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Sex modulates the outcome of subthalamic nucleus deep brain stimulation in patients with Parkinson's disease

Neural Regeneration Research 2023年第4期18卷 901-907页

作者： tian-Shuo yuan Ying-Chuan Chen De-Feng Liu Ruo-yu Ma Xin Zhang Ting-Ting du Guan-yu Zhu Jian-Guo Zhang Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Functional Neurosurgery Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Beijing Key Laboratory of Neurostimulation BeijingChina

There are many documented sex differences in the clinical course,symptom expression profile,and treatment response of Parkinson’s disease,creating additional challenges for patient *** subthalamic nucleus deep brain stimulation is an established therapy for Parkinson’s disease,the effects of sex on treatment outcome are still *** aim of this retrospective observational study,was to examine sex differences in motor symptoms,nonmotor symptoms,and quality of life after subthalamic nucleus deep brain *** measures were evaluated at 1 and 12 months post-operation in 90 patients with Parkinson’s disease undergoing subthalamic nucleus deep brain stimulation aged 63.00±8.01 years(55 men and 35 women).Outcomes of clinical evaluations were compared between sexes via a Student’s t-test and within sex via a paired-sample t-test,and generalized linear models were established to identify factors associated with treatment efficacy and intensity for each *** found that subthalamic nucleus deep brain stimulation could improve motor symptoms in men but not women in the on-medication condition at 1 and 12 months *** legs syndrome was alleviated to a greater extent in men than in *** demonstrated poorer quality of life at baseline and achieved less improvement of quality of life than men after subthalamic nucleus deep brain ***,Hoehn-Yahr stage was positively correlated with the treatment response in men,while levodopa equivalent dose at 12 months post-operation was negatively correlated with motor improvement in *** conclusion,women received less benefit from subthalamic nucleus deep brain stimulation than men in terms of motor symptoms,non-motor symptoms,and quality of *** found sex-specific factors,i.e.,Hoehn-Yahr stage and levodopa equivalent dose,that were related to motor *** findings may help to guide subthalamic nucleus deep brain stimulation patient selection,progn

关键词： chronic effect deep brain stimulation generalized linear model initial effect motor symptoms non-motor symptoms Parkinson’s disease quality of life sex subthalamic nucleus

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Influence of particulate morphology on microstructure and tribological properties of cold sprayed A380/Al2O3 composite coatings

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Journal of Materials Science & Technology 2020年第9期44卷 9-18页

作者： Xiang Qiu Naeem ul Haq Tariq Lu Qi Jun-Rong Tang Xin-yu Cui Hao du Ji-Qiang Wang tian-Ying Xiong Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Department of Metallurgy and Materials Engineering Pakistan Institute of Engineering and Applied SciencesNiloreIslamabadPakistan

In this study,three kinds of A380/Al2O3 composite coatings were prepared by cold spray(CS)using spherical,irregular and spherical+irregular shaped Al2O3 particulates separately mixed in the original A380 alloy *** influence of Al2O3 particulates’morphology on the microstructural characteristics(*** of Al2O3 content in coatings,coating/matrix interfacial bonding,pore size distribution and morphology etc.)and wear performance of the coatings was investigated by scanning electron microscopy(SEM),X-ray computed tomography(XCT)and 3-D optical *** indicated that the spherical Al2O3 showsobvious tamping effect during deposition *** a result,the interfaceshowedawavy shape while the matrix and particulates were mechanical interlocked with much improved *** addition,the porosity of the coating was minimized and the pores exhibited curved spherical structure with reduced *** irregular Al2O3 particles predominantly displayed the embedding effect together with fragmentation of Al2O3 ***,poor coating/matrix interfacial bonding,high porosity and the formation of angular-shaped pores were resulted in the *** sliding wear tests results revealed that the wear resistance of the coating is directly related with the retained content of Al2O3 in the *** coating containing irregular Al2O3 particulates displayed superior wear performance with its wear rate one seventh of that of the pure A380 alloy *** coating containing both kinds of Al2O3 particulates showed mixed characteristics of above two kinds of Al2O3 composite coatings.

