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Highly efficient H-β Fraunhofer line optical parametric oscillator pumped by a single-frequency 355 nm laser

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Chinese Optics Letters 2018年第8期16卷 62-66页

作者： Jian Ma Tingting Lu Xiaolei Zhu Xiuhua Ma Shiguang Li tianhua Zhou Weibiao chen Key Laboratory of Space Laser Communication and Detection Technology Shangtlai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 China University of Chinese Academy of Sciences Beijing 100049 China

A highly efficient laser system output at the H-13 Fraunhofer line of 486.1 nm has been demonstrated. A high pulse energy single-frequency hybrid 1064 nm master oscillator power amplifier was frequency-tripled to achieve 355 nm laser pulses, which acted as the pmnp source of the beta barium borate nanosecond pulse optical para- metric oscillator. With pump energy of 190 mJ, the laser system generated a maximum output of 62 mJ blue laser pulses at 486.1 nm, corresponding to conversion efficiency of 32.6%. The laser spectrum width was measured to be around 0.1 ran, being in conformity with the spectrum width of the solar Fraunhofer line.

关键词： Fraunhofer line optical parametric oscillator pumped by a single-frequency 355 nm laser Highly efficient H OPO

Reducing nitrogen application with dense planting increases nitrogen use efficiency by maintaining root growth in a double-rice cropping system

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The Crop Journal 2021年第4期9卷 805-815页

作者： Jin chen Xiangcheng Zhu Jiang Xie Guoqiang Deng tianhua Tu Xianjiao Guan Zhen Yang Shan Huang Xianmao chen Caifei Qiu Yinfei Qian Caihong Shao Minggang Xu Chunrui Peng Jiangxi Academy of Agricultural Sciences Key Laboratory of Crop Ecophysiology and Farming System for the Middle and Lower Reaches of the Yangtze RiverMinistry of Agriculture and Rural AffairsNational Engineering and Technology Research Center for Red Soil ImprovementNanchang 330200JiangxiChina College of Life Science and Environmental Resources Yichun UniversityYichun 336000JiangxiChina Agricultural Technology Extension Center in Yifeng County of Jiangxi Province Yichun 343100JiangxiChina Jiangxi Key Laboratory of Crop Physiology Ecology and Genetic BreedingJiangxi Agricultural UniversityNanchang 330045JiangxiChina Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural SciencesNational Engineering Laboratory for Improving Quality of Arable LandBeijing 100081China

Rational nitrogen(N) application can greatly increase rice(Oryza sativa L.) yield. However, excessive N input can lead not only to low N use efficiency(NUE) but also to severe environmental *** N application rate with a higher planting density(RNHD) is recommended to maintain rice yield and improve NUE. The effects of RNHD on fertilizer N fate and rice root growth traits remain unclear. We accordingly conducted a two-year field experiment to investigate the influence of RNHD on rice yield, fertilizer 15N fate, and root growth in a double-rice cropping system in China. In comparison with the conventional practice of high N application with sparse planting, RNHD resulted in similar yield and biomass production as well as plant N uptake. RNHD increased agronomic NUEs by 23.3%–31.9%(P 17.4%–24.1%(P 15N recovery rate by 14.5%–34.7%(P 15 N retention rate by 9.2%–12.0%(P < 0.05). Although a reduced N rate led to significantly reduced root length, surface area, volume, and biomass, these root traits were significantly increased by higher planting density. RNHD did not affect these root morphological traits and reduced activities of nitrate reductase(NR) and glutamine synthetase(GS) only at tillering stage. Plant N uptake was significantly positively correlated with these root traits, but not correlated with NR and GS activities. Together, these findings show that reducing N application with dense planting can lead to high plant N uptake by maintaining rice root growth and thus increase NUE.

