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全球及中国的肝癌流行病学特征:基于《2022全球癌症统计报告》解读

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中国普外基础与临床杂志 2024年第7期31卷 781-789页

作者：郝运李川文天夫彭伟四川大学华西医院普通外科肝脏外科病房成都610041

目的了解全球及中国最新的肝癌流行病学特征情况。方法本团队通过对2024年4月国际癌症研究机构团队在其旗下权威杂志《临床医师癌症杂志》(CA:A Cancer Journal for Clinicians)发布的《最新全球癌症统计报告》及近期中国疾病预防控制... 详细信息

目的了解全球及中国最新的肝癌流行病学特征情况。方法本团队通过对2024年4月国际癌症研究机构团队在其旗下权威杂志《临床医师癌症杂志》(CA:A Cancer Journal for Clinicians)发布的《最新全球癌症统计报告》及近期中国疾病预防控制中心国家慢性病和非传染性疾病控制与预防中心研究团队在Lancet Public Health上发表的《2005–2020年中国癌症负担变化》这2篇报告中的结果进行整理并做简要解读,分析了2018–2022年肝癌在全球和中国的流行趋势变化、2022年全球不同人类发展指数和收入水平国家肝癌的ASIRW(世界标准人口年龄标准化发病率)和ASMRW(世界标准人口年龄标准化死亡率)变化情况、2022年全球和中国不同年龄段肝癌的发病和死亡情况以及2005–2020年中国肝癌的疾病负担变化。结果2022年全球肝癌新发病例865269例,死亡病例757948例,是全球第6大新发癌症及第3大癌症致死病因。全球和中国2018–2022年肝癌发病和死亡情况均趋于平稳或呈下降趋势,它们在男性人群中均高于女性,而且在中国总体人群和男性人群中均明显高于全球。2022年肝癌ASIRW和ASMRW在高人类发展指数和中等偏上收入水平国家人群中均最高。全球及中国2022年的肝癌ASIRW和ASMRW均随年龄增长而增高。我国2005–2020年所有年龄段死亡例数、ASMRW、生命损失年和年龄标准化生命损失年率的平均年度百分比变化均为负值,提示各指标均呈现下降趋势,而2020年我国男性和女性的肝癌ASMRW均随年龄增长而增高。结论肝癌在中国和全球仍面临巨大的疾病负担,在未来贯彻落实肝癌一级和二级预防策略仍是防治肝癌的重要措施,同时仍需继续做好肝癌全程多学科规范化管理。

关键词：肝癌全球估计中国估计发病率死亡率 GLOBOCAN 2022

Can a laparoscopic surgery be an alternative to transjugular intrahepatic portosystemic shunts (TIPS) for the treatment of portal hypertensive bleeding?

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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 151-154页

作者： Bin Huang tianfu wen Liver Transplantation Center Department of Liver SurgeryWest China Hospital of Sichuan UniversityChengduChina

We read with great confusion the guidance written by Garcia-Tsao et al.(1).In the practice guidance developed by the American Association for the Study of Liver Diseases(AASLD),there is no trail of surgical operation for the treatment of portal hypertensive bleeding in cirrhosis at ***,it is well known that surgical shunts played an important role in this setting before the emergence of transjugular intrahepatic portosystemic shunts(TIPS),existing studies have shown that surgical shunt still has better long-term patency and survival than TIPS(2),and surgical portoazygous devascularization is still considered as the most direct and effective way of hemostasis in some countries(3).

关键词： TIPS hypertensive shunt

Safety of elective hepatectomy performed on weekend for patients with hepatocellular carcinoma

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Chinese Medical Journal 2022年第21期135卷 2596-2598页

作者： Junlong Dai Junyi Shen Xiaoyun Zhang Wei Peng tianfu wen Chuan Li Department of Liver Surgery Liver Transplantation CenterWest China HospitalSichuan UniversityChengduSichuan 610041China

The incidence of hepatocellular carcinoma(HCC)is increasing year by *** International Agency for Research on Cancer(IARC)reported that more than 630,000 people were diagnosed with HCC in 2020 and more than half of new cases of HCC were in *** increasing number of patients overburdens the medical system and the waiting time before the surgery becomes longer and *** poses a new challenge to the applicability of traditional surgical management *** elective surgery performed on weekend could provide an efficient solution to the ***,the safety of weekend surgery is controversial because surgical patients have a higher severe complication incidence and postoperative mortality on the weekend compared to the weekday(ie,weekend effect).

关键词： patients hepatocellular surgery

Orthotopic liver transplantation for patients with Caroli’s disease

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Hepatobiliary & Pancreatic Diseases International 2008年第1期7卷 97-100页

作者： ZhenXia Wang LuNan Yan Bo Li Yong Zeng tianfu wen wenTao Wang Liver Transplantation Division Department of General Surgery West China Hospital Sichuan University Chengdu 610041 China.

