检索结果-南通市图书馆

Impact of Sheath Boundary Conditions and Magnetic Flutter on Evolution and Distribution of Transient Particle and Heat Fluxes in the Edge-Localized Mode Burst by Experimental Advanced Superconducting Tokamak Simulation

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2019年第4期36卷 51-55页

作者： Yan-Bin Wu tian-yang xia Fang-Chuan Zhong Bin Gui EAST Team College of Science Donghua UniversityShanghai 201620 School of Physics and Electronic Engineering Anqing Normal UniversityAnqing 246133 Institute of Plasma Physics Chinese Academy of SciencesHefei 230031 不详

To study the evolution and distribution of the transient particle and heat fluxes during the edge-localized modes(ELMs) burst on the experimental advanced superconducting tokamak(EAST), the BOUT++six-field two-fluid model with sheath boundary conditions(SBCs) and magnetic flutter terms in the parallel thermal conduction is used to simulate the evolution of the profiles and growing process of the fluxes at divertor targets. Although SBCs hardly play a role in the linear phase, in the nonlinear phase both SBCs and magnetic flutter can change the dominant toroidal mode. SBCs are able to broaden the frequency distribution of the turbulence. The magnetic flutter increases the ELM size from 2.8% to 8.4%, and it doubles the amplitudes of the radial heat and particle transport coefficients at outer midplane(OMP), at around 1.0 m^2 s^(-1). It is then able to increase the particle and heat flux at the divertor targets and to broaden the radial distribution of the parallel heat flux towards the targets.

关键词： evolution distribution conditions

Immune landscape and response to oncolytic virus-based immunotherapy

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2024年第3期18卷 411-429页

作者： Chaolong Lin Wenzhong Teng yang tian Shaopeng Li Ningshao xia Chenghao Huang State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratoryDepartment of Laboratory MedicineSchool of Public HealthXiamen UniversityXiamen361102China National Institute of Diagnostics and Vaccine Development in Infectious Diseases State Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsXiamen UniversityXiamen361102China

Oncolytic virus(OV)-based immunotherapy has emerged as a promising strategy for cancer treatment,offering a unique potential to selectively target malignant cells while sparing normal ***,the immunosuppressive nature of tumor microenvironment(TME)poses a substantial hurdle to the development of OVs as effective immunotherapeutic agents,as it restricts the activation and recruitment of immune *** review elucidates the potential of OV-based immunotherapy in modulating the immune landscape within the TME to overcome immune resistance and enhance antitumor immune *** examine the role of OVs in targeting specific immune cell populations,including dendritic cells,T cells,natural killer cells,and macrophages,and their ability to alter the TME by inhibiting angiogenesis and reducing tumor ***,we explore strategies to optimize OV-based drug delivery and improve the efficiency of OV-mediated *** conclusion,this review offers a concise and comprehensive synopsis of the current status and future prospects of OV-based immunotherapy,underscoring its remarkable potential as an effective immunotherapeutic agent for cancer treatment.

关键词： oncolytic virus immunotherapy immunotherapeutic agents immune landscape

Recent Advance in Electrocatalytic Water Splitting for Hydrogen Production by Layered Double Hydroxides

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2024年第4期40卷 577-589页

作者： xia tian REN Qinghui yang Jiangrong LI Zhenhua SHAO Mingfei DUAN Xue State Key Laboratory of Chemical Resource Engineering College of ChemistryBeijing University of Chemical TechnologyBeijing100029P.R.China Quzhou Institute for Innovation in Resource Chemical Engineering Quzhou324000P.R.China

Collecting green hydrogen(H2)from water splitting driven by renewable energy is a new competition to implement the construction of H2 energy industry and promote new economic growth for global *** common strategy to enhance the efficiency of H2 production is to reduce the potential of electrolytic cell that is the mainstream way to prepare efficient *** double hydroxides(LDHs)are one of the most active electrocatalysts with adjustable active sites in contemporary *** this review,we discuss the recent advanced progress of LDHs for hydrogen evolution reaction(HER)on cathode and oxygen evolution reaction(OER)or organic oxidation on anode and emphasize the influence of LDHs structure regulation in water electrolysis process(HER/OER)as well as the current development status of organic oxidation catalyzed by active oxygen species on ***,we propose the current challenges of LDHs in electrocatalysis and prospect their developing tendency and further application.

