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神奇的表面化学——油水分离膜的制备及应用

大学化学 2024年第5期39卷 218-227页

作者：马兰何彩露刘子琪杨耀涵明清霞罗雪何天凤张李云西华大学理学院成都610039

日常生活中的表面化学应用无处不在,从“荷叶效应”的自然现象,到特种工业制品的防水、防冻,抗污等性能,这看似生活化、简单的现象背后却蕴含着鲜为人知的表面原理。本实验通过在熔喷布膜表面层层自组装沉积植物多酚——单宁酸(TA)和铁... 详细信息

日常生活中的表面化学应用无处不在,从“荷叶效应”的自然现象,到特种工业制品的防水、防冻,抗污等性能,这看似生活化、简单的现象背后却蕴含着鲜为人知的表面原理。本实验通过在熔喷布膜表面层层自组装沉积植物多酚——单宁酸(TA)和铁离子Fe(Ⅲ)配位化合物使其形成亲水涂层,再利用高碘酸钠(NaIO_(4))氧化儿茶酚基团促进多酚-金属网络在熔喷布膜表面的固定,进而实现织物从疏水到亲水的改性,最后利用油水分离装置展示膜的分离效果。实验通过展示材料的改性过程及材料改性前后性能差异,层层解析其背后蕴含的物理化学本质。此科普实验所用试剂绿色、操作简单、观赏性及互动性强、改性后的膜具有可循环利用的优势。在面向不同阶段的科普对象时我们采用梯度科普,深入浅出地讲解现象背后蕴含的原理和本质,让公众在获得知识的同时感受到表面化学的神奇和化学之美。该实验不仅可以用于科普实验也可以用于课堂教学,并且具有优异的应用前景。

关键词：表面化学润湿反转膜材料多酚-金属配合物油水分离

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Designing macrophage membrane-engineered ruthenium/selenium nanoparticles to block bone metastasis of breast cancer

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Nano Research 2024年第8期17卷 7504-7512页

作者： Meijin Yang Zhiying Tang Xiaoying Li Yanzi Yu Lizhen he tianfeng Chen College of Chemistry and Materials Science Department of Oncology of The First Affiliated HospitalJinan UniversityGuangzhou 510632China

Bone metastasis along with osteolysis is a common complication of advanced breast cancer,which directly destroys bone function and becomes one of the major causes of cancer-related *** is crucial to develop a new strategy to achieve effective cancer therapy and inhibition of osteolytic bone *** ruthenium(Ru)complexes exhibit therapeutic potential in cancer ***,the clinical applications of Ru complexes were limited by poor bioavailability,lacking targeting,nonspecific ***,in this study,engineering of cell membrane biomimetic modification was used to construct a highly biocompatible nanoplatform with carrying Ru metal complex of RuPOP and Se nanoparticles(SeNPs).Strikingly,the obtained RPSR nanoparticles can efficiently inhibit the proliferation,invasion and migration of breast cancer cells(MDA-MB-231 cells)in *** importantly,RPSR nanoparticles can induce cycle arrest,apoptosis by generating excessive intracellular(reactive oxygen species,ROS)to disrupt the normal redox balance and induce DNA damage in tumor ***,RPSR nanoparticles can also reshape bone microenvironment by regulating selenoproteins to inhibit osteoclasts and avoid osteolytic bone metastasis induced by tumor *** together,this study not only provides an effective cell membrane biomimetic strategy to enhance the shortcomings of metal complexes,but also demonstrates potential clinical significance for the combined treatment of anti-cancer and bone metastasis inhibition.

