaluate AI intelligence and invent a way of autonomous intelligence evolution.However,there is,currently,nearly no standard technical framework for objective and quantitative intelligence evaluation.In this article,based on a parallel system framework,a method is established to objectively and quantitatively assess the intelligence level of an AI agent for active power corrective control of modern power systems,by resorting to human intelligence evaluation theories.On this basis,this article puts forward an AI self-evolution method based on intelligence assessment through embedding a quantitative intelligence assessment method into automated reinforcement learning(AutoRL)systems.A parallel system based quantitative assessment and self-evolution(PLASE)system for power grid corrective control AI is thereby constructed,taking Bayesian Optimization as the measure of AI evolution to fulfill autonomous evolution of AI under guidance of their intelligence assessment results.Experiment results exemplified in the power grid corrective control AI agent show the PLASE system can reliably and quantitatively assess the intelligence level of the power grid corrective control agent,and it could promote evolution of the power grid corrective control agent under guidance of intelligence assessment results,effectively,as well as intuitively improving its intelligence level through selfevolution.

关键词： AI quantitative intelligence assessment and self-evolution automated reinforcement learning Bayesian optimization corrective control parallel system

Effect of nano-CaO particle on the microstructure,mechanical properties and corrosion behavior of lean Mg-1Zn alloy

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Journal of Magnesium and Alloys 2024年第2期12卷 794-814页

作者： Guangxin Shen Shaoyuan Lyu Leiting Yu tianlu Li Chen You Xuewei wang Minfang Chen Bin Jiang School of Materials Science and Engineering Tianjin University of TechnologyTianjin 300384China Key Laboratory of Display Materials and Photoelectric Device(Ministry of Education) Tianjin University of TechnologyTianjin 300384China National Demonstration Center for Experimental Function Materials Education Tianjin University of TechnologyTianjin 300384China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

The effects of nano-CaO contents on the microstructure,mechanical properties and corrosion resistance of lean Mg-1Zn alloy were investigated.The results showed that the addition of nano-CaO significantly refined the grain size and improved mechanical properties of the Mg-1Zn alloy.At the same time,CaO reacted with molten Mg in situ to form nano-MgO,whose corrosion product in SBF solution was the same with the degradation product of Mg matrix,resulting in the enhanced compactness of the Mg(OH)_(2) layer and reduced corrosion rate of matrix.The Mg-1Zn alloy had lower corrosion resistance due to excessively large grain size and shedding of corrosion products.The composite with 0.5 wt.%CaO had the best corrosion resistance with a weight loss of 9.875 mg·y^(-1)·mm^(-2)due to the small number of Ca_(2)Mg_(6)Zn_(3) phase and suitable grain size.While for composites with high content of CaO(0.7 wt.%and 1.0 wt.%),they had lower corrosion resistance due to the coexistence of large number of Ca_(2)Mg_(6)Zn_(3) and Mg_(2)Ca at grain boundaries,especially for 1.0 wt.%CaO composite,resulting from the strong micro-galvanic corrosion.

关键词： Lean Mg alloy In situ MgO Nanoparticles Grain refinement Corrosion resistance

Neutrophil elastase:From mechanisms to therapeutic potential

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Journal of Pharmaceutical Analysis 2023年第4期13卷 355-366页

作者： Weilin Zeng Yingqiu Song Runze wang Rong He tianlu wang Department of Radiotherapy Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang110000China Department of Surgery Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang110000China

Neutrophil elastase(NE),a major protease in the primary granules of neutrophils,is involved in microbicidal activity.NE is an important factor promoting inflammation,has bactericidal effects,and shortens the inflammatory process.NE also regulates tumor growth by promoting metastasis and tumor microenvironment remodeling.However,NE plays a role in killing tumors under certain conditions and promotes other diseases such as pulmonary ventilation dysfunction.Additionally,it plays a complex role in various physiological processes and mediates several diseases.Sivelestat,a specific NE inhibitor,has strong potential for clinical application,particularly in the treatment of coronavirus disease 2019(COVID-19).This review discusses the pathophysiological processes associated with NE and the potential clinical applications of sivelestat.

关键词： Neutrophil elastase Sivelestat COVID-19 Pathophysiological mechanisms Therapeutic potential

Quantitative characterization of cell physiological state based on dynamical cell mechanics for drug efficacy indication

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Journal of Pharmaceutical Analysis 2023年第4期13卷 388-402页

作者： Shuang Ma Junfeng Wu Zhihua Liu Rong He Yuechao wang Lianqing Liu tianlu wang Wenxue wang State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016China Institutes for Robotics and Intelligent Manufacturing Chinese Academy of SciencesShenyang 110169China University of Chinese Academy of Sciences Beijing 100049China Department of Thoracic Surgery Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042China Department of Radiotherapy Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042China

Cell mechanics is essential to cell development and function,and its dynamics evolution reflects the physiological state of cells.Here,we investigate the dynamical mechanical properties of single cells under various drug conditions,and present two mathematical approaches to quantitatively characterizing the cell physiological state.It is demonstrated that the cellular mechanical properties upon the drug action increase over time and tend to saturate,and can be mathematically characterized by a linear timeinvariant dynamical model.It is shown that the transition matrices of dynamical cell systems significantly improve the classification accuracies of the cells under different drug actions.Furthermore,it is revealed that there exists a positive linear correlation between the cytoskeleton density and the cellular mechanical properties,and the physiological state of a cell in terms of its cytoskeleton density can be predicted from its mechanical properties by a linear regression model.This study builds a relationship between the cellular mechanical properties and the cellular physiological state,adding information for evaluating drug efficacy.