关键词： Cold spray Al2O3 particulates X-ray computed tomography Wear test

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The Analysis of Impact of Brexit on the Post-Brexit EU Using Intervented Multivariate Time Series

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Acta Mathematicae Applicatae Sinica 2021年第3期37卷 441-458页

作者： yu tian Shao-pei MA Rong-xiang RUI Zhen yu Mao-zai tian Institute for Diplomacy and International Governance Loughborough University LondonE203BSUK Center for Applied Statistics School of StatisticsRenmin University of ChinaBeijing 100872China College of Medical Engineering and Technology Xinjiang Medical UniversityUrumqi 830011China School of Statistics and Data Science Xinjiang University of Finance and EconomicsUrumqi 830012China School of Statistics Lanzhou University of Finance and EconomicsLanzhou 730101China

The UK is the most important partner of the EU in terms of economic and other fields due to the geographical *** was one of the largest economies in the EU and its per capita income is higher than the EU average,so it is a net contributor to the *** UKs membership of the EU ended on 31 January 2019,there are concerns that the Brexit may have a significant impact on the EU,resulting in social,economic,political,and institutional changes,*** *** the impact of Brexit on the UK has always been the subject of considerable scholarly interest in recent years,there is relatively little literature on the impact of Brexit on the *** paper focuses on the evaluation of the impact of Brexit on the EU economy and other relevant aspects along three dimensions:GDP,PPP,Quarterly GDP *** powerful quantitative analysis technology that includes vector autoregression model,multivariate time series model with intervention variables,and autoregression integrated moving average,this paper obtains the important and novel evidence about the potential impact of Brexit on the EU economy,pointing out that Brexit is of far-reaching significance to the *** analysis uses several statistical models to screen out several key influencing factors,which can be used to predict the total GDP of EU in the next five *** results show that EU economy will react negatively to"no-deal"Brexit,and its growth rate of economy will slow down significantly in next 5 ***,we put forward relevant policy suggestions on how to deal with the negative impact of Brexit on EU.

关键词： intervention multivariate time series model Brexit economy gaping Brexit hole no-deal Brexit post-Brexit EU

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Structure Regulation of Electric Double Layer via Hydrogen Bonding Effect to Realize High-Stability Lithium-Metal Batteries

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Energy & Environmental Materials 2024年第3期7卷 72-83页

作者： Sheng Liu Chaozhu Shu yu Yan Dayue du Longfei Ren Ting Zeng Xiaojuan Wen Haoyang Xu Xinxiang Wang Guilei tian Ying Zeng College of Materials and Chemistry&Chemical Engineering Chengdu University of Technology1#DongsanluErxianqiaoChengdu 610059China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 611731China State Key Laboratory of Polymer Materials Engineering Polymer Research InstituteSichuan UniversityChengdu 610065China

The interfacial chemistry of solid electrolyte interphases(SEI)on lithium(Li)electrode is directly determined by the structural chemistry of the electric double layer(EDL)at the ***,a strategy for regulating the structural chemistry of EDL via the introduction of intermolecular hydrogen bonds has been proposed(p-hydroxybenzoic acid(pHA)is selected as proof-of-concept).According to the molecular dynamics(MD)simulation and density functional theory(DFT)calculation results,the existence of hydrogen bonds realizes the anion structural rearrangement in the EDL,reduces the lowest unoccupied molecular orbital(LUMO)energy level of anions in the EDL,and the number of free solvent molecules,which promotes the formation of inorganic species-enriched SEI and eventually achieves the dendrite-free Li *** on this strategy,Li‖Cu cells can stably run over 185 cycles with an accumulated active Li loss of only 2.27 mAh cm^(-2),and the long-term cycle stability of Li‖Li cells is increased to 1200 *** addition,the full cell pairing with the commercial LiFePO_(4)(LFP)cathodes exhibits stable cycling performance at 1C,with a capacity retention close to 90%after 200 cycles.