BACKGROUND:Caroli’s disease, a rare congenital hepatic disease, has a poor prognosis, especially in patients with diffuse dilatation of the bile ducts. But liver transplantation has been a curative option. The aim of this study was to investigate the feasibility and rationality of orthotopic liver transplantation as an indication for patients with diffuse Caroli’s disease. METHODS:The data from 3 patients with diffuse Caroli’s disease who had undergone orthotopic liver transplantation in our unit were analyzed retrospectively. RESULTS:On postoperative day 7, patient 1 had acute rejection which was relieved after pulse treatment with methyprednisolone. He was discharged from hospital on postoperative day 27 and has been in good health for 82 months. Patient 2 had no acute rejection or severe complications, but died of chronic graft dysfunction 34 months postoperatively. Patient 3 had acute rejection on postoperative days 10 and 35, complicated with pulmonary infection, pleural effusion and opportunistic infection. After successful treatment, she resumed work and has been followed up for 47 months. Her condition is good. CONCLUSION:Liver transplantation can offer an effective therapy for patients with diffuse Caroli’s disease, and can provide satisfactory long-term results.

关键词： liver transplantation Caroli’s disease prognosis

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主动分洪下鄱阳湖莲北圩洪水演进模拟与分析

中国防汛抗旱 2024年第8期34卷 27-31页

作者：万志豪雷声温天福贾磊牛娇江西省水利科学院南昌330029 河海大学水利水电学院南京210098 江西省鄱阳湖水资源与水环境重点实验室南昌330029

2020年鄱阳湖大洪水单退圩发挥了重要的分蓄洪水作用,但部分单退圩蓄洪过程存在进洪溃口较大且靠近村庄、淹没损失较大、撤离时间不足等问题。为了分析鄱阳湖单退圩的分洪效果,以莲北圩为例,应用MIKE21建立了莲北圩内洪水演进模拟模型... 详细信息

2020年鄱阳湖大洪水单退圩发挥了重要的分蓄洪水作用,但部分单退圩蓄洪过程存在进洪溃口较大且靠近村庄、淹没损失较大、撤离时间不足等问题。为了分析鄱阳湖单退圩的分洪效果,以莲北圩为例,应用MIKE21建立了莲北圩内洪水演进模拟模型。针对2020年鄱阳湖大洪水,调整进洪方式,在远离村庄处的位置设置闸门宽度分别为40 m、65 m、85 m、110 m和140 m的5种主动分洪方案,详细分析防洪保护区内的淹没水深、流速和洪水演进过程等。结果表明:闸门设置在合适位置,宽度大于等于65 m,进洪过程更加合理,龙口村等部分村庄受灾时间延后10 h,莲北圩进洪时长可以满足圩堤管理要求。本研究可为鄱阳湖区单退圩运行管理及防洪规划提供技术参考。

关键词：单退圩主动分洪洪水演进 MIKE21 鄱阳湖

Conversion resection for patients with hepatocellular carcinoma and inferior vena cava tumor thrombus: a consecutive case series

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Chinese Medical Journal 2022年第12期135卷 1486-1488页

作者： Xiaoyun Zhang Wei Peng Chuan Li Wusheng Lu Zhiping Li Jiayin Yang tianfu wen Department of Liver Surgery and Liver Transplantation Center West China Hospital of Sichuan UniversityChengduSichuan 610041China Laboratory of Liver Transplantation Frontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengduSichuan 610041China Laboratory of Pathology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041China

To the Editor:The incidence of hepatocellular carcinoma(HCC)with inferior vena cava tumor thrombus(IVCTT)*** 1.4%.Owing to direct cancercll dissemination into the systemic circulation,HCC-IVCTT is frequently associated with synchronous and metachronous extrahepatic *** treatment,the median survival time is only 3 months for patients with HCC-IVCTT.

关键词： thrombus patients hepatocellular

Tenofovir *** on recurrence of hepatitis B virus-related hepatocellular carcinoma beyond Milan criteria after hepatectomy

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Chinese Medical Journal 2022年第3期135卷 301-308页

作者： Junyi Shen Weili Qi Junlong Dai Shusheng Leng Kangyi Jiang Yu Zhang Shun Ran Chuan Li tianfu wen Department of Liver Surgery and Liver Transplantation Center West China HospitalSichuan UniversityChengduSichuan 610041China Laboratory of Liver Transplantation Frontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengduSichuan 610041China Institute of Clinical Pathology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Hepatobiliary and Pancreatic Surgery The Affiliated Hospital of Chengdu UniversityChengduSichuan 610072China Department of Hepatobiliary and Pancreatic Surgery The People's Hospital of LeshanLeshanSichuan 614700China Department of Hepatobiliary Surgery Sichuan Provincial People's HospitalChinese Academy of SciencesChengduSichuan 610072China Department of Hepatobiliary Surgery Affiliated Cancer Hospital of Guizhou Medical UniversityGuiyangGuizhou 550000China

