检索结果-南通市图书馆

Antiviral effects of natural small molecules on aquatic rhabdovirus by interfering with early viral replication

Zoological Research 2022年第6期43卷 966-976页

作者： Yan Zhou tian-xiu qiu Yang Hu Lei Liu Jiong Chen State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products Ningbo UniversityNingboZhejiang 315211China Laboratory of Biochemistry and Molecular Biology School of Marine SciencesMeishan CampusNingbo UniversityNingboZhejiang 315832China Key Laboratory of Applied Marine Biotechnology of Ministry of Education Meishan CampusNingbo UniversityNingboZhejiang 315832China

Spring viremia of carp virus(SVCV)is globally widespread and poses a serious threat to aquatic ecology and aquaculture due to its broad host *** develop effective agents to control SVCV infection,we selected 16 naturally active small molecules to assess their anti-SVCV ***,dihydroartemisinin(DHA)(100μmol/L)and(S,S)-(+)-tetrandrine(TET)(16μmol/L)exhibited high antiviral effects in epithelioma papulosum cyprinid(EPC)cells,with inhibitory rates of 70.11%and 73.54%,*** possible antiviral mechanisms were determined as follows:*** with DHA and TET decreased viral particle infectivity in fish cells,suggesting that horizontal transmission of SVCV in the aquatic environment was disrupted;*** neither had an effect on viral adhesion,TET(but not DHA)interfered with SVCV entry into host cells(>80%),suggesting that TET may have an antiviral function in early viral *** in vivo study,both agents enhanced the survival rate of SVCV-infected zebrafish by 53.3%,significantly decreased viral load,and modulated the expression of antiviralrelated genes,indicating that DHA and TET may stimulate the host innate immune response to prevent viral ***,our findings indicated that DHA and TET had positive effects on suppressing SVCV infection by affecting early-stage viral replication,thus holding great potential as immunostimulants to reduce the risk of aquatic rhabdovirus disease outbreaks.

关键词： Spring viremia of carp virus Natural small molecules Antiviral effects Virus internalization Danio rerio

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hydroxycoumarin efficiently inhibits spring viraemia of carp virus infection in vitro and in vivo

引用

Zoological Research 2020年第4期41卷 395-409页

作者： Lei Liu Da-Wei Song Guang-Lu Liu Li-Peng Shan tian-xiu qiu Jiong Chen State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo UniversityNingboZhejiang 315211China Laboratory of Biochemistry and Molecular Biology School of Marine SciencesMeishan CampusNingbo UniversityNingboZhejiang 315832China Key Laboratory of Applied Marine Biotechnology of Ministry of Education Meishan CampusNingbo UniversityNingboZhejiang 315832China School of Chemistry&Chemical Engineering Zhoukou Normal UniversityZhoukouHenan 466001China

Spring viremia of carp virus(SVCV)causes devastating losses in *** has an advantageous structure for the design of novel antiviral agents with high affinity and *** this study,we evaluated a hydroxycoumarin medicine,i.e.,7-(6-benzimidazole)coumarin(C10),regarding its anti-SVCV effects in vitro and in *** showed that up to 12.5 mg/L C10 significantly inhibited SVCV replication in the epithelioma papulosum cyprini(EPC)cell line,with a maximum inhibitory rate of>97%.Furthermore,C10 significantly reduced cell death and relieved cellular morphological damage in SVCV-infected *** mitochondrial membrane potential(ΔΨm)also suggested that C10 not only protected mitochondria,but also reduced apoptosis in SVCVinfected *** in vivo studies,intraperitoneal injection of C10 resulted in an anti-SVCV effect and substantially enhanced the survival rate of virusinfected ***,C10 significantly enhanced antioxidant enzyme activities and decreased reactive oxygen species(ROS)to maintain antioxidant-oxidant balance within the host,thereby contributing to inhibition of SVCV *** up-regulation of six interferon(IFN)-related genes also demonstrated that C10 indirectly activated IFNs for the clearance of SVCV in *** was beneficial for the continuous maintenance of antiviral effects because of the low viral loads in ***,C10 is suggested as a therapeutic agent with great potential against SVCV infection in aquaculture.

