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Metal-organic frameworks for electrochemical reduction of carbon dioxide: The role of metal centers

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Journal of Energy Chemistry 2020年第1期29卷 156-170,I0006页

作者： Ping Shao Luocai Yi Shumei Chen tianhua zhou Jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002FujianChina College of Chemistry Fuzhou UniversityFuzhou 350002FujianChina

Direct electrochemical reduction of CO2 into valuable chemicals and fuel is one of the most promising approaches to address the current energy crisis and lower CO2 ***,numerous metal-organic framework(MOF)and their derived materials have extensively been developed as electrocatalysts for CO2 reduction owing to their unique structure including porosity,large specific surface area,and tunable chemical *** this review,the recent progress of MOF-based electrocatalysts for CO2 reduction was summarized and *** discussions mainly focus on the synthesis and mechanism of pristine MOFs and MOF-derived materials for electrocatalytic CO2 *** examples are expected to provide clues to rational design and synthesis of stable and high-performance MOFs-based electrocatalysts for CO2 reduction.

关键词： Metal organic framework Electrocatalyst Carbon dioxides Reduction reaction Nanomaterials

Regulation of m^(6)Am RNA modification and its implications in human diseases

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Journal of Molecular Cell Biology 2024年第3期16卷 1-8页

作者： Hao Jin zhouyuanjing Shi tianhua zhou Shanshan Xie Children’s Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Cell Biology Zhejiang University School of MedicineHangzhou 310058China Department of Gastroenterology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310020China Center for Medical Research and Innovation in Digestive System Tumors Ministry of EducationHangzhou 310020China

N^(6),2′-O-dimethyladenosine(m^(6)Am)is a prevalent modification frequently found at the 5′cap-adjacent adenosine of messenger RNAs(mRNAs)and small nuclear RNAs(snRNAs)and the internal adenosine of *** dynamic and reversible modification is under the regulation of methyltransferases phosphorylated CTD interacting factor 1 and methyltransferase-like protein 4,along with the demethylase fat mass and obesity-associated protein.m^(6)Am RNA modification plays a crucial role in the regulation of pre-mRNA splicing,mRNA stability,and translation,thereby influencing gene *** recent years,there has been growing interest in exploring the functions of m^(6)Am and its relevance to human *** this review,we provide a comprehensive overview of the current knowledge concerning m^(6)Am,with a focus on m^(6)Am-modifying enzymes,sequencing approaches for its detection,and its impacts on pre-mRNA splicing,mRNA stability,and translation ***,we highlight the roles of m^(6)Am in the context of obesity,viral infections,and cancers,unravelling its underlying regulatory mechanisms.

关键词： m^(6)Am RNA modification gene regulation obesity viral infection cancer

Emerging roles of NudC family： from molecular regulation to clinical implications

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维普期刊数据库

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Science China(Life Sciences) 2016年第5期59卷 455-462页

作者： Qiqin Fu Wei Wang tianhua zhou Yuehong Yang Department of Cell Biology and Program in Molecular Cell Biology Zhejiang University School of Medicine Hangzhou 310058 China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hanezhou 310003 China

Nuclear distribution gene C （NudC） was first found in Aspergillus nidulans as an upstream regulator of NudF, whose mamma- lian homolog is Lissencephaly 1 （Lisl）. NudC is conserved from fungi to mammals. Vertebrate NudC has three homologs： NudC, NudC-like protein （NudCL）, and NudC-like protein 2 （NudCL2）. All members of the NudC family share a conserved p23 domain, which possesses chaperone activity both in conjunction with and independently of heat shock protein 90 （Hsp90）. Our group and the others found that NudC homologs were involved in cell cycle regulation by stabilizing the components of the LIS l/dynein complex. Additionally, NudC plays important roles in cell migration, ciliogenesis, thrombopoiesis, and the in- flammatory response. It has been reported that NudCL is essential for the stability of the dynein intermediate chain and cilio- genesis via its interaction with the dynein 2 complex. Our data showed that NudCL2 regulates the LISl/dynein pathway by stabilizing LIS 1 with Hsp90 chaperone. The fourth distantly related member of the NudC family, CML66, a tumor-associated antigen in human leukemia, contains a p23 domain and appears to promote oncogenesis by regulating the IGF-1R-MAPK sig- naling pathway. In this review, we summarize our current knowledge of the NudC family and highlight its potential clinical relevance.