Background:Hepatectomy for hepatocellular carcinoma(HCC)beyond the Milan criteria is shown to be ***,a high rate of post-operative HCC recurrence hinders the long-term survival of the *** study aimed to investigate and compare the impacts of tenofovir(TDF)and entecavir(ETV)on the recurrence of hepatitis B viral(HBV)-related HCC beyond the Milan ***:Data pertaining to 1532 patients who underwent hepatectomy and received antiviral therapy between January 2014 and January 2019 were collected from five ***-free survival(RFS)analysis was performed using the Kaplan-Meier *** proportional hazards regression analysis was performed to determine prognostic factors for HCC ***:The analysis incorporates 595 HBV-related HCC *** overall 5-year RFS was 21.3%.Among them,533 and 62 patients received ETV and TDF treatment,*** 1-,3-,and 5-year RFS rates were 46.3%,27.4%,and 19.6%,respectively,in the ETV group compared with 65.1%,41.8%,and 37.2%,respectively,in the TDF group(P<0.001).Multivariate analysis showed that TDF treatment(hazard ratio[HR]:0.604,P=0.005),cirrhosis(HR:1.557,P=0.004),tumor size(HR:1.037,P=0.008),microvascular invasion(MVI)(HR:1.403,P=0.002),portal vein tumor thrombus(PVTT)(HR:1.358,P=0.012),capsular invasion(HR:1.228,P=0.040),and creatinine levels(CREA)(HR:0.993,P=0.031)were statistically significant prognostic factors associated with ***:Patients with HCC beyond the Milan criteria exhibited a high rate of HCC recurrence after *** to the ETV therapy,TDF administration significantly lowered the risk of HCC recurrence.

关键词： Hepatocellular carcinoma Hepatitis B virus Antiviral drugs Recurrence Hepatectomy

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基于PSO算法的伦潭水库兴利调度

江西水利科技 2024年第3期50卷 194-198页

作者：刘鑫温天福刘章君鄢笑宇徐珺恺胡斌江西省水利科学院江西省鄱阳湖流域生态水利技术创新中心江西南昌330029 江西省鄱阳湖水利枢纽建设办公室江西南昌330009

水库调度是在不改变水库工程规模前提下解决防洪减灾与提高水资源高效利用的关键方法。近些年,江西旱灾频发,为协调水库发电效益与基本生产、生活、生态用水需求的矛盾,以江西省伦潭水库为例,以充分发挥水库灌溉、工业、生活、生态、发... 详细信息

水库调度是在不改变水库工程规模前提下解决防洪减灾与提高水资源高效利用的关键方法。近些年,江西旱灾频发,为协调水库发电效益与基本生产、生活、生态用水需求的矛盾,以江西省伦潭水库为例,以充分发挥水库灌溉、工业、生活、生态、发电等兴利调度功能为目标,将农业灌溉用水、居民生活用水、工业生产用水和河道基本生态流量需水转化为刚性约束,采用粒子群智能算法,寻求发电效益最大的水库最优调度方案。

关键词：伦潭水库粒子群算法兴利调度发电效益

Reducing biliary complications in adult-to-adult living donor liver transplantation using right lobe graft:experience of 124 cases

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Frontiers of Medicine 2008年第2期2卷 130-133页

作者： Lunan YAN tianfu wen wentao WANG Jiayin YANG Mingqing XU Zheyu CHEN Hong WU Liver Transplantation Division Department of SurgeryWest China HospitalSichuan University Medical SchoolChengdu 610041China

The aim of this paper is to summarize our experience of using right lobe liver grafts to reduce biliary complications in adult-to-adult(A-A)living donor liver transplantation(LDLT).From January 2002 to October 2007,124 adult patients underwent living donor liver transplantation using right lobe grafts at the West China Hospital,Sichuan University Medical School,*** was no death in all *** reconstruction for 178 hepatic duct orifices from 124 donor grafts was performed which included 106 reconstructions of duct-to-duct anastomoses and 72 *** recipients had biliary complications including six bile lea-kages(four from the anastomotic site and two from the cut surface of the liver graft)and three biliary *** the improved techniques for biliary reconstruction,we have achieved good results in 124 recipients of A-A *** ascribe our success to the introduction of microsurgical techniques and the use of fixed operators which help in decreasing the biliary complications of LDLT.

关键词： living donor liver transplantation adult-to adult right lobe graft surgical technique biliary com-plication