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Beam oscillating parameters on pore inhibition,recrystallization and grain boundary characteristics of laser-arc hybrid welded AZ31 magnesium alloy

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Journal of Magnesium and Alloys 2024年第6期12卷 2489-2502页

作者： Kangda hao Yongkang Gao Lianyong Xu Yongdian Han Lei Zhao Wenjin ren Hongyang Jing School of Materials Science and Engineering Tianjin UniversityTianjin300350PR China tianjin Key Laboratory of Advanced Joining Technology Tianjin300350PR China

Oscillating laser-arc hybrid welding of AZ31B magnesium alloy was carried out,the effects of beam oscillation parameters on pore inhibition,microstructure,grain boundary characteristics and tensile properties were *** results showed that the pore formation can be inhibited with oscillating frequency higher than 75 Hz and radius smaller than 0.5 *** columnar grains neighboring the fusion line can be broken by the beam oscillation behavior,while the grain growth was promoted with the increase of frequency or *** should be noted that the coincidence site lattice(CSL)boundaries were mainlyΣ13b andΣ29 boundaries,which were contributed by{10■2}tensile twins and{11■2}compression twins,*** total fraction of CSL boundaries reached maximum at radius of 0.25 mm and frequency of 75 Hz,which was also confirmed as the optimized *** this case,the elongation rate increased up to 13.2%,12.8%higher than that of the weld without beam ***,the pore formation and inhibition mechanisms were illustrated according to the state of melt flow and keyhole formation,the abnormal growth was discussed basing on secondary recrystallization,and the relationship among the pore formation,grain size,boundary characteristics and weld toughness were finally established.

关键词： Magnesium alloy Laser-arc hybrid welding Beam oscillation Recrystallization Mechanical properties

Constructing thermoresponsive PNIPAM-based microcarriers for cell culture and enzyme-free cell harvesting

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Chinese Chemical Letters 2024年第7期35卷 412-416页

作者： Yunan Yuan Zhimin Luo Jie Chen Chaoliang He Kai hao Huayu tian CAS Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China Jilin Biomedical Polymers Engineering Laboratory Changchun 130022China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China

The development of large-scale cell cultivation and non-invasive cell harvesting is highly desired in various fields,including biological regeneration and pharmaceutical *** using traditional microcarriers for cell culture,trypsinization is often necessary during cell collection,leading to partial cells *** this work,we developed a thermoresponsive glass microcarrier modified with poly(γ-propargyl-L-glutamate)(PPLG)and poly(N-isopropylacrylamide)(PNIPAM).We utilized these microcarriers for three-dimensional cell culture and enzyme-free cell harvesting,and the results indicated that the prepared microcarriers exhibited excellent non-invasive cell culture performance.

关键词： Microcarrier Temperature-responese PNIPAM Polymers Cell culture

Effect of the Retarder on Initial Hydration and Mechanical Properties of the"one-step"Alkaliactivated Composite Cementitious Materials

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1199-1213页

作者： DING Rui HE Yue LI Xingchen LI Han tian hao WANG Hongen School of Materials Science and Engineering Jilin Jianzhu UniversityChangchun 130118China Ziyang Urban Construction Investment Group Co. LtdNanchong 637000China Shandong Taihe Urban Construction Development Co. Ltd.Jining 272000China

This paper studied the effects of different retarders on the performance of the"one-step"alkali-activated composite cementitious material(ACCM)which is composed of ground granulated blast slag(GGBS)and fly ash(FA),and analyzed its mechanical properties,hydration mechanism,and retardation *** effects of retarders on the hydration products,mechanical properties,and hydration kinetics of ACCM were investigated using XRD,SEM,FTIR,EDS,and thermoactive *** results showed that Na_(2)B_(4)O_(7)·10H_(2)O(B)delayed the exotherm during the alkali activation process and could effectively delay the setting time of ACCM,but the mechanical properties were slightly *** setting time of ACCM increased with the increase in SG content,but the mechanical properties of ACCM decreased with the increase in SG content.C1_(2)H_(22)O_(11)(CHO)could effectively delay the hydration reaction of ACCM and weakly enhanced the compressive strength.H_(3)PO_(4)(HP)at a concentration of 0.05 mol/L had a certain effect on ACCM retardation,but HP at a concentration of 0.07 and 0.09 mol/L had an effect of promoting the setting and hardening time of ACCM.

