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Nuclear reprogramming: the strategy used in normal development is also used in somatic cell nuclear transfer and parthenogenesis

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Cell Research 2007年第2期17卷 135-150页

作者： tianlong gao~(1,*) junke zheng~(2,*) fengying xing~(2,*) haiyan fang~2 feng sun~1 ayong yan~2 xun gong~2 hui ding~3 fan tang~2 hui z sheng~2 ~1program for graduation studies,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china ~2Center for Developmental Biology,Xinhua Hospital,shanghai Jiao Tong University,School of Medicine,1665 Kong Jiang Road,shanghai 200092,china ~3School of Animal Science and Technology,yangzhou University,yangzhou 225009,china program for graduation studies Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China Center for Developmental Biology Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China School of Animal Science and Technology Yangzhou University Yangzhou China

Somatic cell nuclear transfer(SCNT)and parthenogenesis are alternative forms of reproduction and development,building new life cycles on differentiated somatic cell nuclei and duplicated maternal chromatin,*** thepreceding paper(sun F,et al.,Cell Res 2007;17:117-134.),we showed that an"erase-and-rebuild"strategy is used innormal development to transform the maternal gene expression profile to a zygotic ***,we investigate if the samestrategy also applies to SCNT and *** relationship between chromatin and chromatin factors(CFs)during SCNT and parthenogenesis was examined using immunochemical and GFP-fusion protein *** fromthese studies indicated that soon after nuclear transfer,a majority of CFs dissociated from somatic nuclei and were re-distributed to the cytoplasm of the *** erasure process in oogenesis is recaptured during the initial phase in *** CFs entered pseudo-pronuclei shortly after their *** parthenogenesis,all parthenogenotes underwentnormal oogenesis,and thus had removed most CFs from chromosomes before the initiation of *** CFswere subsequently re-associated with female pronuclei in time and sequence similar to that in fertilized *** these data,we conclude that the"erase-and-rebuild"process observed in normal development also occurs in SCNTand in parthenogenesis,albeit in altered *** process is responsible for transcription reprogramming in ***"erase"process in SCNT is compressed and the efficiency is compromised,which likely contribute tothe developmental defects often observed in nuclear transfer(nt)***,results from this study indicatedthat the cytoplasm of an egg contains most,if not all,essential components for assembling the zygotic program and canassemble them onto appropriate diploid chromatin of distinct origins.

关键词： nuclear reprogramming SCNT parthenogenesis chromatin factors chromatin embryogenesis

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