关键词： Layered double hydroxide Hydrogen production Hydrogen evolution reaction(HER) Oxygen evolution reaction(OER) Electrocatalytic organic oxidation

Influence of Different Compensation Modes on Morphological and Electrical Characteristics of Secondary Arcs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2024年第5期10卷 2245-2254页

作者： Hongshun Liu Zhiyuan Zhang tian xia Jingjing yang Qiuqin Sun Qingquan Li School of Electrical Engineering Shandong UniversityJinan 250061China State Grid Jinan Power Supply Company Jinan 250012China State Grid tianjin Chengdong Electric Power Supply Branch Tianjin 300171China College of Electrical and Information Engineering Hunan UniversityChangsha 410082China

UHV transmission lines are usually equipped with high-voltage shunt *** reactors and the resulting degree of compensation affect the voltage,current,and other electrical characteristics of secondary *** this paper,a low-voltage experimental simulation setup to produce secondary arcs in different compensation modes is established,and the morphological and electrical characteristics of recorded arc images and discharge waveforms are *** morphological characteristics,the degree of secondary arcs is compared for different compensation *** electrical characteristics,the arc waveform,volt–current characteristics,and zero-current time of secondary arcs are compared for different compensation *** results provide a foundation to determine the time of extinction of secondary arcs on overhead lines in the case of compensation,as well as technical support to develop effective arc suppression and extinction techniques.

关键词： Compensation mode electrical characteristic morphological characteristic secondary arc

Buckling optimization of curvilinear fiber-reinforced composite structures using a parametric level set method

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Mechanical Engineering 2024年第1期19卷 149-160页

作者： Ye tian Tielin SHI Qi xia State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China

Owing to their excellent performance and large design space,curvilinear fiber-reinforced composite structures have gained considerable attention in engineering fields such as aerospace and *** addition to the stiffness and strength of such structures,their stability also needs to be taken into account in the *** study proposes a level-set-based optimization framework for maximizing the buckling load of curvilinear fiber-reinforced composite *** the proposed method,the contours of the level set function are used to represent fiber *** a composite laminate with a certain number of layers,one level set function is defined by radial basis functions and expansion coefficients for each ***,the fiber angle at an arbitrary point is the tangent orientation of the contour through this *** the finite element of buckling,the stiffness and geometry matrices of an element are related to the fiber angle at the element *** study considers the parallelism constraint for fiber *** the sensitivity calculation of the objective and constraint functions,the method of moving asymptotes is utilized to iteratively update all the expansion coefficients regarded as design *** numerical examples under different boundary conditions are given to validate the proposed *** show that the optimized curved fiber paths tend to be parallel and equidistant regardless of whether the composite laminates contain holes or ***,the buckling resistance of the final design is significantly improved.

关键词： buckling optimization curvilinear fiber composite structure level set method manufacturing constraint

A super sandstorm altered the abundance and composition of airborne bacteria in Beijing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第10期144卷 35-44页

作者： Fanxuan xia Zhuo Chen Enze tian Jinhan Mo Beijing Key Laboratory of Indoor Air Quality Evaluation and Control Department of Building ScienceTsinghua UniversityBeijing 100084China Songshan Lake Materials Laboratory Dongguan 523808China Institute of Physics Chinese Academy of SciencesBeijing 100190China College of Civil and Transportation Engineering Shenzhen UniversityShenzhen 518060China Key Laboratory of Coastal Urban Resilient Infrastructures(Shenzhen University) Ministry of EducationShenzhen 518060China Key Laboratory of Eco Planning&Green Building(Tsinghua University) Ministry of EducationBeijing 100084China

Sandstorm,which injects generous newly emerging microbes into the atmosphere covering cities,adversely affects the air quality in built ***,few studies have examined the change of airborne bacteria during severe sandstorm *** this work,we analyzed the airborne bacteria during one of the strongest sandstorms in East Asia onMarch 15th,2021,which affected large areas of China and *** characteristics of the sandstorm were compared with those of the subsequent clean and haze *** composition of the bacterial community of air samples was investigated using quantitative polymerase chain reaction(qPCR)and high-throughput sequencing *** the sandstorm,the particulate matter(PM)concentration and bacterial richnesswere extremely high(PM2.5:207μg/m3;PM10:1630μg/m3;5700 amplicon sequence variants/m3).In addition,the sandstorm brought 10 pathogenic bacterial genera to the atmosphere,posing a grave hazard to human *** the sandstorm subsided,small bioaerosols(0.65–1.1μm)with a similar bacterial community remained suspended in the atmosphere,bringing possible long-lasting health risks.

关键词： Airborne bacteria Sandstorm Bioaerosol Haze Pathogen

A dynamical neural network approach for distributionally robust chance-constrained Markov decision process

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Mathematics 2024年第6期67卷 1395-1418页

作者： tian xia Jia Liu Zhiping Chen School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an710049China

In this paper,we study the distributionally robust joint chance-constrained Markov decision *** the logarithmic transformation technique,we derive its deterministic reformulation with bi-convex terms under the moment-based uncertainty *** cope with the non-convexity and improve the robustness of the solution,we propose a dynamical neural network approach to solve the reformulated optimization *** results on a machine replacement problem demonstrate the efficiency of the proposed dynamical neural network approach when compared with the sequential convex approximation approach.