关键词： "one-step"alkali-activated composite cementitious materials solid activator hydration mechanism retarder retarding mechanism

FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury

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Military Medical Research 2024年第4期11卷 521-542页

作者： Mi Zhou Yang-Wu-Yue Liu Yu-Hang He Jing-Yu Zhang hao Guo hao Wang Jia-Kui ren Yi-Xun Su Teng Yang Jia-Bo Li Wen-Hui He Peng-Jiao Ma Man-tian Mi Shuang-Shuang Dai Department of Biochemistry and Molecular Biology School of Basic MedicineArmy Medical UniversityChongqing 400038China Research Center for Nutrition and Food Safety Chongqing Key Laboratory of Nutrition and HealthInstitute of Military Preventive MedicineArmy Medical UniversityChongqing 400038China Department of Neurosurgery Daping HospitalArmy Medical UniversityChongqing 400042China Department of Trauma and Emergency Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Histology and Embryology Chongqing Key Laboratory of NeurobiologyBrain and Intelligence Research Key Suyixun Laboratory of Chongqing Education CommissionArmy Medical UniversityChongqing 400038China Research Center Seventh Affiliated Hospital of Sun Yat-Sen UniversityShenzhen 518107GuangdongChina

Background:Neutrophils are traditionally viewed as first responders but have a short onset of action in response to traumatic brain injury(TBI).However,the heterogeneity,multifunctionality,and time-dependent modulation of brain damage and outcome mediated by neutrophils after TBI remain poorly ***:Using the combined single-cell transcriptomics,metabolomics,and proteomics analysis from TBI patients and the TBI mouse model,we investigate a novel neutrophil phenotype and its associated effects on TBI outcome by neurological deficit scoring and behavioral *** also characterized the underlying mechanisms both invitro and invivo through molecular simulations,signaling detections,gene expression regulation assessments[including dual-luciferase reporter and chromatin immunoprecipitation(ChIP)assays],primary cultures or co-cultures of neutrophils and oligodendrocytes,intracellular iron,and lipid hydroperoxide concentration measurements,as well as forkhead box protein O1(FOXO1)conditional knockout ***:We identified that high expression of the FOXO1 protein was induced in neutrophils after TBI both in TBI patients and the TBI mouse *** of these FOXO1high neutrophils in the brain was detected not only in the acute phase but also in the chronic phase post-TBI,aggravating acute brain inflammatory damage and promoting late TBI-induced *** the acute stage,FOXO1 upregulated cytoplasmic Versican(VCAN)to interact with the apoptosis regulator B-cell lymphoma-2(BCL-2)-associated X protein(BAX),suppressing the mitochondrial translocation of BAX,which mediated the antiapoptotic effect companied with enhancing interleukin-6(IL-6)production of FOXO1high *** the chronic stage,the“FOXO1-transferrin receptor(TFRC)”mechanism contributes to FOXO1high neutrophil ferroptosis,disturbing the iron homeostasis of oligodendrocytes and inducing a reduction in myelin basic protein,which contributes to the progression of late depression afte

关键词： Traumatic brain injury(TBI) Neutrophil Forkhead box protein O1(FOXO1) Acute stage Chronic stage

Stable hydrogen-bonded organic frameworks and their photo-and electro-responses

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Nano Research 2024年第8期17卷 7675-7699页

作者： Ying Hou Xin-Song Huang Sheng-hao Gong Chen Liu Yangyang Liu tian-Fu Liu State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry and Biochemistry California State UniversityLos AngelesCalifornia 90032USA College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China

Hydrogen-bonded organic frameworks(HOFs)are a recent class of porous materials that have garnered considerable research interest owing to their distinctive *** can be constructed through judicious selection of H-bonding motifs,which are further enforced by other weak intermolecular interactions such asπ–πstacking,van der Waals forces,and framework *** advantage of these interactions,we can expand the functional field of HOFs by introducing active ***,researchers have made substantial advancements in using HOFs for chemical sensing,catalysis,proton conduction,biological applications,and *** low bonding energy of H-bonds allows for precise control over the concentration of ligands in solvents,forming diverse HOF *** varied structures offer significant advantages for producing HOFs with photo-responsive and electro-responsive ***,the presence of H-bonds in HOFs results in their inherent lower stability compared to metal-organic frameworks(MOFs)and covalent-organic frameworks(COFs)formed via coordination and covalent bonds,*** a result,the pursuit of stable and innovative HOF materials with novel functional sites remains an ongoing *** review provides an overview of recent research progress in the development of new strategies for stable HOF synthesis and applications of HOFs with stimuli-responsive *** first classified all synthetic methods reported to date and discussed the stable HOFs synthesized,as well as their unique properties and *** addition,we summarized the applications of HOFs utilizing their synergistic responses to external stimuli,including photo,electrical,pressure,and chemical *** systematically reviewed stable HOF synthesis and applications,which may lead to a deeper understanding of the structure–activity relationship for these materials and guide future HOF design.

