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Asian Journal of Pharmaceutical Sciences 2019年第6期14卷 609-620页

作者： tianhe huang Qianqian Zhao Yan Su Defang Ouyang State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences (ICMS) University of Macao

Cyclodextrin complexation is a wise strategy to enhance aqueous solubility of waterinsoluble ***,the aggregation mechanism of drug-cyclodextrin complexes is still *** research aimed to investigate the molecular aggregation mechanism of glipizide/cyclodextrin complexation by the combination of experimental and modeling *** free energies between glipizide and cyclodextrins from modeling calculations were higher than those by the phase solubility diagram *** experimental and modeling results showed that methylated-β-cyclodextrin exhibited the best solubilizing capability to ***-measurement results confirmed the aggregation between glipizide and all four cyclodextrins in high ***/γ-cyclodextrin and glipizide/β-cyclodextrin complexes showed stronger aggregation trend than HP-β-cyclodextrin and methylated-β-*** substituted groups in the rim of HP-β-cyclodextrin and methylated-β-cyclodextrin lead to weak *** research provided us a clear molecular mechanism of glipizide/cyclodextrin complexation and *** research will also benefit the formulation development of cyclodextrin solubilization.

关键词： Glipizide Cyclodextrin Molecular modeling Aggregation Molecular mechanism

AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第3期24卷 232-247页

作者： Yi LI Wenyan SHE Xiaoran XU Yixin LIU Xinyu WANG Sheng TIAN Shiyi LI Miao WANG Chaochao YU Pan LIU tianhe huang Yongchang WEI Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityHubei Cancer Clinical Study Center&Hubei Key Laboratory of Tumor Biological BehaviorsWuhan 430071China College of Chemistry and Molecular Science Wuhan UniversityWuhan 430071China Department of Integrated Chinese and Western Medicine Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430071China

Drastic surges in intracellular reactive oxygen species(ROS)induce cell apoptosis,while most chemotherapy drugs lead to the accumulation of ***,we constructed an organic compound,arsenical N-(4-(1,3,2-dithiarsinan-2-yl)phenyl)acrylamide(AAZ2),which could prompt the ROS to trigger mitochondrial-dependent apoptosis in gastric cancer(GC).Mechanistically,by targeting pyruvate dehydrogenase kinase 1(PDK1),AAZ2 caused metabolism alteration and the imbalance of redox homeostasis,followed by the inhibition of phosphoinositide-3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)pathway and leading to the activation of B-cell lymphoma 2(Bcl2)/Bcl2-associated X(Bax)/caspase-9(Cas9)/Cas3 ***,our in vivo data demonstrated that AAZ2 could inhibit the growth of GC ***,our data suggested that AAZ2 could contribute to metabolic abnormalities,leading to mitochondrial-dependent apoptosis by targeting PDK1 in GC.

关键词： N-(4-(1,3,2-dithiarsinan-2-yl)phenyl)acrylamide(AAZ2) Gastric cancer Reactive oxygen species(ROS) Apoptosis Pyruvate dehydrogenase kinase 1(PDK1) Glucose metabolism

Computational prediction of solid dispersion formulations by machine learning approaches

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Computational prediction of solid dispersion formulations by...

口腔内镜辅助高速涡轮钻拔除阻生智齿的临床研究

2019中国化学会第十五届全国计算（机）化学学术会议

作者： Run Han Hui Xiong Zhuyifan Ye Yilong Yang tianhe huang Fuzheng Ren 欧阳德方 State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences (ICMS) University of Macau Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology 澳门大学

