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Nano Research 2024年第4期17卷 2555-2562页

作者： Guangyuan Yan tianlu wang Biwei Zhao Wenjing Gao Tong Wu Liming Ou School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China

Medium-entropy oxides(MEOs)with broad compositional tunability and entropy-driven structural stability,are receiving booming attention as a promising candidate for oxygen evolution reaction(OER)***,ultrathin two-dimensional(2D)nanostructure offers extremely large specific surface area and is therefore considered to be an ideal catalyst ***,it remains a grant challenge to synthesize ultrathin 2D MEOs due to distinct nucleation and growth kinetics of constituent multimetallic elements in 2D anisotropic *** this work,an ultrathin 2D MEO(MnFeCoNi)O was successfully synthesized by a facile and low-temperature ionic layer epitaxy *** from multi-metal synergistic effects within ultrathin 2D nanostructure,this 2D MEO(MnFeCoNi)O revealed excellent OER electrocatalytic performance with a quite low overpotential of 117 mV at 10 mA·cm^(-2) and an impressive stability for 120 h continuous operation with only 6.9%***,the extremely high mass activity(5584.3 A·g^(-1))was three orders of magnitude higher than benchmark RuO_(2)(3.4 A·g^(-1))at the same overpotential of 117 *** work opens up a new avenue for developing highly efficient and stable electrocatalysts by creating 2D nanostructured MEOs.

关键词： medium-entropy oxide two-dimensional nanomaterials ionic layer epitaxy oxygen evolution reaction electrocatalysis

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小檗碱治疗肺部感染的药理作用研究进展

现代药物与临床 2024年第6期39卷 1642-1646页

作者：舒小童夏红汪天露重庆市大足区人民医院感染科重庆402360 重庆市大足区人民医院无痛中心重庆402360

肺部感染临床常以肺炎形式存出现,治疗核心为抗感染,但多数病原菌对传统药物具有较高的耐药性。小檗碱是从黄连中提取的活性成分,具有多种活性,可通过降低病原菌耐药性,阻止病原菌复制,减轻肺部炎症反应,调节免疫功能,抑制肺纤维化进程... 详细信息

肺部感染临床常以肺炎形式存出现,治疗核心为抗感染,但多数病原菌对传统药物具有较高的耐药性。小檗碱是从黄连中提取的活性成分,具有多种活性,可通过降低病原菌耐药性,阻止病原菌复制,减轻肺部炎症反应,调节免疫功能,抑制肺纤维化进程,保护血管内皮细胞以治疗肺部感染,减轻肺组织损伤。综述了小檗碱用于肺部感染治疗的药理作用研究进展,为小檗碱临床治疗肺部感染提供依据。

关键词：小檗碱肺部感染耐药性病原菌复制炎症反应免疫功能肺纤维化血管内皮细胞

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Neutrophil elastase:From mechanisms to therapeutic potential

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Journal of Pharmaceutical Analysis 2023年第4期13卷 355-366页

作者： Weilin Zeng Yingqiu Song Runze wang Rong He tianlu wang Department of Radiotherapy Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang110000China Department of Surgery Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang110000China

Neutrophil elastase(NE),a major protease in the primary granules of neutrophils,is involved in microbicidal *** is an important factor promoting inflammation,has bactericidal effects,and shortens the inflammatory *** also regulates tumor growth by promoting metastasis and tumor microenvironment ***,NE plays a role in killing tumors under certain conditions and promotes other diseases such as pulmonary ventilation ***,it plays a complex role in various physiological processes and mediates several ***,a specific NE inhibitor,has strong potential for clinical application,particularly in the treatment of coronavirus disease 2019(COVID-19).This review discusses the pathophysiological processes associated with NE and the potential clinical applications of sivelestat.

