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Active component of Isatidis Radixon insulin resistance in diabetes mellitus rat

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中国药理学与毒理学杂志 2015年第S1期29卷 68-69页

作者： Ji-ping LI tian-jiao hu Zhen JIANG Mo-xiang LIU Department of Pharmacology Yangzhou University Institute of Natural Medicine and Chinese Medicine Research Yangzhou University Yangzhou 225001 China

OBJECTIVE To investigate the role of active component of Isatidis Radix on insulin resistance in the diabetes mellitus *** To induce diabetic rat model with long-term high sugar and high fat plus low-dose streptozotocin(25 mg·kg-1).Then rats were randomly divided into 6 groups:control group,model group,rosiglitazone maleate group(0.3mg·kg-1),high(100mg·kg-1),middle(50mg·kg-1)and low(25 mg·kg-1)active component of Isatidis Radix *** were adiministered orally once a *** four weeks,following substances were measured:serum fasting blood glucose,total cholesterol,triglycerides,high density lipoprotein,low density lipoprotein,free fatty acids,fasting insulin,insulin index,pathological observation and immunohistochemistry technology of pancreas *** High and middle active component of Isatidis Radix group could decrease serum FBG,TC,TG,LDL,FFA,FINS and increase serum HDL,ISI;the damage of the pancreas islet has been restoration *** Active component of Isatidis Radix could improve insulin resistance in diabetic rats,which might be related to improvement of the function of pancreas islet.

关键词： diabetes mellitus insulin resistance active compon

Facile preparation of antibacterial polymer coatings via thiol-yne click photopolymerization

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Chinese Chemical Letters 2016年第5期27卷 681-684页

作者： Chuan Zhou Yi-He Li Zhen-hua Jiang Kwang-Duk Ahn tian-jiao hu Qing-hua Wang Chun-hua Wang Department of Chemistry and Biology College of Science National University of Defense Technology Polymer Research Center Korea Institute of Science and Technology

Novel antibacterial polymer coatings were prepared by a facile thiol-yne click photopolymerization of 1-propargyl-3-allYl-l,3-diazanyl-2,4-cyclopentadiene bromide （[PAIMIBr） and tetra（3-mercapto-pro- pionate）pentaerythritol （PETMP）（2：1 molar ratio） using 2,2-dimethoxy-2-phenylacetophenone （DMPA） as initiator. The antibacterial activity of the coatings was tested against Staphylococcus aureus （ATCC 292130） and Escherichia coli （ATCC 25922） by the dynamic shake method. The evaluation results revealed the antibacterial polymer coatings exhibited excellent inhibitory activity against S. aureus and E. coil, especially for S. aureus.

关键词： Antibacterial polymer Thiol-yneClick chemistry UV-curing Coatings

Poly[(mercaptopropyl)methylsiloxane](PMMS)-based antibacterial polymer coatings prepared by a two-step sequential thiol–ene click chemistry

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Chinese Chemical Letters 2016年第5期27卷 685-688页

作者： Chuan Zhou Yi-He Li Zhen-hua Jiang Kwang-Duk Ahn tian-jiao hu Qing-hua Wang Chun-hua Wang Department of Chemistry and Biology. College of Science National University of Defense Technology Changsha 410073 China State Key Laboratory of NBC Protection for Civilian Beijing 102205 China Polymer Research Center Korea Institute of Science and Technology Seoul 136-791 Republic of Korea

Poly[（mercaptopropyl）methylsiloxane] （PMMS）-based antibacterial polymer coatings have been prepared through a two-step sequential thiol-ene click chemistry utilizing 1-allyl-3-decylimidazolium bromide （ADIm） as antibacterial monomer and triallyl cyanurate （TAC） as the crosslinker. These films with different content of ADIm were characterized by thermogravimetric analysis （TGA）, dynamic mechanical analysis （DMA） and pencil hardness. It was found that the mechanical and thermal properties of these films were largely influenced by the content of ADIm in the films. Films with imidazolium bromide groups displayed excellent antimicrobial activity against Staphylococcus aureus with 100% killing efficiency.

关键词： Antibacterial polymerThiol-ene UV-curing Click chemistry Coatings

SensFL:Privacy-Preserving Vertical Federated Learning with Sensitive Regularization

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 385-404页

作者： Chongzhen Zhang Zhichen Liu Xiangrui Xu Fuqiang hu jiao Dai Baigen Cai Wei Wang School of Automation and Intelligence Beijing Jiaotong UniversityBeijing100044China Shuohuang Railway Development Co. Ltd.National Energy GroupCangzhou062350China Beijing Key Laboratory of Security and Privacy in Intelligent Transportation School of Computer Science and TechnologyBeijing Jiaotong UniversityBeijing100044China

In the realm of Intelligent Railway Transportation Systems,effective multi-party collaboration is crucial due to concerns over privacy and data *** Federated Learning(VFL)has emerged as a promising approach to facilitate such collaboration,allowing diverse entities to collectively enhance machine learning models without the need to share sensitive training ***,existing works have highlighted VFL’s susceptibility to privacy inference attacks,where an honest but curious server could potentially reconstruct a client’s raw data from embeddings uploaded by the *** vulnerability poses a significant threat to VFL-based intelligent railway transportation *** this paper,we introduce SensFL,a novel privacy-enhancing method to against privacy inference attacks in ***,SensFL integrates regularization of the sensitivity of embeddings to the original data into the model training process,effectively limiting the information contained in shared *** reducing the sensitivity of embeddings to the original data,SensFL can effectively resist reverse privacy attacks and prevent the reconstruction of the original data from the *** experiments were conducted on four distinct datasets and three different models to demonstrate the efficacy of *** results show that SensFL can effectively mitigate privacy inference attacks while maintaining the accuracy of the primary learning *** results underscore SensFL’s potential to advance privacy protection technologies within VFL-based intelligent railway systems,addressing critical security concerns in collaborative learning environments.

