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AIPerf: Automated Machine Learning as an AI-HPC Benchmark

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Big Data Mining and Analytics 2021年第3期4卷 208-220页

作者： Zhixiang Ren Yongheng Liu tianhui Shi Lei Xie Yue zhou Jidong Zhai Youhui Zhang Yunquan Zhang Wenguang Chen Peng Cheng National Laboratory Shenzhen 518000China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China Institute of Computing Technology Chinese Academy of SciencesBeijing 100086China

The plethora of complex Artificial Intelligence(AI)algorithms and available High-Performance Computing(HPC)power stimulates the expeditious development of AI components with heterogeneous ***,the need for cross-stack performance benchmarking of AI-HPC systems has rapidly *** particular,the de facto HPC benchmark,LINPACK,cannot reflect the AI computing power and input/output performance without a representative *** popular AI benchmarks,such as MLPerf,have a fixed problem size and therefore limited *** address these issues,we propose an end-to-end benchmark suite utilizing automated machine learning,which not only represents real AI scenarios,but also is auto-adaptively scalable to various scales of *** implement the algorithms in a highly parallel and flexible way to ensure the efficiency and optimization potential on diverse systems with customizable *** utilize Operations Per Second(OPS),which is measured in an analytical and systematic approach,as a major metric to quantify the AI *** perform evaluations on various systems to ensure the benchmark’s stability and scalability,from 4 nodes with 32 NVIDIA Tesla T4(56.1 Tera-OPS measured)up to 512 nodes with 4096 Huawei Ascend 910(194.53 Peta-OPS measured),and the results show near-linear weak *** a flexible workload and single metric,AIPerf can easily scale on and rank AI-HPC,providing a powerful benchmark suite for the coming supercomputing era.

关键词： High-Performance Computing(HPC) Artificial Intelligence(AI) automated machine learning

Whole brain radiotherapy concomitant or sequential Vm26/DDP in treating small cell lung cancer patients with brain metastases

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The Chinese-German Journal of Clinical Oncology 2010年第1期9卷 17-21页

作者： Mingyue Liu Yun zhou Qian Han tianhui Gao Zhifen Luo Wenyu Wang Department of Oncology Henan Provincial People＇s Hospital Zhengzhou 450003 China Department of Radiology Henan Provincial People＇s Hospital Zhengzhou 450003 China

Objective： The aim of the study was to compare efficacies and safeties of 2 different treatments of whole brain radiotherapy （WBRT） sequential or concomitant Vm26/DDP for small cell lung cancer （SCLC） patients with brain metastases. Methods： A total of 39 patients were randomly divided into sequential chemoradiotherapy regime （A group, 20 patients） and concomitant chemoradiotherapy regime （B group, 19 patients）. The close of WBRT was 36 Gy in 18-20 fractions, chemotherapy of Vm26/DDP regimen with teniposide 60 mg/m^2 on dl to d3 and cisplatin 20 mg/m^2 on dl to d5, repeating every 3 weeks. The response was evaluated after WBRT and 2 cycles of chemotherapy. Results： Total response rates of A and B groups were 70.0% and 78.9% respectively （P = 0.520）. The median survival was 11 months in A group and 10 months in B group. Six, twelve and eighteen months cumulative survival rates of A and B groups were 75.0%, 42.5%, 26.2%, and 81.6%, 26.4%, 10.5%, respectively （χ^2 = 0.383, P 〉 0.05）. Response rate and the number of brain metastases were independent prognostic factors. Conclusion： Both sequential and concomitant chemoradiotherapy groups are effective, and the main toxicity with myelosuppression is tolerable after therapy. It can be applied firstly and effectively to the SCLC patients with brain metastases in clinic.