关键词： nuclear distribution gene C heat shock protein 90 p23 dynein Lissencephaly 1 cell cycle ciliogenesis

Macrophage-evading and tumor-specific apoptosis inducing nanoparticles for targeted cancer therapy

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Acta Pharmaceutica Sinica B 2023年第1期13卷 327-343页

作者： Zimo Liu Xuefei zhou Qi Li Youqing Shen tianhua zhou Xiangrui Liu Department of Pharmacology and Department of Gastroenterology of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027China International Institutes of Medicine The Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000China Cancer Center Zhejiang UniversityHangzhou 310058China Department of Cell Biology School of MedicineZhejiang UniversityHangzhou 310058China

Extended circulation of anticancer nanodrugs in blood stream is essential for their clinical ***,administered nanoparticles are rapidly sequestered and cleared by cells of the mononuclear phagocyte system(MPS).In this study,we developed a biomimetic nanosystem that is able to efficiently escape MPS and target tumor *** fabricated nanoparticles(TM-CQ/NPs)were coated with fibroblast cell membrane expressing tumor necrosis factor(TNF)-related apoptosis inducing ligand(TRAIL).Coating with this functionalized membrane reduced the endocytosis of nanoparticles by macrophages,but increased the nanoparticle uptake in tumor ***,this membrane coating specifically induced tumor cell apoptosis via the interaction of TRAIL and its cognate death ***,the encapsulated chloroquine(CQ)further suppressed the uptake of nanoparticles by macrophages,and synergized with TRAIL to induce tumor cell *** vigorous antitumor efficacy in two mice tumor models confirmed our nanosystem was an effective approach to address the MPS challenge for cancer ***,our TM-CQ/NPs nanosystem provides a feasible approach to precisely target tumor tissues and improve anticancer efficacy.

关键词： TRAIL Fibroblast Nanoparticles Mononuclear phagocyte system Membrane coating Chloroquine Cancer therapy Drug delivery

Engineering nanointerface of molybdenum-based heterostructures to boost the electrocatalytic hydrogen evolution reaction

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Journal of Energy Chemistry 2021年第7期30卷 370-376页

作者： Tong Liu Shuqing zhou Jing Qi Kaiwen Wang Lirong Zheng Qingming Huang tianhua zhou Jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002FujianChina School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an 710000ShaanxiChina Beijing Key Laboratory and Institute of Microstructure and Property of Advanced Materials Beijing University of TechnologyBeijing 100124China Beijing Synchrotron Radiation Facility(BSRF) Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Testing Center Fuzhou UniversityFuzhou 350116FujianChina

Rational heterostructure-design in electrocatalysts represents a promising approach toward high performance in the electrocatalytic hydrogen evolution reaction(HER).In specific,optimizing the H adsorption behavior at the surface/interface of heterostructure is of key importance to improve the catalytic ***,we demonstrate the construction of a heterostructure from a well-defined oxygenbridged Co/Mo heterometallic zeolitic imidazolate framework(MOZ) as an efficient electrocatalyst for *** optimized hybrid exhibits high catalytic activity and stability in electrolytes with a wide pH *** XPS,XAS and theoretical studies reveal that the regulation of metal species can tailor the lattice of Mo_(2)C within the hybrid and induce the formation of defect sites,which could not only induce surface charge transfer between the atoms and provide an additional active site,but also affect the H adsorption behavior at the interface of a *** work provides an effective strategy to design a heterostructure with tailored active sites for energy conversion.

关键词： Electrocatalysis Metal-organic framework Water splitting Heterostructure

MoS_3 loaded TiO_2 nanoplates for photocatalytic water and carbon dioxide reduction

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Journal of Energy Chemistry 2016年第3期25卷 500-506页

作者： Wei Zhang tianhua zhou Jindui Hong Rong Xu School of Chemistry & Chemical Engineering Shaanxi Normal University School of Chemical & Biomedical Engineering Nanyang Technological University SinBeRISE CREATE National Research Foundation C4T CREATE National Research Foundation

Photocatalytic water splitting and carbon dioxide reduction provide us clean and sustainable energy resources. The carbon dioxide reduction is also the redemption of the greenhouse effect. MoS/TiOphotocatalysts based on TiOnanoplates have been synthesized via a hydrothermal acidification route for water and carbon dioxide reduction reactions. This facile approach generates well dispersed Mo S3 with low crystallinity on the surface of TiOnanoplates. The as-synthesized MoS/TiOphotocatalyst showed considerable activity for both water reduction and carbon dioxide reduction. The thermal treatment effects of TiO, the loading percentage of MoSand the crystalline phase of TiOhave been investigated towards the photocatalytic performance. TiOnanoplate synthesized through hydrothermal reaction with the presence of HF acid is an ideal semiconductor material for the loading of MoSfor photocatalytic water and carbon dioxide reduction simultaneously in EDTA sacrificial solution.

