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Prediction of Tumor Microenvironment Characteristics and Treatment Response in Lung Squamous Cell Carcinoma by Pseudogene OR7E47P-related Immune Genes

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Current Medical Science 2023年第6期43卷 1133-1150页

作者： Ya-qi ZHAO Hao-han ZHANG Jie WU Lan LI Jing LI Hao ZHONG Yan JIN tian-yu lei Xin-yi ZHAO Bin XU Qi-bin SONG Jie HE Cancer Center Renmin Hospital of Wuhan UniversityWuhan430060China Department of Medical Oncology First Affiliated Hospital of Kunming Medical UniversityKunming650000China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100032China

Objective Pseudogenes are initially regarded as nonfunctional genomic sequences,but some pseudogenes regulate tumor initiation and progression by interacting with other genes to modulate their transcriptional *** receptor family 7 subfamily E member 47 pseudogene(OR7E47P)is expressed broadly in lung tissues and has been identified as a positive regulator in the tumor microenvironment(TME)of lung adenocarcinoma(LUAD).This study aimed to elucidate the correlation between OR7E47P and tumor immunity in lung squamous cell carcinoma(LUSC).Methods Clinical and molecular information from The Cancer Genome Atlas(TCGA)LUSC cohort was used to identify OR7E47P-related immune genes(ORIGs)by weighted gene correlation network analysis(WGCNA).Based on the ORIGs,2 OR7E47P clusters were identified using non-negative matrix factorization(NMF)clustering,and the stability of the clustering was tested by an extreme gradient boosting classifier(XGBoost).LASSO-Cox and stepwise regressions were applied to further select prognostic ORIGs and to construct a predictive model(ORPScore)for *** Botling cohorts and 8 immunotherapy cohorts(the Samstein,Braun,Jung,Gide,IMvigor210,Lauss,Van Allen,and Cho cohorts)were included as independent validation *** OR7E47P expression was positively correlated with immune cell infiltration and enrichment of immune-related pathways in LUSC.A total of 57 ORIGs were identified to classify the patients into 2 OR7E47P clusters(Cluster 1 and Cluster 2)with distinct immune,mutation,and stromal *** to Cluster 1,Cluster 2 had more infiltration by immune and stromal cells,lower mutation rates of driver genes,and higher expression of immune-related *** clustering performed well in the internal and 5 external validation *** on the 7 ORIGs(HOPX,STX2,WFS,DUSP22,SLFN13,GGCT,and CCSER2),the ORPScore was constructed to predict the prognosis and the treatment *** addition,the ORPScore was a bette

关键词： pseudogene olfactory receptor family 7 subfamily E member 47 pseudogene-related immune gene tumor microenvironment immunotherapy lung squamous cell carcinoma

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Experimental observations on the nonproportional multiaxial ratchetting of cast AZ91 magnesium alloy at room temperature

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 1115-1125页

作者： Binghui Hu yu lei Hang Li Ziyi Wang Chao yu Guozheng Kang Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province School of Mechanics and Aerospace EngineeringSouthwest Jiaotong UniversityChengdu 610031China

The nonproportional multiaxial ratchetting of cast AZ91 magnesium (Mg) alloy was examined by performing a sequence of axial-torsional cyclic tests controlled by stress with various loading paths at room temperature (RT).The evolutionary characteristics and path dependence of multiaxial ratchetting were *** illustrate that the cast AZ91 Mg alloy exhibits considerable nonproportional additional softening during cyclic loading with multiple nonproportional multiaxial loading paths;multiaxial ratchetting presents strong path dependence,and axial ratchetting strains are larger under nonproportional loading paths than under uniaxial and proportional45°linear loading paths;multiaxial ratchetting becomes increasingly pronounced as the applied stress amplitude and axial mean stress ***,stress-strain curves show a convex and symmetrical shape in axial/torsional *** ratchetting exhibits quasi-shakedown after certain loading *** abundant experimental data obtained in this work can be used to develop a cyclic plasticity model of cast Mg alloys.

