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HBV DNA vaccine with adjuvant cytokines induced specific immune responses against HBV infection

World Journal of Gastroenterology 2003年第1期9卷 108-111页

作者： De-WeiDu zhan-Shengjia guang-YuLi Yong-YingZhou DepartmentofInfectiousDiseases TangduHospitalFourthMilitaryMedicalUniversity'Xi'an710038ShaanxiProvinceChina DepartmentofInfectiousDiseases TangduHospitalFourthMilitaryMedicalUniversity'Xi'an710038ShaanxiProvinceChina

AIM:To seek for an effective method to improve the immune responses induced by DNA vaccine expressing HBV surface antigen(pCR3.1-S)in Balb/c mice(H-2~d). METHODS:The pCR3.1-S plasmid and the eukaryotic expression vectors expressing murine IL-2(pDOR-IL-2)or IL-12(pWRG3169)were injected into mice subcutaneously. The immune responses to pCR3.1-S and the adjuvant effect of the cytokines plasmid were *** the effect of pCR3.1-S on anti-translated subcutaneous tumor of P815 mastocytoma cells stably expressing HBsAg(P815-HBV-S) was also ***-HBs in serum was detected by enzyme- linked immunoadsordent assay(ELISA)and HBsAg specific cytotoxic T lymphocytes(CTLs)activity was measured by ^(51)Cr release *** three weeks of DNA immunization,the cells of P815-HBV-S were inoculated into mice subcutaneously and the tumor growth was measured every five *** survival rate and living periods of mice were also calculated. RESULTS:After 8 wk DNA immunization,the A 450 nm values of sera in mice immunized with pCR3.1,pCR3.1-S and pCR3.1-S codeliveried with IL-2 or IL-12 plasmids were 0.03+0.01,1.24±0.10,1.98±0.17 and 1.67±0.12 *** in mice codeliveried pCR3.1-S with IL-2 or IL-12 plasmids were significantly higher than that of mice injected pCR3.1 or pCR3.1-S *** HBsAg specific CTL activities in mice coinjected with pCR3.1-S and IL-2 or IL- l2 eukaryotic expression vectors were(61.9±7.1)% and (73.3±8.8)%,which were significantly higher than that of mice injected with pCR3.1(10.1±2.1)% or pCR3.1-S(50.5 ±6.4)%.The HBsAg specific CTL activities in mice injected with pCR3.1,pCR3.1-S,pCR3.1-S combined with IL-2 or IL- l2 eukaryotic expression vectors decreased significantly to (3.2±0.8)%,(10.6±1.4)%,(13.6±1.3)% and(16.9±2.3) % respectively after the spleen cells were treated by anti- CD8^+ monoclonal antibody,but presented no significant change to anti-CD4^+ monoclonal antibody or unrelated to monoclonal *** HBV-S DNA vaccine(pCR3.1-S

关键词：乙型肝炎 HBV-DNA疫苗免疫反应细胞因子酶联免疫法

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Effect of anti-tuberculosis therapy on liver function of pulmonary tuberculosis patients infected with hepatitis B virus

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World Journal of Gastroenterology 2005年第16期11卷 2518-2521页

作者： LeiPan zhan-ShengJia LinChen En-QingFu guang-YuLi CenterofInfectiousDiseases TangduHospitalFourthMilitaryMedicalUniversityXi'an710038ShaanxiProvinceChina RespiratoryDepartment TangduHospitalFourthMilitaryMedicalUniversityXi'an710038ShaanxiProvinceChina

AIM: To observe the effect of anti-tuberculosis therapy on liver function of pulmonary tuberculosis patients with hepatitis B virus (HBV) infection, and to compare the differences of liver function by two treatments of ***: Forty-seven TB patients with HBV infection and 170 TB patients without HBV infection were divided into HPBE(S) and HLAMKO treatment groups. Liver function tests before and after the treatments were performed once in 2 wk or monthly, and their clinical manifestations were ***: The rate of hepatotoxicity occurred in 26 (59%)TB patients with HBV during anti-TB treatment, higher than that in 40 (24%) TB patients without HBV. Hepatotoxicity occurred in 66 out of 217 patients, and the incidence of liver dysfunction was 46.1% in HPBE(S) group, significantly higher than that in HLAMKO group (12.7%) (P＜0.01).CONCLUSION: TB patients with HBV should choose HLAMKO treatment because of fewer hepatotoxicity.

