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NOX4 promotes tumor progression through the MAPK-MEK1/2-ERK1/2 axis in colorectal cancer

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1421-1436页

作者： yu-Jie Xu Ya-Chang Huo Qi-Tai Zhao Jin-Yan Liu Yi-Jun tian lei-lei Yang Yi Zhang Biotherapy Center and Cancer Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Oncology Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhou 450003Henan ProvinceChina

BACKGROUND Metabolic reprogramming plays a key role in cancer progression and clinical outcomes;however,the patterns and primary regulators of metabolic reprogramming in colorectal cancer(CRC)are not well *** To explore the role of nicotinamide adenine dinucleotide phosphate oxidase 4(NOX4)in promoting progression of *** We evaluated the expression and function of dysregulated and survival-related metabolic genes using Gene Ontology and Kyoto Encyclopedia of Genes and *** clustering was used to cluster CRC based on dysregulated metabolic genes.A prediction model was constructed based on survival-related metabolic *** formation,migration,invasion,proliferation,apoptosis and clone formation was used to evaluate the biological function of NOX4 in *** sequencing was utilized to explore the alterations of gene expression NOX4 over-expression tumor *** vivo subcutaneous and lung metastasis mouse tumor model was used to explore the effect of NOX4 on tumor *** We comprehensively analyzed 3341 metabolic genes in CRC and identified three clusters based on dysregulated metabolic *** these genes,NOX4 was highly expressed in tumor tissues and correlated with worse *** vitro,NOX4 overexpression induced clone formation,migration,invasion,and stemness in CRC ***,RNA-sequencing analysis revealed that NOX4 overexpression activated the mitogen-activated protein kinase-MEK1/2-ERK1/2 signaling ***,a MEK1/2 inhibitor,abolished the NOX4-mediated tumor *** vivo,NOX4 overexpression promoted subcutaneous tumor growth and lung metastasis,whereas trametinib treatment can reversed the *** Our study comprehensively analyzed metabolic gene expression and highlighted the importance of NOX4 in promoting CRC metastasis,suggesting that trametinib could be a potential therapeutic drugs of CRC clinical therapy targeting NOX4.

关键词： Colorectal cancer Metabolic reprogramming Metastasis Nicotinamide adenine dinucleotide phosphate oxidase 4 Mitogen-activated protein kinase signaling

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Fracture geometry and breakdown pressure of radial borehole fracturing in multiple layers

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Petroleum Science 2024年第1期21卷 430-444页

作者： yu-Ning Yong Zhao-Quan Guo Shou-Ceng tian Lu-Yao Ma tian-yu Wang Mao Sheng National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China Beijing Petroleum Machinery Company Limited CNPC Engineering Technology R&D Company LimitedBeijing102206China Smart Energy Co. LtdChina Xiongan GroupXiong’an New Area071000HebeiChina

Radial borehole fracturing that combines radial boreholes with hydraulic fracturing is anticipated to improve the output of tight oil and gas *** paper aims to investigate fracture propagation and pressure characteristics of radial borehole fracturing in multiple layers.A series of laboratory experiments with artificial rock samples(395 mm×395 mm×395 mm)was conducted using a true triaxial fracturing *** crucial factors corresponding to the vertical distance of adjacent radial borehole layers(vertical distance),the azimuth and diameter of the radial borehole are *** results show that radial borehole fracturing in multiple layers generates diverse fracture *** types of fractures are identified based on the connectivity between hydraulic fractures and radial *** vertical distance significantly influences fracture propagation perpendicular to the radial borehole *** increase in the vertical distance impedes fracture connection across multiple radial borehole layers and reduces the fracture propagation distance along the radial borehole *** azimuth also influences fracture propagation along the radial borehole *** the azimuth reduces the guiding ability of radial boreholes,which makes the fracture quickly curve to the maximum horizontal stress *** breakdown pressure correlates with diverse fracture geometries *** the fractures connect multi-layer radial boreholes,increasing the vertical distance decreases the breakdown *** the azimuth and increasing the diameter also decrease the breakdown *** extrusion force exists between the adjacent fractures generated in radial boreholes in multiple rows,which plays a crucial role in enhancing the guiding ability of radial boreholes and results in higher breakdown *** research provides valuable theoretical insights for the field application of radial borehole fracturing technology in tight oil and g

关键词： Multi-layer radial boreholes Hydraulic fracturing Fracture propagation Pressure characteristic

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Characteristics of a pre-combustion plasma jet igniter

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Chinese Journal of Aeronautics 2024年第7期37卷 178-189页

作者： Jinlu yu Baowen ZHANG Yang yu Bingbing ZHAO lei ZHANG Aviation Engineering School Air Force Engineering UniversityXi’an 710038China Equipment Management and Unmanned Aerial Vehicle Engineering School Air Force Engineering UniversityXi’an 710038China

