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Inhibition of hepatic interleukin-18 production by rosiglitazone in a rat model of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2008年第47期14卷 7240-7246页

作者： Hai-Ning Wang Yan-Rong Wang Guo-Qiang Liu Zhe Liu pei-Xian Wu Xiao-Ling Wei tian-pei hong Departmentof Endocrinology Peking University Third Hospital Beijing100191 China

AIM:To investigate the effects of rosiglitazone(RGZ) on expression of interleukin-18(IL-18) and caspase-1 in liver of non-alcoholic fatty liver disease(NAFLD) ***:Twenty-eight Sprague-Dawley(SD) rats were randomly divided into control,NAFLD,and RGZ treated NAFLD groups.A NAFLD rat model of NAFLD was established by feeding the animals with a high-fat diet for 12 *** NAFLD animals were treated with RGZ or vehicle for the last 4 wk(week 9-12) and then sacrificed to obtain liver *** changes were analyzed with HE,oil red O and Masson's trichrome *** of IL-18 and caspase-1 were detected using immunohistochemical staining and semi-quantitative reverse-transcription polymerase chain reaction(RT-PCR) ***:The expression levels of both IL-18 and caspase-1 were higher in the liver of NAFLD group than in the control ***,inflammation and fibrosis,found in the liver of NAFLD rats,were significantly improved 4 wk after RGZ *** elevated hepatic IL-18 and caspase-1 expressions in NAFLD group were also significantly attenuated after RGZ ***:RGZ treatment can ameliorate increased hepatic IL-18 production and histological changes in liver of NAFLD *** beneficial effects of RGZ on NAFLD may be partly due to its inhibitory effect on hepatic IL-18 production.

关键词： Insulin resistance Interleukin-18 Nonalcoholic fatty liver Rosiglitazone

Beneficial metabolic effects of nateglinide versus acarbose in patients with newly-diagnosed type 2 diabetes

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Acta Pharmacologica Sinica 2007年第4期28卷 534-539页

作者： hong-wei GAO Chao XIE Hai-ning WANG Yu-jing LIN tian-pei hong Department of Endocrinology,Peking University Third Hospital,Beijing 100083,China DepartmentofEndocrinology PekingUniversityThirdHospitalBeijing100083China

Aim:To investigate the acute and chronic effects of nateglinide versus acarboseon plasma asymmetric dimethylarginine (ADMA) levels and lipid profiles inpatients with newly-diagnosed type 2 ***:A crossover trial ofnateglinide and acarbose was conducted on 16 drug-nave patients with newly-diagnosed type 2 diabetes during a total period of 9 *** glucose,seruminsulin,free fatty acids (FFA),lipids and lipoproteins,and plasma ADMA ***:The efficiencies of a single dose of nateglinide (120 mg) andacarbose (50 mg) for lowering postprandial hyperglycemia were ***-pared to acarbose,nateglinide significantly increased postprandial insulin releaseafter a standard meal test in patients with type 2 *** acutelydecreased postprandial 120 min FFA concentrations and 240 min ADMA levelsmore significantly than *** fasting high-density lipoprotein choles-terol level increased and the low-density lipoprotein cholesterol level decreasedsignificantly,but the fasting levels of triglycerides,total cholesterol,and ADMAwere unchanged after 4 weeks of treatment with *** did notaffect fasting lipid profiles or the ADMA levels after 4 weeks of ***:These results suggest that the reduction of postprandial FFA andADMA concentrations induced by nateglinide may be associated with the partialrestoration of early-phase insulin secretion and may impart a cardiovascularadvantage in comparison with acarbose.

关键词： nateglinide acarbose free fatty acids asymmetric dimethylarginine

Efficacy and Safety of Avandamet or Uptitrated Metformin Treatment in Patients with Type 2 Diabetes Inadequately Controlled with Metformin Alone： A Multicenter, Randomized,Controlled Trial

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Chinese Medical Journal 2015年第10期128卷 1279-1287页