关键词： cast magnesium alloy ratchetting multiaxial loading loading path stress level

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Acidic electroreduction CO_(2)to formic acid via interfacial modification of Bi nanoparticles at industrial-level current

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Nano Research 2024年第7期17卷 5817-5825页

作者： tian Dong Hongdong Li Zhenhui Wang Yanling Geng Rui Chang Xiaofeng tian Jianping Lai Shouhua Feng lei Wang Key Laboratory of Eco-Chemical Engineering International Science and Technology Cooperation Base of Eco-Chemical Engineering and Green ManufacturingCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China Shandong Engineering Research Center for Marine Environment Corrosion and Safety Protection College of Environment and Safety EngineeringQingdao University of Science and TechnologyQingdao 266042China

Electrocatalytic CO_(2)reduction reaction(CO_(2)RR)in acidic media is a promising approach to overcome the unavoidable formation of carbonates in alkaline or neutral ***,the proton-rich environment near the catalyst surface favors hydrogen evolution reactions(HER),leading to lower energy efficiency of the desired products,especially in industrial-level current ***,quaternary ammonium cationic surfactant(cetyltrimethylammonium bromide(CTAB))was introduced into acidic electrolyte to modulate the interfacial microenvironment,which greatly enhanced CO_(2)electroreduction to formic acid(HCOOH)at the Bi/C nanoparticles *** a Bi/C nanoparticles electrode with CTAB added,constant production of formic acid was enabled with a cathodic energy efficiency of>40%and maximum FE_(HCOOH)(FE=Faradaic efficiency)of 86.2%at−400 mA·cm^(−2)over 24 *** with in-situ attenuated total reflection Fourier transform infrared spectroscopy,the concentration of*OCHO intermediates significantly increased after CTAB modification,confirming that the hydrophobic interface microenvironment formed by dynamic adsorption of positively charged long alkyl chains on Bi/C nanoparticle electrodes inhibited HER and improved the selectivity of CO_(2)RR to HCOOH.

关键词： acidic media CO_(2)electrolysis electrolyte additive hydrophobic interfacial microenvironment industrial-level current

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Huangqin Decoction Delays Progress of Colitis-Associated Carcinogenesis by Regulating Nrf2/HO-1 Antioxidant Signal Pathwayin Mice

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Chinese Journal of Integrative Medicine 2024年第2期30卷 135-142页

作者： GU Li-mei LI He-zhong GAO lei LI Hui WEI Lan-fu PAN Cheng-yu WU Ke-xuan tian Yao-zhou Department of Gastrointestinal Endoscopy Affiliated Hospital of Nanjing University of Chinese MedicineNanjing(210029)China Department of Gastroenterology Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing(210028)China School of Integrated Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing(210023)China

Objective:To investigate the effect of Huangqin Decoction(HQD)on nuclear factor erythroid 2 related-factor 2(Nrf2)/heme oxygenase(HO-1)signaling pathway by inducing the colitis-associated carcinogenesis(CAC)model mice with azoxymethane(AOM)/dextran sodium sulfate(DSS).Methods:The chemical components of HQD were analyzed by liquid chromatography-quadrupole-time-of-flight mass spectrometry(LC-Q-TOF-MS/MS)to determine the molecular constituents of *** 48 C57BL/6J mice were randomly divided into 6 groups by a random number table,including control,model(AOM/DSS),mesalazine(MS),low-,medium-,and high-dose HQD(HQD-L,HQD-M,and HQD-H)groups,8 mice in each *** for the control group,the mice in the other groups were intraperitoneally injected with AOM(10 mg/kg)and administrated with 2.5%DSS orally for 1 week every two weeks(totally 3 rounds of DSS)to construct a colitis-associated carcinogenesis mouse *** mice in the HQD-L,HQD-M and HQD-H groups were given HQD by gavage at doses of 2.925,5.85,and 11.7 g/kg,respectively;the mice in the MS group was given a suspension of MS at a dose of 0.043 g/kg(totally 11 weeks).The serum levels of malondialdehyde(MDA)and superoxide dismutase(SOD)were measured by enzyme-linked immunosorbent *** mRNA and protein expression levels of Nrf2,HO-1,and inhibitory KELCH like ECH-related protein 1(Keap1)in colon tissue were detected by quantitative real-time PCR,immunohistochemistry,and Westem blot,***:LC-Q-TOF-MS/MS analysis revealed that the chemical constituents of HQD include baicalin,paeoniflorin,and glycyrrhizic *** to the control group,significantly higher MDA levels and lower SOD levels were observed in the model group(P<0.05),whereas the expressions of Nrf2 and HO-1 were significantly decreased,and the expression of Keap1 increased(P<0.01).Compared with the model group,serum MDA level was decreased and SOD level was increased in the HQD-M,HQD-H and MS groups(P<0.05).Higher expressions of

关键词： Huangqin Decoction colitis-associated carcinogenesis nuclear factor erythroid 2 related-factor 2/heme oxygenase signaling pathway oxidative stress Chinese medicine

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De-biased knowledge distillation framework based on knowledge infusion and label de-biasing techniques

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Journal of Electronic Science and Technology 2024年第3期22卷 57-68页

