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Impacts of proppant distribution on development of tight oil reservoirs with threshold pressure gradient

Petroleum Science 2024年第1期21卷 445-457页

作者： Ming Yue Wei-Yao Zhu Fei-Fei Gou tian-ru song Yu-Chun You Qi-Tao Zhang State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development Beijing102206China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing100083China

Field evidence indicates that proppant distribution and threshold pressure gradient have great impacts on well *** at the development of unconventional oil reservoirs in Triassic Chang-7 Unit,Ordos Basin of China,we presented an integrated workflow to investigate how(1)proppant placement in induced fracture and(2)non-linear flow in reservoir matrix would affect well productivity and fluid flow in the *** with our research before(Yue et al.,2020),here we extended this study into the development of multi-stage fractured horizontal wells(MFHWs)with large-scale complicated fracture *** integrated workflow is based on the finite element method and consists of simulation models for proppant-laden fluid flow,fracture flow,and non-linear seepage flow,*** results indicate that the distribution of proppant inside the induced cracks significantly affects the productivity of the *** we assign an idealized proppant distribution instead of the real distribution,there will be an overestimation of 44.98%in daily oil rate and 30.63%in cumulative oil production after continuous development of 1000 ***,threshold pressure gradient(TPG)also significantly affects the well performance in tight oil *** we simply apply linear Darcy’s law to the reservoir matrix,the overall cumulative oil production can be overrated by 77%after 1000 days of *** general,this research provides new insights into the development of tight oil reservoirs with TPG and meanwhile reveals the significance of proppant distribution and non-linear fluid flow in the production scenario design.

关键词： Proppant distribution Tight oil reservoir Multi-stage fractured horizontal well Threshold pressure gradient Moving boundary

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Separation of the ionospheric and thermospheric contributions in the data from the Triple Ionosophere Photo Meter onboard the Feng-Yun 3E satellite

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Science China Earth Sciences 2025年第1期68卷 172-184页

作者： Fang JIANG tian MAO Jin-song WANG Xiu-Qing HU Xiao-Xin ZHANG Liping FU Nan JIA tianfang WANG National Space Science Center Chinese Academy of Sciences Beijing Key Laboratory of Space Environment Exploration Key Laboratory of Environmental Space Situation Awareness Technology National Satellite Meteorological Center China Meteorological Administration

The Triple Ionosphere Photo Meter （TRIPM） is a far ultraviolet nadir-view photometer that is onboard the secondgeneration,polar-orbiting Chinese meteorological satellite Feng-Yun 3E （FY-3E）,which was launched on July 5,*** has three channels,and each is used to measure different types of emissions:（1） 135.6 nm airglow produced by the recombination of the O+ions and electrons in the absence of sunlight （nighttime channel）;（2） 135.6 nm airglow from the OI when sunlight is present （daytime/dusk-dawn 135.6 nm channel）;and （3） Airglow in the N2LBH of the TRIPM （daytime/dusk-dawn N2LBH channel）.FY-3E is a satellite operating in the early morning ***,the data are mostly distributed on the dawndusk side or at times when the solar zenith angle is relatively *** this study,combined with simulation calculations,the data are *** further explore the application value of the data products,a model is used to separate the ionospheric radiative recombination contribution from the thermosphere photoelectron impact excitation contribution in the data from the daytime/dusk-dawn 135.6 nm *** approach not only improves the accuracy of O/N2derived from the 135.6 nm channel and N2LBH channel but also provides the ionospheric 135.6 nm radiance at the same time as the *** results show that the 135.6 nm radiance originating from the combination of O+and electrons extracted from the measurement data exhibits similar equatorial anomaly peak structure characteristics and seasonal variations as the corresponding GPS total electron content （TEC） *** the other hand,the separated 135.6 nm radiance generated from the thermosphere photoelectron collision excitation does not contain radiative recombination contributions;thus,the ionosphere influence is greatly avoided when the O/N2is obtained.

关键词： Far ultraviolet 135.6 nm emission intensity Photoelectron impact excitation Radiative recombination excitation

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Deep learning-based end-to-end depth estimation from a single-frame fringe pattern with the FDSUNet++ network

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Optoelectronics Letters 2025年

作者： ZHU Xinjun ZHANG Jialei song Limei WANG Hongyi tian ruiqin School of Artificial Intelligence， tiangong University School of Control Science and Engineering， tiangong University

Recently the depth estimation methods based on deep learning (DL) retains challenging to estimate high-precision in fringe projection structured light three-dimensional (3D) measurement with limited information from a single-frame fringe pattern. In this letter， we proposed a FDSUNet++ convolutional neural network， which consists of a UNet++ base model， an improved squeeze-and-excitation (ISE) block， a Fourier transform (FT) data preprocessing block， and a discrete wavelet transform (DWT) block. The proposed ISE block can improve the ability of feature extraction and the designed FT data preprocessing block preserves the key features of the fringe pattern by Fourier transform. The introduced DWT block reduces the complexity and training cost of the model. By integrating these three blocks into the UNet++ network， it can better achieve depth estimation. Experimental results from two structured light datasets demonstrate that the proposed FDSUNet++ outperforms the state-of-art networks such as UNet， SUNet， R2U-Net， PCTNet and MSUNet++， achieving the best performance in both qualitative and quantitative evaluation.