关键词： Rice Planting density N recovery efficiency Root morphology South China

疏肝安神汤联合艾司唑仑片治疗肝郁气滞、痰热内扰型失眠临床研究

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新中医 2024年第5期56卷 67-71页

作者：郭子华李丹张丹张天华吴茜吴平荣王晨开封市第二中医院脑病科河南开封475004 开封市中医院药学部河南开封475000 开封市中医院脑病科河南开封475000 开封市中医院男科河南开封475000

目的:观察疏肝安神汤联合艾司唑仑片治疗肝郁气滞、痰热内扰型失眠的临床疗效。方法:选取80例失眠患者,按随机数字表法分为对照组和研究组各40例。对照组给予艾司唑仑片治疗,研究组在对照组基础上加用疏肝安神汤治疗。2组持续治疗4周。... 详细信息

目的:观察疏肝安神汤联合艾司唑仑片治疗肝郁气滞、痰热内扰型失眠的临床疗效。方法:选取80例失眠患者,按随机数字表法分为对照组和研究组各40例。对照组给予艾司唑仑片治疗,研究组在对照组基础上加用疏肝安神汤治疗。2组持续治疗4周。比较2组匹兹堡睡眠质量指数(PSQI)、多导睡眠图参数以及血清神经递质水平,并统计2组用药期间不良反应。结果:研究组总有效率为95.00%,高于对照组72.50%(P<0.05)。治疗后,2组总睡眠时间及睡眠效率较治疗前升高,睡眠潜伏期时间及觉醒时间较治疗前降低(P<0.05);且研究组总睡眠时间及睡眠效率高于对照组,睡眠潜伏期时间及觉醒时间低于对照组(P<0.05)。治疗后,2组去甲肾上腺素(NE)、γ-氨基丁酸(GABA)、5-羟色胺(5-HT)水平较治疗前升高(P<0.05);且研究组NE、GABA、5-HT水平高于对照组(P<0.05)。治疗后,2组PSQI评分、各项中医证候评分较治疗前降低(P<0.05);且研究组PSQI评分、各项中医证候评分低于对照组(P<0.05)。结论:基于“少阳为枢”理论运用疏肝安神汤治疗肝郁气滞、痰热内扰型失眠效果显著,能延长患者睡眠时间,改善睡眠质量,缓解失眠症状,且安全性较好。

关键词：失眠疏肝安神汤 “少阳为枢”理论多导睡眠图参数匹兹堡睡眠质量指数神经递质

丽江金沙江流域烟草病毒电镜观测与宏病毒组分析

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云南农业大学学报（自然科学版） 2024年第2期39卷 17-26页

作者：矣小鹏周旭东韩天华申云鑫贺彪陈齐斌何永宏杨佩文云南农业大学植物保护学院云南昆明650201 云南省农业科学院农业环境资源研究所云南昆明650205 云南省烟草公司玉溪市公司澄江分公司云南玉溪652500 云南省烟草公司丽江市公司云南丽江674100

【目的】明确丽江金沙江流域烟草病毒病的病毒种类及其分布特点,为病害防控提供依据。【方法】采集烟区具有明显病毒病症状的烟株样品53份,采用宏病毒组测序技术分析各病毒属的丰度,并构建遗传进化树;进一步采用扫描电镜观测病毒形态;... 详细信息

