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Coupled interactive effects of ammonia and hydrogen additions on ethylene diffusion flames: A detailed kinetic study

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Science China(Technological Sciences) 2024年第3期67卷 930-948页

作者： XIAO JiaYi XU TingTing SHU ZhiMei deng QiGe ZHAO Xuan YING YaoYao LI tianjiao LIU Dong MIIT Key Laboratory of Thermal Control of Electronic Equipment School of Energy and Power EngineeringNanjing University of Science and TechnologyNanjing 210094China Advanced Combustion Laboratory School of Energy and Power EngineeringNanjing University of Science and TechnologyNanjing210094China

In order to create effective combustion technologies and fuels with low or no carbon emissions,the research was conducted to assess the coupled interactive effects of NH_(3) and H_(2) additions on ethylene counterflow diffusion flames from a kinetic *** effects of the NH_(3)/H_(2) combination on flame temperatures,major species,key radicals,important intermediate species,representative oxygenated species and NO_xwere *** results of the study utilizing fictitious inert NH_(3) and/or H_(2) revealed the chemical effects of the two *** was found that the NH_(3)/H_(2) coupled effects had a more effective inhibitory effect on soot precursors than the effects of corresponding sum of single NH_(3) or H_(2) *** production of soot precursors was promoted by the coupled chemical effects of NH_(3) and H_(2),but the coupled dilution and thermal effects were observed to have a greater impact,resulting in a decrease of the mole fractions of soot *** for the interaction of NH_(3) and H_(2) effects,the presence of H_(2) decreased the chemical effects of NH_(3) on the augmentation of C_(2)H_(2),A1,A2,and CH_(3)CHO mole *** NH_(3) addition alleviated the H_(2) chemical effects on increasing C_(2)H_(2),C_(3)H_(3),A1 and A2 ***,the NH_(3)chemical effects on C_(3)H_(3),OH and CH_(3)CHO were enhanced when H_(2) was *** presence of NH_(3) augmented the chemical effects of H_(2) on the growth of OH mole ***,the H_(2) chemical effects hindered the production of NO and NO_(2) in the presence of NH_(3).

关键词： NH_(3)/H_(2)addition kinetic analysis coupled interactive effects chemical effects

Comprehensive kinetic study on ammonia/ethylene counter-flow diffusion flames:influences of diluents

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International Journal of Coal Science & Technology 2024年第1期11卷 232-249页

作者： Zhimei Shu Tingting Xu Jiayi Xiao Qige deng Xuan Zhao tianjiao Li Yaoyao Ying Dong Liu MIIT Key Laboratory of Thermal Control of Electronic Equipment School of Energy and Power EngineeringNanjing University of Science and TechnologyNanjing210094China Advanced Combustion Laboratory School of Energy and Power EngineeringNanjing University of Science and TechnologyNanjing210094China

This study aimed to investigate the effects of ammonia addition on ethylene counter-flow diffusion flames with different diluents on the fuel or oxidizer side,using kinetic analyses.A special emphasis was put on assessing the coupled chemical effects of NH_(3) and CO_(2) on C2H4 combustion *** chemical effects could be evaluated by comparing fictitious inert NH_(3) or CO_(2) with normal active NH_(3) or CO_(2).The results revealed that the addition of NH_(3) decreased the mole fractions and production rates of key soot precursors,such as acetylene,propynyl,and *** CO_(2) was used as the dilution gas,the coupled chemical effects of NH_(3) and CO_(2) were affected by the chemical effects of CO_(2) to varying *** the oxidizer-side CO_(2) addition,the coupled chemical effects of NH_(3) and CO_(2) reduced the mole fractions of H,O,OH radicals,acetylene,propynyl,and benzene,while the effects differed from the fuel-side CO_(2) *** coupled chemical effects of NH_(3) and CO_(2) also promoted the formation of aldehyde contaminants,such as acetaldehyde,to some extent,particularly with CO_(2) addition on the oxidizer side.