关键词： Cellular mechanical properties Cytoskeleton Drug efficacy evaluation Cell system modelling Linear regression

Metal matrix nanocomposites in tribology: Manufacturing, performance, and mechanisms

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Friction 2022年第10期10卷 1596-1634页

作者： Shuaihang PAN Kaiyuan JIN tianlu wang Zhinan ZHANG Long ZHENG Noritsugu UMEHARA Department of Mechanical and Aerospace Engineering University of California Los Angeles(UCLA)Los AngelesCA 90095USA Physical Intelligence Department Max Planck Institute for Intelligent SystemsStuttgart 70569Germany Stake Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Bionic Engineering(Ministry of Education) College of Biological and Agricultural EngineeringJilin UniversityChangchun 130022China Micro-Nano Mechanical Science Laboratory Department of Micro-Nano Mechanical Science and EngineeringGraduate School of EngineeringNagoya UniversityChikisa-ku Furo-choNagoyaAichi 464-8601Japan

Metal matrix nanocomposites(MMNCs)become irreplaceable in tribology industries,due to their supreme mechanical properties and satisfactory tribological behavior.However,due to the dual complexity of MMNC systems and tribological process,the anti-friction and anti-wear mechanisms are unclear,and the subsequent tribological performance prediction and design of MMNCs are not easily possible:A critical up-to-date review is needed for MMNCs in tribology.This review systematically summarized the fabrication,manufacturing,and processing techniques for high-quality MMNC bulk and surface coating materials in tribology.Then,important factors determining the tribological performance(mainly anti-friction evaluation by the coefficient of friction(CoF)and anti-wear assessment with wear rate)in MMNCs have been investigated thoroughly,and the correlations have been analyzed to reveal their potential coupling/synergetic roles of tuning tribological behavior of MMNCs.Most importantly,this review combined the classical metal/alloy friction and wear theories and adapted them to give a(semi-)quantitative description of the detailed mechanisms of improved anti-friction and anti-wear performance in MMNCs.To guarantee the universal applications of these mechanisms,their links with the analyzed influencing factors(e.g.,loading forces)and characteristic features like tribo-film have been clarified.This approach forms a solid basis for understanding,predicting,and engineering MMNCs’tribological behavior,instead of pure phenomenology and experimental observation.Later,the pathway to achieve a broader application for MMNCs in tribo-related fields like smart materials,biomedical devices,energy storage,and electronics has been concisely discussed,with the focus on the potential development of modeling,experimental,and theoretical techniques in MMNCs’tribological processes.In general,this review tries to elucidate the complex tribo-performances of MMNCs in a fundamentally universal yet straightforward way,and the discussion and summary in this

关键词： metal matrix nanocomposites nanophases tribology manufacturing processes anti-wear performance strengthening effects anti-wear mechanisms

Consensus on rapid screening for prodromal Alzheimer's disease in China

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General Psychiatry 2024年第1期37卷 1-16页

作者： Lin Huang Qinjie Li Yao Lu Fengfeng Pan Liang Cui Ying wang Ya Miao tianlu Chen Yatian Li Jingnan Wu Xiaochun Chen Jianping Jia Qihao Guo Department of Gerontology Shanghai Sixth People's Hospital Afiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina shanghai BestCovered ShanghaiChina ADepartment of Neurology Fujan Medical University Union HospitalFuzhouChina Department of Neurology National Clinical Research Center for Geriatric DiseasesBeijingChina

Alzheimer's disease(AD)is a common cause of dementia,characterised by cerebral amyloid-βdeposition,pathological tau and neurodegeneration.The prodromal stage of AD(pAD)refers to patients with mild cognitive impairment(MCl)and evidence of AD's pathology.At this stage,disease-modifying interventions should be used to prevent the progression to dementia.Given the inherent heterogeneity of MCl,more specific biomarkers are needed to elucidate the underlying AD's pathology.Although the uses of cerebrospinal fluid and positron emission tomography are widely accepted methods for detecting AD's pathology,their clinical applications are limited by their high costs and invasiveness,particularly in low-income areas in China.Therefore,to improve the early detection of Alzheimer's disease(AD)pathology through cost-effective screening methods,a panel of 45neurologists,psychiatrists andgerontologistswas invited to establish a formal consensus on the screening of pAD in China.The supportive evidence and grades of recommendations are based on a systematic literature review andfocus group discussion.National meetings were held to allow participants to review,vote and provide their expert opinions to reach a consensus.A majority(two-thirds)decision was used for questions for which consensus could not be reached.Recommended screening methods are presented in this publication,including neuropsychological assessment,peripheral biomarkers and brain imaging.In addition,a general workflow for Screening pAD in China is established,which will help clinicians identify individuals at high risk and determine therapeutic targets.