关键词： electric double layer electrolyte additives intermolecular hydrogen bonds Li metal batteries p-Hydroxybenzoic acid

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Hydrothermal Synthesis and Structure of a New Two-dimensional Zincophosphite: Zn_2(HPO_3)_3·H_2DACH(DACH = 1,2-diaminocyclohexane)

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Chinese Journal of Structural Chemistry 2004年第8期23卷 850-854页

作者： PANJian-Xin ZHENGShou-tian YANGGuo-yu StateKeyLaboratoryofStructuralChemistry FujianInstituteofResearchontheStructureofMatter TheChineseAcademyofSciencesFuzhouFujian350002China

A new open-framework zincophosphite, Zn2(HPO3)3H2DACH 1, was hydro- thermally synthesized in the presence of 1,2-diaminocyclohexane (DACH) as structure-directing agent. Its structure was determined by single-crystal X-ray diffraction and further characterized by FTIR, elemental analysis, powder X-ray diffraction and thermogravimetric analysis. Crystal data for 1: Mr = 486.88, monoclinic, space group P21/c with a = 10.2287(11), b = 9.7624(11), c = 16.1686(18) , b = 92.573(2), V = 1612.9(3) 3, Z = 4, Dc = 2.005 g/cm3, F(000) = 984, = 3.314 mm-1 and S = 1.152. The final R = 0.0473 and wR = 0.1121 for 2456 observed reflections with I > 2s(I). The inorganic layer consisting of four- and eight-membered rings is constructed of alternating ZnO4 tetrahedra and HPO3 pseudo pyramids by sharing vertices. The organic template molecules reside in the interlayer region and interact with the inorganic network through H-bonds.

关键词： zincophosphite hydrothermal synthesis crystal structure open-framework

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In memoriam:Shizhu Wen(1932-2023)

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Friction 2024年第7期12卷 1341-1346页

作者： Jianbin LUO Yonggang MENG yu tian State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China

Professor Shizhu Wen,the winner of the 2015 Tribology Gold Medal,passed away due to illness on November 3,2023,at the age of *** was a professor of Tsinghua University,an academician of the Chinese Academy of Sciences,and the Honorary President of the Chinese Tribology Institute(CTI)from 1997 to *** Wen was born in 1932 in Jiangxi Province of China and graduated from Tsinghua University in 1955,where he was awarded the Outstanding Graduate Gold Medal and then remained as an assistant professor at the *** Wen was promoted to full professor in *** had undertaken tribology research at the Imperial College London in 1979 and *** 1985,he presided over the establishment of the State Key Laboratory of Tribology(SKLT)of Tsinghua University and served as the first director of the SKLT.

关键词： sided professor zhu

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Luminescence properties of Pr^(3+) and Bi^(3+) co-doped NaCaTiNbO_6 phosphor for red-LEDs

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Journal of Rare Earths 2018年第3期36卷 243-247页

作者： Di Xu Panlong yu Lianhua tian Department of Physics Yanbian University

This paper investigates the photoluminescence properties of NaCaTiNbO6：Pr^3＋ and NaCaTiNbO6：Pr^3＋,Bi^3＋ phosphors. NaCaTiNbO6：Pr^3＋ and NaCaTiNbO6：Pr^3＋,Bi^3＋ powder were synthesized successfully by solid state reaction method. Phase purity was checked using X-ray powder diffractometry（XRD）. The excitation and emission spectra were recorded to elucidate the photoluminescence properties of NaCaTiNbO6：Pr^3＋ and NaCaTiNbO6：Pr^3＋,Bi^3＋. Furthermore,fluorescence lifetime measurements were performed. The excitation spectra of NaCaTiNbO6：Pr^3＋ show a main band centered at around 357 *** luminescence spectra of NaCaTiNbO6：Pr^3＋ exhibit a red emission peak at 615 nm from the ^1 D2→^3 H4 transition of Pr^3＋ ions. With the introduction of the Bi^3＋ ion into NaCaTiNbO6：Pr^3＋, the luminescence intensity is enhanced nearly two times. Meanwhile,the absorption band edge of NaCaTiNbO6：Pr^3＋ is shifted from 380 to 420 nm. Thus, this study shows that the red phosphor NaCaTiNbO6：Pr^3＋ incorporated with Bi^3＋ is advantageous for light-emitting diode applications.

