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Targeted delivery of RNAi to cancer cells using RNA-ligand displaying exosome

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1383-1399页

作者： Nasir Uddin Daniel WBinzel Dan Shu tian-min fu Peixuan Guo Center for RNA Nanobiotechnology and Nanomedicine Division of Pharmaceutics and PharmacologyCollege of Pharmacythe Ohio State UniversityColumbusOH 43210USA Dorothy M.Davis Heart and Lung Research Institute the Ohio State UniversityColumbusOH 43210USA James Comprehensive Cancer Center College of Medicinethe Ohio State UniversityColumbusOH 43210USA Department of Biological Chemistry&Pharmacology College of Medicinethe Ohio State UniversityColumbusOH 43210USA

Exosome is an excellent vesicle for in vivo delivery of therapeutics,including RNAi and chemical *** extremely high efficiency in cancer regression can partly be attributed to its fusion mechanism in delivering therapeutics to cytosol without endosome ***,being composed of a lipidbilayer membrane without specific recognition capacity for aimed-cells,the entry into nonspecific cells can lead to potential side-effects and *** engineering approaches for targeting-capacity to deliver therapeutics to specific cells is *** with chemical modification in vitro and genetic engineering in cells have been reported to decorate exosomes with targeting *** nanoparticles have been used to harbor tumor-specific ligands displayed on exosome *** negative charge reduces nonspecific binding to vital cells with negatively charged lipid-membrane due to the electrostatic repulsion,thus lowering the side-effect and *** this review,we focus on the uniqueness of RNA nanoparticles for exosome surface display of chemical ligands,small peptides or RNA aptamers,for specific cancer targeting to deliver anticancer therapeutics,highlighting recent advances in targeted delivery of siRNA and miRNA that overcomes the previous RNAi delivery *** understanding of exosome engineering with RNA nanotechnology promises efficient therapies for a wide range of cancer subtypes.

关键词： RNA interference RNA nanotechnology Endolysosome trapping Exosome engineering Targeted delivery Chemical drug delivery

Solid particle size characterization by a high-frequency collision response in pneumatic particulate flow

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Particuology 2024年第3期86卷 39-54页

作者： Kai Wang Yichen Li Ziang Chang min Qin Guangming fu Bangtang Yin Gang Wang jiaqi tian School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580China Key Laboratory of Unconventional Oil&Gas Development China University of Petroleum(East China)Ministry of EducationQingdao266580China National Engineering Research Center of Oil&Gas Drilling and Completion Technology Qingdao266580China Shock and Vibration of Engineering Materials and Structures Key Lab ofSichuan Province Southwest University of Science and TechnologyMianyang621000China

A novel triaxial vibration method is developed for the real-time characterization of the solid particle size distribution(PsD)in pneumatic particulate flow,which is critical for chemical *** this work,the particle-wall collision and friction behaviours were analysed by the time-domain statistical and timefrequency joint methods to narrow the high-frequency response range by the initial experiment of free fall for a single particle,interparticle,and multiple ***,verification experiments of PSD characterization in pneumatic flow were ***,the quantitative triaxial energy response model that considers the particle size,shape,and mass factors were ***,a good agreement of the particle number identification was found between the triaxial vibration energy and mean particle size of 150-550μ***,the performance with the best accuracy was focused on a range of 42-43 kHz in the x-axis and z-axis and 36.8-38.8 kHz in the ***,the individual particle energy was inversely analysed by the triaxial vibration response within the optimized frequency bands,and the PSD was characterized in real-time by a low error rate,that is,5.2% from the XZ-axis direction of sand(42-43 kHz)and 5.6% from the XYZ-axis of glass(30.9-33.9 kHz,46.2-47.2 kHz,38.3-41.3 kHz for each axis response).Therefore,this research complements the existing approaches for PsD characterization in particulate multiphase flow.