【目的】明确丽江金沙江流域烟草病毒病的病毒种类及其分布特点,为病害防控提供依据。【方法】采集烟区具有明显病毒病症状的烟株样品53份,采用宏病毒组测序技术分析各病毒属的丰度,并构建遗传进化树;进一步采用扫描电镜观测病毒形态;调查各病毒病在烟区的发生情况。【结果】宏病毒组测序分析结果表明:属水平上,华坪县(S1)样品中马铃薯Y病毒属(Potyvirus)、黄瓜花叶病毒属(Cucumovirus)和正番茄斑萎病毒属(Orthotospovirus)丰度分别为66.08%、20.83%和5.91%;玉龙纳西族自治县(S2)样品中正番茄斑萎病毒属丰度为97.20%;宁蒗彝族自治县(S3)样品中马铃薯Y病毒属和正番茄斑萎病毒属丰度分别为96.29%和2.20%。系统进化树结果显示:S1样品病原为烟草马铃薯Y病毒(potato virus Y,PVY)、烟草番茄斑萎病毒(tomato spotted wilt virus,TSWV)和烟草黄瓜花叶病毒(cucumber mosaic virus,CMV),S2样品病原为TSWV,S3样品病原为PVY和TSWV。电镜观察到样品中线状病毒粒体直径10~15 nm,长度700~900 nm;球状病毒粒体包括2种,一种为直径25~30 nm、无包膜,另一种为直径80~120 nm、表面有1层包膜。宏病毒组测序分析、系统进化树和电镜观测结果相吻合。田间调查结果表明:华坪县PVY、TSWV和CMV的发病率分别为42.34%~68.25%、12.59%~26.52%和29.27%~72.31%;玉龙县TSWV的发病率为5.66%~20.34%;宁蒗县PVY和TSWV的发病率分别为19.18%~36.27%和1.08%~4.92%。【结论】危害丽江金沙江流域烟区的烟草病毒种类主要为TSWV、PVY和CMV,其中,TSWV和PVY的检出率最高、发生最普遍。

关键词：金沙江流域烟草病毒病电镜观测宏病毒组

维普期刊数据库博看期刊

不同专业中医本科生生理学期末试卷的数据分析

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中国中医药现代远程教育 2024年第12期22卷 185-188页

作者：高蔚李海燕程薇朱庆文倪磊刘天华陈俞材郭健北京中医药大学中医学院生理教研室北京102488

目的提高生理学试卷质量及教学水平。方法运用北京中医药大学试卷分析系统,对北京中医药大学2019级五年制不同专业(中医学、中医学实验班、针灸推拿学)生理学期末考试试卷的难度、区分度、信度和效度进行评价,并统计分析试卷成绩。结果... 详细信息

目的提高生理学试卷质量及教学水平。方法运用北京中医药大学试卷分析系统,对北京中医药大学2019级五年制不同专业(中医学、中医学实验班、针灸推拿学)生理学期末考试试卷的难度、区分度、信度和效度进行评价,并统计分析试卷成绩。结果共分析了生理学期末试卷603份。试卷分析发现,该试卷难度适中、区分度较好,主观题难度大于客观题;学生成绩分布基本合理,成绩真实可靠。通过试卷成绩统计分析发现,中医学和中医学实验班在平均分、主观题、客观题的得分,以及及格率和优秀率上,都明显优于针灸推拿学(P<0.05)。结论文章为教师面对不同专业方向的学生开展有针对性的生理学教学活动提供了数据支持,也为提高生理学试卷出题质量和教学水平提供了参考依据。

关键词：生理学试卷分析系统成绩分析

ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover

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Protein & Cell 2023年第9期14卷 653-667页

作者： Maomao Pu Wenhui Zheng Hongtao Zhang Wei Wan Chao Peng Xuebo chen Xinchang Liu Zizhen Xu tianhua Zhou Qiming Sun Dante Neculai Wei Liu Metabolic Medicine Center International Institutes of Medicinethe Fourth Affiliated HospitalZhejiang University School of MedicineYiwu 322000China Joint Institute of Genetics and Genomics Medicine between Zhejiang University and University of Toronto Hangzhou 310058China National Center for Protein Science Shanghai Institute of Biochemistry and Cell BiologyShanghai Institutes of Biological SciencesChinese Academy of SciencesShanghai200031China

Lipophagy,the selective engulfment of lipid droplets(LDs)by autophagosomes for lysosomal degradation,is critical to lipid and energy *** we show that the lipid transfer protein ORP8 is located on LDs and mediates the encapsulation of LDs by autophagosomal *** function of oRP8 is independent of its lipid transporter activity and is achieved through direct interaction with phagophore-anchored LC3/*** lipophagy induction,ORP8 has increased localization on LDs and is phosphorylated by AMPK,thereby enhancing its affinity for LC3/*** of ORP8 or interruption of ORP8-LC3/GABARAP interaction results in accumulation of LDs and increased intracellular *** of ORP8 alleviates LD and triglyceride deposition in the liver of ob/ob mice,and Osbpl8 mice exhibit liver lipid clearance *** results suggest that ORP8 is a lipophagy receptor that plays a key role in cellular lipid metabolism.