关键词： small cell lung cancer (SCLC) brain metastases chemoradiotherapy Vm26 DDP survival analysis

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渭河源流域源汇景观演变对径流泥沙的影响

生态学报 2022年第1期42卷 58-66页

作者：周添惠杨磊赵方凯李旭春邓居礼李敏黄勇段兴武云南大学国际河流与生态安全研究院昆明650500 中国科学院生态环境研究中心城市与区域生态国家重点实验室北京100085 甘肃省定西市水土保持科学研究所定西743000 甘肃省定西水文水资源勘测局定西743000

探讨源汇景观演变特征与径流泥沙的关系对定量识别源汇景观功能对生态过程的影响具有重要的科学意义。以位于黄土高原和西秦岭山地交错区域的渭河源为例,分析了流域源汇景观格局演变与降雨耦合驱动对径流和泥沙的影响,结果表明:(1)研究... 详细信息

探讨源汇景观演变特征与径流泥沙的关系对定量识别源汇景观功能对生态过程的影响具有重要的科学意义。以位于黄土高原和西秦岭山地交错区域的渭河源为例,分析了流域源汇景观格局演变与降雨耦合驱动对径流和泥沙的影响,结果表明:(1)研究区1982—2017年汇景观比例逐渐增加并超过源景观,源汇景观功能演变主要发生在黄土丘陵区,源汇景观负荷比指数呈逐年下降趋势;(2)影响流域径流和泥沙的主要因素不同,洪峰流量与含沙量主要受源景观面积比例和源汇景观负荷比的影响,呈显著的下降趋势,而径流量仅与降水量存在相关性;(3)基于信息理论方法的相对重要性分析表明,降雨对流域径流量的相对重要性高于源汇景观负荷比,而源汇景观负荷比对洪峰流量和含沙量的相对重要性较高,传输距离和海拔分布对径流泥沙和洪峰流量具有重要影响。在长时间尺度上,源汇景观格局演变影响了径流及泥沙特征,并且对泥沙影响的相对重要性高于径流。源汇景观合理的时空分布可以有效调控水土流失过程,对黄土高原生态可持续发展具有重要意义。

关键词：源汇景观泥沙径流景观格局水土保持

Berberine might block colorectal carcinogenesis by inhibiting the regulation of B-cell function by Veillonella parvula

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Chinese Medical Journal 2023年第22期136卷 2722-2731页

作者： Yun Qian Ziran Kang Licong Zhao Huimin Chen Chengbei zhou Qinyan Gao Zheng Wang Qiang Liu Yun Cui Xiaobo Li Yingxuan Chen tianhui Zou Jingyuan Fang Division of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseaseNHC Key Laboratory of Digestive DiseasesState Key Laboratory for Oncogenes and Related GenesRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200001China Department of General Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200001China Department of Pathology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200001China

Background:Colorectal carcinogenesis and progression are related to the gut microbiota and the tumor immune *** previous clinical trial demonstrated that berberine(BBR)hydrochloride might reduce the recurrence and canceration of colorectal adenoma(CRA).The present study aimed to further explore the mechanism of BBR in preventing colorectal cancer(CRC).Methods:We performed metagenomics sequencing on fecal specimens obtained from the BBR intervention trial,and the differential bacteria before and after medication were validated using quantitative polymerase chain *** further performed Apc Min/+animal intervention tests,RNA sequencing,flow cytometry,immunohistochemistry,and enzyme-linked immunosorbent ***:The abundance of fecal Veillonella parvula(***)decreased significantly after BBR administration(P=0.0016)and increased through the development from CRA to *** with CRC with a higher *** abundance had worse tumor staging and a higher lymph node metastasis *** intestinal immune pathway of Immunoglobulin A production was activated,and the expression of TNFSF13B(Tumor necrosis factor superfamily 13b,encoding B lymphocyte stimulator[BLyS]),the representative gene of this pathway,and the genes encoding its receptors(interleukin-10 and transforming growth factor beta)were significantly *** experiments revealed that *** promoted colorectal carcinogenesis and increased BLyS levels,while BBR reversed this ***:BBR might inhibit *** and further weaken the immunomodulatory effect of B cells induced by ***,thereby blocking the development of colorectal *** Registraion:***,***02226185.

