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Androgen receptor inhibits the hair follicle induction potential of dermal papilla cells by binding with Tcf4 at the A574 binding site

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Genes & Diseases 2023年第1期10卷 51-54页

作者： Nanlan Yu tianxing hu Haichao Yangg Lian Zhang Lin Zhu Xiaofang Zhou Fei Xiang Xichuan Yang Yuhong Li Department of Dermatology Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Cell Biology Army Medical UniversityChongqing 400038China Institute of Burn Research State Key Laboratory of TraumaBurns and Combined InjurySouthwest HospitalArmy Medical UniversityChongqing 400038China

Androgenic alopecia(AGA)is the most common type of clinical *** receptor(AR)is the most logical candidate gene for regulating the occurrence of *** papilla cells(DPCs)are a special kind of mesenchymal cells,located in the hair bulb of hair *** play a role in maintaining and inducing the periodic cycling of hair follicles,and are considered as a key cell target of androgen in hair follicles.

关键词： clinical hair cycling

Wnt4 increases the thickness of the epidermis in burn wounds by activating canonical Wnt signalling and decreasing the cell junctions between epidermal cells

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Burns & Trauma 2023年第1期11卷 46-61页

作者： Fei Xiang Pei Wang Hao Gong Jia Luo Xin Zhou Chenglin Zhan tianxing hu Mengru Wang Yizhan Xing Haiying Guo Gaoxing Luo Yuhong Li Institute of Burn Research State Key Laboratory of TraumaBurns and Combined InjurySouthwest HospitalArmy Medical UniversityChongqing 400038PR China Department of Cell Biology Army Medical UniversityChongqing 400038PR China

Background:Burn wound healing is a complex process and the role of Wnt ligands varies in this *** and how Wnt4 functions in burn wound healing is not well *** this study,we aim to reveal the effects and potential mechanisms of Wnt4 in burn wound ***:First,the expression of Wnt4 during burn wound healing was determined by immunoflu-orescence,Western blotting and ***,Wnt4 was overexpressed in burn *** healing rate and healing quality were analysed by gross photography and haematoxyline and eosin *** secretion was observed by Masson *** formation and fibroblast distribution were observed by ***,Wnt4 was knocked down in HaCaT *** migration of HaCaT cells was analysed by scratch healing and transwell ***,the expression ofβ-catenin was detected by Western blotting and *** binding of Frizzled2 and Wnt4 was detected by coimmunoprecipitation and ***,the molecular changes induced by Wnt4 were analysed by RNA sequencing,immunofluorescence,Western blotting and qPCR in HaCaT cells and burn wound healing ***:The expression of Wnt4 was enhanced in burn wound *** of Wnt4 in burn wound skin increased the thickness of *** secretion,vessel formation and fibroblast distribution were not significantly impacted by Wnt4 *** Wnt4 was knocked down in HaCaT cells,the ratio of proliferating cells decreased,the ratio of apoptotic cells increased and the ratio of the healing area in the scratch healing assay to the number of migrated cells in the transwell assay *** nuclear translocation ofβ-catenin decreased in shRNA of Wnt4 mediated by lentivirus-treated HaCaT cells and increased in Wnt4-overexpressing epidermal ***-sequencing analysis revealed that cell junction-related signalling pathways were significantly impacted by Wnt4 *** expression of the cell junction prote

关键词： Wnt4 Wnt signalling pathway Burn wound healing Cell junction Cell migration

基于流守恒和傅立叶谱分析的混合型Wigner-Poisson方程组求解

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计算物理 2023年第2期40卷 248-257页

作者：胡天行盛正卯吴栋浙江大学物理学院聚变理论与模拟中心浙江杭州310027 上海交通大学物理与天文学院激光等离子体研究所惯性约束聚变科学与应用协同创新中心上海200240

提出一种基于流守恒和傅立叶分析的混合型离散欧拉网格法来求解Wigner-Poisson方程组。在坐标和速度空间分别采用不同的时间推进算法。与一般的离散欧拉法相比,可以显著提高非线性模拟结果的可靠性。通过该方法求解一些常见静电动理学... 详细信息

提出一种基于流守恒和傅立叶分析的混合型离散欧拉网格法来求解Wigner-Poisson方程组。在坐标和速度空间分别采用不同的时间推进算法。与一般的离散欧拉法相比,可以显著提高非线性模拟结果的可靠性。通过该方法求解一些常见静电动理学不稳定性在量子等离子体中的行为变化;通过线性的本征解验证代码的可靠性,然后进行一些非线性现象的模拟,包含非线性朗道阻尼以及双流不稳定性的非线性饱和等。

