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OsNAC120 balances plant growth and drought tolerance by integrating GA and ABA signaling in rice

Plant Communications 2024年第3期5卷 197-215页

作者： Zizhao Xie Liang Jin Ying Sun Chenghang zhan.Siqi Tang tian Qin Nian Liu Junli Huang Key Laboratory of Biorheological Science and Technology of Ministry of Education Bioengineering College of Chongqing UniversityChongqingChina

The crosstalk between gibberellin(GA)and abscisic acid(ABA)signaling is crucial for balancing plant growth and adaption to environmental ***,the molecular mechanism of their mutual antagonism still remains to be fully *** this study,we found that knockout of the rice NAC(NAM,ATAF1/2,CUC2)tran-scription factor gene OsNAC120 inhibits plant growth but enhances drought tolerance,whereas OsNAC120 overexpression produces the opposite *** GA can rescue the semi-dwarf phenotype of osnac120 mutants,and further study showed that OsNAC120 promotes GA biosynthesis by transcriptionally activating the GA biosynthetic genes OsGA20ox1 and *** DELLA protein SLENDER RICE1(SLR1)interacts with OsNAC120 and impedes its transactivation ability,and GA treatment can remove the inhi-bition of transactivation activity caused by *** the other hand,OsNAC120 negatively regulates rice drought tolerance by repressing ABA-induced stomatal *** investigation revealed that OsNAC120 inhibits ABA biosynthesis via transcriptional repression of the ABA biosynthetic genes OsNCED3 and *** OSMOTIC STRESS/ABA-ACTIVATED PROTEIN KINASE 9(OsSAPK9)physically interacts with OsNAC120 and mediates its phosphorylation,which results in OsNAC120 *** treatment ac-celerates OsNAC120 degradation and reduces its transactivation ***,our findings provide evidence that OsNAC120 plays critical roles in balancing GA-mediated growth and ABA-induced drought tolerance in *** research will help us to understand the mechanisms underlying the trade-off between plant growth and stress tolerance and to engineer stress-resistant,high-yielding crops.

关键词： abscisic acid ABA drought stress gibberellin GA OsNAC120 OsSAPK9 rice Oryza sativa L. SLR1

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Loading-free supramolecular organic framework drug delivery systems(sof-DDSs) for doxorubicin:normal plasm and multidrug resistant cancer cell-adaptive delivery and release

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Chinese Chemical Letters 2017年第4期28卷 893-899页

作者： Chi Yao Jia tian Hui Wang Dan-Wei zhan. Yi Liu Fan zhan. zhan.Ting Li Collaborative Innovation Center of Chemistry for Energy Materials(iChEM) Department of ChemistryFudan University The Molecular Foundry Lawrence Berkeley National Laboratory

Four water-soluble porous supramolecular organic framework drug delivery systems（sof-DDSs） have been used to adsorb doxorubicin（DOX） in water at physiological pH of 7.4,which is driven exclusively by *** resulting complexes DOX@SOFs are formed instantaneously upon dissolving the components in *** drug-adsorbed sof-DDSs can undergo plasm circulation with important maintenance of the drug and overcome the multidrug resistance of human breast MCF-7/Adr cancer *** is released readily in the cancer cells due to the protonation of its amino group in the acidic medium of cancer *** vitro and in vivo experiments reveal that the delivery of SOF-a-d remarkably improve the cytotoxicity of DOX for the MCF-7/Adr cells and tumors,leading to 13-19-fold reduction of the 1C_（50）values as compared with that of *** new sof-DDSs strategy omits the indispensable loading process required by most of reported nano-scaled carriers for neutral hydrophobic chemotherapeutic agents,and thus should be highly valuable for future development of low-cost delivery systems.

关键词： Supramolecular organic framework Doxorubicin Drug delivery In situ preparation Hydrophobicity Human breast cancer Controlled release

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Two clinically relevant pressures of carbon dioxide pneumoperitoneum cause hepatic injury in a rabbit model

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World Journal of Gastroenterology 2011年第31期17卷 3652-3658页

作者： Jun Li Ying-Hai Liu zhan.Yong Ye He-Nian Liu Shan Ou Fu-Zhou tian The Postdoctoral Workstation General Surgery Center of PLAGeneral Hospital of Chengdu Military CommandChengdu 610083Sichuan ProvinceChina De partment of Anesthesia General Hospital of Chengdu Military Command AreaChengdu 610083Sichuan ProvinceChina

