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Desulfovibrio desulfuricans aggravates atherosclerosis by enhancing intestinal permeability and endothelial TLR4/NF-kB pathway in Apoe^(-/-) mice

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Genes & Diseases 2023年第1期10卷 239-253页

作者： Kun Zhang Xian Qin Juhui Qiu Tong Sun Kai Qu Ahmad Ud Din Wenhua Yan tianhan li Yidan Chen Wei Gu Xiancai Rao Guixue Wang Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsCollege of BioengineeringChongqing UniversityChongqing 400044China College of Information and Management Sciences Henan Agricultural UniversityZhengzhouHenan 450046China School of Medicine Chongqing UniversityChongqing 400030China Department of Microbiology College of Basic Medical SciencesArmy Medical University(Third Military Medical University)Chongqing 400037China

It is increasingly aware that gut microbiota is closely associated with ***,which and how specific gut bacteria regulate the progression of atherosclerosis is still poorly *** this study,modified linear discriminant analysis was performed in comparing the gut microbiota structures of atherosclerotic and non-atherosclerotic mice,and Desulfovibrio desulfuricans(***)was found to be associatedwith ***-treated Apoe^(-/-) mice showed significantly aggravated *** proatherogenic effect of *** was attributed to its ability to increase intestinal permeability and subsequent raise in the transit of lipopolysaccharide(LPS)from the intestine to the *** LPS in the blood can elicit local and systemic inflammation and activate Toll-like receptor 4(TLR4)/nuclear factor-kB(NF-kB)signaling of endothelial ***-242,a specific inhibitor of TLR4,can ameliorate the development of *** atherosclerosis by blocking the LPS-induced activation of TLR4/NF-kB signaling.

关键词： Atherosclerosis Desulf ovibrio desulfuricans Gut microbiota linear discriminant analysis TAK-242

G3BP2 regulates oscillatory shear stress-induced endothelial dysfunction

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Genes & Diseases 2022年第6期9卷 1701-1715页

作者： tianhan li Juhui Qiu Tingting Jia Yinming liang Kun Zhang Wenhua Yan Zhengjun Hou Shiwei Yang Lushan liu Wenhao Xiong Yaokai Chen Guixue Wang Key Laboratory for Biorheological Science and Technology of Ministry of Education State Key Laboratory of Mechanical TransmissionState and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing 400044PR China Laboratory of Genetic Regulators in the Immune System Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory MedicineXinxiang Medical UniversityXinxiangHenan 45003PR China Department of Vascular Surgery First Affiliated HospitalArmy Medical University(Third Military University)Chongqing 400038PR China Institute of Cardiovascular Disease Key Laboratory for Arteriosclerology of Hunan ProvinceHunan International Scientific and Technological Cooperation Base of Arteriosclerotic DiseaseHengyang Medical CollegeUniversity of South ChinaHengyangHunan 421001PR China Division of Infectious Diseases Chongqing Public Health Medical CenterChongqing 400030PR China

GTPase-activating SH3 domain-binding protein 2(G3BP2)is a mediator that responds to environmental stresses through stress granule formation and is involved in the progression of chronic ***,no studies have examined the contribution of G3BP2 in the oscillatory shear stress(OSS)-induced endothelial *** we assessed the effects of G3BP2 in endothelial cells(ECs)function and investigated the underlying *** shear stress apparatus and partial ligation model,we identified that stress granulerelated genes in ECs could be induced by OSS with RNA-seq,and then confirmed that G3BP2 was highly and specifically expressed in athero-susceptible endothelia in the OSS regions.G3bp2e/eApoee/e mice had significantly decreased atherosclerotic lesions associated with deficiency of G3BP2 in protecting endothelial barrier function,decreasing monocyte adhesion to ECs and inhibiting the proinflammatory cytokine ***,loss of G3BP2 diminished OSS-induced inflammation in ECs by increasing YAP nucleocytoplasmic shuttling and *** data demonstrate that G3BP2 is a critical OSS regulated gene in regulating ECs function and that G3BP2 inhibition in ECs is a promising atheroprotective therapeutic strategy.