关键词： Alzheimer income screening

Concise Synthesis of Lactococcus garvieae Lipoteichoic Acids Through an Additive-Modulated Preactivation Protocol and the Immunological Studies

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CCS Chemistry 2024年第2期6卷 403-414页

作者： tianlu Li Tong Li Yue Yang Haoru Zhuang Jianwu Lv Ning Zhou Miaomiao Zhang Fengshan wang Yiqun Geng Richard R.Schmidt Peng Peng National Glycoengineering Research Center Shandong Key Laboratory of Carbohydrate Chemistry and GlycobiologyNMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate Based MedicineShandong UniversityQingdao 266237 State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050 Department of Chemistry University of KonstanzD-78457 Konstanz

Lipoteichoic acids(LTAs)are macroamphiphiles composed of alditol,lipid,phosphate,and carbohydrate units.Due to their inherent complexity,it is a severe challenge to access LTAs with structural integrity from natural sources for biological or immunological evaluation.Here,we describe the first total synthesis of Lactococcus garvieae LTA(type II LTA),containing five distinct 1,2-cis gluco/galactopyranosidic linkages,via a novel additive-modulated O-glycosyl trichloroacetimidate preactivation glycosidation strategy.This strategy features(1)high glycosidation yields and excellent 1,2-cis stereoselectivities independent of the donor anomeric configuration,(2)common and inexpensive reagents as promoters and additives,(3)application to standard glycosyl imidate donors without resorting to participating protection,and(4)general application to reactive and less reactive glycosyl acceptors.Thus,via the precise stereocontrolled construction of three galactopyranosidic and two glucopyranosidic bonds on a multigram scale,a series of structurally well-defined LTA molecules were successfully assembled.Immunological evaluation of these type II synthetic LTAs showed a structure–activity relationship in the stimulation of a proinflammatory response.

关键词： 1,2-cis glycosidation stereoselectivity lipoteichoic acid total synthesis additive-modulated trichloroacetimidate glycosidation immune response

非煤保护层工作面能量应力演化规律及顶底板结构对强矿震的影响

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煤矿安全 2024年第6期55卷 126-133页

作者：张田录窑街煤电集团有限公司

保护层开采作为一种有效的冲击地压区域防治手段被广泛应用，而保护层本身也存在强矿震和冲击地压风险。以海石湾煤矿油页岩工作面保护层开采过程中发生的强矿震事件为工程背景，通过数值模拟、理论分析等方法，对强矿震的震源机制和主... 详细信息

保护层开采作为一种有效的冲击地压区域防治手段被广泛应用，而保护层本身也存在强矿震和冲击地压风险。以海石湾煤矿油页岩工作面保护层开采过程中发生的强矿震事件为工程背景，通过数值模拟、理论分析等方法，对强矿震的震源机制和主控因素进行了分析。结果表明：油页岩工作面强矿震多以应力集中下的压缩剪切破坏为主；被保护层工作面回采对保护层工作面底板区域的应力和能量分布影响更为显著；工作面坚硬顶板岩层、底板薄岩层、保护层与被保护层间岩层厚度变化等对强矿震事件发生存在显著影响。

关键词：油页岩工作面保护层开采强矿震冲击地压岩层结构

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小檗碱治疗肺部感染的药理作用研究进展

现代药物与临床 2024年第6期39卷 1642-1646页

作者：舒小童夏红汪天露重庆市大足区人民医院感染科重庆市大足区人民医院无痛中心

肺部感染临床常以肺炎形式存出现，治疗核心为抗感染，但多数病原菌对传统药物具有较高的耐药性。小檗碱是从黄连中提取的活性成分，具有多种活性，可通过降低病原菌耐药性，阻止病原菌复制，减轻肺部炎症反应，调节免疫功能，抑制肺纤... 详细信息

肺部感染临床常以肺炎形式存出现，治疗核心为抗感染，但多数病原菌对传统药物具有较高的耐药性。小檗碱是从黄连中提取的活性成分，具有多种活性，可通过降低病原菌耐药性，阻止病原菌复制，减轻肺部炎症反应，调节免疫功能，抑制肺纤维化进程，保护血管内皮细胞以治疗肺部感染，减轻肺组织损伤。综述了小檗碱用于肺部感染治疗的药理作用研究进展，为小檗碱临床治疗肺部感染提供依据。

关键词：小檗碱肺部感染耐药性病原菌复制炎症反应免疫功能肺纤维化血管内皮细胞