AIM:To observe the hepatic injury induced by carbon dioxide pneumoperitoneum(CDP) in rabbits,compare the eects olow-and high-pressure pneumoperitoneum,and to determine the degree o hepatic injury induced by these two clinically relevant CDP ***:Thirty healthy male New Zealand rabbits weighing 3.0 to 3.5 kg were randomly divided into three groups(n = 10 for each group) and subjected to the ollowing to CDP pressures:no gas control,10 mmHg,or 15 *** changes in liver tissues were observed with hematoxylin and eosin staining and transmission electron *** unction was evaluated using an automatic biochemical *** nucleotide translocator(ANT) activity in liver tissue was detected with the atractyloside-inhibitor stop *** and Bcl-2 expression levels were detected bywestern ***:Liver Functions in the 10 mmHg and 15 mmHg experimental groups were significantly disturbed compared with the control *** CDP,the levels or alanine transaminase and aspartate transaminase were 77.3 ± 14.5 IU/L and 60.1 ± 11.4 IU/L,respectively,in the 10 mmHg experimental group and 165.1 ± 19.4 IU/L and 103.8 ± 12.3 IU/L,respectively,in the 15 mmHg experimental group,which were all higher than those of the control group(p < 0.05).There was no difference in pre-albumin concentration between the 10 mmHg experimental group and the control group,but the prealbumin level of the 15 mmHg experimental group was significantly lower than that of the control group(p < 0.05).No significant differences were observed in the levels of total bilirubin or albumin among the three *** 30 and 60 min of CDP,pH was reduced(p < 0.05) and fa CO2 was elevated(p < 0.05) in the 10 mmHg group compared with controls,and these changes were more pronounced in the 15 mmHg *** and eosin staining showed no significant change in liver morphology,except for mild hyperemia in the two experimental *** electron microscop

关键词： Carbon dioxide pneumoperitoneum Hepatic injury Rabbit Mitochondria Apoptosis

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Slag Melting Characteristic of Slag Forming and Slag Splashing for BOF Less Slag Smelting

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Journal of Iron and Steel Research International 2012年第7期19卷 20-25,32页

作者： WU Wei MENG Hua-dong LIU Liu YUAN tian-xiang BAI Yan-jiang YAN zhan.hui Metallurgical Technology Research Department Central Iron and Steel Research InstituteBeijing 100081China Steelmaking Works Shougang Jingtang Iron and Steel Co LtdTangshan 063200HebeiChina

The slag melting characteristic of slag forming and slag splashing for 300 t BOF less slag process is researched by combining the methods of the slag chemical composition, the melting point determination and the petrographic analysis. The results show that the melting point of final slag for less slag smelting is 20 ~C lower than that for conventional smelting. According to results of the petrographic analysis, the C3S （3CaO ~ SiO2） and C2S （2CaO · SiO2） content for less slag smelting are lower than those for conventional smelting, while the RO （FeO, MgO, MnO, etc） phase and C4AF （4CaO · Al2O3· Fe2O3） phase are higher than those for conventional smelting. According to results of the chemical analysis, the （CaO） content and slag basicity for less slag smelting are higher than those for conventional smelting, while （FeO） and （MgO） content in slag for less slag smelting are almost equal to those for conventional smelting. The reason why slag melting point for less slag smelting is lower than that for con- ventional smelting is that the quantity of added fluorite for less slag smelting is more than that for conventional smel- ting. According tO the analysis results the slag melting point is determined by the C3S, C2S, RO phase and C4AF content. According to the results of slag melting characteristic before and after slag splashing for less slag smelting, the present adjusting slag process has little effect. It is important to adjust the composition of BOF final slag. The （FeO） content in slag is to be reduced at the slag splashing and adjusting slag process for less slag smelting.

关键词： less slag smelting melting point determination petrographic analysis slag forming process slag splashing

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Effects of Lactiplantibacillus plantarum WLPL01 fermentation on antioxidant activities,bioactive compounds,and flavor profile of Artemisia argyi

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Food Bioscience 2022年第5期49卷 616-625页

作者： Hui zhan.Wenfeng Xu Xiangxiang Zhao Linlin tian Fen zhan. Hua Wei Xueying Tao State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang330047China