关键词： vivo thereby maintain

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Potential aquatic environmental risks of trifloxystrobin:Enhancement of virus susceptibility in zebrafish through initiation of autophagy

引用

Zoological Research 2021年第3期42卷 339-349页

作者： Huan Wang tian-xiu qiu Jian-Fei Lu Han-Wei Liu Ling Hu Lei Liu Jiong Chen State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo UniversityNingboZhejiang 315211China Laboratory of Biochemistry and Molecular Biology School of Marine SciencesMeishan CampusNingbo UniversityNingboZhejiang 315832China Key Laboratory of Applied Marine Biotechnology of Ministry of Education Meishan CampusNingbo UniversityNingboZhejiang 315832China Ningbo Customs District Technology Center NingboZhejiang 315832China

Chronic pollution in aquatic ecosystems can lead to many adverse effects,including a greater susceptibility to pathogens among resident ***(TFS)is a strobilurin fungicide widely used in Asia to control soybean ***,it has the potential to enter aquatic ecosystems,where it may impair fish resistance to viral *** explore the potential environmental risks of TFS,we characterized the antiviral capacities of fish chronically exposed to TFS and subsequently infected with spring viraemia of carp virus(SVCV).Although TFS exhibited no significant cytotoxicity at the tested environmental concentrations during viral challenge,SVCV replication increased significantly in a time-dependent manner within epithelioma papulosum cyprini(EPC)cells and zebrafish exposed to 25μg/L *** showed that the highest viral load was more than 100-fold that of the *** biochemical assays indicated that autophagy was induced by TFS,and associated changes included an increase in autophagosomes,conversion of LC3-II,accumulation of Beclin-1,and degradation of P62 in EPC cells and *** addition,TFS markedly decreased the expression and phosphorylation of mTOR,indicating that activation of TFS may be associated with the mTORmediated autophagy *** study provides new insights into the mechanism of the immunosuppressive effects of TFS on non-target aquatic hosts and suggests that the existence of TFS in aquatic environments may contribute to outbreaks of viral diseases.

关键词： Trifloxystrobin Autophagy SVCV Chronic toxicity Susceptibility

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Crystallization and Phase Behavior in Block Copolymer Solution:An in Situ Small Angle X-ray Scattering Study

引用

Chinese Journal of Polymer Science 2019年第11期37卷 1162-1168页

作者： Hong-Yan Zhu Feng tian xiu-Hong Li Hui-Bin qiu Jie Wang Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China University of Chinese Academy of Sciences Beijing 100049 China Shanghai Advanced Research Institute Zhangjiang Lab Chinese Academy of Science Shanghai 201204 China School of Chemistry and Chemical Engineering State Key Lab of Metal Matrix Composites Shanghai Jiao Tong University Shanghai 200240 China

Amphiphilic diblock copolymers self-assemble into a variety of micellar structures with diverse shapes in selective solvents. Here, we study the concentration and temperature dependence of the packing structure of spherical micelles of a polyisoprene-b-poly(2- vinylpyridine)(PI-b-P2VP) diblock copolymer in toluene using synchrotron radiation small angle X-ray scattering (SR-SAXS) and atomic force microscopy (AFM) techniques. Randomly packed spherical micelles are detected in dilute solutions, while in concentrated solutions, face-centered cubic (FCC), body-centered cubic (BCC) mixed crystal structures, and pure BCC crystal structures are observed with an increase in concentration. In situ SAXS experiments on the FCC/BCC mixed crystal structures reveal a novel FCC/BCC → BCC → Disorder → BCC phase behavior during the thermal annealing process. These results demonstrated that the BCC phase is apparently more stable than the FCC phase in the current sphere-packing system and FCC/BCC is a metastable state. The incompatibility of the PI and P2VP blocks decreases at a higher temperature and renders the variation of domain spacing.