关键词：量子等离子体动理学欧拉法非线性效应

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浅析延安农业信息网络平台的开发与应用

价值工程 2012年第18期31卷 213-214页

作者：呼天星延安职业技术学院延安716000

笔者就延安农业信息网络服务平台建设,系统开发技术路线、系统功能、数据库设计、新闻发布系统实现、网页设计等六个方面阐述了延安农业信息网络服务平台的开发过程,服务功能及取得的结果,目的在于同行探讨借鉴。

关键词：农业信息网络平台开发与应用

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小标本二步酶消化法分离人头皮毛乳头细胞

中华皮肤科杂志 2020年第9期53卷 725-728页

作者：胡天星余南岚杨海潮朱琳杨希川陆军军医大学第一附属医院皮肤科重庆400038

目的探索小标本高效快速分离培养头皮毛乳头细胞的方法。方法2018年9月至2019年1月于陆军军医大学第一附属医院皮肤科收集3例头部色素痣、6例皮脂腺痣患者切除术后废弃的含毛皮肤标本,大小为0.5 cm×0.5 cm^0.5 cm×1 cm。剪下含有毛囊... 详细信息

目的探索小标本高效快速分离培养头皮毛乳头细胞的方法。方法2018年9月至2019年1月于陆军军医大学第一附属医院皮肤科收集3例头部色素痣、6例皮脂腺痣患者切除术后废弃的含毛皮肤标本,大小为0.5 cm×0.5 cm^0.5 cm×1 cm。剪下含有毛囊的皮下脂肪层,用眼科镊分选出其中的毛囊,0.6%分离酶Ⅱ消化30 min,然后采用0.2%胶原酶Ⅳ37℃消化30~60 min,离心获得毛乳头。对分离的毛乳头进行形态学观察,同时培养、传代、鉴定毛乳头细胞。结果小标本二步酶消化法分离的头皮毛乳头镜下呈倒梨形,形态完整,部分可见残留真皮鞘,而一步酶消化法未分离出毛乳头。小标本二步酶消化法毛乳头分离率为60.8%±2.1%,72 h毛乳头细胞贴壁率为86.6%±3.9%,细胞迁出时间0.5~3.0 d,实验总操作时间2.0~3.0 h,实际操作时间1.0~1.5 h。小标本二步酶消化法分离的头皮毛乳头细胞早期可呈凝集性生长,从第9代细胞开始呈非凝集性生长。结论小标本二步酶消化法是一种简单、高效分离人头皮毛乳头细胞的方法。

关键词：毛囊细胞分离细胞培养技术头皮毛乳头细胞

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基于SNMP协议的网络层拓扑测量的研究

科学技术与工程 2005年第21期5卷 1661-1664页

作者：赵红毅王中生刘猛呼天星延安机电工程学校洛川727400 陕西省理工学校西安710054 贵州电子信息职业技术学院凯里556000

首先将网络拓扑测量分为网络层拓扑测量和链路层拓扑测量,然后深入地讨论了如何利用SNMP协议获取网络层拓扑节点及其连接关系以自动构造网络拓扑图,并给出基于SNMP协议的网络拓扑测量的实现算法。实验表明该算法在网络拓扑测量中是有效... 详细信息

首先将网络拓扑测量分为网络层拓扑测量和链路层拓扑测量,然后深入地讨论了如何利用SNMP协议获取网络层拓扑节点及其连接关系以自动构造网络拓扑图,并给出基于SNMP协议的网络拓扑测量的实现算法。实验表明该算法在网络拓扑测量中是有效快速的。

关键词：简单网络管理协议管理信息库网络拓扑测量

Single-source-precursor synthesis and air-plasma ablation behavior of(Ti,Zr,Hf)C/SiC ceramic nanocomposites at 2200℃

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Journal of Advanced Ceramics 2024年第7期13卷 1043-1059页

作者： Li Lu Qingbo Wen Jinrun hu tianxing Jiang Xiangchao Ren Yalei Wang Yi Zeng Xiang Xiong State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