关键词： Vertical federated learning privacy defenses

Advances in the Development of Gradient Scaffolds Made of Nano-Micromaterials for Musculoskeletal Tissue Regeneration

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NANO-MICRO LETTERS 2025年第1期17卷 1-46页

作者： Fang, Lei Lin, Xiaoqi Xu, Ruian Liu, Lu Zhang, Yu tian, Feng Li, jiao jiao Xue, Jiajia Beijing Univ Chem Technol Beijing Lab Biomed Mat Beijing 100029 Peoples R China Beijing Univ Chem Technol State Key Lab Organ Inorgan Composites Beijing 100029 Peoples R China Univ Technol Sydney Fac Engn & IT Sch Biomed Engn Sydney NSW 2007 Australia

This review highlights the gradient variations in the structural composition of musculoskeletal tissues and comprehensively examines recent progress in the fabrication and application of biomimetic gradient scaffolds for musculoskeletal *** challenges and prospects of gradient scaffolds for clinical application are discussed. The intricate hierarchical structure of musculoskeletal tissues, including bone and interface tissues, necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered substitutes. This has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic outcomes. Building on the anatomical characteristics of bone and interfacial tissues, this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues, specifically focusing on methods used to construct compositional and structural gradients within the scaffolds. The latest applications of gradient scaffolds for the regeneration of bone, osteochondral, and tendon-to-bone interfaces are presented. Furthermore, the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed, as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

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功能化改性聚硅烷的研究进展及应用前景

高分子学报 2015年第7期25卷 742-757页

作者：浦文婧王春宇胡天娇李效东国防科学技术大学理学院化学与生物学系长沙410073 防化研究院第一研究所北京100191

聚硅烷是一类主链由连续Si原子组成的聚合物,其主链具有类似于大π共轭的σ-σ共轭结构.这种特殊结构使得线型聚硅烷既具有与普通大π共轭导电聚合物相似的电导行为,又具有其它导电聚合物所不具备的优良溶解性和可加工性,是一类潜力巨... 详细信息

聚硅烷是一类主链由连续Si原子组成的聚合物,其主链具有类似于大π共轭的σ-σ共轭结构.这种特殊结构使得线型聚硅烷既具有与普通大π共轭导电聚合物相似的电导行为,又具有其它导电聚合物所不具备的优良溶解性和可加工性,是一类潜力巨大的功能高分子材料.但单纯聚硅烷的光致/电致发光和导电性能与其它功能高分子材料相比还不够突出,自身对水分和空气比较敏感,需要对其进行改性.本文对聚硅烷的结构与性能之间的关系进行了归纳,对聚硅烷的改性方法进行了详细分类并综述,并对聚硅烷的应用方向和研究进展进行了总结,最后对功能化聚硅烷的应用前景进行了展望.

关键词：聚硅烷功能化改性有机功能材料

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

Evaluation of simulation-based training for aircraft carrier marshalling with learning cubic and Kirkpatrick's models

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Chinese Journal of Aeronautics 2015年第1期28卷 152-163页

作者： tian Yongliang Liu hu Yin jiao Luo Mingqiang Wu Guanghui School of Aeronautic Science and Engineering Beihang University Chengdu Aircraft Design Institute Commercial Aircraft Corporation of China Ltd.

Simulation-based training is a promising way to train a carrier flight deck crew because of the complex and dangerous working environment. Quantitative evaluation of simulation-based training quality is vital to make simulation-based training practical for aircraft carrier *** paper develops a personal computer-based aircraft carrier marshalling simulation system and a cave automatic virtual environment（CAVE）-based immersive environment. In order to compare the training effectiveness of simulation-based training and paper-based training, a learning cubic model is proposed and a contrast experiment is carried out as well. The experimental data is analyzed based on a simplified Kirkpatrick＇s model. The results show that simulation-based training is better than paper-based training by 26.80% after three rounds of testing, which prove the effectiveness of simulation-based aircraft carrier marshalling training.

关键词： aircraft cubic dangerous simplified questionnaire vital train deviation pyramid judge

Quantum steerability of two qubits mediated by one-dimensional plasmonic waveguides

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Chinese Physics B 2022年第12期31卷 74-80页

作者： Ye-Qi Zhang Xiao-Ting Ding jiao Sun tian-hu Wang Department of Mathematics and Physics North China Electric Power UniversityBeijing 102206China School of Energy Power and Mechanical Engineering North China Electric Power UniversityBeijing 102206China

We study the dynamics of the quantum steering between two separated qubits trapped in a one-dimensional plasmonic *** numerical methods,we calculate the quantum steerability and other quantum correlations,i.e.,entanglement,discord,and coherence,for both cases with and without laser driving *** is found that steerability may exhibit a sudden disappearance and sudden reappearance ***,there exist time windows with no steerability but finite *** effects of plasmon wavenumber and the distance between the two qubits on steerability are also ***,we show that quantum steerability is tunable by adjusting the laser driving fields.

关键词： quantum steering quantum correlations plasmonic waveguide