关键词： In situ SAXS Block copolymers Self-assembly Micelle Phase transition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

考虑盐度影响的粉煤灰固化软土直剪试验

引用

江苏大学学报（自然科学版） 2025年第1期46卷 120-124页

作者：殷杰邱文杰田雪晨江苏大学土木工程与力学学院江苏镇江212013

采用粉煤灰作为固化剂,制备了多组粉煤灰固化软土试样,其孔隙水中盐度分别为0%、2%、4%和6%,养护龄期分别为3 h、7 d和28 d.通过开展室内直剪试验,探讨盐度对粉煤灰固化软土强度特性的影响.试验结果表明:竖向固结压力为50 kPa时,粉煤灰... 详细信息

采用粉煤灰作为固化剂,制备了多组粉煤灰固化软土试样,其孔隙水中盐度分别为0%、2%、4%和6%,养护龄期分别为3 h、7 d和28 d.通过开展室内直剪试验,探讨盐度对粉煤灰固化软土强度特性的影响.试验结果表明:竖向固结压力为50 kPa时,粉煤灰固化软土的剪应力与剪切位移关系曲线呈现软化型,而在竖向固结压力为200 kPa时曲线呈现硬化型;高盐度试样具有较低的峰值剪应力和残余强度,表明高盐度对粉煤灰固化软土强度特性具有不利的影响;随着盐度增加,各养护龄期下软土试样的抗剪强度、黏聚力和内摩擦角的曲线均呈现近似线性下降的趋势,主要原因在于盐度的增加抑制了粉煤灰中活性成分的水化反应.

关键词：粉煤灰软土固化剂盐度养护龄期室内直剪试验

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modeling the Wettability of Microstructured Hydrophobic Surface Using Multiple-relaxation-time Lattice Boltzmann Method

引用

Journal of Bionic Engineering 2022年第5期19卷 1460-1471页

作者： Lei tian Liuchao qiu College of Water Resources and Civil Engineering China Agricultural UniversityBeijing 100083China

Wetting properties are significant for a hydrophobic surface and normally characterized by the equilibrium contact *** this manuscript,a mesoscopic method based on multiphase multiple-relaxation-time Lattice Boltzmann method has been presented and applied to simulate the contact angle at three-phase interfaces of a solid surface with micro-pillar *** influence of different parameters including pillar height,pillar width,inter-pillar spacing,intrinsic contact angle and the volume of the liquid drop on the equilibrium contact angle has been comprehensively *** effect of geometry parameters of the micro-pillar structure on the wetting transition from Cassie–Baxter state to Wenzel state has also been *** results indicate that when the inter-pillar spacing is less than a certain value or the pillar height is greater than a certain value,the contact form between the droplet and the surface satisfies the Cassie–Baxter *** the contact form satisfies the Cassie–Baxter state,the contact angle gradually increases with the increase of the inter-pillar spacing;the contact angle does not change significantly with the pillar height;the contact angle gradually decreases and approaches the intrinsic contact angle with the pillar width ***,the contact angle increases with the increase of the intrinsic contact angle,and the contact angle is not sensitive to the change of droplet volume when the droplet volume is between 0.5 and10μl.

关键词： Bioinspired hydrophobic surface Wettability Cassie-Baxter state Wenzel state Lattice Boltzmann method Mesoscale simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Method for Evaluating Digital Video Electromagnetic Information Leakage from Video Cable

引用

Chinese Journal of Electronics 2021年第5期30卷 978-985页

作者： WANG Sen qiu Yang tian Jin AECC Aero Engine Control System Institute Electromagnetic Compatibility Laboratory Xidian University

Electromagnetic emissions from electrical information equipment may contain useful information and lead to information leakage. In order to detect the electromagnetic information leakage of digital video cable,a rapid testing method for computer video information leakage detection without reconstructing the displayed image is proposed. In this method, the electromagnetic radiation spectrum of typical image transmitted by HDMI cable is simulated. Then the electromagnetic radiation spectrum of the computer when transmitting the same image as the typical image is obtained by conduction and radiation EMC test methods. Finally, the correlation between the spectrum of simulation and the test spectrum is analyzed, and the correlation coefficient is used to judge whether the computer has produced the electromagnetic leakage of video information. The analysis and test results show that when the correlation coefficient is greater than 0.5, the electromagnetic leakage of computer video information can be judged.