关键词： Colorectal cancer Berberine Gut microbiota Intestinal immune pathway B Lymphocytes

Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1213-1224页

作者： Meiyue Song Jiaxin Wang Youliang Sun Junling Pang Xiaona Li Yuan Liu Yitian zhou Peiran Yang tianhui Fan Ying Liu Zhaoguo Li Xianmei Qi Baicun Li Xinri Zhang Jing Wang Chen Wang State Key Laboratory of Medical Molecular Biology Department of PhysiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100730China Tsinghua-Peking Center for Life Sciences Department of BiologyCollege of MedicineTsinghua UniversityBeijing 100084China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China National Clinical Research Center for Respiratory Diseases Beijing 100029China Peking Union Medical College Chinese Academy of Medical SciencesBeijing 100730China Peking Union Medical College MD ProgramBeijing 100730China Department of Respiratory the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of Pulmonary and Critical Care Medicine the First Hospital of Shanxi Medical UniversityTaiyuan 030001China

Silicosis is a leading cause of occupational disease-related morbidity and mortality worldwide,but the molecular basis underlying its development remains *** accumulating body of evidence supports gasdermin D(GSDMD)-mediated pyroptosis as a key component in the development of various pulmonary ***,there is little experimental evidence connecting silicosis and GSDMD-driven *** this work,we investigated the role of GSDMD-mediated pyroptosis in ***-cell RNA sequencing of healthy and silicosis human and murine lung tissues indicated that GSDMD-induced pyroptosis in macrophages was relevant to silicosis *** microscopy we then observed morphological alterations of pyroptosis in macrophages treated with *** of interleukin-1βrelease,lactic dehydrogenase activity,and real-time propidium iodide staining further revealed that silica induced pyroptosis of ***,we verified that both canonical(caspase-1-mediated)and non-canonical(caspase-4/5/11-mediated)signaling pathways mediated silica-induced pyroptosis activation,in vivo and in ***,Gsdmd knockout mice exhibited dramatically alleviated silicosis phenotypes,which highlighted the pivotal role of pyroptosis in this *** together,our results demonstrated that macrophages underwent GSDMD-dependent pyroptosis in silicosis and inhibition of this process could serve as a viable clinical strategy for mitigating silicosis.

关键词： Silicosis Gasdermin D Pyroptosis Macrophage Pulmonary fibrosis

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《天回医简》石法与传世医经刺法的理论探析

中华医史杂志 2024年第2期54卷 75-81页

作者：李卓明周琦顾漫中国中医科学院中国医史文献研究所北京100700

通过对读相关出土文献与传世文献条文,解析《天回医简》中《逆顺五色脉臧验精神》中“石疽。太上石神,石神必已;其次石血,石血得分;其下石脓,石脓十一活”的治法细节,阐发其与传世医经理论的关联。相比马王堆《脉法》与张家山《脉书》... 详细信息

通过对读相关出土文献与传世文献条文,解析《天回医简》中《逆顺五色脉臧验精神》中“石疽。太上石神,石神必已;其次石血,石血得分;其下石脓,石脓十一活”的治法细节,阐发其与传世医经理论的关联。相比马王堆《脉法》与张家山《脉书》中的砭石治法,《天回医简》中治疗痈疽的“石神”之法,用在痈疽血聚、脓成之前,可防止痈疽的病情发展并达到“必已”的疗效。另外,石疽相关的诊疗方法可能在一定程度上启发了后世的“调神”思想及治未病理论。

关键词：《天回医简》砭石石法石神治未病

DHD4,a CONSTANS-like family transcription factor,delays heading date by affecting the formation of the FAC complex in rice

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Molecular Plant 2021年第2期14卷 330-343页

作者： Maohong Cai Shanshan Zhu Mingming Wu Xiaoming Zheng Jiachang Wang Liang zhou tianhui Zheng Song Cui Shirong zhou Chaonan Li Huan Zhang Juntao Chai Xinyue Zhang Xin Jin Zhijun Cheng Xin Zhang Cailin Lei Yulong Ren Qibing Lin Xiuping Guo Lei Zhao Jie Wang Zhichao Zhao Ling Jiang Haiyang Wang Jianmin Wan National Key Facility for Crop Gene Resources end Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China State Key Laboratory for Crop Genetics and Germplasm Enhancement Jiangsu Plant Gene Engineering Research CenterNanjing Agricultural UniversityNanjing210095China