关键词： stable hydrogen-bonded organic frameworks(HOFs) photo-response electro-response photoelectric synergistic response

Polydatin ameliorates hepatic ischemia-reperfusion injury by modulating macrophage polarization

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 25-34页

作者： Hai-Li Bao Chuan-Zhi Chen Chang-Zhen ren Ke-Yan Sun hao Liu Shao-Hua Song Zhi-ren Fu Department of Organ Transplantation Shanghai Changzheng HospitalNavy Military Medical UniversityShanghai 200003China Department of Surgical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Cardiology Shanghai Changzheng HospitalNaval Military Medical UniversityShanghai 200003China Department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Background:Polydatin,a glucoside of resveratrol,has shown protective effects against various ***,little is known about its effect on hepatic ischemia-reperfusion(I/R)*** study aimed to elucidate whether polydatin protects liver against I/R-induced injury and to explore the underlying ***:After gavage feeding polydatin once daily for a week,mice underwent a partial hepatic I/R *** alanine aminotransferase(ALT)/aspartate aminotransferase(AST),hematoxylin-eosin(H&E)and TdT-mediated dUTP nick-end labeling(TUNEL)staining were used to evaluate liver *** severity related to the inflammatory response and reactive oxygen species(ROS)production was also ***,immunofluorescence and Western blotting were used to detect macrophage polarization and the NF-κB signaling pathway in ***:Compared with the I/R group,polydatin pretreatment significantly attenuated I/R-induced liver damage and *** oxidative stress marker(dihydroethidium fluorescence,malondialdehyde,superoxide dismutase and glutathione peroxidase)and I/R related inflammatory cytokines(interleukin1β,interleukin-10 and tumor necrosis factor-α)were significantly suppressed after polydatin *** addition,the result of immunofluorescence indicated that polydatin reduced the polarization of macrophages toward M1 macrophages both in vivo and in *** blotting showed that polydatin inhibited the pro-inflammatory function of RAW264.7 via down-regulating the NF-κB signaling ***:Polydatin protects the liver from I/R injury by remodeling macrophage polarization via NFκB signaling.

关键词： Hepatic ischemia-reperfusion injury Polydatin Macrophage Polarization Inflammation

The swirl and pyrolysis reaction synergistically enhance solid-solid heat transfer and product separation in cyclone pyrolyzer Author links open overlay panel

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Particuology 2024年第8期91卷 118-127页

作者： haorui Niu Jingxuan Yang Wenhao Lian Nan Zhang Yongguo Li Hongzheng ren Xiaogang hao Guoqing Guan College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan030024 China School of Chemical Engineering and Technology North University of ChinaTaiyuan030051 China CNNC Key Laboratory on Radioactive Gas Purification Technology China Institute for Radiation ProtectionTaiyuan030006 China Energy Conversion Engineering Laboratory Institute of Regional InnovationHirosaki University3-BunkyochoHirosaki036-8561Japan

Cyclone pyrolyzer is a novel type of downer that combines centrifugal force field and double-layer cyclone *** on transfer behavior is helpful to optimize the pyrolyzer to meet the needs of *** this study,the Computational Particle Fluid Dynamics(CPFD)model is used to analyze the transfer behavior of binary particles,and finds that the swirl and reaction have a synergistic *** effect can increase the heating rate of the particles to the range of flash pyrolysis,and its mechanism lies in the flow field structure of the *** to the centrifugal force field,the particles gather to the near *** rapid swirl,which facilitates intense gas-solid heat transfer,leads to the rapid heating and pyrolysis of biomass *** the pyrolysis proceeds,the mass of the biomass particles becomes smaller and they are more easily affected by the gas flow in *** the action of gas flow,char particles serve as new heat carrier to form the inner cycle of particles,which strengthens the heating *** pyrolysis products are discharged from the exhaust port in time with the flow field of the pyrolyzer to achieve separation from the heat carrier and inhibit the occurrence of secondary reactions.