作者： Yan Li Tai-Kang tian Meng-yu Zhuang yu-Ting Sun School of Economics and Management University of Electronic Science and Technology of ChinaChengdu611731China School of Economics and Management Beijing University of Posts and TelecommunicationBeijing100876China School of Electrical Engineering and Computer Science The University of QueenslandBrisbane4072Australia

Knowledge distillation,as a pivotal technique in the field of model compression,has been widely applied across various ***,the problem of student model performance being limited due to inherent biases in the teacher model during the distillation process still *** address the inherent biases in knowledge distillation,we propose a de-biased knowledge distillation framework tailored for binary classification *** the pre-trained teacher model,biases in the soft labels are mitigated through knowledge infusion and label de-biasing *** on this,a de-biased distillation loss is introduced,allowing the de-biased labels to replace the soft labels as the fitting target for the student *** approach enables the student model to learn from the corrected model information,achieving high-performance deployment on lightweight student *** conducted on multiple real-world datasets demonstrate that deep learning models compressed under the de-biased knowledge distillation framework significantly outperform traditional response-based and feature-based knowledge distillation models across various evaluation metrics,highlighting the effectiveness and superiority of the de-biased knowledge distillation framework in model compression.

关键词： De-biasing Deep learning Knowledge distillation Model compression

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Li-current collector interface in lithium metal batteries

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Nano Research 2024年第10期17卷 8706-8728页

作者： tian-yu Wang Dingyi Zhao Keyue Liang yuzhang Li Department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesLos AngelesCalifornia 90095USA

Interfaces within batteries,such as the widely studied solid electrolyte interface(SEI),profoundly influence battery *** these interfaces,the solid-solid interface between electrode materials and current collectors is crucial to battery performance but has received less discussion and *** review highlights the latest research advancements on the solid-solid interface between lithium metal(the next-generation anode)and current collectors(typically copper),focusing on factors affecting the Li-current collector interface and improvement strategies from perspectives of current collector substrate(lithiophilicity,crystal facets,mechanical properties,and topological structure),electrolyte chemistry,current density,stacking pressure,SEI,electric field and temperature,and provides a future directions and opportunities on this topic.

关键词： lithium metal anode current collectors Li-current collector interface solid-solid interface improvement strategies

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Evolution of MnO–SiO2–Al_(2)O_(3)–MgO inclusions during heat treatment at 1100℃

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Journal of Iron and Steel Research International 2024年第5期31卷 1221-1231页

作者： Xu-bo lei Jian-li Li Qiang Zeng Hang-yu Zhu yue yu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina

To investigate the evolutionary behavior of the MnO–SiO_(2)–Al_(2)O_(3)–MgO inclusions during heat treatment,water quenched samples were isothermally held at 1100°C for 120 min in Ar and air atmosphere,and the obtaining samples were analyzed by X-ray diffraction,scanning electron microscopy and energy dispersive *** showed that 3MnO·Al_(2)O_(3)·3SiO_(2)and MnO·SiO_(2)were detected in the 5 wt.%MgO system after isothermal holding in Ar atmosphere,while MgO·Al_(2)O_(3),MnO·SiO_(2)and Mn7O8·SiO4 were detected in air *** evolutionary behavior of the 10,15 and 20 wt.%MgO systems after isothermal holding in different atmosphere were *** affected the solid phase transformation of the low MgO content *** calculation results of FactSage 8.1 showed that MgO·Al_(2)O_(3)was formed in the 5 wt.%MgO system with air *** solid phase transformation was accompanied by grain coarsening during the isothermal holding *** differences in the solid phase transformation in different atmosphere of the 5 wt.%MgO system indicated that it was a gas-phase transport grain coarsening *** enrichment of Al element in the liquid phase region at the grain edges,the homogeneous distribution of Mg element and the disappearance of the liquid phase within the crystal revealed that other MgO content systems were liquid–solid transport grain coarsening mechanism.