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Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

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World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na Li Yue-Yue Ren Ying Tang Qi Yang tian-tian Meng song Li Jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

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Effect of Ti contents on interfacial bonding,mechanical and thermal properties of Mo-Cu composites

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Tungsten 2024年第3期6卷 549-554页

作者： Jian-ru Chu Xiao-song Jiang tian-Yan Liu Key Laboratory of Advanced Technologies of Materials Ministry of EducationChengdu 610031China School of Materials Science and Engineering Southwest Jiaotong UniversityChengdu 610031China Reactor Engineering Research Sub-Institute Nuclear Power Institute of ChinaChengdu 610005China

Mo-Cu composites are widely used in electronic packaging,vacuum technology,microwave devices and other fields due to their excellent properties,such as excellent electrical and thermal conductivity,low adjustable coef... 详细信息

关键词： composites thermal properties

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小于胎龄早产儿早期追赶生长状况及其影响因素

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中华新生儿科杂志（中英文） 2018年第3期33卷 175-181页

作者：单春荣冯琪王颖李星张欣桑田茹喜芳宋秀婷北京大学第一医院儿科 100034

目的分析小于胎龄（small for gestational age,SGA）早产儿早期体格追赶生长情况,探讨影响其追赶生长的因素.方法采用单中心、回顾性研究方法,研究对象为2012年1月至2015年10月在我院新生儿重症监护病房住院治疗7d以上且出院时完全... 详细信息

目的分析小于胎龄（small for gestational age,SGA）早产儿早期体格追赶生长情况,探讨影响其追赶生长的因素.方法采用单中心、回顾性研究方法,研究对象为2012年1月至2015年10月在我院新生儿重症监护病房住院治疗7d以上且出院时完全经口喂养的SGA早产儿.追赶生长定义为相应体格指标Z值较出生时上升≥0.67,完成追赶生长定义为体重位于同性别同年龄参考人群的第10百分位以上.根据校正胎龄40±4周、校正年龄（corrected age,CA）3±1.5月、CA6±1.5月时体重有无追赶生长分为追赶生长组和无追赶生长组,分别进行组间特点比较,并寻找预测追赶生长的指标.结果共纳入SGA早产儿81例,男45例,女36例,胎龄（34.6±1.7）周,出生体重（1 617±348）g,出生身长（41.0±3.2） cm,出生头围（29.7±2.0）cm.校正胎龄40 ±4周、CA 3±1.5月、CA 6±1.5月的随访率分别为86.4％、66.7％、58.0％,出现体重追赶生长的比例分别为32.9％、55.6％、66.0％,完成体重追赶生长的比例分别为52.9％、64.8％、66.0％.校正胎龄40±4周时,与无追赶生长组比较,追赶生长组男婴比例高、恢复出生体重时间早、合并动脉导管未闭比例低,差异有统计学意义（P ＜0.05）;CA 3 ±1.5月时,与无追赶生长组比较,追赶生长组出生胎龄大、出院身长百分位数大、住院天数短、合并动脉导管未闭比例低、校正胎龄40周时体重百分位数大,差异有统计学意义（P ＜0.05）;CA 6±1.5月时,与无追赶生长组比较,追赶生长组住院天数短、校正胎龄40周时体重百分位数大、CA 3±1.5月时体重、身长及头围百分位数大,差异有统计学意义（P＜0.05）.多因素分析显示,CA 3±1.5月体重百分位数是影响CA 6±1.5月体重追赶生长的独立因素（P =0.002,OR=1.221,95％CI1.076 ～1.385）;CA 3±1.5月时体重百分位数每提高5个百分位数,CA 6±1.5月时完成体重追赶生长的可能性增加2.965倍（95％ CI1.480 ～5.942）.结论 SGA早产儿校正胎龄40±4周及CA 3±1.5月时,体重和身长均呈快速增加的趋势.各年龄阶段影响完成追赶生长的因素不同,CA 3个月时的体重、身长及头围百分位数可较好的预测CA 6个月是否完成追赶生长.