Artemisia argyi is a traditional Chinese food and medicine which can improve multiple diseases such as asthma and gastrointestinal ***,whether the beneficial bioactivities are associated with microbial fermentation remain *** objective of this study was to investigate the effects of fermentation on bioactive compounds,antioxidant activity,and flavor characteristics of Artemisia argyi fermentation liquid(AAFL-LP)by an autochthonous strain,Lactiplantibacillus plantarum *** WLPL01 was found to utilize sugars and flavonoids to produce abundant organic acids,such as lactic acid and malic acid,improve antioxidant activity of Artemisia argyi including total superoxide dismutase content,1,1-diphenyl-2-picrylhydrazyl(DPPH)radical-scavenging capacity,and Fe-reducing antioxidant power,decrease largely bitter taste notes such as leucine,isoleucine,and phenylalanine,and enhance fruity,sweet,and flora notes such as terpenes and esters of ***,*** WLPL01 could improve the functionality of *** and the flavor of the product,suggesting it a promising candidate in developing functional *** food.

关键词： Artemisia argyi Lactiplantibacillus plantarum WLPL01 Fermentation Antioxidant capacity Bioactive compounds

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Clinical Value of ABCB1 and PAI-1 Gene Polymorphisms in Predicting Glucocorticoid-induced Adverse Reactions in Nephrotic Syndrome Patients

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Current Medical Science 2024年第5期44卷 923-931页

作者： Ya-ling ZHAI Shuai-gang SUN Wen-hui zhan. Hui-juan tian zhan.zheng ZHAO Department of Nephrology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China The Renal Research Institution of Zhengzhou University Zhengzhou450000China

Objective Glucocorticoid(GC)-induced adverse reactions(ARs)have been extensively studied due to their potential impact on patients’*** study aimed to examine the potential correlation between two polymorphisms[adenosine triphosphate-binding cassette B1(ABCB1)C3435T and plasminogen activator inhibitor-1(PAI-1)4G/5G]and various GC-induced ARs in nephrotic syndrome(NS)*** In this study,513 NS patients who underwent GC treatment were ***,the patients were divided into two groups based on ABCB1 C3435T and PAI-14G/5G genotyping,and intergroup comparisons of clinicopathological data and GC-induced ARs were *** and multivariate logistic analyses were subsequently conducted to identify potential risk factors for GC-induced ARs,and a nomogram was subsequently established and validated via the area under the ROC curve(AUC),calibration curve and decision curve analysis(DCA).Results We identified ABCB1 C3435T as an independent risk factor for the development of steroid-associated avascular necrosis of the femoral head(SANFH)(OR:2.191,95%CI:1.258–3.813,P=0.006)but not as a risk factor for the occurrence of steroid diabetes mellitus(S-DM).On the other hand,PAI-14G/5G was identified as an independent risk factor for the development of both SANFH(OR:2.198,95%CI:1.267–3.812,P=0.005)and S-DM(OR:2.080,95%CI:1.166–3.711,P=0.013).Notably,no significant correlation was found between the two gene polymorphisms and other GC-induced *** addition,two nomograms were established and validated to demonstrate strong calibration capability and clinical *** Assessing ABCB1 C3435T and PAI-14G/5G before steroid treatment in NS patients could be useful for identifying patients at a high risk of developing SANFH and S-DM.

关键词： adenosine triphosphate-binding cassette B1 nephrotic syndrome plasminogen activator inhibitor-1 steroid-associated avascular necrosis of the femoral head steroid diabetes

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Self-assembled supramolecular materials for photocatalytic H_(2)production and CO_(2)reduction

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Materials Futures 2022年第4期1卷 94-119页

作者： Jia tian Junlai Yu Qingxuan Tang Jiangshan zhan. Danying Ma Yifei Leiand zhan.Ting Li Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032People’s Republic of China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan University2205 Songhu RoadShanghai 200438People’s Republic of China

Photosynthetic organisms harness solar radiation to produce energy-rich compounds from water and atmospheric CO_(2)via exquisite supramolecular assemblies,which offers a design principle for highly efficient artificial photocatalytic *** an emerging research field,significant effort has been devoted to self-assembled supramolecular materials for photocatalytic H_(2)production and CO_(2)*** this review,we introduce the basic concepts of supramolecular photocatalytic *** that,we will discuss recent advances in the preparation of supramolecular photocatalytic materials from zero-dimension to three-dimension which include molecular assemblies,micelles,hybrid nanoparticles,nanofibers,nanosheets,microcrystals,lipid bilayers,supramolecular organic frameworks,supramolecular metal-organic frameworks,gels,and host-guest metal-organic frameworks,***,we show the recent progress in the photocatalytic properties of supramolecular photocatalytic materials,*** proton reduction,water splitting,CO_(2)to HCOOH,CO_(2)to CO,CO_(2)to CH4 conversions,***,we provide our perspective for the future research,with a focus on the development of new structures and highly efficient photocatalysis.