关键词： Neutrophil elastase Sivelestat COVID-19 Pathophysiological mechanisms Therapeutic potential

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多种炎症标志物对卒中相关性肺炎的预测作用

国际老年医学杂志 2024年第3期45卷 308-313页

作者：王天璐魏然毛晶唐蕾哈尔滨医科大学附属第一医院神经内科哈尔滨150001

目的评估多种炎症因子在急性缺血性脑卒中(AIS)患者并发卒中相关性肺炎(SAP)的预测价值。方法回顾性选取2020年1月-2023年6月在哈尔滨医科大学附属第一医院住院治疗的236例AIS患者,根据住院7 d内是否发生SAP,将其分为SAP组56例(23.73%... 详细信息

目的评估多种炎症因子在急性缺血性脑卒中(AIS)患者并发卒中相关性肺炎(SAP)的预测价值。方法回顾性选取2020年1月-2023年6月在哈尔滨医科大学附属第一医院住院治疗的236例AIS患者,根据住院7 d内是否发生SAP,将其分为SAP组56例(23.73%)和非SAP组180例(76.27%)。通过电子病历系统收集AIS患者的临床资料,采用多因素logistic回归法筛选老年AIS患者继发SAP的独立危险因素,采用ROC曲线评估各炎症指标预测SAP的临床价值。结果与非SAP组比较,SAP组年龄>75岁、糖尿病、吞咽困难的比例以及中性粒细胞淋巴细胞比值(NLR)、全身免疫炎症指数(SII)、C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)均升高,差异均有统计学意义(P75岁、吞咽困难、NLR、SII、CRP是老年AIS患者发生SAP的独立危险因素(P<0.05)。ROC曲线显示,NLR预测老年AIS患者发生SAP的AUC为0.833(95%CI:0.757~0.908),灵敏度为64.29%,特异度为99.44%,预测性能优于其他指标。结论NLR、SII、CRP均与老年AIS患者发生SAP相关,并在一定程度上预测SAP发生风险,其中NLR预测老年AIS患者发生SAP的效能最高,有助于辅助临床早期筛查出高风险人群并及时采取干预措施。

关键词：急性缺血性脑卒中卒中相关性肺炎炎症标志物

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Metal matrix nanocomposites in tribology: Manufacturing, performance, and mechanisms

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Friction 2022年第10期10卷 1596-1634页

作者： Shuaihang PAN Kaiyuan JIN tianlu wang Zhinan ZHANG Long ZHENG Noritsugu UMEHARA Department of Mechanical and Aerospace Engineering University of California Los Angeles(UCLA)Los AngelesCA 90095USA Physical Intelligence Department Max Planck Institute for Intelligent SystemsStuttgart 70569Germany Stake Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Bionic Engineering(Ministry of Education) College of Biological and Agricultural EngineeringJilin UniversityChangchun 130022China Micro-Nano Mechanical Science Laboratory Department of Micro-Nano Mechanical Science and EngineeringGraduate School of EngineeringNagoya UniversityChikisa-ku Furo-choNagoyaAichi 464-8601Japan

Metal matrix nanocomposites(MMNCs)become irreplaceable in tribology industries,due to their supreme mechanical properties and satisfactory tribological ***,due to the dual complexity of MMNC systems and tribological process,the anti-friction and anti-wear mechanisms are unclear,and the subsequent tribological performance prediction and design of MMNCs are not easily possible:A critical up-to-date review is needed for MMNCs in *** review systematically summarized the fabrication,manufacturing,and processing techniques for high-quality MMNC bulk and surface coating materials in ***,important factors determining the tribological performance(mainly anti-friction evaluation by the coefficient of friction(CoF)and anti-wear assessment with wear rate)in MMNCs have been investigated thoroughly,and the correlations have been analyzed to reveal their potential coupling/synergetic roles of tuning tribological behavior of *** importantly,this review combined the classical metal/alloy friction and wear theories and adapted them to give a(semi-)quantitative description of the detailed mechanisms of improved anti-friction and anti-wear performance in *** guarantee the universal applications of these mechanisms,their links with the analyzed influencing factors(e.g.,loading forces)and characteristic features like tribo-film have been *** approach forms a solid basis for understanding,predicting,and engineering MMNCs’tribological behavior,instead of pure phenomenology and experimental ***,the pathway to achieve a broader application for MMNCs in tribo-related fields like smart materials,biomedical devices,energy storage,and electronics has been concisely discussed,with the focus on the potential development of modeling,experimental,and theoretical techniques in MMNCs’tribological *** general,this review tries to elucidate the complex tribo-performances of MMNCs in a fundamentally universal yet straightfor