Heading date(or flowering time)is one of the most important agronomic traits in rice,influencing its regional adaptability and crop *** major-effect genes for rice heading date have been identified,but in practice they are difficult to be used for rice molecular breeding because of their dramatic effects on heading *** with minor effects on heading date,which are more desirable for fine-tuning flowering time without significant yield penalty,were seldom *** this study,we identified a new minor-effect heading date repressor,Delayed Heading Date 4(DHD4).The dhd4 mutant shows a slightly earlier flowering phenotype without a notable yield penalty compared with wild-type plants under natural long-day ***4 encodes a CONSTANS-like transcription factor localized in the ***,biochemical,and genetic assays show that DHD4 can compete with 14-3-3 to interact with OsFD1,thus affecting the formation of the Hd3a-14-3-3-OsFD1 triprotein FAC complex,resulting in reduced expression of OsMADS14 and OsMADS15,and ultimately delaying *** together,these results shed new light on the regulation of flowering time in rice and provide a promising target for fine-tuning flowering time to improve the regional adaptability of rice.

关键词： rice Oryza sativa delayed heading date 4 DHD4 minor-effect OsFD1 heading date

天回医简《治六十病和齐汤法》痹证医方用药规律

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中医药导报 2024年第1期30卷 198-201页

作者：陈小妹周祖亮广西中医药大学基础医学院广西南宁530200

天回医简《治六十病和齐汤法》是一部内容较为完整的古方剂学著作。该方药文献记载了12首治疗痹证的医方,涉及肢体经络痹、脏腑痹、气血痹与其他痹等4类痹证。天回医简治疗痹证医方具有“以辛为主,甘苦相配”“攻补兼施,辨证施药”“治... 详细信息

天回医简《治六十病和齐汤法》是一部内容较为完整的古方剂学著作。该方药文献记载了12首治疗痹证的医方,涉及肢体经络痹、脏腑痹、气血痹与其他痹等4类痹证。天回医简治疗痹证医方具有“以辛为主,甘苦相配”“攻补兼施,辨证施药”“治法灵活,用药精专”等组方用药特点,反映出《治六十病和齐汤法》用药经验已较为成熟并注重内外兼施和预后调护,具有很高的临床应用价值。

关键词：《治六十病和齐汤法》痹证天回医简简帛医药文献用药规律

铅蓄电池中 Pb-Sb 合金的正极腐蚀特性

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上海交通大学学报 1999年第2期33卷 196-199页

作者：杨春生丁桂甫沈天慧周伟舫上海交通大学信息存储研究中心复旦大学化学系

通过稳态恒电位极化曲线测量方法，发现Ｐｂ－Ｓｂ合金与纯Ｐｂ的恒电位腐蚀特性有着至关重要的差别：在ＰｂＯ２／ＰｂＳＯ４电极平衡电位附近区域，纯Ｐｂ表现出为人们所熟知的腐蚀反应活化现象，而Ｐｂ－Ｓｂ合金却仍能保持高度钝化... 详细信息

通过稳态恒电位极化曲线测量方法，发现Ｐｂ－Ｓｂ合金与纯Ｐｂ的恒电位腐蚀特性有着至关重要的差别：在ＰｂＯ２／ＰｂＳＯ４电极平衡电位附近区域，纯Ｐｂ表现出为人们所熟知的腐蚀反应活化现象，而Ｐｂ－Ｓｂ合金却仍能保持高度钝化状态，说明合金中的Ｓｂ能够有效地抑制该电位区Ｐｂ腐蚀反应活化的倾向；而在除此之外的宽广电位区间内，两者之间的差别远没有如此明显．该活化电位区两者腐蚀特性如此显著的差异决定了Ｐｂ－Ｓｂ合金在多数情况下耐腐蚀性会优于纯Ｐｂ．不同极化条件下Ｐｂ和Ｐｂ－Ｓｂ合金腐蚀速率的实验测试结果证实了上述观点．

关键词：恒电位极化铅锑合金铅蓄电池正极腐蚀