关键词： Atherosclerosis Endothelial cells(ECs) G3BP2 Oscillatory shear stress(OSS) YAP

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便携式手握心电监护仪的设计与实现

生物医学工程学杂志 2017年第6期34卷 895-899页

作者：徐效文李天涵中南大学物理与电子学院长沙410083

针对传统电极需要与皮肤直接接触、使用不方便、花费时间长等缺点,本文基于电容耦合原理设计了一种隔着衣物快速检测人体心电信号的便携式手握心电监护仪。该监护仪主要由手握心电传感器和嵌入式终端两部分构成。本系统将感应电极隔着... 详细信息

针对传统电极需要与皮肤直接接触、使用不方便、花费时间长等缺点,本文基于电容耦合原理设计了一种隔着衣物快速检测人体心电信号的便携式手握心电监护仪。该监护仪主要由手握心电传感器和嵌入式终端两部分构成。本系统将感应电极隔着衣物放置于胸前,检测获取心电信号,并经单端差动放大、滤波和主放大后,由CC2540模块进行A/D转换和心电信号传输。然后嵌入式终端对接收到的心电信号进行数字滤波和数据处理,最后在屏幕上显示波形和心率值。实测结果表明利用手握心电监护仪能实现隔着衣物实时检测人体心电信号,具有操作简单、便携性和快速检测等优点。

关键词：电容耦合快速检测感应电极手握式

Distinct palmitoylation of Foxp3 regulates the function of regulatory T cells via palmitoyltransferases

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Cellular & Molecular Immunology 2024年第7期21卷 787-789页

作者： Binhui Zhou Mengjie Zhang Haoyuan Ma Ying Wang Juanjuan Qiu Yang liu liaoxun Lu tianhan li lichen Zhang Rong Huang Yanrong Gu Eryan Kong Yinming liang Second Affiliated Hospital of Xinxiang Medical University Xinxiang453003China Laboratory of Mouse Genetics Institute of Psychiatry and NeuroscienceXinxiang Medical UniversityXinxiang453003China Laboratory of Genetic Regulators in the Immune System Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory MedicineXinxiang Medical UniversityXinxiang453003China Basic Medical College Xinxiang Medical UniversityXinxiang453003China Center of Disease Model and Immunology Hunan Academy of Chinese MedicineChangshaChina

Regulatory T cells(Tregs)play pivotal roles in maintaining immune homeostasis and preventing excessive immune responses in *** key players in suppressing immune reactions,they help to preserve immune tolerance and are thus crucial for preventing autoimmune *** the tumor microenvironment(TME),Tregs facilitate tumor immune evasion by impairing the activity of effector cells via multiple mechanisms,thus contributing to the initiation and progression of tumors[1].To perform this regulatory function,Tregs depend on the master transcription factor forkhead box protein p3(Foxp3)[2].The expression of Foxp3 has emerged as indispensable for the development and optimal function of Tregs[3].Interestingly,different posttranslational modifications,including phosphorylation,ubiquitination,glycosylation,and acetylation,exert significant regulatory effects on the biological function of Foxp3[4-8].

关键词： Foxp3 homeostasis function

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基于电容耦合的多导联心电监测系统研究

传感技术学报 2017年第11期30卷 1752-1757页

作者：李天涵徐效文梁莹中南大学物理与电子学院湖南长沙410083

传统的非接触式心电监测系统在硬质印刷电路板构建的电容电极基础上,使用单导联方式进行心电监测,且仅根据心率变化进行心脏异常诊断,无法满足当前临床诊断标准。基于电容耦合原理,设计了一款多导联心电监测系统,将3个由导电织布构成的... 详细信息

传统的非接触式心电监测系统在硬质印刷电路板构建的电容电极基础上,使用单导联方式进行心电监测,且仅根据心率变化进行心脏异常诊断,无法满足当前临床诊断标准。基于电容耦合原理,设计了一款多导联心电监测系统,将3个由导电织布构成的柔性电容电极集成于椅座背部,用于获取标准肢体导联Ⅰ、Ⅱ、Ⅲ和加压单极肢体导联a VR、a VL、a VF等6导联心电信号。借由导电织布式柔性电容电极与人体表面较好的接触效应,可以有效减小运动伪影的产生。通过与硬质PCB电极输出的心电波形相比,使用本系统的患者在移动情况下输出的心电波形保持相对平稳状态,无明显运动伪影。系统实验证实了此新型多导联心电监测仪的有效性,不仅可以满足个人日常心电监测使用,而且适于长期动态心电监测。

关键词：心电监测多导联电容耦合柔性电容电极

离子液体氯化1-辛基-3-甲基咪唑对洋葱的遗传毒性作用

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生态毒理学报 2017年第2期12卷 102-107页

作者：包小丹李天函郭梦龙杨威利李耀华王文锋井长勤新乡医学院生命科学技术学院新乡453003

为探讨咪唑类离子液体氯化1-辛基-3-甲基咪唑([C_8mim][C1])对洋葱的遗传毒性,用浓度分别为2.5、5、10和20mmol·L^(-1)的[C_8mim][C1]处理洋葱内表皮细胞和洋葱根尖8 h,用浓度为10 mmol·L^(-1)的[C_8mim][C1]处理洋葱内表皮细胞和洋... 详细信息