作者： Xiao-Ling Cai Ying-Li Chen Jia-Jun Zhao Zhong-Yan Shan Ming-Cai Qiu Cheng-Jiang Li Wei Gu Hao-Ming tian Hua-Zhang Yang Yao-Ming Xue Jin-Kui Yang tian-pei hong Li-Nong Ji Department of Endocrinology and Metabolism Peking University People's HospitalBeijing 100044China Department of Endocrinology and Metabolism Shandong Provincial HospitalJinanShandong 250021China Department of Endocrinology and Metabolism First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Endocrinology and Metabolism Tianjin Medical University General HospitalTianjin 300070China Department of Endocrinology and Metabolism First Affiliated Hospital of School of MedicineZhejiang UniversityHangzhouZhejiang 310003China Department of Endocrinology and Metabolism Second Affiliated Hospital of School of MedicineZhejiang UniversityHangzhouZhejiang 310009China Department of Endocrinology and Metabolism West China Hospital Sichuan University Chengdu Sichuan 610041 China Department of Endocrinology and Metabolism Guangdong General Hospital Guangzhou Guangdong 510080 China Department of EndocrinoLogy and Metabolism South Hospital Guangzhou Guangdong 510515 China Department of Endocrinology and Metabolism Beijing Tongren Hospital Beijing 100730 China Department of Endocrinology and Metabolism Peking University Third Hospital Beijing 100191 China

Background：At present,China has listed the compound tablet containing a fixed dose ofrosiglitazone and metformin,Avandamet,which may improve patient *** aim of this study was to evaluate the efficacy and safety of Avandamet or uptitrated metformin treatment in patients with type 2 diabetes inadequately controlled with metformin ***：This study was a 48-week,multicenter,randomized,open-labeled,active-controlled *** with inadequate glycaemic control （glycated hemoglobin [HbA1c] 7.5-9.5%） receiving a stable dose of metformin （≥1500 mg） were recruited from 21 centers in China （from 19 November,2009 to 15 March,2011）.The primary objective was to compare the proportion of patients who reached the target of HbA1c ≤7% between Avandamet and metformin ***：At week 48,83.33% of patients reached the target of HbA 1 c ≤7% in Avandamet treatment and 70.00% in uptitrated metformin treatment,with significantly difference between *** target of HbAlc ≤6.5% was reached in 66.03% of patients in Avandamet treatment and 46.88% in uptitrated metformin *** target of fasting plasma glucose （FPG） ≤6.1 mmol/L was reached in 26.97% of patients in Avandamet treatment and 19.33% in uptitrated metformin *** target of FPG ≤7.0 mmol/L was reached in 63.16% of patients in Avandamet treatment and 43.33% in uptitrated metformin *** insulin decreased 3.24 ±0.98 μU/ml from baseline in Avandamet treatment and 0.72 ＆#177; 1.10 μU/ml in uptitrated metformin *** adverse event （AE） rates and serious AE rates were similar between *** occurred rarely in both ***：Compared with uptitrated metformin,Avandamet treatment provided significant improvements in key parameters ofglycemic control and was generally well *** number：ChiCTR-TRC-13003776.

关键词： Avandamet Efficacy Type 2 Diabetes

Oxygen vacancy boosting Fenton reaction in bone scaffold towards fighting bacterial infection

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International Journal of Extreme Manufacturing 2024年第1期6卷 296-311页

作者： Cijun Shuai Xiaoxin Shi Feng Yang Haifeng tian pei Feng State Key Laboratory of Precision Manufacturing for Extreme Service Performance College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083People’s Republic of China Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013People’s Republic of China College of Mechanical Engineering Xinjiang UniversityUrumqi 830017People’s Republic of China

Bacterial infection is a major issue after artificial bone transplantation due to the absence of antibacterial function of bone scaffold,which seriously causes the transplant failure and even amputation in severe *** this study,oxygen vacancy(OV)defects Fe-doped Ti O2(OV-FeTiO2)nanoparticles were synthesized by nano TiO2and Fe3O4via high-energy ball milling,which was then incorporated into polycaprolactone/polyglycolic acid(PCLGA)biodegradable polymer matrix to construct composite bone scaffold with good antibacterial activities by selective laser *** results indicated that OV defects were introduced into the core/shell-structured OV-FeTiO2nanoparticles through multiple welding and breaking during the high-energy ball milling,which facilitated the adsorption of hydrogen peroxide(H2O2)in the bacterial infection microenvironment at the bone transplant *** accumulated H2O2could amplify the Fenton reaction efficiency to induce more hydroxyl radicals(·OH),thereby resulting in more bacterial deaths through·OH-mediated oxidative *** antibacterial strategy had more effective broad-spectrum antibacterial properties against Gram-negative Escherichia coli(***)and Gram-positive Staphylococcus aureus(***).In addition,the PCLGA/OV-FeTiO2scaffold possessed mechanical properties that match those of human cancellous bone and good biocompatibility including cell attachment,proliferation and osteogenic differentiation.