关键词： metal matrix nanocomposites nanophases tribology manufacturing processes anti-wear performance strengthening effects anti-wear mechanisms

多种炎症标志物与急性缺血性脑卒中患者血管内治疗近中期预后的相关性

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国际老年医学杂志 2024年第2期45卷 152-156页

作者：唐蕾毛晶王天璐魏然哈尔滨医科大学附属第一医院神经内科哈尔滨150001

目的探究多种炎症标志物在急性缺血性脑卒中患者血管内治疗后近中期预后中的预测作用。方法选取2020年1月—2022年12月哈尔滨医科大学附属第一医院神经内科接受血管内治疗的376例急性缺血性脑卒中患者进行回顾性分析。根据术后90 d的... 详细信息

目的探究多种炎症标志物在急性缺血性脑卒中患者血管内治疗后近中期预后中的预测作用。方法选取2020年1月—2022年12月哈尔滨医科大学附属第一医院神经内科接受血管内治疗的376例急性缺血性脑卒中患者进行回顾性分析。根据术后90 d的改良Rankin量表(mRS)评分,将其分为预后不良组184例(mRS≤2分)和预后良好组192例(mRS>2分)。通过电子病历系统收集所有患者的临床资料,采用多因素logistic回归模型筛选老年急性缺血性脑卒中患者预后不良的危险因素,采用ROC曲线评估术前各炎症指标对其预后不良的预测价值。结果单因素分析显示,预后不良组年龄>75岁的比例和伴糖尿病比例均高于预后良好组(P75岁、NLR、SII、FAR是老年急性缺血性脑卒中患者近中期预后不良的独立危险因素(P<0.05),mTICI分级≥2b级是其保护因素(P<0.05)。ROC曲线显示,SII预测预后不良的曲线下面积最大,其次为NLR、FAR。结论术前NLR、SII、FAR均是老年急性缺血性脑卒中患者血管内治疗后近中期预后不良的危险因素,这些指标可预测预后不良的风险,尤以SII的预测价值最高。

关键词：急性缺血性脑卒中炎症反应血管内治疗

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后疫情时代“双线同步”教学质量评价体系研究

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淮南职业技术学院学报 2024年第3期24卷 91-93页

作者：张红东王安妮王天禄甘肃林业职业技术学院甘肃天水741020 舟曲职业中等专业学校甘肃舟曲746300

教学质量评价可以对教学过程和教学结果进行价值判断,更是对教学目标是否完成做出检验。基于决策导向型评价模型设计“双线同步”教学质量评价指标体系,应用分层分析法(AHP)计算各个层次指标权重,构建了“双线同步”教学质量评价体系。... 详细信息

教学质量评价可以对教学过程和教学结果进行价值判断,更是对教学目标是否完成做出检验。基于决策导向型评价模型设计“双线同步”教学质量评价指标体系,应用分层分析法(AHP)计算各个层次指标权重,构建了“双线同步”教学质量评价体系。选取教育专家、一线教师、学生组成评价主体,采用5分制加权评分法对“双线同步”教学质量状况实施评价,找出当前制约“双线同步”教学发展的短板弱项,提出了提高“双线同步”教学质量的策略和方法,为“双线同步”教育教学实践提供理论参考。

关键词：双线同步决策导向型评价模型教学质量评价体系

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Quantitative characterization of cell physiological state based on dynamical cell mechanics for drug efficacy indication

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Journal of Pharmaceutical Analysis 2023年第4期13卷 388-402页

作者： Shuang Ma Junfeng Wu Zhihua Liu Rong He Yuechao wang Lianqing Liu tianlu wang Wenxue wang State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016China Institutes for Robotics and Intelligent Manufacturing Chinese Academy of SciencesShenyang 110169China University of Chinese Academy of Sciences Beijing 100049China Department of Thoracic Surgery Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042China Department of Radiotherapy Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042China