关键词： supramolecular materials self-assembly photocatalysis hydrogen production carbon dioxide reduction

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Molecular basis of pathogenesis of postharvest pathogenic Fungi and control strategy in fruits: progress and prospect

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Molecular Horticulture 2021年第1期1卷 183-192页

作者： zhan.Quan zhan. Tong Chen Bo-Qiang Li Guo-Zheng Qin Shi-Ping tian Key Laboratory of Plant Resources Institute of BotanyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China

The disease caused by pathogenic fungi is the main cause of postharvest loss of fresh *** formulation of disease control strategies greatly depends on the understanding of pathogenic mechanism of fungal pathogens and control *** recent years,based on the application of various combinatorial research methods,some pathogenic genes of important postharvest fungal pathogens in fruit have been revealed,and their functions and molecular regulatory networks of virulence have been *** progresses not only provide a new perspective for understanding the molecular basis and regulation mechanism of pathogenicity of postharvest pathogenic fungi,but also are beneficial to giving theoretical guidance for the creation of new technologies of postharvest disease ***,we synthesized these recent advances and illustrated conceptual frameworks,and identified several issues on the focus of future studies.

关键词： Pathogenic genes Regulation mechanism Postharvest disease Control strategy Fruit

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Water-dispersible and soluble porous organic polymers for biomedical applications

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Aggregate 2022年第5期3卷 144-158页

作者： Jia tian Furong Lin Shang-Bo Yu Junlai Yu Qingxuan Tang zhan.Ting Li Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Chinese Academy of SciencesShanghai Institute of Organic ChemistryShanghaiChina Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghaiChina College of Chemistry Zhengzhou UniversityZhengzhouChina

Porous organic polymers(POPs)have become an emerging class of advanced porous organic materials owing to their structural diversity and tailored functions in solid state and organic *** water-soluble and related water-dispersible POPs is still very challenging in the research area of porous organic *** porosity-based functions with diverse topological architectures in aqueous media offer promising platforms in bio-related *** review highlights recent progress on water soluble or dispersible POPs for biomedical applications including bioimaging and biosensing,nanocarriers for drug delivery and tumor targeting,phototherapeutics,protein and gene delivery,biomacromolecule encapsulation and discrimination,and anti-microbial activity.

关键词： biomaterials biomedical applications porous organic polymers water dispersible water soluble

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Unusual presentation of congenital radioulnar synostosis with osteoporosis,fragility fracture and nonunion:A case report and review of literature

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World Journal of Clinical Cases 2020年第8期8卷 1538-1546页

作者： zhan.Yu Yang Jiang-Dong Ni Ze Long Le-tian Kuang Shi-Bin Tao Department of Orthopedics The Second Xiangya HospitalCentral South UniversityChangsha 410000Hunan ProvinceChina

BACKGROUND Congenital radioulnar synostosis(CRUS)is a rare deformity of the upper *** is characterized by loss of rotation of the involved forearm and functional limitations in daily *** studies on CRUS with osteoporosis have been reported to date,and osteoporosis is usually recognized as an important dimension of genetic disorder in *** discuss the possible relationship among this disorder,osteoporosis and fracture nonunion,investigate the strict surgical indications and recommended *** SUMMARY A 14-year-old male patient with bilateral CRUS with osteoporosis,fragility fracture and nonunion of fractures in ulna and radius presented our institution for further treatment,complaining of limitation in *** bone mineral density of the hip and lumbar spine was 0.687 g/cm2 and 0.705 g/cm2,respectively,and the Z-score for both was-2.1,which revealed osteoporosis and a high risk of *** serum bone turnover markers indicated an imbalance of bone *** for ulna fracture with autogenous bone grafting and a postoperative physiotherapy program were adopted rather than the separation of pathological *** examination,observational posture assessment and limb function scale were evaluated before and 1 year after *** 1 year,the fracture nonunion had almost recovered,forearm movement function on the fracture side was restored,and function on the healthy side was significantly improved compared with that before *** Surgical indications for CRUS vary from person to *** should not be the first choice of treatment,and physiotherapy is not inferior to surgical treatment.

关键词： Congenital radioulnar synostosis Surgical indication Osteoporosis Fragility fracture Nonunion Case report

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