关键词： Photocatalytic Water reduction Carbon dioxide reduction Molybdenum sulfide Titanium oxide

ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover

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Protein & Cell 2023年第9期14卷 653-667页

作者： Maomao Pu Wenhui Zheng Hongtao Zhang Wei Wan Chao Peng Xuebo Chen Xinchang Liu Zizhen Xu tianhua zhou Qiming Sun Dante Neculai Wei Liu Metabolic Medicine Center International Institutes of Medicinethe Fourth Affiliated HospitalZhejiang University School of MedicineYiwu 322000China Joint Institute of Genetics and Genomics Medicine between Zhejiang University and University of Toronto Hangzhou 310058China National Center for Protein Science Shanghai Institute of Biochemistry and Cell BiologyShanghai Institutes of Biological SciencesChinese Academy of SciencesShanghai200031China

Lipophagy,the selective engulfment of lipid droplets(LDs)by autophagosomes for lysosomal degradation,is critical to lipid and energy *** we show that the lipid transfer protein ORP8 is located on LDs and mediates the encapsulation of LDs by autophagosomal *** function of oRP8 is independent of its lipid transporter activity and is achieved through direct interaction with phagophore-anchored LC3/*** lipophagy induction,ORP8 has increased localization on LDs and is phosphorylated by AMPK,thereby enhancing its affinity for LC3/*** of ORP8 or interruption of ORP8-LC3/GABARAP interaction results in accumulation of LDs and increased intracellular *** of ORP8 alleviates LD and triglyceride deposition in the liver of ob/ob mice,and Osbpl8 mice exhibit liver lipid clearance *** results suggest that ORP8 is a lipophagy receptor that plays a key role in cellular lipid metabolism.

关键词： ORP8 lipophagy lipid autophagy

NudCL2 is required for cytokinesis by stabilizing RCC2 with Hsp90 at the midbody

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Protein & Cell 2024年第10期15卷 766-782页

作者： Xiaoyang Xu Yuliang Huang Feng Yang Xiaoxia Sun Rijin Lin Jiaxing Feng Mingyang Yang Jiaqi Shao Xiaoqi Liu tianhua zhou Shanshan Xie Yuehong Yang Department of Cell Biology Institute of Gastroenterology of the Second Affliated HospitalZhejiang University School of MedicineHangzhou 310009China Research Center for Children's Health and Innovation Binjiang Institute of Zhejiang UniversityHangzhou 310053China Department of Biochemistry Purdue UniversityWest LafayetteIN 47907United States Cancer Center Zhejiang UniversityHangzhou 310058China Center for RNA Medicine International Institutes of Medicinethe Fourth Affliated Hospital of Zhejiang University School of MedicineYiwu 322000China Children's Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China

Cytokinesis is required for faithful division of cytoplasmic components and duplicated nuclei into two daughter ***,a protein-dense organelle that forms at the intercellular bridge,is indispensable for success-ful ***,the regulatory mechanism of cytokinesis at the midbody still remains ***,we unveil a critical role for NudC-like protein 2(NudCL2),a co-chaperone of heat shock protein 90(Hsp90),in cytokinesis regulation by stabilizing regulator of chromosome condensation 2(RCC2)at the midbody in mam-malian ***2 localizes at the midbody,and its downregulation results in cytokinesis failure,multinu-cleation,and midbody *** iTRAQ-based quantitative proteomic analysis,we find that RCC2 levels are decreased in NudCL2 knockout(KO)***,Hsp90 forms a complex with NudCL2 to stabilize RCC2,which is essential for ***2 depletion mirrors phenotypes observed in NudCL2-downregulated ***,ectopic expression of RCC2 rescues the cytokinesis defects induced by NudCL2 deletion,but not vice ***,our data reveal the significance of the NudCL2/Hsp90/RCC2 pathway in cytokinesis at the midbody.

关键词： cytokinesis midbody NudCL2 Hsp90 RCC2

PD-L1 regulates genomic stability via interaction with cohesin-SAl in the nucleus

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Signal Transduction and Targeted Therapy 2021年第3期6卷 608-610页

作者： Wen Zhang Jiali Jin Yanjin Wang Lan Fanq Liu Min Xinbo Wang Lin Ding Linjun Weng Tan Xiao tianhua zhou Ping Wang Tongji University Cancer Center Shanghai Tenth People's Hospital of Tongji UniversitySchool of MedicineTongji UniversityShanghaiChina Deportment of Cell Biology and Cancer Institute of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhouChina School of Life Sciences and Technology Tongji UniversityShanghaiChina Cancer Center Zhejiang UniversityHangzhouChina Department of Molecular Genetics University of TorontoTorontoONCanada

Dear Editor,Programmed death ligand-1(PD-L1)is a type 1 transmembrane protein and highly expressed in various cancers that binds to PD-1 on T cells,inhibits T cell activity and proliferation,facilitates cancer cells to escape T cell-mediated immune *** by PD-L1/PD-1 blockade have shown effectiveness against different cancer types and revolutionizes cancer treatment in the ***,the response rate to anti-PD-L1/PD-1 antibody remains at about 15-30%as a single agent.1 Thus,there is more to understand regarding the function of PD-L1 in cancer.

关键词： cancer death interaction