关键词： Markov decision process chance constraints distributionally robust optimization moment-based ambiguity set dynamical neural network

Regio-and Stereoselective Polymerization of Bio-based Ocimene by Rare-Earth Metal Catalysts

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第2期42卷 223-229,I0008页

作者： Qi-Yuan Wang Li-Peng Sang Zhen Zhang yang Jiang Hui tian xia Zhao xiang Guo Shi-Hui Li State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China Science and Technology on Aerospace Chemical Power Laboratory Hubei Institute of Aerospace ChemotechonologyXiangyang441003China Shanxi Coal Chemical Industry Technology Research Institute Xi’an710000China Hubei Institute of Aerospace Chemotechonology Xiangyang441003China

Coordination polymerization of renewable β-ocimene has been investigated using asymmetric diiminophosphinate lutetium complex1, β-diketiminate yttrium complex 2, bis(phosphino)carbazolide yttrium complex 3, half-sandwich benzyl fluorenyl scandium complex 4 and pyridyl-methylene-fluorenyl rare-metal complexes 5a–5c. Complexes 1, 4 and 5a–5c show trans-1,2-regioselectivities and high activities, of which 5c exhibits excellent isoselectivity(mmmm>99%). Conversely, complexes 2 and 3 promote β-ocimene polymerization to produce isotactic cis-1,4-polyocimenes(cis-1,4>99%, mm>95%). Diblock copolymers cis-1,4-PIP-block-cis-1,4-POc and cis-1,4-PBD-block-cis-1,4-POc are obtained in one-pot reactions of β-ocimene with isoprene and butadiene using complex 3. Epoxidation and hydroxylation of polyocimene afford functionalized polyolefins with enhanced T_(g)(from-20 ℃ to 79 ℃ and 74 ℃) and hydrophilicity.

关键词： Biobased monomer Terpenes Ocimene Rare-earths Polymerization Regio/stereoselectivity Elastomer

Differentiation and immunosuppressive function of CD19^(+)CD24^(hi)CD27^(+) regulatory B cells are regulated through the miR-29a-3p/NFAT5 pathway

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 472-480页

作者： Jin-yang Li tian-Shuo Feng Ji Gao Xin-xiang yang xiang-Cheng Li Zhen-Hua Deng Yong-xiang xia Zheng-Shan Wu Hepatobiliary Center the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Key Laboratory of Liver Transplantation Chinese Academy of Medical SciencesNanjing 210029China NHC Key Laboratory of Living Donor Liver Transplantation Nanjing Medical UniversityNanjing 210029China

Background: Regulatory B cells(Bregs) is an indispensable element in inducing immune tolerance after liver transplantation. As one of the microRNAs(miRNAs), mi R-29a-3p also inhibits translation by degrading the target mRNA, and yet the relationship between Bregs and mi R-29a-3p has not yet been fully explored. This study aimed to investigate the impact of miR-29a-3p on the regulation of differentiation and immunosuppressive functions of memory Bregs(m Bregs) and ultimately provide potentially effective therapies in inducing immune tolerance after liver transplantation. Methods: Flow cytometry was employed to determine the levels of Bregs in peripheral blood mononuclear cells. TaqMan low-density array miRNA assays were used to identify the expression of different miRNAs, electroporation transfection was used to induce mi R-29a-3p overexpression and knockdown, and dual luciferase reporter assay was used to verify the target gene of miR-29a-3p. Results: In patients experiencing acute rejection after liver transplantation, the proportions and immunosuppressive function of m Bregs in the circulating blood were significantly impaired. mi R-29a-3p was found to be a regulator of m Bregs differentiation. Inhibition of miR-29a-3p, which targeted nuclear factor of activated T cells 5(NFAT5), resulted in a conspicuous boost in the differentiation and immunosuppressive function of m Bregs. The inhibition of mi R-29a-3p in CD19~+ B cells was capable of raising the expression levels of NFAT5, thereby promoting B cells to differentiate into m Bregs. In addition, the observed enhancement of differentiation and immunosuppressive function of m Bregs upon mi R-29a-3p inhibition was abolished by the knockdown of NFAT5 in B cells. Conclusions: mi R-29a-3p was found to be a crucial regulator for m Bregs differentiation and immunosuppressive function. Silencing mi R-29a-3p could be a potentially effective therapeutic strategy for inducing immune tolerance after liver transplantation.

关键词： Regulatory B cells miR-29a-3p NFAT5 Liver transplantation