关键词：婴儿,早产婴儿,小于胎龄追赶生长危险因素

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分离纯化重组解脂耶氏酵母发酵液中虫草素的研究

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食品与发酵工业 2025年第1期51卷 26-31页

作者：宋丽萍段希宇王翀卢向阳田云湖南农业大学生物科学技术学院湖南长沙410128 沅江市芦小妹食品有限公司湖南益阳413000

多项研究证明以解脂耶氏酵母作为虫草素生物合成的细胞工厂,是获得虫草素的有效途径。为获得下游虫草素分离纯化工艺,该研究采用不同规格的大孔吸附树脂对重组解脂耶氏酵母发酵液中的虫草素进行静态、动态纯化。结果显示,以NKA-Ⅱ大孔... 详细信息

多项研究证明以解脂耶氏酵母作为虫草素生物合成的细胞工厂,是获得虫草素的有效途径。为获得下游虫草素分离纯化工艺,该研究采用不同规格的大孔吸附树脂对重组解脂耶氏酵母发酵液中的虫草素进行静态、动态纯化。结果显示,以NKA-Ⅱ大孔吸附树脂作为吸附材料,在虫草素质量浓度为3 mg/mL、pH值为9的上样液以上样流速为3 BV/h、上样体积为10 BV、洗杂流速为2 BV/h、洗杂体积为3 BV、洗脱剂为体积分数为30%乙醇、洗脱流速为3 BV/h、洗脱体积为15 BV时,发酵液中虫草素回收率可达到87.67%,纯度达65.82%。该研究为今后利用重组解脂耶氏酵母大规模生产制备虫草素提供数据参考。

关键词：虫草素解脂耶氏酵母分离纯化大孔吸附树脂甘蔗糖蜜

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Chalcone derivatives as novel,potent and selective inhibitors against human Notum:Structure–activity relationships and biological evaluations

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Chinese Chemical Letters 2024年第3期35卷 321-325页

作者： Jin-Hui Shi Bei Zhao Li-Lin song Yu-Qing song Meng-ru Sun tian tian Hong-Yu Chen Yun-Qing song Jian-Ming Sun Guang-Bo Ge Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 201203China Dalian Engineering Research Center for Carbohydrate Agricultural Preparations Liaoning Provincial Key Laboratory of CarbohydratesDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine Shanghai 200137China

Human Notum(hNotum)inhibitors could be used for treating Wnt signalling-associated diseases including colorectal ***,two series of chalcone derivatives were designed and synthesized aiming to find selective and potent hNotum ***–activity relationship(SAR)studies showed that 2-methoxyl and 5-bromine substitutions on A-ring significantly enhanced anti-hNotum effect,while 4’-ethoxyl and 3’-alkyl substitutions on B-ring were beneficial for hNotum *** all tested chalcones,B11 displayed the most potent anti-Notum effect(IC_(50)=3.6 nmol/L),good selectivity,excellent chemical stability and suitable metabolic *** investigations showed that B11 acted as a competitive inhibitor of hNotum,while this agent(5μmol/L)significantly weaken the migration abilities of colorectal cancer ***,this study deciphers the SARs of chalcones as hNotum inhibitors and reports a novel and potent hNotum inhibitor with the anti-migration effect on colorectal cancer cells,which offers a promising lead compound to develop novel anti-cancer agents.

关键词： Human notum(hNotum) Chalcone Computer-assisted drug discovery Structure–activity relationship(SAR) Anti-colorectal cancer agent

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TPII:tracking personally identifiable information via user behaviors in HTTP traffic

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Frontiers of Computer Science 2020年第3期14卷 175-187页

作者： Yi LIU tian song Lejian LIAO School of Computer Science Beijing Institute of TechnologyBeijing 100081China Network Information Center Yan'an UniversityYan'an 716000China School of Computer ScienceBeijing Institute of TechnologyBeijing 100081China

It is widely common that mobile applications collect non-critical personally identifiable information(PII)from users'devices to the cloud by application service providers(ASPs)in a positive manner to provide precise and recommending ***,Internet service providers(ISPs)or local network providers also have strong requirements to collect PIIs for finer-grained traffic control and security ***,it is a challenge to locate PIIs accurately in the massive data of network traffic just like looking a needle in a *** this paper,we address this challenge by presenting an efficient and light-weight approach,namely TPII,which can locate and track PIIs from the HTTP layer rebuilt from raw network *** approach only collects three features from HTTP fields as users'behaviors and then establishes a tree-based decision model to dig PIIs efficiently and *** any priori knowledge,TPII can identify any types of PIIs from any mobile applications,which has a broad vision of *** evaluate the proposed approach on a real dataset collected from a campus network with more than 13k *** experimental results show that the precision and recall of TPII are 91.72%and 94.51%respectively and a parallel implementation of TPII can achieve 213 million records digging and labelling within one hour,reaching near to support 1Gbps wirespeed inspection in *** approach provides network service providers a practical way to collect PIIs for better services.

关键词： network traffic analysis personally identifiable information privacy leakage mobile applications HTTP

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