关键词： Solid particulate flow Triaxial vibration High-frequency response Particle wall Particle size distribution

Preparation of Self-limiting Heating Cables with Excellent Processability, Mechanical Properties and PTC Effect via Thermal and Electrical Treatments

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Chinese Journal of Polymer Science 2024年第4期42卷 511-520页

作者： tian-Hao Yang Tong Wu Qiang fu State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu610065China State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu610065China

Polymer/conductive filler composites have been widely used for the preparation of self-limiting heating cables with the positive temperature coefficient (PTC) effect. The control of conductive filler distribution and network in polymer matrix is the most critical for performance of PTC materials. In order to compensate for the destruction of the filler network structure caused by strong shearing during processing, an excessive conductive filler content is usually added into the polymer matrix, which in turn sacrifices its processability and mechanical properties. In this work, a facile post-treatment of the as-extruded cable, including thermal and electrical treatment to produce high-density polyethylene (HDPE)/carbon black (CB) cable with excellent PTC effect, is developed. It is found for the as-extruded sample, the strong shearing makes the CB particles disperse uniformly in HDPE matrix, and 25 wt% CB is needed for the formation of conductive paths. For the thermal-treated sample, a gradually aggregated CB filler structure is observed, which leads to the improvement of PTC effect and the notable reduction of CB content to 20 wt%. It is very interesting to see that for the sample with combined thermal and electrical treatment, CB particles are agglomerated and oriented along the electric field direction to create substantial conductive paths, which leads to a further decrease of CB content down to 15 wt%. In this way, self-limiting heating cables with excellent processability, mechanical properties and PTC effect have simultaneously been achieved.

关键词： Self-limiting heating cables Positive temperature coefficient Thermal treatment Electrical treatment

Short-time maritime target detection based on polarization scattering characteristics

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Journal of Systems Engineering and Electronics 2024年第1期35卷 55-64页

作者： CHEN Shichao LUO Feng tian min LYU Wanghan College of Computer and Information Engineering(College of Artificial Intelligence) Nanjing Tech UniversityNanjing 211816China Hangzhou Institute of Technology Xidian UniversityHangzhou 311200China

In this paper,a detection method combining Cameron decomposition based on polarization scattering characteristics in sea clutter background is ***,the Cameron decomposition is exploited to fuse the radar echoes of full polarization channels at the data *** to the artificial material structure on the surface of the target,it can be shown that the non-reciprocity of the target cell is stronger than that of the clutter ***,based on the analysis of the decomposition results,a new feature with scattering geometry characteristics in polarization domain,denoted as Cameron polarization decomposition scattering weight(CPD-SW),is extracted as the test statistic,which can achieve more detailed descriptions of the clutter scattering characteristics utilizing the difference between their scattering ***,the superiority of the proposed CPD-SW detector over traditional detectors in improving detection performance is verified by the IPIX measured dataset,which has strong stability under short-time observation in threshold detection and can also improve the separability of feature space zin anomaly detection.

关键词： sea clutter small target radar detection Cameron decomposition characteristics analysis

Data-driven rational design of single-atom materials for hydrogen evolution and sensing

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Nano Research 2024年第4期17卷 3352-3358页

作者： Lei Zhou Pengfei tian Bowei Zhang fu-Zhen Xuan Shanghai Key Laboratory of Intelligent Sensing and Detection Technology East China University of Science and TechnologyShanghai 200237China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Key Laboratory of Pressure Systems and Safety of ministry of Education East China University of Science and TechnologyShanghai 200237China

Herein we proposed a data-driven high-throughput principle to screen high-performance single-atom materials for hydrogen evolution reaction(HER)and hydrogen sensing by combing the theoretical computations and a topology-based multi-scale convolution kernel machine learning *** the rational training by 25 groups of data and prediction of all 168 groups of single-atom materials for HER and sensing,respectively,a high prediction accuracy(>0.931 R^(2) score)was achieved by our *** show that the promising HER catalysts include Pt atoms in C_(4) and Sc atoms in C_(1)N_(3) coordination ***,Y atoms in C_(4) coordination environment and Cd atoms in C_(2)N_(2)-ortho coordination environment were predicted with great potential as hydrogen sensing *** method provides a way to accelerate the discovery of innovative materials by avoiding the time-consuming empirical principles in experiments.