关键词： Ammonia addition Diluents Coupled chemical effects Kinetic analysis

Circuit-Specific Control of Blood Pressure by PNMT‑Expressing Nucleus Tractus Solitarii Neurons

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神经科学通报:英文版 2023年第8期39卷 1193-1209页

作者： Shirui Jun Xianhong Ou Luo Shi Hongxiao Yu tianjiao deng Jinting Chen Xiaojun Nie Yinchao Hao Yishuo Shi Wei Liu Yanming Tian Sheng Wang Fang Yuan Department of Neurobiology Hebei Medical UniversityShijiazhuang 050017China Institute of Cardiovascular Research Southwest Medical UniversityLuzhou 646000China Core Facilities and Centers Institute of Medicine and HealthHebei Medical UniversityShijiazhuang 050017China Hebei Key Laboratory of Neurophysiology Shijiazhuang 050017China

The nucleus tractus solitarii(NTS)is one of the morphologically and functionally defined centers that engage in the autonomic regulation of cardiovascular ***-characterized NTS neurons have been implicated in the differential regulation of blood pressure(BP).Here,we investigated whether phenylethanolamine N-methyltransferase(PNMT)-expressing NTS(NTS^(PNMT))neurons contribute to the control of *** demonstrate that photostimulation of NTS^(PNMT)neurons has variable effects on BP.A depressor response was produced during optogenetic stimulation of NTS^(PNMT)neurons projecting to the paraventricular nucleus of the hypothalamus,lateral parabrachial nucleus,and caudal ventrolateral ***,photostimulation of NTS^(PNMT)neurons projecting to the rostral ventrolateral medulla produced a robust pressor response and *** addition,genetic ablation of both NTS^(PNMT)neurons and those projecting to the rostral ventrolateral medulla impaired the arterial ***,we revealed the neuronal phenotype-and circuit-specific mechanisms underlying the contribution of NTS^(PNMT)neurons to the regulation of BP.

关键词： Nucleus tractus solitarii Blood pressure Rostral ventrolateral medulla Optogenetics Neural circuit

古龙页岩油高温高压注CO_(2)驱动用效果

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大庆石油地质与开发 2024年第1期43卷 42-51页

作者：李斌会邓森张江曹胜郭天娇徐全霍迎冬多资源协同陆相页岩油绿色开采全国重点实验室黑龙江大庆163712 中国石油大庆油田有限责任公司勘探开发研究院黑龙江大庆163712 黑龙江省油层物理与渗流力学重点实验室黑龙江大庆163712

为了明确古龙页岩油高温高压注CO_(2)驱动用效果,首先根据页岩压汞和氮气吸附实验结果,给出页岩T2值与孔喉半径转换系数,根据饱和页岩的T2谱特征,将页岩孔隙分为小孔、中大孔和页理缝;然后通过计算页岩油采出程度,考察吞吐周期、闷井时... 详细信息

为了明确古龙页岩油高温高压注CO_(2)驱动用效果,首先根据页岩压汞和氮气吸附实验结果,给出页岩T2值与孔喉半径转换系数,根据饱和页岩的T2谱特征,将页岩孔隙分为小孔、中大孔和页理缝;然后通过计算页岩油采出程度,考察吞吐周期、闷井时间、裂缝对吞吐驱油效果的影响,并且分析吞吐后岩心孔隙结构的改变程度;最后对比页岩油CO_(2)吞吐和CO_(2)驱替的驱油效果,并给出最优的驱油方式。结果表明:吞吐动用幅度最大的是中大孔和页理缝中的页岩油,小孔中的页岩油采出程度最低,增加闷井时间,页岩油采出程度仅提高0.81百分点,压裂可以使小孔中的页岩油采出程度提高11.33百分点,使小孔中的页岩油得到有效动用;吞吐比驱替可以使页岩油采出程度提高30.98百分点,并且可以动用干岩样中的页岩油,效果优于驱替;驱吞结合驱油方式比只进行吞吐可以使页岩油采出程度提高12.88百分点以上,并且可以大幅度提高小孔中页岩油的采出程度;吞吐后岩心孔隙结构发生明显变化,页岩砂砾含量不同是导致页岩吞吐前后孔隙结构变化差异大的重要原因。研究成果可为古龙页岩油矿场实践提供重要的基础参数。

关键词：古龙页岩油孔隙结构 CO_(2)驱替 CO_(2)吞吐高温高压核磁共振

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金属丝网位置对氢气/甲烷/空气火焰传播特性的影响

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安全与环境学报 2024年第7期24卷 2593-2600页