关键词： Optical materials Luminescence Phosphors Rare earths

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Mitochondrial transplantation as a promising therapy for mitochondrial diseases

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1028-1035页

作者： tian-guang Zhang Chao-yu Miao Department of Pharmacology Second Military Medical University/Naval Medical UniversityShanghai 200433China

Mitochondrial diseases are a group of inherited or acquired metabolic disorders caused by mitochondrial dysfunction which may affect almost all the organs in the body and present at any ***,no satisfactory therapeutic strategies have been available for mitochondrial diseases so *** transplantation is a burgeoning approach for treatment of mitochondrial diseases by recovery of dysfunctional mitochondria in defective cells using isolated functional *** models of mitochondrial transplantation in cells,animals,and patients have proved effective via various routes of mitochondrial *** review presents different techniques used in mitochondrial isolation and delivery,mechanisms of mitochondrial internalization and consequences of mitochondrial transplantation,along with challenges for clinical *** some unknowns and challenges,mitochondrial transplantation would provide an innovative approach for mitochondrial medicine.

关键词： Mitochondria Mitochondrial transplantation Mitochondrial disease Mitochondrial isolation Mitochondrial delivery Mitochondrial storage Mitochondrial transplantation rejection Ethical issue

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Fracture geometry and breakdown pressure of radial borehole fracturing in multiple layers

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Petroleum Science 2024年第1期21卷 430-444页

作者： yu-Ning Yong Zhao-Quan Guo Shou-Ceng tian Lu-Yao Ma tian-yu Wang Mao Sheng National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China Beijing Petroleum Machinery Company Limited CNPC Engineering Technology R&D Company LimitedBeijing102206China Smart Energy Co. LtdChina Xiongan GroupXiong’an New Area071000HebeiChina

Radial borehole fracturing that combines radial boreholes with hydraulic fracturing is anticipated to improve the output of tight oil and gas *** paper aims to investigate fracture propagation and pressure characteristics of radial borehole fracturing in multiple layers.A series of laboratory experiments with artificial rock samples(395 mm×395 mm×395 mm)was conducted using a true triaxial fracturing *** crucial factors corresponding to the vertical distance of adjacent radial borehole layers(vertical distance),the azimuth and diameter of the radial borehole are *** results show that radial borehole fracturing in multiple layers generates diverse fracture *** types of fractures are identified based on the connectivity between hydraulic fractures and radial *** vertical distance significantly influences fracture propagation perpendicular to the radial borehole *** increase in the vertical distance impedes fracture connection across multiple radial borehole layers and reduces the fracture propagation distance along the radial borehole *** azimuth also influences fracture propagation along the radial borehole *** the azimuth reduces the guiding ability of radial boreholes,which makes the fracture quickly curve to the maximum horizontal stress *** breakdown pressure correlates with diverse fracture geometries *** the fractures connect multi-layer radial boreholes,increasing the vertical distance decreases the breakdown *** the azimuth and increasing the diameter also decrease the breakdown *** extrusion force exists between the adjacent fractures generated in radial boreholes in multiple rows,which plays a crucial role in enhancing the guiding ability of radial boreholes and results in higher breakdown *** research provides valuable theoretical insights for the field application of radial borehole fracturing technology in tight oil and g

关键词： Multi-layer radial boreholes Hydraulic fracturing Fracture propagation Pressure characteristic

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Martian Thermosphere Response to Solar Flares:MAVEN NGIMS Observations

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Research in Astronomy and Astrophysics 2023年第5期23卷 190-197页

作者： Zi-Chuan Li yu-tian Cao National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Planetary Environmental and Astrobiological Research Laboratory(PEARL) School of Atmospheric SciencesSun Yat-Sen UniversityZhuhai 519082China

The solar flare is a sudden eruptive solar phenomenon with significant enhancements in solar X-ray and Extreme Ultraviolet radiations,resulting in large amounts of energy being injected into the planetary *** studies have been extensively presented to analyze the effect of extremely large flares on the Martian upper atmosphere,but the general features of the Martian thermospheric response to flares are still poorly *** this work,we select 12 intense solar flares that occurred between 2015 and 2017 and investigate the densities and compositional variations of the dayside Martian thermosphere to these flares with the aid of the measurements made by the Mars Atmosphere and Volatile *** statistical studies indicate that the responses of the Martian thermosphere to flares are complicated that both the class of the flare and the wavelength of the enhanced radiation may have prominent influences on the thermal expansion of the atmosphere and the atmospheric photochemical reactions.

关键词： Sun flares-planets and satellites atmospheres-planets and satellites individual(Mars)

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