Cell mechanics is essential to cell development and function,and its dynamics evolution reflects the physiological state of ***,we investigate the dynamical mechanical properties of single cells under various drug conditions,and present two mathematical approaches to quantitatively characterizing the cell physiological *** is demonstrated that the cellular mechanical properties upon the drug action increase over time and tend to saturate,and can be mathematically characterized by a linear timeinvariant dynamical *** is shown that the transition matrices of dynamical cell systems significantly improve the classification accuracies of the cells under different drug ***,it is revealed that there exists a positive linear correlation between the cytoskeleton density and the cellular mechanical properties,and the physiological state of a cell in terms of its cytoskeleton density can be predicted from its mechanical properties by a linear regression *** study builds a relationship between the cellular mechanical properties and the cellular physiological state,adding information for evaluating drug efficacy.

关键词： Cellular mechanical properties Cytoskeleton Drug efficacy evaluation Cell system modelling Linear regression

5-Formylcytosine and 5-Carboxylcytosine Significantly Reduce the Catalytic Activity of Hhal DNA Methyltransferase

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Chinese Journal of Chemistry 2017年第6期35卷 853-856页

作者： Tingting Hong Fan Wu Boshi Fu Yushu Yuan Jinglei Xu tianlu wang Xiang Zhou College of Chemistry and Molecular Sciences The lnstitute for Advanced Studies Wuhan University Wuhan Hubei 430072 China

DNA methylation is an essential epigenetic modification, and found to be dynamically changed due to the ob- servation of active DNA demethylation. During active demethylation, 5-methylcytosine （5mC） was oxidized step- wise by ten-eleven translocation （TET） enzymes into 5-hydroxymethylcytosine （5hmc）, 5-formylcytosine （5fC）, and 5-carboxylcytosine （5caC）. Then, the subsequent excision of 5fC and 5caC combined with base excision repair further restored cytosine, which completes the demethylation process. Here, we report that 5-formylcytosine and 5-carboxylcytosine significantly reduce the activity of HhaI DNA methyltransferase to methylate target cytosines when present on the hemi-modified sequence of the complementary DNA. This finding demonstrates that 5fC and 5caC function as more than intermediates for active DNA demethylation.

关键词： 5-formylcytosine 5-carboxylcytosine Hhal methyltransferase base flipping

Mid-infrared Period-Luminosity Relations of Gaia DR3 Long Period Variables

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Research in Astronomy and Astrophysics 2024年第7期24卷 56-70页

作者： Xiaohan Chen Xiaodian Chen Licai Deng Shu wang tianlu Chen Department of Physics College of ScienceTibet UniversityLhasa 850000China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of the Chinese Academy of SciencesBeijing 100049China Department of Astronomy China West Normal UniversityNanchong 637009China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China

Long period variable(LPV)stars are very promising distance indicators in the infrared *** selected asymptotic giant branch(AGB)stars in the Large and Small Magellanic Cloud(LMC and SMC)from the Gaia Data Release 3 LPV catalog,and classified them into oxygen-rich(O-rich)and carbon-rich(C-rich)AGB *** the Wide-field Infrared Survey Explorer database,we determined the W1-and W2-band period-luminosity relations(PLRs)for each pulsation-mode sequence of AGB *** dispersion of the PLRs of O-rich AGB stars in sequences C'and C is relatively small,around 0.14 *** PLRs of LMC and SMC are consistent in each *** the W2 band,the PLR of large-amplitude C-rich AGB stars is steeper than that of small-amplitude C-rich AGB stars,due to their more circumstellar *** two methods,we find that some PLR sequences of O-rich AGB stars in the LMC are dependent on *** coefficients of the metallicity effect areβ=-0.533±0.213 mag dex~1andβ=-0.767±0.158 mag dex~1for sequence C in W1 and W2 bands,*** significance of the metallicity effect in W1 band for the four sequences is 2.2-3.5σ.Both of these imply that distance measurements using O-rich Mira may need to take the metallicity effect into account.

关键词： stars variables general-stars distances-infrared stars

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