Amorphous solid dispersion（SD） is an effective solubilization technique for water-insoluble drugs. However, physical stability issue of solid dispersions still heavily hindered the development of this technique. Traditional stability experiments need to be tested at least three to six months, which is time-consuming and unpredictable. In this research, a novel prediction model for physical stability of solid dispersion formulations was developed by machine learning techniques. 646 stability data points were collected and described by over 20 molecular descriptors. All data was classified into the training set（60%）, validation set（20%）, and testing set（20%） by the improved maximum dissimilarity algorithm（MD-FIS）. Eight machine learning approaches were compared and random forest（RF） model achieved the best prediction accuracy（82.5%）. Moreover, the RF models revealed the contribution of each input parameter, which provided us the theoretical guidance for solid dispersion formulations. Furthermore, the prediction model was confirmed by physical stability experiments of 17β-estradiol（ED）-PVP solid dispersions and the molecular mechanism was investigated by molecular modeling technique. In conclusion, an intelligent model was developed for the prediction of physical stability of solid dispersions, which benefit the rational formulation design of this technique. The integrated experimental, theoretical, modeling and data-driven AI methodology is also able to be used for future formulation development of other dosage forms.

关键词： solid dispersion physical stability machine learning molecular modeling

来源： cnki会议评论

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医学研究杂志 2012年第2期41卷 168-170页

作者：黄田河刘继华深圳市宝安区石岩人民医院 518108

目的探讨口腔内镜辅助高速涡轮牙钻法拔除下颌阻生智齿的临床疗效。方法随机选取280例需拔除下颌阻生智齿的患者,分为口腔内镜辅助高速涡轮钻(实验组,130例)和单纯高速涡轮牙钻法(对照组,150例)。对比观察两组平均手术时间及术后肿胀、... 详细信息

目的探讨口腔内镜辅助高速涡轮牙钻法拔除下颌阻生智齿的临床疗效。方法随机选取280例需拔除下颌阻生智齿的患者,分为口腔内镜辅助高速涡轮钻(实验组,130例)和单纯高速涡轮牙钻法(对照组,150例)。对比观察两组平均手术时间及术后肿胀、疼痛、张口受限及干槽症等并发症的发生情况。结果实验组与对照组患者下颌阻生智齿分布比较,差异无统计学意义(P>0.05)。实验组患者下颌阻生智齿平均拔除时间较对照组明显缩短,差异有统计学意义(P0.05)。结论口腔内镜辅助高速涡轮牙钻法拔除下颌阻生智齿能显著缩短手术时间,减少患者术后并发症,值得临床推广。

关键词：下颌阻生智齿高速涡轮牙钻口腔内镜

ICP-AES法测定镍铬烤瓷合金中多元素的初步研究

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口腔材料器械杂志 2013年第4期22卷 193-195页

作者：陈满花于丹黄田河深圳市宝安石岩人民医院口腔科广东518108 汕头大学医学院第一附属医院口腔科广东515041

目的初步探讨ICP-AES法测定镍铬烤瓷合金中除镍元素以外的其他多元素的可行性。方法准确称取0.00899g^0.08176g样品经混酸(盐酸与硝酸体积比为7:2)完全溶解后,优化仪器条件,以基体匹配法配制工作曲线标样,消除基体干扰。从而测定镍铬烤... 详细信息

目的初步探讨ICP-AES法测定镍铬烤瓷合金中除镍元素以外的其他多元素的可行性。方法准确称取0.00899g^0.08176g样品经混酸(盐酸与硝酸体积比为7:2)完全溶解后,优化仪器条件,以基体匹配法配制工作曲线标样,消除基体干扰。从而测定镍铬烤瓷合金中多元素(Cr、Al、Mo、Co、Be、Fe、Cu)的含量。结果测定样品巾元素含量(wt%)平均为Cr 11.90%、Al 1.895%、Mo 6.905%、Co 0.205%、Be 1.67%、Fe 0.045%和Cu 0.03%;6次测定的相对标准差在0.51%~1.48%范围内,加标回收率89.72%~100.90%,仪器检出限在0.11ng/ml^9.33ng/ml之间。结论本实验初步提示ICP-AES法可测定镍铬烤瓷合金中除镍元素以外的其他多元素的含量,且该方法简便和快速。