关键词： machine learning single-atom materials sensing hydrogen evolution

Stability mechanism and control of the pumpable supports in longwall recovery room

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International Journal of mining Science and Technology 2024年第7期34卷 957-974页

作者： Dong Zhang Jianbiao Bai Zhijun tian Zizheng Zhang Yonghong Guo Rui Wang Ying Xu Hao fu Shuai Yan min Deng Shuaigang Liu State Key Laboratory of Coal Resources and Safe mining China University of Mining and TechnologyXuzhou 221116China Key Laboratory of Xinjiang Coal Resources Green mining Xinjiang Key Laboratory of Coal-bearing Resources Exploration and ExploitationXinjiang Engineering Research Center of Green Intelligent Coal MiningXinjiang Institute of EngineeringUrumqi 830023China Work Safety Key Laboratory on Prevention and Control of Gas and Roof Disasters for Southern Goal mines Hunan Provincial Key Laboratory of Safe Mining Techniques of Coal MinesHunan University of Science and TechnologyXiangtan 411201China School of mines China University of Mining and TechnologyXuzhou 221116China

The load-bearing performance(LBP)of pumpable supports(PPS)is crucial for the stability of longwall pre-driven recovery room(PRR)surrounding ***,the unbalanced bearing coefficient(UBC)of the PPS(undertaking unequal load along the mining direction)has not been investigated.A mechanical model of the PRR was established,considering the main roof cantilever beam structure,to derive an assessment formula for the load,the failure criteria,and the UBC of the ***,the generation mechanisms,and influencing factors of the UBC were *** sensitivity analysis shows that the main roof hanging length(l_(2))and the spacing between the PPS(r)significantly impact the UBC.A novel design of the PPS and the coupling control technology were proposed and applied to reduce the UBC of the PPS in the adjacent longwall *** results showed no failure of the PPS at the test site,with the UBC(ζ)reduced to 1.1 consistent with the design value(1.15)basically,fully utilizing the collaborative LBP of the ***,the maximum roof-to-floor convergence of the PRR was 234 mm,effectively controlling the stability of the surrounding rock of the PRR and ensuring the mining equipment recovery.

关键词： Pre-driven recovery room Pumpable supports Unbalanced bearing coefficient Hydraulic fracture Stability analysis Surrounding rock control

Effect of Al content in molten steel on interaction between MgO-C refractory and SPHC steel

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Journal of Iron and Steel Research International 2024年第4期31卷 838-848页

作者： fu-bin Gao fu-ming Wang Xiang Zhang tian-yu Du Xin-hua Wangg School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Handan Iron and Steel Company Hegang GroupHandan 056015HebeiChina The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The effect of Al content in molten steel on the interaction between SPHC steel(0.005-0.068 wt.%Al,and 19×10^(-4)-58×10^(-4)wt.%O)and MgO-C refractory(11.63 wt.%C)was ***-metallic inclusions in the steel were examined at various periods(0,5,15,30,45,and 60 min)as well as the MgO-C interface after 60 min of corrosion at 1600℃.The results show that when MgO-C refractory comes into contact with SPHC steel,the refractory interface consists of three layers arranged from the innermost to the outermost,including the original refractory layer,the dense MgO layer,and the iron infiltration *** carbon in the MgO-C refractories and the Al content in the molten steel undergo a reaction with the MgO in the refractories,resulting in an increase in Mg concentration in the *** Al content in the molten steel from 0.005 to 0.068 wt.%causes a spinel layer to appear at the interface,and the disappearance time of Al_(2)O_(3) inclusions in the steel decreases from 60 to 30 min,while the average MgO content in inclusions ***,controlling the Al content in the molten steel and the smelting duration can help regulate the formation of spinel inclusionsinthe steel.