关键词： lead rapid testing method computer video information leakage detection displayed image electrical information equipment evaluating digital video electromagnetic information leakage test spectrum typical image electromagnetic leakage electromagnetic radiation spectrum HDMI cable correlation coefficient electromagnetic emissions digital video broadcasting electromagnetic compatibility digital video cable

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Quantum corrections to the entropy in a driven quantum Brownian motion model

引用

Communications in Theoretical Physics 2021年第9期73卷 136-144页

作者： tian qiu Hai-Tao Quan School of Physics Peking UniversityBeijing 100871China Collaborative Innovation Center of Quantum Matter Beijing 100871China Frontiers Science Center for Nano-optoelectronics Peking UniversityBeijing100871China

The quantum Brownian motion model is a typical model in the study of nonequilibrium quantum *** is one of the most fundamental physical concepts in *** this work,by solving the quantum Langevin equation,we study the von Neumann entropy of a particle undergoing quantum Brownian *** obtain the analytical expression of the time evolution of the Wigner function in terms of the initial Wigner *** result is applied to the thermodynamic equilibrium initial state,which reproduces its classical counterpart in the high temperature *** on these results,for those initial states having well-defined classical counterparts,we obtain the explicit expression of the quantum corrections to the entropy in the weak coupling ***,we find that for the thermodynamic equilibrium initial state,all terms odd inÿ are exactly *** results bring important insights to the understanding of entropy in open quantum systems.

关键词： quantum Brownian motion time-dependent evolution quantum entropy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel stochastic collocation method for uncertainty propagation in complex mechanical systems

引用

Science China(Physics,Mechanics & Astronomy) 2015年第2期58卷 47-54页

作者： QI WuChao tian SuMei qiu ZhiPing Faculty of Aerospace Engineering Shenyang Aerospace University Institute of Solid Mechanics Beijing University of Aeronautics and Astronautics

This paper presents a novel stochastic collocation method based on the equivalent weak form of multivariate function integral to quantify and manage uncertainties in complex mechanical systems. The proposed method, which combines the advantages of the response surface method and the traditional stochastic collocation method, only sets integral points at the guide lines of the response surface. The statistics, in an engineering problem with many uncertain parameters, are then transformed into a linear combination of simple functions' statistics. Furthermore, the issue of determining a simple method to solve the weight-factor sets is discussed in detail. The weight-factor sets of two commonly used probabilistic distribution types are given in table form. Studies on the computational accuracy and efforts show that a good balance in computer capacity is achieved at present. It should be noted that it's a non-gradient and non-intrusive algorithm with strong portability. For the sake of validating the procedure, three numerical examples concerning a mathematical function with analytical expression, structural design of a straight wing, and flutter analysis of a composite wing are used to show the effectiveness of the guided stochastic collocation method.

关键词： uncertainty propagation stochastic collocation method equivalent weak form guided surface statistics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Corrosion behavior of three Ag–50Cu alloys prepared by different processes in NaCl solutions

引用

Rare Metals 2017年第1期36卷 61-68页

作者： Zhong-qiu Jia qiu-Ying Liang qiu-Yue tian Zhong-qiu Cao Yan Wang College of Chemistry-and Chemical Engineering Shenyang Normal University Shenyang 110034 China

Corrosion behavior of two nanocrystalline bulk Ag–50Cu alloys and one coarse-grained counterpart prepared by liquid-phase reduction(LPR), mechanical alloying(MA) and powder metallurgy(PM) methods,respectively, were investigated in Na Cl solutions. They were finished by means of PARM273 A and M5210 electrochemical apparatus through potentiodynamic polarization method and electrochemical impedance spectroscopy(EIS) technique. The results show that corrosion rates of three Ag–50Cu alloys increase with the increment of Na Cl solution concentrations. Corrosion rates of LPRAg–50Cu alloy are a little higher than those of PMAg–50Cu alloy,but evidently lower than those of MAAg–50Cu alloy. The difference in corrosion rates is attributed to the large reduction in the grain size and homogeneous microstructure of nanocrystalline alloys. Passive current densities decrease and afterward increase for PMAg–50Cu alloy,decrease for MAAg–50Cu alloy, and increase for LPRAg–50Cu alloy with the increment of Na Cl solution concentrations. After the grain sizes are refined, passive current densities become lower.

关键词： Copper alloys Corrosion Corrosion rate Corrosive effects Electrochemical corrosion Electrochemical impedance spectroscopy Electrochemistry Grain size and shape Mechanical alloying Nanocrystals Powder metallurgy Reduction Silver Silver alloys

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：