关键词：电感耦合等离子发射光谱法镍铬烤瓷合金金属元素

Secure Two-Party Distance Computation Protocol Based on Privacy Homomorphism and Scalar Product in Wireless Sensor Networks

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Tsinghua Science and Technology 2016年第4期21卷 385-396页

作者： Haiping huang tianhe Gong Ping Chen Reza Malekian Tao Chen Nanjing University of Posts and Telecommunications Jiangsu High Technology Research Key Laboratory for Wireless Sensor Networks Department of Electrical Electronic and Computer EngineeringUniversity of Pretoria

Numerous privacy-preserving issues have emerged along with the fast development of the Internet of Things. In addressing privacy protection problems in Wireless Sensor Networks （WSN）, secure multi-party computation is considered vital, where obtaining the Euclidian distance between two nodes with no disclosure of either side＇s secrets has become the focus of location-privacy-related applications. This paper proposes a novel Privacy-Preserving Scalar Product Protocol （PPSPP） for wireless sensor networks. Based on PPSPP, we then propose a Homomorphic-Encryption-based Euclidean Distance Protocol （HEEDP） without third parties. This protocol can achieve secure distance computation between two sensor nodes. Correctness proofs of PPSPP and HEEDP are provided, followed by security validation and analysis. Performance evaluations via comparisons among similar protocols demonstrate that HEEDP is superior; it is most efficient in terms of both communication and computation on a wide range of data types, especially in wireless sensor networks.

关键词： secure two-party computation privacy-preserving wireless sensor networks scalar product distancecalculation privacy homomorphism

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水泥-膨润土复合固化市政污泥强度试验研究

河北工程大学学报（自然科学版） 2023年第3期40卷 84-90页

作者：易进翔方佳聪于文霞黄天河郑振江浩东华理工大学土木与建筑工程学院江西南昌330013

针对固化污泥的强度问题,以水泥作为复合剂的固化基质材料,采用材料比选强度试验,优选复合剂的外掺剂;开展了不同水泥添加量和不同膨润土添加量条件下固化污泥的强度试验,研究固化污泥的强度特性。结果表明:膨润土可作为优选的外掺剂,... 详细信息

针对固化污泥的强度问题,以水泥作为复合剂的固化基质材料,采用材料比选强度试验,优选复合剂的外掺剂;开展了不同水泥添加量和不同膨润土添加量条件下固化污泥的强度试验,研究固化污泥的强度特性。结果表明:膨润土可作为优选的外掺剂,其特殊的离子交换和团粒化作用,使得膨润土复合水泥固化市政污泥相比于黏土、页岩效果更好;固化污泥土的无侧限抗压强度总体上随着水泥、膨润土添加量的增加而增大,试验表明水泥和膨润土复合可有效固化市政污泥,提高污泥的强度特性;基于试验数据建立的固化污泥土强度预测模型,可以对固化污泥土的无侧限抗压强度进行准确预测。

关键词：污泥固化材料比选膨润土应力应变关系无侧限抗压强度

Dusty cloud radiative forcing derived from satellite data for middle latitude regions of East Asia

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Progress in Natural Science:Materials International 2006年第10期16卷 1084-1089页

作者： huang Jianping , WANG Yujie, WANG tianhe and YI Yuhong ( College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China Gansu Provincial Meteorological Bureau, Lanzhou 730020, China) College of Atmospheric Sciences Lanzhou University Lanzhou 730000 China Gansu Provincial Meteorological Bureau Lanzhou 730020 China