关键词： cell membrane nanoparticles biomimetic modification ruthenium complexes selenium nanoparticles tumor bone metastasis

穴位敏感点揿针配合中药治疗多发性抽动症的疗效观察

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上海针灸杂志 2024年第7期43卷 713-718页

作者：丁金磊刘伙生王红何天峰马洁张立娜陶善平上海市嘉定区中医医院上海201899 上海市宝山区中冶医院上海200941

目的观察穴位敏感点揿针配合中药治疗多发性抽动症的临床疗效。方法将150例多发性抽动症患者随机分为治疗组、对照1组和对照2组,每组50例。治疗组采用穴位敏感点揿针配合中药治疗,对照1组采用揿针配合中药治疗,对照2组采用口服盐酸硫... 详细信息

目的观察穴位敏感点揿针配合中药治疗多发性抽动症的临床疗效。方法将150例多发性抽动症患者随机分为治疗组、对照1组和对照2组,每组50例。治疗组采用穴位敏感点揿针配合中药治疗,对照1组采用揿针配合中药治疗,对照2组采用口服盐酸硫必利片治疗。观察3组治疗前后耶鲁抽动程度综合量表(Yale global tic severity scale, YGTSS)各项评分及各项中医症候积分的变化情况,比较3组临床疗效及不良反应发生率。结果治疗组总有效率为89.6%,对照1组为80.4%,对照2组为69.6%,治疗组总有效率明显高于对照1组和对照2组(P<0.05),对照1组总有效率明显高于对照2组(P<0.05)。3组治疗后中医证候积分及YGTSS各项评分均较同组治疗前显著下降,差异均具有统计学意义(P<0.05)。治疗组和对照1组治疗后中医证候积分及YGTSS各项评分均明显低于对照2组,差异均具有统计学意义(P<0.05)。治疗组治疗后运动抽动、烦躁易怒、精神倦怠、纳差积分及YGTSS各项评分均明显低于对照1组,差异均具有统计学意义(P<0.05)。治疗组治疗期间不良反应发生率为6.3%,对照1组为8.7%,对照2组为26.1%,治疗组和对照1组不良反应发生率均明显低于对照2组,差异均有统计学意义(P<0.05)。结论穴位敏感点揿针配合中药治疗脾虚肝旺型多发性抽动症有较好的临床疗效,能够改善多发性抽动症患者的临床症状,安全性较高。

关键词：针刺疗法抽动症揿针皮肤针疗法中药针药并用

基于社区医院的结核病预防与咨询门诊建设模式探索与实践

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中国公共卫生管理 2024年第4期40卷 615-618页

作者：张冰凌李冰吴锋李萍萍陈同罗丽张君任伟明贺天锋宁波市第九医院医疗健康集团庄桥院区浙江宁波315000 宁波市江北区疾病预防控制中心宁波市疾病预防控制中心

在宁波市庄桥街道社区医院开展研究,探讨在社区医院中建立结核病预防与咨询门诊的模式及其实施效果,旨在通过专业化的结核病咨询、筛查和预防性的治疗服务,提升公众对结核病的认知,降低结核潜伏感染者发展为活动性结核病的风险,提升社... 详细信息

在宁波市庄桥街道社区医院开展研究,探讨在社区医院中建立结核病预防与咨询门诊的模式及其实施效果,旨在通过专业化的结核病咨询、筛查和预防性的治疗服务,提升公众对结核病的认知,降低结核潜伏感染者发展为活动性结核病的风险,提升社区结核病的防治水平。社区医院通过设立结核病预防门诊,实施“三筛两管一动员”策略,对社区内结核病患者和潜伏感染者进行早期发现、诊断和规范化管理。同时,门诊引入现代化信息系统,实现了患者健康档案的电子化管理,优化了门诊服务流程。结果显示,门诊累计为38名咨询者提供服务,开展了5名患者的免疫治疗,提高了结核病的防治效果。文章总结了社区医院在结核病预防门诊建设和管理中的经验,提出了进一步优化全流程管理和预防性治疗的对策,为其他社区医院提供了可借鉴的实践经验。

关键词：基层医疗卫生机构结核病预防控制

Metal complex catalysts broaden bioorthogonal reactions

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Science China Chemistry 2024年第2期67卷 428-449页

作者： Hanjie Zhang Xiaoyu Qin Junping Wang Li Ma tianfeng Chen Department of Chemistry Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinan UniversityGuangzhou510632China