作者：程方明葛汉漳邓军罗振敏葛天姣苟籽妍西安科技大学安全科学与工程学院西安710054 陕西省工业过程安全与应急救援工程技术研究中心西安710054 西安市城市公共安全与消防救援重点实验室西安710054

为研究管道内不同位置金属丝网对氢气/甲烷/空气预混火焰传播的影响,在半封闭管道中研究了金属丝网位置对其阻火效果的影响以及阻火失效后火焰传播特性的变化。结果表明,位置会影响金属丝网对预混火焰的阻火效果,金属丝网距点火位置越近... 详细信息

为研究管道内不同位置金属丝网对氢气/甲烷/空气预混火焰传播的影响,在半封闭管道中研究了金属丝网位置对其阻火效果的影响以及阻火失效后火焰传播特性的变化。结果表明,位置会影响金属丝网对预混火焰的阻火效果,金属丝网距点火位置越近,阻火效果越好。当火焰未被淬熄时,金属丝网距点火位置越远,对火焰传播的促进作用越小。当金属丝网距点火位置较远时,与无金属丝网工况相比,火焰传播时间和“I”形火焰存在时长显著增加,郁金香火焰首现时间也延迟,呈现出一定的抑制作用。此外,随着金属丝网距点火位置距离的增加,火焰振荡的周期和振幅明显降低,火焰不稳定性减弱。

关键词：安全工程阻火火焰形态火焰传播速度火焰不稳定性

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Metabolic engineering of yeasts for green and sustainable production of bioactive ginsenosides F2 and 3β,20S-Di-O-Glc-DM

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3167-3176页

作者： Fenglin Jiang Chen Zhou Yan Li Haidong deng Ting Gong Jingjing Chen tianjiao Chen Jinling Yang Ping Zhu State Key Laboratory of Bioactive Substance and Function of Natural Medicines NHC Key Laboratory of Biosynthesis of Natural ProductsCAMS Key Laboratory of Enzyme and Biocatalysis of Natural DrugsInstitute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Both natural ginsenoside F2 and unnatural ginsenoside 3β,20S-Di-O-Glc-DM were reported to exhibit anti-tumor *** approaches for producing them rely on direct extraction from Panax ginseng,enzymatic catalysis or chemical synthesis,all of which result in low yield and high *** engineering of microbes has been recognized as a green and sustainable biotechnology to produce natural and unnatural *** we engineered the complete biosynthetic pathways of F2 and 3β,20S-Di-OGlc-DM in Saccharomyces cerevisiae via the CRISPR/Cas9 *** titers of F2 and 3β,20S-Di-O-GlcDM were increased from 1.2 to 21.0 mg/L and from 82.0 to 346.1 mg/L at shake flask level,respectively,by multistep metabolic engineering ***,pharmacological evaluation showed that both F2and 3β,20S-Di-O-Glc-DM exhibited anti-pancreatic cancer activity and the activity of 3β,20S-Di-O-GlcDM was even ***,the titer of 3β,20S-Di-O-Glc-DM reached 2.6 g/L by fed-batch fermentation in a 3 L *** our knowledge,this is the first report on demonstrating the anti-pancreatic cancer activity of F2 and 3β,20S-Di-O-Glc-DM,and achieving their de novo biosynthesis by the engineered *** work presents an alternative approach to produce F2 and 3β,20S-Di-O-Glc-DM from renewable biomass,which lays a foundation for drug research and development.

关键词： Ginsenoside UDP-glycosyltransferase Metabolic engineering Synthetic biology Saccharomyces cerevisiae CRISPR/Cas9 system Microbial cell factory Anti-pancreatic cancer activity

Self-assembly of CXCR4 antagonist peptide-docetaxel conjugates for breast tumor multi-organ metastasis inhibition

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药学学报:英文版 2023年第9期13卷 3849-3861页

作者： Chen Li Jiayan Lang Yazhou Wang Zhaoxia Cheng Mali Zu Fenfen Li Jingyi Sun Yating deng tianjiao Ji Guangjun Nie Ying Zhao CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center of Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Pancreas Centre the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhou 450001China School of Basic Medical Sciences Zhengzhou UniversityZhengzhou 450001China

As a representative chemotherapeutic drug,docetaxel(DTX)has been used for breast cancer treatment for ***,the poor solubility of DTX limits its efficacy,and the DTX based therapy increases the metastasis risk due to the upregulation of C-X-C chemokine receptor type 4(CXCR4)expression during the ***,we conjugated CXCR4 antagonist peptide(CTCE)with DTX(termed CTCE-DTX)as an anti-metastasis agent to treat breast ***-DTX could selfassemble to nanoparticles,targeting CXCR4-upregulated metastatic tumor cells and enhancing the DTX ***,the CTCE-DTX NPs achieved promising efficacy on inhibiting both bonespecific metastasis and lung metastasis of triple-negative breast *** work provided a rational strategy on designing peptide-drug conjugates with synergistic anti-tumor efficacy.