为探讨咪唑类离子液体氯化1-辛基-3-甲基咪唑([C_8mim][C1])对洋葱的遗传毒性,用浓度分别为2.5、5、10和20mmol·L^(-1)的[C_8mim][C1]处理洋葱内表皮细胞和洋葱根尖8 h,用浓度为10 mmol·L^(-1)的[C_8mim][C1]处理洋葱内表皮细胞和洋葱根尖4 h、8 h、12 h和24 h,研究[C_8mim][C1]对洋葱内表皮细胞核的影响和对洋葱根尖有丝分裂指数和染色体畸变的影响。结果显示,与对照组相比,随着[C_8mim][Cl]处理浓度和时间的增加,洋葱内表皮细胞核偏移率明显升高,根尖细胞有丝分裂指数显著降低,染色体畸变现象明显,畸变率升高。研究表明,当浓度达到2.5 mmol·L^(-1)时,[C_8mim][Cl]对洋葱具有遗传毒性。

关键词： [C8mim][Cl] 洋葱遗传毒性

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富尔江引水隧洞监控量测微机管理技术研究

水电站设计 1997年第4期13卷 43-50页

作者：贺清录陈希富李天汉辽宁省水利水电科学研究院

通过对富尔江引水隧洞的监控量测，叙述了数据微机管理系统在该工程中的应用。系统主要包括建立量测断面数据库、数据的回归分析和用典型类比分析法对实测数据进行分析与反分析。结果表明，取得了良好的效果。

关键词：变形观测数据处理监测系统引水隧洞微机

Controlled Islanding Strategy Considering Uncertainty of Renewable Energy Sources Based on Chance-constrained Model

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 471-481页

作者： Shengyuan liu tianhan Zhang Zhenzhi lin Yilu liu Yi Ding li Yang the School of Electrical Engineering Zhejiang UniversityHangzhou 310027China the Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTN 37996USA the School of Electrical Engineering Shandong UniversityJinan 250061China Electrical and Electronics Systems Research Division Oak Ridge National LaboratoryOak RidgeTN 37830USA

Controlled islanding plays an essential role in preventing the blackout of power *** there are several studies on this topic in the past,no enough attention is paid to the uncertainty brought by renewable energy sources(RESs)that may cause unpredictable unbalanced power and the observabilit>T of power systems after islanding that is essential for back-up black-start ***,a novel controlled islanding model based on mixed-integer second-order cone and chance-constrained programming(MISOCCP)is proposed to address these ***,the uncertainty of RESs is characterized by their possibility distribution models with chance constraints,and the requirements,e.g.,system observability,for rapid back-up black-start measures are also ***,a law of large numbers(LLN)based method is em-ployed for converting the chance constraints into deterministic ones and reformulating the non-convex model into convex ***,case studies on the revised IEEE 39-bus and 118-bus power systems as well as the comparisons among different models are given to demonstrate the effectiveness of the proposed *** results show that the proposed model can result in less unbalanced power and better observability after islanding compared with other models.

关键词： Controlled islanding second-order cone chance-constrained programming renewable energy source(RES) black-start observability.

Highly Active Sulfided NiPMo Hydrodesulfurization Catalyst Prepared from Keggin-type Phosphomolybdic Acid

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China Petroleum Processing & Petrochemical Technology 2023年第1期25卷 133-143页

作者： Zhu tianhan li Wenxu Wang Haiyong Wang Chenguang Yang Bin Guangzhou Institute of Energy Conversion Chinese Academy of SciencesGuangzhou 510640China

A highly active sulfided NiPMo/MCM-41(NiPMo-S/M41)hydrodesulfurization(HDS)catalyst was successfully synthesized using Keggin-type phosphomolybdic acid as the phosphorus and molybdenum source and thioacetamide as the sulfur *** supported catalysts NiPMo/M41,Ni_(2)P-Mo/M41,and Ni_(2)P/M41 were also prepared to investigate the effects of Mo,S,and the Keggin structure on the HDS *** HDS activities of NiPMo/M41 and NiPMo-S/M41 toward dibenzothiophene were much higher than that of Ni_(2)P-Mo/M41,demonstrating that the active phases in the Keggin-structured catalysts were significantly superior to the Mo-modified Ni_(2)P *** HDS activities of the catalysts followed the order NiPMo-S/M41(96.7%)>NiPMo/M41(89.9%)>Ni_(2)P-Mo/M41(53.5%)>Ni_(2)P/M41(48.9%).For Ni_(2)P/M41,Ni_(2)P-Mo/M41,and NiPMo/M41,cyclohexylbenzene(CHB)was formed in low concentrations(lity,which was ascribed to a metal-acid synergistic effect.

关键词： Keggin-type phosphomolybdic acid hydrodesulfurization dibenzothiophene