Bioorthogonal reactions involving transition metals have diversified applications in imaging,drug development,chemical catalysis and other *** metals used to catalyze the bioorthogonal reaction mainly include ruthenium,palladium,copper,and ***,the great potential for translational applications of bioorthogonal reaction needs to be further expanded and their reaction efficiency should be ***,it is an urgent need for the development of this field to find more suitable catalysts to efficiently catalyze existing biological orthogonal reactions and expand the types of biological orthogonal ***,this review not only summarizes those transition metal complexes-based catalysts participating in bioorthogonal reaction and some bioorthogonal reactions involving transition metals inside the cells,but also sheds light into the discovery of new transition metal complexes and their future development in applications.

关键词： transition metal complexes bioorthogonal reactions biological applications

Regulation effect of the grille spacing of a funnel-type grating water–sediment separation structure on the debris flow performance

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Journal of Mountain Science 2024年第7期21卷 2283-2304页

作者： LI Shuai GU tianfeng WANG Jiading WANG Fei LI Pu State Key Laboratory of Continental Dynamics/Department of Geology Northwest UniversityXi’an 710069China Chengdu Institute of Mountain Hazards and Environment Ministry of Water Resources&Chinese Academy of SciencesChengdu 610299China

The size of pores or the grille spacing of water–sediment separation structures directly affects their regulation effect on the debris flow performance.A suitable pore size or grille spacing can effectively improve the water–sediment separation ability of the *** new funnel-type grating water–sediment separation structure(FGWSS)combines vertical and horizontal structures and provides a satisfactory water–sediment separation ***,the regulation effect of the grille spacing of the structure on the debris flow performance has not been *** regulation effect of the structure grille spacing on the debris flow performance is studied through a flume test,and the optimal structure grille spacing is *** empirical equation of the relationship between the relative grille spacing of the structure and the sediment separation rate is ***,the influence of the water–sediment separation structure on the regulation effect of debris flows is examined from two aspects:external factors(properties of debris flows)and internal factors(structural factors).The experimental results show that the gradation characteristics of solid particles in debris flows constitute a key factor affecting the regulation effect of the structure on the debris flow *** optimum grille spacing of the FGWSS matches the particle size corresponding to the material distribution curves d85~d90 of the debris *** total separation rate of debris flow particles is related to the grille spacing of the structure and the content of coarse and fine particles in the debris flow.

关键词： Debris flow Water–sediment separation structure Grille spacing Performance regulation effect

Alignment error modeling and control of a double-sided microlens array during precision glass molding

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Microsystems & Nanoengineering 2024年第2期10卷 311-322页

作者： Zihao Zeng tianfeng Zhou Qian Yu Jia Zhou Gang Wang Qiuchen Xie Zifan Wang Xiaoqiang Yao Yubing Guo School of Medical Technology Beijing Institute of TechnologyNo.5 Zhongguancun South StreetHaidian DistrictBeijing100081China School of Mechanical Engineering Beijing Institute of TechnologyNo.5 Zhongguancun South StreetHaidian DistrictBeijing100081China

Double-sided microlens arrays(DSMLAs)include combinations of two single-sided MLAs to overcome positioning errors and greatly improve light transmissivity compared to other types of *** glass molding(PGM)is used to fabricate DSMLAs,but controlling alignment errors during this process is *** this paper,a mold assembly was manufactured with a novel combination of materials to improve the alignment accuracy of mold cores during PGM by using the nonlinear thermal expansion characteristics of the various materials to improve the DSMLA alignment *** establishing a mathematical model of the DSMLA alignment error and a thermal expansion model of the mold-sleeve pair,the relationship between the maximum alignment error of the DSMLA and the mold-sleeve gap was *** research provides a method to optimize the mold-sleeve gap and minimize the alignment error of the *** measured DSMLA alignment error was 10.56μm,which is similar to the predicted maximum alignment *** measurements showed that the uniformity of the homogenized beam spot was 97.81%,and the effective homogeneous area accounted for 91.66%of the total *** proposed method provides a novel strategy to improve the performance of DSMLAs.