关键词： Triple-negative breast cancer CXCR4 Docetaxel Drug delivery Peptide-drug conjugates Tumor metastasis Drug formulation

Dynamic metal patterns of wrinkles based on photosensitive layers

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Science Bulletin 2022年第21期67卷 2186-2195页

作者： Shuai Chen Kaiming Hu Shuzhen Yan tianjiao Ma Xinlu deng Wenming Zhang Jie Yin Xuesong Jiang School of Chemistry&Chemical Engineering Frontiers Science Center for Transformative MoleculesState Key Laboratory for Metal Matrix Composite MaterialsShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Mechanical Systems and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Regulating metal surfaces with micro-/nanoscale structures is of great significance for both material science and potential ***,the intrinsic properties of metals,such as fixed isotropic moduli and inflexible structures,in a sense present major limitations in developing next-generation smart patterned *** this work,a facile and general patterning strategy is proposed to endow insensitive metal surfaces with controllable spontaneous topologies and dynamic performance by exquisitely introducing an essential photosensitive *** arresting anthracene-containing photocrosslinking interlayer can selectively predetermine the anisotropic property of compliant bilayers without damaging metals’homogeneous properties,and realize a changeable stiff/soft ***,the mechanical transition mechanism of the self-adaptive wrinkling modes in metalbased trilayer systems is revealed to pave the pathway for regulating functional wrinkled metal *** photodriven metal patterning strategy can promote the development of brand-new methods for tuning the instability of multilayered materials,and be potentially applied in smart optical devices with dynamic reflectance,including light gratings and"magic"mirrors.

关键词： Smart surfaces Dynamic metal patterning Self-adaptive wrinkling Multilayered systems Optical devices

Structural and functional analysis of a potent human neutralizing antibody against enterovirus A71

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Science China(Life Sciences) 2022年第12期65卷 2517-2526页

作者： Zhe Chen Linlin Bao Bin Zhu Hua Fu Shuangli Zhu tianjiao Ji Ying Xue Chuan Liu Xurong Wang Fengdi Li Qi Lv Feifei Qi Pin Yu Wei deng Wenbo Xu Chuan Qin Hongrong Liu Qi Jin MOH Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases NHC Key Laboratory of Human Disease Comparative MedicineInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China School of Computer Science and Engineering Hunan University of Science and TechnologyXiangtan 411201China National Institute for Viral Disease Control and Prevention China CDCBeijing 102206China Ministry of Education Key Laboratory of Protein Sciences Beijing Advanced Innovation Center for Structural BiologyTsinghua UniversityBeijing 100084China Key Laboratory for Matter Microstructure and Function of Hunan Province Key Laboratory of Low-dimensional Quantum Structures and Quantum ControlSchool of Physics and ElectronicsHunan Normal UniversityChangsha 410081China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310058China

Enterovirus A71(EV-A71) causes major outbreaks of hand,foot,and mouth disease(HFMD) in many countries,most frequently affecting children,and a small proportion of cases may lead to ***,no vaccine is available in most endemic regions,and no licenced treatments for EV-A71 infection are ***,we characterize a human monoclonal antibody(Hu MAb),E1,by screening a Fab antibody phage library derived from patients who recovered from EV-A71 infection.E1 exhibits strong neutralizing activity against EV-A71 virus in *** cryo-electron microscopy(cryo-EM) structures of the EV-A71 virion in complex with E1 Fab fragments demonstrated that E1 recognized an epitope formed by residues in the BC and HI loops of *** a mouse model,E1 effectively protected against lethal EV-A71 challenge in both prophylactic and therapeutic *** particular,E1 significantly reduces virus titers and muscle damage.E1 might represent a potential adjunct to EV-A71 treatment.

关键词： enterovirus A71 antibody mouse models cryo-electron microscopy