关键词： MgO-C refractory SPHC steel Inclusion-Spinel Al-killed steel Interfacial reaction

Revealing the Structure-Property Difference of Natural Rubber Prepared by Different Methods: Protein and Gel Content are Key Factors

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Chinese Journal of Polymer Science 2024年第4期42卷 457-467页

作者： Shao-Qi Huang Jun-Qi Zhang Yong Zhu Ling-min Kong Lu-Sheng Liao fu-Quan Zhang Zheng-tian Xie Jin-Rong Wu State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu610065China Hainan Provincial Key Laboratory of Natural Rubber Processing Agricultural Products Processing Research Institute of Chinese Academy of Tropical Agricultural SciencesZhanjiang524001China

Natural rubber (NR) is widely used in various fields including aerospace, military industry and transportation due to its superior elasticity and comprehensive mechanical properties. Nonetheless, the commercial NR prepared by different methods usually exhibits different mechanical properties, primarily due to variations in processing conditions during the conversion from latex to bulk rubber material. Consequently, this poses challenges in scientific research and industrial production of NR. In order to assess the properties of various commercially available NR and identify key structural and compositional components, this study systematically compares and analyzes four representative NR raw materials: air dried sheet (ADS), ribbed smoked sheets (RSS), constant viscidity NR (CV), and whole field latex rubber (WF). The investigation focuses on evaluating their static mechanical behavior, SIC behavior, wear resistance, and fatigue resistance. The findings indicate that protein and gel content exhibit a crucial influence on the NR properties. These constituents contribute to the formation of a high-crosslinking density region, generating a heterogeneous network structure within the rubber. This structure amplifies strains during deformation, leading to earlier and stronger strain-induced crystallization (SIC). Among the four commercial NR brands, RSS demonstrates superior overall mechanical and dynamic properties owing to its high protein and gel content. This study serves as a valuable reference for comprehending the differences in properties among various commercial NR, thereby offering guidance for the actual processing and selection of NR.

关键词： Natural rubber Processingmethod Protein Gel content Property

Critical precipitation behavior of MnTe inclusions in resulfurized steels during solidification

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International Journal of minerals,Metallurgy and Materials 2024年第8期31卷 1849-1857页

作者： Xiangyu Xu Lu Zhang Zifei Wang Qianren tian Jianxun fu Xuemin Wang Center for Advanced Solidification Technology(CAST) School of Materials Science and EngineeringShanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China Yangjiang Branch Guangdong Laboratory for Materials Science and Technology(Yangjiang)Advanced Alloys LaboratoryYangjiang 529500China

Te treatment is an effective method for modifying sulfide inclusions,and MnTe precipitation has an important effect on thermal brittleness and steel corrosion *** most actual industrial applications of Te treatment,MnTe precipitation is *** critical precipitation behavior of MnTe inclusions was investigated through scanning electron microscopy,transmission electron microscopy,machine learning,and first-principles *** preferentially precipitated at the container mouth for sphere-like sulfides and at the interface between MnS grain boundaries and steel matrix for rod-like *** MnS/MnTe interface was semicoherent.A composition transition zone with a rock-salt structure exhibiting periodic changes existed to maintain the semicoherent *** critical precipitation behavior of MnTe inclusions in resulfurized steels involved three stages at varying ***,Mn(S,Te)precipitated during ***,MnTe with a rock-salt structure precipitated from Mn(S,Te).Third,MnTe with a hexagonal NiAs structure transformed from the rock-salt *** solubility of Te in MnS decreased with decreasing *** critical precipitation behavior of MnTe inclusions in resulfurized steels was related to the MnS precipitation *** the increase in MnS precipitation temperature,the critical Te/S weight ratio *** consideration of the cost-effectiveness of Te addition for industrial production,the Te content in resulfurized steels should be controlled in accordance with MnS precipitation temperature and S content.

关键词： resulfurized steels modification of inclusion manganese telluride precipitation