关键词： bacterial infection bone scaffold selective laser sintering Fenton reaction antibacterial properties

Exogeneous metal ions as therapeutic agents in cardiovascular disease and their delivery strategies

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Regenerative Biomaterials 2024年第2期3卷 1-16页

作者： Xiaoqian hong Geer tian Yang Zhu Tanchen Ren Department of Cardiology of the Second Affliated Hospital and State Key Laboratory of Transvascular Implantation Devices Cardiovascular Key Laboratory of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310o09China Binjiang Institute of Zhejiang University Hangzhou 310053China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Metal ions participate in many metabolic processes in the human body,and their homeostasis is crucial for *** cardiovascular diseases(CVDs),the equilibriums of metal ions are frequently interrupted,which are related to a variety of disturbances of physiological processes leading to abnormal cardiac *** supplement of metal ions has the potential to work as therapeutic strategies for the treatment of *** with other therapeutic drugs,metal ions possess broad availability,good stability and safety and diverse drug delivery *** delivery strategies of metal ions are important to exert their ther-apeutic effects and reduce the potential toxic side effects for cardiovascular applications,which are also receiving increasing *** local delivery strategies for metal ions based on various biomaterials are constantly being *** this review,we comprehensively summarized the positive roles of metal ions in the treatment of cVDs from three aspects:protecting cells from oxidative stress,inducing angiogenesis,and adjusting the functions of ion *** addition,we introduced the transferability of metal ions in vascular reconstruction and cardiac tissue repair,as well as the currently available engineered strategies for the precise delivery of metal ions,such as integrated with nanoparticles,hydrogels and scaffolds.

关键词： metal ions cardiovascular disease tissue engineering oxidative stress angiogenesis ion channel

Hollow Metal-Organic Framework/MXene/Nanocellulose Composite Films for Giga/Terahertz Electromagnetic Shielding and Photothermal Conversion

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Nano-Micro Letters 2024年第9期16卷 161-179页

作者： tian Mai Lei Chen pei‑Lin Wang Qi Liu Ming‑Guo Ma Research Center of Biomass Clean Utilization MOE Engineering Research Center of Forestry Biomass Materials and BioenergyBeijing Key Laboratory of Lignocellulosic ChemistryCollege of Materials Science and TechnologyBeijing Forestry UniversityBeijing 100083People’s Republic of China State Silica-Based Materials Laboratory of Anhui Province Bengbu 233000People’s Republic of China

With the continuous advancement of communication technology,the escalating demand for electromagnetic shielding interference(EMI)materials with multifunctional and wideband EMI performance has become *** the electrical and magnetic components and designing the EMI material structure have attracted extensive interest,but remain a huge ***,we reported the alternating electromagnetic structure composite films composed of hollow metal-organic frameworks/layered MXene/nanocellulose(HMN)by alternating vacuum-assisted filtration *** HMN composite films exhibit excellent EMI shielding effectiveness performance in the GHz frequency(66.8 dB at Kaband)and THz frequency(114.6 dB at 0.1-4.0 THz).Besides,the HMN composite films also exhibit a high reflection loss of 39.7 dB at 0.7 THz with an effective absorption bandwidth up to 2.1 ***,HMN composite films show remarkable photothermal conversion performance,which can reach 104.6℃under 2.0 Sun and 235.4℃under 0.8 W cm^(−2),*** unique micro-and macrostructural design structures will absorb more incident electromagnetic waves via interfacial polarization/multiple scattering and produce more heat energy via the local surface plasmon resonance *** features make the HMN composite film a promising candidate for advanced EMI devices for future 6G communication and the protection of electronic equipment in cold environments.

关键词： Metal-organic frameworks MXene Nanocellulose Electromagnetic shielding Photothermal conversion

Chemical derivatization strategies for enhancing the HPLC analytical performance of natural active triterpenoids

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Journal of Pharmaceutical Analysis 2024年第3期14卷 295-307页

作者： Xiao-Feng Huang Ying Xue Li Yong tian-tian Wang pei Luo Lin-Sen Qing Chengdu Institute of Biology Chinese Academy of SciencesChengdu610041China State Key Laboratory for Quality Research in Chinese Medicines Macao University of Science and TechnologyMacaoChina Sichuan Center for Disease Control and Prevention Chengdu610041China University of Chinese Academy of Sciences Beijing100049China