关键词： sided alignment error

PD-L1-driven efficient enrichment and elimination of circulating cancer cells by magnetic MoSe_(2) nanosheet

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Nano Research 2024年第5期17卷 4350-4358页

作者： Hongjie Huang Binhua Zou Shanlin Zhu Xingchen Zhang Jiale Huang Jinlin Wang Xiaoling Li tianfeng Chen The Sixth Affiliated Hospital Jinan UniversityDongguan 523566China Department of Chemistry Institute of Food Safety and NutritionJinan UniversityGuangzhou 510632China Department of Rehabilitation Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Pulmonary and Critical Care Medicine Guangzhou Institute of Respiratory HealthNational Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineState Key Laboratory of Respiratory DiseasesThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China

Circulating tumor cells(CTCs)are important biomarkers in the development and progression of lung cancer because they can reach other organs through the blood circulation and form distant metastases,exacerbating lung cancer *** presence of CTCs is also the main reason for the failure of nanomedicine-based lung cancer ***,magnetic MoSe_(2) nanosheets loaded with programmed death-ligand 1(PD-L1),named PD-L1-MFP NS,were employed here to precisely capture lung cancer CTCs in the blood circulation through the tumor-targeting effect of PD-L1 killing CTCs with highly effective photothermal therapy(PTT).In addition,by increasing the expression of cytomegalovirus UL16-binding protein(ULBP)ligands on tumor cells,the PD-L1-MFP NS further activated natural killer(NK)cells and triggered NK cell-induced cancer immunotherapy,thereby enhancing the overall tumor-killing *** summary,this material designed to capture CTCs provides a substantial advancement for personalized PTT-triggered immunotherapy and has great clinical translational potential.

关键词： circulating tumor cells selenide photothermal therapy(PTT) natural killer(NK)cell immunotherapy

Meta-Analysis of Smoking and the Risk of Gastric Cancer among the Chinese Population

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Clinical oncology and cancer resexreh 2009年第4期6卷 296-302页

作者： Na Liu Yueping Shen Liqiang Qin tianfeng he Yinmei Liu Department of Epidemiology and healthStatistics Radiation Medicine and PublicHealth School of Soochow University Suzhou215123 Jiangsu Province China. Department of Nutrition and Food Hygiene Radiation Medicine and Public Health Schoolof Soochow University Suzhou 215123 Ji-angsu Province China.

OBJECTIVE To reevaluate the effect of tobacco smoking on therisk of developing gastric cancer among the Chinese *** Thirty articles from the literature both in Chineseand English from January,1988 to present were identified andfrom which adjusted odd ratios(ORs)or relative risks(RRs)werecombined by *** least squares(GLS)fortrend estimation of summarized dose-response data was *** the analyses were performed using software of STATAversion *** Comparing current smokers with subjects who havenever smoked,the summary effect values on gastric cancer witha 95% confidence interval(CI)were 1.67(1.43-1.96)for case-control studies and 1.52(1.17-1.96)for cohort studies,*** combined effect values with a 95%CI for the comparison ofsmoking quantity of current smokers with the referent groupwere 1.41(1.15-1.72)for case-control studies and 1.24(1.02-1.52)for cohort studies,*** combined effect values witha 95%CI for the comparison of accumulative years smoked ofcurrent smokers with the referent group were 1.07(0.89-1.28)for case-control studies and 1.28(0.95-1.74)for cohort studies,***-response meta-analysis showed that the gastriccancer risk will increase 50%(OR=1.50,95%CI:1.34-1.67)witheach 20 cigarette per day increment and increase 14%(OR=1.14,95%CI:1.10-1.18)with each 10 year increment of *** The gastric cancer risk among the Chinesepopulation is significantly associated with tobacco smoking andthe smoking quantity per *** cessation should be morestrongly advocated.

关键词： Meta分析风险人口胃癌吸烟