Dense monolithic(Ti,Zr,Hf)C/SiC ceramic nanocomposites with four different molar ratios of metallic elements in the(Ti,Zr,Hf)C phase(i.e.,Ti:Zr:Hf=1:1:1,2:3:5,2:3:3,and 1:2:1)were prepared upon pyrolysis of novel(Ti,Zr,Hf)-containing single-source precursors(SSPs),followed by spark plasma sintering(SPS).A thorough characterization was conducted to elucidate the synthesis of the SSPs,polymer-to-ceramic transformation,chemical/phase compositions,and microstructure of the SiTiZrHfC-based *** results revealed the feasibility of synthesizing nanocomposites with high(Ti,Zr,Hf)C contents using the SSP *** nanocomposites were characterized by a unique microstructure with in situ generated(Ti,Zr,Hf)C@C core-shell nanoparticles homogeneously mixed withβ-*** ablation behavior of the nanocomposites was evaluated on an air-plasma device for 60 ***,the nanocomposites exhibited excellent ablation resistance,and the lowest linear ablation rate reached−0.58μm/s at 2200°***,the ablation resistance can be dramatically improved by precisely tailoring the atomic ratios of metal elements within the(Ti,Zr,Hf)C phase via the molecular design of the *** formation of a multiple-oxide layer with both a high-meltingpoint phase((Ti,Zr,Hf)O_(2))and low-melting-point phases((Zr,Hf)TiO_(4))and glassy SiO_(2),as well as their structure,played a critical role in the enhanced ablation *** uniform distribution of the high-melting-point(Ti,Zr,Hf)O_(2)nano/microparticles throughout the glassy SiO_(2)matrix significantly enhanced the viscosity and stability of the oxide layer by the pinning effect,offering superior protection against the ingress of oxygen atoms and excellent resistance to mechanical erosion.

关键词： ultrahigh-temperature ceramics(UHTCs) multicomponent carbide nanocomposites ablation behavior multiple oxides

In-situ study on hydrogen bubble evolution in the liquid Al/solid Ni interconnection by synchrotron radiation X-ray radiography

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Journal of Materials Science & Technology 2019年第7期35卷 1388-1392页

作者： Zongye Ding Qiaodan hu Wenquan Lu Xuan Ge Sheng Cao Siyu Sun tianxing Yang Mingxu Xia Jianguo Li Shanghai Key Laboratory of Materials Laser Processing Modification School of Materials Science and EngineeringShanghai Jiao Tong University200240ShanghaiChina Monash Centre for Additive Manufacturing (MCAM) Monash UniversityClaytonVIC3800Australia

Synchrotron X-ray radiography was used to carry out an in-situ observation of the hydrogen bubble evolution in the liquid Al/solid Ni interconnection. The individual bubble mainly grows in a stochastic way during heating. The size distribution for groups of bubbles follows a Gaussian distribution in the early stage and Lifshitz-Slyozov-Wagner(LSW) diffusion controlled distribution in the final stage. The intermetallic compounds(IMCs) first form during solidification, following by the hydrogen bubbles. The bubbles between two adjacent Al3Ni grains grow unidirectionally along the liquid channel, with the bottom being impeded by the Al3Ni phase and the radius of the growth front being smaller. For the bubbles at triple junctions, they grow along the liquid channel and the crack with morphology transition.

关键词： Synchrotron radiation Liquid Al/solid Ni interconnection Hydrogen bubble Intermetallic compounds Growth behavior

Unveiling the Growth Mechanism of Faceted Primary Al_(2)Cu with Complex Morphologies During Solidification

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Acta Metallurgica Sinica(English Letters) 2022年第1期35卷 124-132页

作者： Zongye Ding Qiaodan hu Fan Yang Liao Yu tianxing Yang Naifang Zhang Wenquan Lu Jingwei Yang Jian Qiao Jianguo Li School of Mechatronic Engineering and Automation Foshan UniversityFoshan528225China Shanghai Key Laboratory of Materials Laser Processing and Modification School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China

The growth characteristic of primary faceted Al_(2)Cu intermetallic compounds(IMCs)during solidification was observed directly by synchrotron *** formation and transition mechanisms of Al_(2)Cu IMCs with diverse morphologies were elucidated by first-principle calculations combined with electron backscatter diffraction *** Al_(2)Cu crystals preferred to grow along the[001]direction and were bounded by{110}planes with the lowest surface *** faceted Al_(2)Cu rod-like clusters consisted of multiple crystals with complete rod,hollowness and partial sides,which was attributed to the increase in strain energy and solute redistribution during *** faceted Al_(2)Cu with branches was characteristic with the perpendicular relationship between the main branches and side steps and partial coalescence at the junction,which was ascribed to the continuous propagation and growth of newly formed crystals along the diagonal direction.

关键词： Solidification Synchrotron radiography Internetallic compounds Crystal growth Morphology