Triterpenoids widely exist in nature,displaying a variety of pharmacological *** triterpenoids in different matrices,especially in biological samples holds great ***-performance liquid chromatography(HPLC)has become the predominant method for triterpenoids analysis due to its exceptional analytical ***,due to the structural similarities among botanical samples,achieving effective separation of each triterpenoid proves challenging,necessitating significant improvements in analytical ***,triterpenoids are characterized by a lack of ultraviolet(UV)absorption groups and chromophores,along with low ionization efficiency in mass ***,routine HPLC analysis suffers from poor *** derivatization emerges as an indispensable technique in HPLC analysis to enhance its *** the structural characteristics of triterpenoids,various derivatization reagents such as acid chlorides,rhodamines,isocyanates,sulfonic esters,and amines have been employed for the derivatization analysis of *** review comprehensively summarized the research progress made in derivatization strategies for HPLC detection of ***,the limitations and challenges encountered in previous studies are discussed,and future research directions are proposed to develop more effective derivatization methods.

关键词： Triterpenoid HPLC Derivatization Quantification

Fungal residues were more sensitive to nitrogen addition than bacterial residues in a meadow grassland soil

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Soil Ecology Letters 2024年第3期6卷 61-70页

作者： Zhifu pei Mei hong Inner Mongolia Key Laboratory of Soil Quality and Nutrient Resources Key Laboratory of Agricultural Ecological Security and Green Development at Universities of Inner Mongolia Autonomous RegionInner Mongolia Agricultural UniversityHohhot 010018China

Nitrogen(N)addition can significantly affect the amount of soil carbon(C)pools through biological routes,and microbial residues are important components of soil carbon ***,it remains unclear how N addition affects the accumulation of soil microbial residues in meadow *** study analyzed the effects of N addition on microbial residues in a meadow grassland soil,and the key factors affecting the accumulation of microbial residues under N addition were analyzed in combination with soil physicochemical properties and microbial community *** results showed that N addition significantly changed the structure of the microbial communities and the accumulation of microbial residues,mainly manifested by a significant decrease in fungal biomass and the fungal/bacterial ratio(F/B),but had no significant effect on bacterial or total microbial biomass(PLFAs).N addition significantly increased the accumulation of fungal residues(7.45%),but had no significant effect on the accumulation of bacterial residues or total amino sugar(TAS).We found that fungal residues were more affected by soil environmental factors than bacterial *** results of the random forest analysis showed that bacterial biomass under N addition was the most important predictor of soil bacterial residues,whereas total N(TN),pH and F/B were the most important predictors of soil fungal *** summary,our results indicate that fungal communities and residues accumulation play important roles in regulating the response of grassland soil C to N addition,further enhancing our understanding of the mechanisms of soil carbon pool to N addition.

关键词： nitrogen addition microbial residues microbial community composition soil organic carbon

A passive sampler for synchronously measuring inorganic and organic pollutants in sediment porewater:Configuration and field application

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Journal of Environmental Sciences 2024年第2期136卷 201-212页

作者： pei Lei Mingying Chen Nan Rong Wenzhong Tang hong Zhang School of Environment Nanjing Normal UniversityNanjing 210023China State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China South China Institute of Environmental Sciences Ministry of Ecology and EnvironmentGuangzhou 510530China State Environmental Protection Key Laboratory of Water Environmental Simulation and Pollution Control Guangzhou 510530China University of Chinese Academy of Sciences Beijing 100049China

In situ measurement of multiple pollutants coexisting in sediment porewater is an essential step in comprehensively assessing the bioavailability and risk of pollutants,but to date,this needs to be better *** this study,a passive sampler,consisting of an“I-shaped”supporting frame and inorganic/organic sampling units,incorporating equilibrium dialysis theory and kinetic/equilibrium sorption principle,was developed for the synchronous measurement of inorganic(e.g.,phosphorus and metal(loid)s)and organic pollutants(e.g.,parent and substituted PAHs).The equilibrium time and sampling rates were explored in laboratory tests to support in situ *** of pollutants in porewater within a vertical resolution of centimeters,i.e.,1 cm and 2 cm for inorganic and organic pollutants,respectively,were obtained by field deployment of the sampler for further estimation of diffusive fluxes across the sediment-water *** results suggested that the role of sediments for a specific pollutant may change(e.g.,from“sink”to“source”)during the sampling *** study demonstrated the feasibility of synchronous measurement of inorganic and organic pollutants in sediment porewater by the passive *** addition,it provided new insight for further investigation into the combined pollution effects of various pollutants in sediments.

关键词： Passive sampling Bioavailability Polycyclic aromatic hydrocarbons Combined pollution Diffusive flux