关键词： Biomass pyrolysis Cyclone pyrolyzer Intra-particle circulation Synergistic effect

Abnormal mechanochemical effect in ultraprecision machining of an additively manufactured precipitation-strengthened high-entropy alloy

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Journal of Materials Science & Technology 2024年第3期170卷 221-237页

作者： Long Xu Yuchao Bai Yunfa Guo Chang ren Xiaohua Tan Yandong Jia Gang Wang hao Wang Institute of Materials Shanghai UniversityShanghai 200444China Zhejiang Institute of Advanced Materials Shanghai UniversityJiashan 314100China Department of Mechanical Engineering National University of SingaporeSingapore 117575Singapore

Recently,researchers have explored the use of precipitation strengthening and finer microstructures with high-density dislocations in additive manufacturing to produce high-entropy alloys(HEAs)with adjustable ***,the inherent surface roughness and lack of machinability research in AMed HEAs limit their engineering *** this study,we systematically investigated the microstructural characteristics,mechanical properties,and machinability of Fe_(29.3)Co_(28.7)Ni_(28.6)Al_(6.8)Ti_(6.6)(at.%)HEAs with three different structures:single FCC phase cellular(SPC),dual precipitation-strengthened(DPS),and single precipitation-strengthened(SPS).These structures were fabricated by selective laser melting and isothermally annealing at 780 and 940℃.Compared to SPC HEA,DPS HEA exhibits a significant increase in yield strength and ultimate tensile strength but with a dramatic sacrifice in *** HEA exhibits similar mechanical properties to SPC HEA due to the pronounced coarsening of L21 *** ultraprecision machining micro-cutting test showed that SPC HEA had a significant mechanochem-ical effect,as evidenced by a sharp drop in cutting force for inked workpieces,but not DPS *** abnormal finding was that the negligible reflection of cutting force for SPS HEAs suggested a negative mechanochemical effect,even though SPS HEA had equally excellent plasticity like SPC *** was found that nanocrystallization-induced strength enhancement and ductility reduction of SPS HEA lead to chips’deformation dominated by shear avalanche rather than chip folding of SPC HEA,which involves the reduction of surface energy and friction of chips’***,these results and our research findings may guide the machining of AMed precipitation-strengthened HEAs and accelerate their engineering ap-plication.

关键词： High-entropy alloy Selective laser melting Precipitation strengthening Machinability Mechanochemical effect

Enhancing Offensive Language Detection with Data Augmentation and Knowledge Distillation

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Research 2024年第2期6卷 29-40页

作者： Jiawen Deng Zhuang Chen hao Sun Zhexin Zhang Jincenzi Wu Satoshi Nakagawa Fuji ren Minlie Huang The CoAl group DCSTInstitute for Artificial InteligenceState Key Lab of Intelligent Technology and SystemsBeijing National Research Center for Information Science and TechnologyTsinghua UniversityBeijing 100084China Graduate School of Information Science&Technology The University of Tokyo.Tokyo 1138654Japan School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengduSichuan611731China

Offensive language detection has received important attention and plays a crucial role in promoting healthy communication on social platforms,as well as promoting the safe deployment of large language *** data is the basis for developing detectors;however,the available offense-related dataset in Chinese is severely limited in terms of data scale and coverage when compared to English *** significantly affects the accuracy of Chinese offensive language detectors in practical applications,especially when dealing with hard cases or out-of-domain *** alleviate the limitations posed by available datasets,we introduce AugCOLD(Augmented Chinese Offensive Language Dataset),a large-scale unsupervised dataset containing 1 million samples gathered by data crawling and model ***,we employ a multiteacher distillation framework to enhance detection performance with unsupervised *** is,we build multiple teachers with publicly accessible datasets and use them to assign soft labels to *** soft labels serve as a bridge for knowledge to be distilled from both AugCOLD and multiteacher to the student network,i.e.,the final offensive *** conduct experiments on multiple public test sets and our well-designed hard tests,demonstrating that our proposal can effectively improve the generalization and robustness of the offensive language detector.

关键词： COLD dealing limitations