Plasma ignition technology has delivered good performance in the aerospace industry. In this study, a pre-combustion plasma jet igniter was designed, and its characteristics were examined from three aspects: the morphology, temperature, and discharge characteristics and process of ignition. Images of the OH distribution were obtained by using an OH Planar Laser-Induced Fluorescence(OH-PLIF) experimental system. Results have shown that the proposed plasma jet had a higher OH concentration, longer length, and larger area than those of a traditional igniter. The stability of discharge of the igniter was improved as the equivalence ratio φ was increased, and reducing gas flow reduced the pulsation of the plasma jet. When the input current was increased from 15A to 35 A, the highest average temperature increased from 5127 K to 7987 K. An increase in the equivalence ratio reduced the region of arc ionization, but expanded the regions of the core combustion reaction and the outer flame. Herein, this study has obtained a deep understanding of the jet and ignition law and developed a new idea for the application of plasma in the ignition field.A pre-combustion plasma jet igniter can significantly improve the efficiency of ignition and shorten the ignition process compared with a traditional igniter.

关键词： Pre-combustion plasma igniter Plasma Jet temperature field Ignition process Arc Flame

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Deep kernel extreme learning machine classifier based on the improved sparrow search algorithm

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The Journal of China Universities of Posts and Telecommunications 2024年第3期31卷 15-29页

作者： Zhao Guangyuan lei yu School of Automation Xi'an University of Posts and TelecommunicationsXi'an 710000China

In the classification problem,deep kernel extreme learning machine(DKELM)has the characteristics of efficient processing and superior performance,but its parameters optimization is *** improve the classification accuracy of DKELM,a DKELM algorithm optimized by the improved sparrow search algorithm(ISSA),named as ISSA-DKELM,is proposed in this *** at the parameter selection problem of DKELM,the DKELM classifier is constructed by using the optimal parameters obtained by ISSA *** order to make up for the shortcomings of the basic sparrow search algorithm(SSA),the chaotic transformation is first applied to initialize the sparrow ***,the position of the discoverer sparrow population is dynamically adjusted.A learning operator in the teaching-learning-based algorithm is fused to improve the position update operation of the ***,the Gaussian mutation strategy is added in the later iteration of the algorithm to make the sparrow jump out of local *** experimental results show that the proposed DKELM classifier is feasible and effective,and compared with other classification algorithms,the proposed DKELM algorithm aciheves better test accuracy.

关键词： deep kernel extreme learning machine(DKELM) improved sparrow search algorithm(ISSA) classifier parameters optimization

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Chord length sampling correction analysis for dispersion fuel in Monte Carlo simulation

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Nuclear Science and Techniques 2024年第4期35卷 57-64页

作者： Zhao-yu Liang Ding She yu-Tong Wen lei Shi Institute of Nuclear and New Energy Technology(INET) Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of EducationTsinghua UniversityBeijing 100084China

Dispersion fuels,knowned for their excellent safety performance,are widely used in advanced reactors,such as hightemperature gas-cooled *** with deterministic methods,the Monte Carlo method has more advantages in the geometric modeling of stochastic *** explicit modeling method has high computational accuracy and high computational *** chord length sampling(CLS)method can improve computational efficiency by sampling the chord length during neutron transport using the matrix chord length?s probability density *** study shows that the excluded-volume effect in realistic stochastic media can introduce certain deviations into the CLS.A chord length correction approach is proposed to obtain the chord length correction factor by developing the Particle code based on equivalent transmission *** numerical analysis against reference solutions from explicit modeling in the RMC code,it was demonstrated that CLS with the proposed correction method provides good accuracy for addressing the excludedvolume effect in realistic infinite stochastic media.

关键词： Stochastic media Monte Carlo Chord length sampling Excluded-volume effect Chord length correction

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Cage-confinement synthesis of MoC nanoclusers as efficient sulfiphilic and lithiophilic regulator for superior Li–S batteries

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Rare Metals 2024年第2期43卷 624-634页

作者： Xing-yuan Zhang Mei-Na lei Shan tian Jian-Gan Wang State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene(NPU)Xi’an710072China

High-energy-density Li-S batteries are subjected to serious sulfur deactivation and short cycle lifetime caused by undesirable polysulfide shuttle effect and frantic lithium dendrite *** this work,a controllable cage-confinement strategy to fabricate molybdenum carbide(MoC)nanoclusters as a high-efficient sulfiphilic and lithiophilic regulator to mitigate the formidable issues of Li-S batteries is *** sub-2 nm MoC nanoclusters not only guarantee robust chemisorption and fast electrocatalytic conversion of polysulfides to enhance the sulfur electrochemistry,but also homogenize Li^(+) flux to suppress the lithium dendrite *** a consequence,the MoC-modified separator endows the batteries with boosted reaction kinetics,promoted sulfur utilization,and improved cycling stability.A reversible capacity of 701 mAh·g^(−1) at a high rate of 5.0C and a small decay rate of 0.076%per cycle at 1.0C over 600 cycles are *** study offers a rational route for design and synthesis of bifunctional nanoclusers with both sulfiphilicity and lithiophilicity for high-performance Li-S batteries.

