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Methylenetetrahydrofolate Reductase Genotypes, Dietary Habits and Susceptibility to Stomach Cancer

Chinese Journal of Clinical Oncology 2004年第3期1卷 162-166页

作者： ChangmingGao TakezakiToshiro JianzhongWu JianhuoDing YantingLiu SupingLi PingSu XuHu tianliongxu HamajimaNobuyuki TajimaKazuo DivisionofEpidemiology JiangsuProvinceInstituteofCancerResearchNanjing210009China. DivisionofEpidemiologyandPrevention AichiCancerCenterResearchInstituteNagoya464-8681Japan. PublicHealthCenterofChuzhouDistrict Huaian221300China.

OBJECTIVE To study the relation among methylenetetrahydrofolate reductase (MTHFR) C677T genotypes, dietary habits and the risk of stomach cancer (SC).METHODS A case-control study was conducted with 107 cases of SC and 200 population-based controls in Chuzhou district, Huaian, Jiangsu province, China. The epidemiological data were collected, and DNA of peripheral blood leukocytes was obtained from all of the subjects..MTHFR genotypes were detected by PCR-RFLP. RESULTS (1) The prevalence of the MTHFR C/T or T/T genotypes was found to be significantly different between controls (68.5%) and SC cases (79.4%,P=0.0416), the increased risk had an adjusted OR of 1.79 (95%C1:1.01-3.19). (2) Among subjects who had a low intake of garlic or Chinese onion, MTHFR C/T or T/T genotypes significantly increased the risk of developing SC. Among non-tea drinkers or among subjects who had a frequent intakeof meat, the carriers of the MTHFR C/T or T/T genotypes had a higher risk of SC than individuals with the C/C type MTHFR. CONCLUSION The polymorphism of MTHFR C677T was associated with increased risk of developing SC, and that individuals with differing genotypes may have different susceptibilities to SC, based on their exposure level to environmental factors.

关键词：亚甲基四氢叶酸还原酶基因型饮食习惯易感性胃癌肿瘤

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