关键词： Evolution Glassy phase Inclusion Heat treatment MgO·Al_(2)O_(3)

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Hydration lubrication modulated by water structure at TiO2–aqueous interfaces

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Friction 2024年第4期12卷 591-605页

作者： Pingsu MA yuan LIU Ke HAN yu tian Liran MA State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China

The nature of solid-liquid interfaces is of great significance in *** advances have been made in lubrication based on hydration ***,a detailed molecular-level understanding is still ***,we investigated water molecule behaviors at the TiO2-aqueous interfaces by the sum-frequency generation vibrational spectroscopy(SFG-VS)and atomic force microscope(AFM)to elucidate the fundamental role of solid-liquid interfaces in *** contributions of water structures and hydration effects were revealed,where water structures played the dominant role in lubrication for TiO2 surfaces of varying hydrophilicity,while hydration effects dominated with the increasing of ion *** lubrication is observed on the initial TiO2 surfaces with strongly H-bonded water molecules compared to the hydrophilic TiO2 surfaces with more disordered *** stable ordered water arrangement with strong hydrogen bonds and the shear plane occurring between the ordered water layer and subsequent water layer may play a significant role in achieving lower *** adsorbed hydrated molecules with the increasing ionic concentration perturb ordered water but lead to the enhancement of hydration effects,which is the main reason for the improved lubrication for both *** work provides more insights into the detailed molecular-level understanding of the mechanism of hydration lubrication.

关键词： hydration lubrication interfacial water structures hydration effects titanium dioxide(TiO2)

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MSADCN:Multi-Scale Attentional Densely Connected Network for Automated Bone Age Assessment

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Computers, Materials & Continua 2024年第2期78卷 2225-2243页

作者： Yanjun yu lei yu Huiqi Wang Haodong Zheng Yi Deng College of Computer and Information Science Chongqing Normal UniversityChongqing401331China College of Mathematics and Statistics Chongqing UniversityChongqing401331China

Bone age assessment(BAA)helps doctors determine how a child’s bones grow and develop in clinical *** BAA methods rely on clinician expertise,leading to time-consuming predictions and inaccurate *** deep learning-based BAA methods feed the extracted critical points of images into the network by providing additional *** operation is costly and *** address these problems,we propose a multi-scale attentional densely connected network(MSADCN)in this *** constructs a multi-scale dense connectivity mechanism,which can avoid overfitting,obtain the local features effectively and prevent gradient vanishing even in limited training ***,MSADCN designs multi-scale structures in the densely connected network to extract fine-grained features at different ***,coordinate attention is embedded to focus on critical features and automatically locate the regions of interest(ROI)without additional *** addition,to improve the model’s generalization,transfer learning is applied to train the proposed MSADCN on the public dataset IMDB-WIKI,and the obtained pre-trained weights are loaded onto the Radiological Society of North America(RSNA)***,label distribution learning(LDL)and expectation regression techniques are introduced into our model to exploit the correlation between hand bone images of different ages,which can obtain stable age *** experiments confirm that our model can converge more efficiently and obtain a mean absolute error(MAE)of 4.64 months,outperforming some state-of-the-art BAA methods.

关键词： Bone age assessment deep learning attentional densely connected network muti-scale

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Selective adsorption of tetracycline by β-CD-immobilized sodium alginate aerogel coupled with ultrafiltration for reclaimed water

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Chinese Journal of Chemical Engineering 2024年第4期68卷 27-34页

作者： Xi Quan Jun Zhang Linlin Yin Wei Zuo yu tian State Key Laboratory of Urban Water Resource and Environment(SKLUWRE) School of EnvironmentHarbin Institute of TechnologyHarbin 150090China

In this work,a novel composite material based on β-cyclodextrin-immobilized sodium alginate aerogel(β-CD/NaAlg) was developed utilizing cross-linker of epichlorohydrin and applied as an adsorbent to remove tetracycline antibiotics from reclaimed wastewater.A series of characterizations were utilized to confirm the successful synthesis of the adsorbent and this β-CD/NaAlg presented a three-dimensional network at the nanoscale or *** optimal conditions(pH=4,t=8 h,β-CD:NaAlg=9,adsorbent dosage = 1.5 g·L-1),the maximum removal rate of β-CD/NaAlg to tetracycline was 70%.The adsorption behavior of tetracycline on β-CD/NaAlg conformed to the Freundlich isotherm model(R2=0.9977) and the pseudo-second-order kinetic model(R^(2)=0.9993).Moreover,the adsorbent still removed 55.3% of tetracycline after five ***,the adsorbent was integrated with ultrafiltration to adsorb tetracycline antibiotics from simulated reclaimed wastewater,and the removal rate of tetracycline reached 78.9% within 2 *** existence of Cr(Ⅵ) had a negligible impact on tetracycline removal,while the presence of humic acid exhibited a promoting *** possible adsorption mechanisms were also elucidated through X-ray photoelectron spectroscopy and density functional theory *** summary,β-CD/NaAlg represents an environmentally friendly,efficient,and sustainable adsorbent for removing tetracycline antibiotics from reclaimed water.

关键词： b-CD/NaAlg aerogel Covalent grafting Tetracycline antibiotics Ultrafiltration Selective adsorption Reclaimed water

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