关键词： ORP8 lipophagy lipid autophagy

Increased expression of osteoprotegerin in vascular smooth muscle cells from spontaneously hypertensive rats

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Journal of Geriatric Cardiology 2004年第1期1卷 49-54页

作者： Yongshan MOU tianhua LEI Luning ZHAO Xiaojun ZHU Mingui FU Yuqing E chen Cardiovascular Research Institute Morehouse School of Medicine 720 Westview Drive SW Atlanta GA 30310 USA Cardiovascular Research Institute Peking University Health Science Center 38 Xue Yuan Road Beijing 100083 China

Background Osteoprotegerin (OPG) is a secreted protein of the tumor necrosis factor receptor family, which regulates bone mass by inhibiting osteoclast differentiation and activation. Although OPG is expressed ubiquitously and abundantly in many tissues and cell types including vascular cells, the role of OPG in other tissues is *** previous studies demonstrated that OPG was highly expressed in vascular smooth muscle cells (VSMC) and upregulated during vascular lesion formation. Methods and Results We documented, by Northern blot analysis,that the expression of OPG was more prevalent in the aorta and cultured VSMC from spontaneously hypertensive rats (SI-IR) compared to Wistar-Kyoto rats (WKY). In addition, we found that the expression of Angiotensin II (Ang II)type I receptor (AT1R) in SHR VSMC was at significantly increased levels than in WKY VSMC. Furthermore, Ang II potently induced the expression of OPG in VSMC in a time- and dose-dependent manner through the AT1R signaling pathway. Conclusions OPG expression was substantially greater in SHR VSMC, suggesting that OPG may be an important determinant of vascular remodeling in SHR.

关键词： osteoprotegerin hypertension vascular smooth muscle cells gene expression

The amplifying effect of southern continental shelf of the East China Sea on semidiurnal tides

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Acta Oceanologica Sinica 1988年第3期 356-359页

作者： Zhou tianhua and chen Zongyong Shandong College of Oceanography, Qingdao, China

The coast of Zhejiang Province is a zone of maximum tidal ranges in China. One of the causes is the influence of the adjacent continental shelf. A model is presented in this paper, whose theory suggests that the amplitudes of semidiurnal tides should be amplified on the southern continental shelf of the East China Sea, while those of diurnal tides should not. The values computed from the equations are basically in agreement with observations.

关键词： The amplifying effect of southern continental shelf of the East China Sea on semidiurnal tides

基于Blackboard平台的生理学线上教学资源构建与应用——以北京中医药大学为例

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中医教育 2024年第2期43卷 101-104页

作者：刘天华程薇李海燕朱庆文陈俞材倪磊高蔚张朔郭健北京中医药大学中医学院北京100029

在“互联网+”时代背景下,高等中医药院校生理学教学需要加强课程思政建设,以更好地培养学生自主学习能力、实现知识迁移融合、提高科研创新意识。以北京中医药大学生理学线上教学资源为例,介绍了基于Blackboard平台的教学资源建设情况... 详细信息

在“互联网+”时代背景下,高等中医药院校生理学教学需要加强课程思政建设,以更好地培养学生自主学习能力、实现知识迁移融合、提高科研创新意识。以北京中医药大学生理学线上教学资源为例,介绍了基于Blackboard平台的教学资源建设情况。该平台包括基础教学模块、课程思政模块和高阶创新模块,通过这些模块的建设和应用,可以有效地提高生理学教学的质量和效果,为构建生理学线上线下双线混融教学新模式提供参考。

关键词：课程思政 Blackboard平台生理学教学