关键词： Li-S batteries Nanocluster Electrocatalyst Polysulfide shuttle Li dendrites

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Development and evaluation of an online monitoring single-particle optical particle counter with polarization detection

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Journal of Environmental Sciences 2024年第4期138卷 585-596页

作者： Weijie Yao Xiaole Pan yu tian Hang Liu yuting Zhang Shandong lei Junbo Zhang Yinzhou Zhang LinWu Yele Sun Zifa Wang State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China

We developed a single-particle optical particle counter with polarization detection(SOPC)for the real-time measurement of the optical size and depolarization ratio(defined as the ratio of the vertical component to the parallel component of backward scattering)of atmospheric particles,the polarization ratio(DR)value can reflect the irregularity of the *** SOPC can detect aerosol particles with size larger than 500 nm and the maximum particle count rate reaches~1.8×10^(5)particles per *** SOPC uses a modulated polarization laser to measure the optical size of particles according to forward scattering signal and the DR value of the particles by backward S and P signal *** sampling rate of the SOPC was 106#/(sec·channel),and all the raw data were processed *** calibration curve was obtained by polystyrene latex spheres with sizes of 0.5-10μm,and the average relative deviation of measurement was 3.96% for sub 3μm particles.T-matrix method calculations showed that the DR value of backscatter light at 120°could describe the variations in the aspect ratio of particles in the above size *** performed insitu observations for the evaluation of the SOPC,the mass concentration constructed by the SOPC showed good agreement with the PM_(2.5)measurements in a nearby state-controlled monitoring *** instrument could provide useful data for source appointment and regulations against air pollution.

关键词： Instrument development Single particle detection Measurement uncertainty Optical simulation Mass concentration

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Photo-induced grease/oil switched lubricant for friction regulation

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Friction 2024年第8期12卷 1696-1706页

作者： Zheng ZHANG Shuangxi TANG Liran MA yu tian State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China

Controllable friction regulation has drawn much interest in both scientific and industrial *** there have been many researches on friction regulation by many physical fields and chemical ***-sensitive materials are promising because it is relatively easy to change their properties compared with ***,a new kind of photo-induced grease/oil switched lubricant is designed and shows great reversibility under ultraviolet(UV)and visible(Vis)*** viscosity can change more than 50 times under different irradiation,and the coefficients of friction(COFs)obviously increase under Vis irradiation and decrease under UV irradiation,which performs better than those of the common *** to the experimental results,the phenomena are contributed to the break and reconstruction of the three-dimensional network inside the *** a switchable grease/oil state under different irradiation,this work provides a new principle for designing a smart lubricant with controllable friction regulation.

关键词： photo-induced spiropyran switched lubricant friction regulation

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Photoinduced superlubricity on TiO_(2) surfaces

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Friction 2024年第3期12卷 428-438页

作者： Ke HAN Liran MA yu tian Jianbin LUO State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China Received:16 September 2022/Revised:28 October 2022/Accepted:27 December 2022The author(s)2022.

Superlubricity control is of great interest in both industry and scientific research,and several methods have been proposed to achieve this *** this work,ultraviolet(UV)light was introduced into titanium dioxide(TiO_(2))and silicon nitride(Si_(3)N_(4))tribosystems to accomplish photoinduced *** friction coefficients(COFs)between Si_(3)N_(4) balls and TiO_(2) plates in the mixtures of sulfuric acid(H^(2)SO_(4))solution and glycerol solution were obviously reduced,and the system entered the superlubricity region(COF<0.01)after UV illumination at a speed of 56 mm/***,the COF was much larger without UV treatment than that with UV *** formation of silica(SiO_(2))layers on the surfaces of Si_(3)N_(4) balls and the elastohydrodynamic effects were determined to be fundamental to the low friction in this experiment,and the enhancement of the combination between the TiO_(2) surface and the hydroxy group of glycerol by UV illumination was the key to the photoinduced superlubricity in this *** findings showed one method for achieving superlubricity by introducing a light field that could be further applied to special working conditions.

关键词： light control friction superlubricity glycerol titanium dioxide(TiO_(2))

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Molecules for COVID-19 treatment

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Chinese Chemical Letters 2024年第7期35卷 59-65页

作者： Zhigang Zeng Changzhou Liao lei yu Hubei Key Laboratory of Radiation Chemistry and Functional Materials School of Nuclear Technology and Chemistry&BiologyHubei University of Science and TechnologyXianning 437100China Hubei Industry Technology Research Institute of Intelligent Health Xianning 437100China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China

COVID-19 is a major event with worldwide *** the beginning of the epidemic,pharmaceutical chemists have paid attention to the therapeutic effect of a variety of small molecule medicines on COVID-19 infection.A series of organic molecules are designed and found to be effective in the treatment of COVID-19 *** fact,no matter how effective they are,with the development of the COVID-19 epidemic,various small molecule medicines are gradually recognized by *** is equivalent to a good science popularization of pharmaceutical *** review aims to introduce the molecules for COVID-19 treatment on the basis of their chemical structures,synthetic methods as well as their effects.

关键词： COVID-19 Small molecule medicines "Star"drugs Chemical structure Synthetic method

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