The dusty cloud radiative forcing over the middle latitude regions of East Asia was estimated by using the 2-year (July 2002-June 2004) data of collocated clouds and the Earth's radiant energy system (CERES) scanner and moderate resolution imaging spectroradiometer (MODIS) from Aqua Edition IB SSF (single scanner footprint). The dusty cloud is defined as the cloud in dust storm environment or dust contaminated clouds. For clouds growing in the presence of dust, the instantaneous short-wave (SW) forcing at the top of the atmosphere (TOA) is about - 275. 7 W/m for cloud over dust (COD) region. The clouds developing in no-dust cloud (CLD) regions yield the most negative short-wave (SW) forcing ( - 311.0 W/m2), which is about 12.8% stronger than those in COD regions. For long-wave (LW) radiative forcing, the no-dust cloud (CLD) is around 102.8 W/m2 , which is 20% less than the LW forcing from COD regions. The instantaneous TOA net radiative forcing for the CLD region is about - 208.2 W/m2, which is 42.1 % larger than the values of COD regions. The existence of dust aerosols under clouds significantly reduces the cooling effect of clouds.

关键词： dust storm cloud radiative forcing global warming dust aerosol-cloud-climate interaction.

An Overview of Mineral Dust Modeling over East Asia

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Journal of Meteorological Research 2017年第4期31卷 633-653页

作者： Siyu CHEN Jianping huang Yun QIAN Chun ZHAO Litai KANG Ben YANG Yong WANG Yuzhi LIU Tiangang YUAN tianhe WANG Xiaojun MA Guolong ZHANG Key Laboratory for Semi-Arid Climate Change of the Ministry of Education Lanzhou University Atmospheric Science and Global Change Division Pacific Northwest National Laboratory School of Atmospheric Sciences Nanjing University Department of Earth System Science Tsinghua University

East Asian dust（EAD） exerts considerable impacts on the energy balance and climate/climate change of the earth system through its influence on solar and terrestrial radiation, cloud properties, and precipitation efficiency. Providing an accurate description of the life cycle and climate effects of EAD is therefore critical to better understanding of climate change and socioeconomic development in East Asia and even worldwide. Dust modeling has undergone substantial development since the late 1990 s, associated with improved understanding of the role of EAD in the earth system. Here, we review the achievements and progress made in recent decades in terms of dust modeling research,including dust emissions, long-range transport, radiative forcing（RF）, and climate effects of dust particles over East Asia. Numerous efforts in dust/EAD modeling have been directed towards furnishing more sophisticated physical and chemical processes into the models on higher spatial resolutions. Meanwhile, more systematic observations and more advanced retrieval methods for instruments that address EAD related science issues have made it possible to evaluate model results and quantify the role of EAD in the earth system, and to further reduce the uncertainties in EAD simulations. Though much progress has been made, large discrepancies and knowledge gaps still exist among EAD simulations. The deficiencies and limitations that pertain to the performance of the EAD simulations referred to in the present study are also discussed.

关键词： East Asia dust aerosol dust modeling dust emissions long-range dust transport dust radiative forcing

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水下声速场构建方法综述

哈尔滨工程大学学报 2023年第11期44卷 2005-2017页

作者：黄威高凡王君婷徐天河中国海洋大学信息科学与工程学部山东青岛266100 山东大学空间科学研究院山东威海264209

实时、精确地构建区域声速场是建设水下综合定位、导航、授时与通信体系的重要组成部分。本文梳理并分析了水下声速场构建领域的研究现状,总结了声速剖面直接测量方法与反演方法。声速反演法相比于直接测量法具有更高的便捷性和可接受... 详细信息

实时、精确地构建区域声速场是建设水下综合定位、导航、授时与通信体系的重要组成部分。本文梳理并分析了水下声速场构建领域的研究现状,总结了声速剖面直接测量方法与反演方法。声速反演法相比于直接测量法具有更高的便捷性和可接受的精度性能。然而,声速反演方法依赖于声呐观测数据,因此难以适用于无水下观测系统覆盖的地区,并且无法对未来时刻的声速分布进行预测。如何在无声场观测数据情况下,综合利用历史先验信息进行智能化、高精度地全海深声速场构建,弹性化为水下用户提供不同精度、实时性需求的声速分布估计服务,是未来声速场构建研究主流趋势。

关键词：水下声速场声速剖面反演射线声学理论匹配场处理正交经验函数分解启发式算法压缩感知深度学习神经网络