关键词： Anti-tuberculosis HBV

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Domain Decomposition Method for a System of Quasivariational Inequalities

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Acta Mathematicae Applicatae Sinica 2009年第1期25卷 75-82页

作者： Shu-zi Zhou zhan-yong Zou guang-hua Chen Department of Applied Mathematics Hunan University Changsha 410082 China School of Mathematics & Computational Science Guangdong University of Business Studies Guangzhou510320 China

We propose a domain decomposition method for a system of quasivariational inequalities related to the HJB equation. The monotone convergence of the algorithm is also established.

关键词： Domain decomposition method system of quasivariational inequalities HJB equation monotoneconvergence

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UAV maneuvering decision-making algorithm based on deep reinforcement learning under the guidance of expert experience

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Journal of Systems Engineering and Electronics 2024年第3期35卷 644-665页

作者： zhan guang zhanG Kun LI Ke PIAO Haiyin School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710072China Science and Technology on Electro-Optic Control Laboratory Luoyang 471009China

Autonomous umanned aerial vehicle(UAV) manipulation is necessary for the defense department to execute tactical missions given by commanders in the future unmanned battlefield. A large amount of research has been devoted to improving the autonomous decision-making ability of UAV in an interactive environment, where finding the optimal maneuvering decisionmaking policy became one of the key issues for enabling the intelligence of UAV. In this paper, we propose a maneuvering decision-making algorithm for autonomous air-delivery based on deep reinforcement learning under the guidance of expert experience. Specifically, we refine the guidance towards area and guidance towards specific point tasks for the air-delivery process based on the traditional air-to-surface fire control ***, we construct the UAV maneuvering decision-making model based on Markov decision processes(MDPs). Specifically, we present a reward shaping method for the guidance towards area and guidance towards specific point tasks using potential-based function and expert-guided advice. The proposed algorithm could accelerate the convergence of the maneuvering decision-making policy and increase the stability of the policy in terms of the output during the later stage of training process. The effectiveness of the proposed maneuvering decision-making policy is illustrated by the curves of training parameters and extensive experimental results for testing the trained policy.

关键词： unmanned aerial vehicle(UAV) maneuvering decision-making autonomous air-delivery deep reinforcement learning reward shaping expert experience

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NO_x reduction in the sintering process

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International Journal of Minerals,Metallurgy and Materials 2009年第2期16卷 143-148页

作者： Yan-guang Chen zhan-cheng Guo Zhi Wang Gen-sheng Feng State Key Laboratory of Multiphase Complex System Institute of Process Engineering Chinese Academy Sciences Beijing 100190 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of the Ministry of Education of China for Recycling ＆ Ecologic Metallurgy University of Science and Technology Beijing Beijing 100083China

A new process, NOx reduction with recycling flue gas and modifying coke breeze, was proposed. The effects of modified coke breeze and recycled flue gas on NOx reduction were investigated by sinter pot tests. The results show that the NOx reduction rate is over 10wt% in the sintering of modified coke breeze, the effects of the additives on NOx reduction are： CeO2〉CaO〉K2CO3. The NOx reduction rate increases with the amount of recycled flue gas, and is 22.35wt% in the sintering with recycling 30vol% of the flue gas. When 30vol% of the flue gas is recycled into the sintering of CeO2, CaO, and K2CO3 modified coke breeze, the NOx reduction rates are 36.10wt%, 32.56wt%, and 32.17wt%, respectively.

关键词： nitrogen oxide flue gas coke breeze cerium oxide sintering

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Farmers using insurance and cooperatives to manage agricultural risks: A case study of the swine industry in China

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Journal of Integrative Agriculture 2019年第12期18卷 2910-2918页

作者： zhanG Yan-yuan JU guang-wei zhan Jin-tao College of Economics and Management Nanjing Forestry UniversityNanjing 210037P.R.China Chinese Academy of Agricultural Sciences Beijing 100081P.R.China College of Economics and Management Nanjing Agricultural UniversityNanjing 210095P.R.China

Purchasing agricultural insurance and joining agricultural cooperatives are two prevalent instruments used by farmers in China for dealing with agricultural risks. Data from 443 swine farmers in Jiangsu and Henan provinces of China were collected. Factors affecting the farmers’ decision to purchase agricultural insurance and join agricultural cooperatives were assessed. The possibility of simultaneous use of both instruments and the potential correlation between these two decisions was considered as well. Results showed that the farmers’ decision to use agricultural insurance and cooperatives was positively correlated, indicating that farmers who purchased agricultural insurance which mainly used to mitigate production risks were more likely to join agricultural cooperatives which more used to share market risks, and vice versa. Farmers’ knowledge of swine insurance and trust in the local government positively impacted the purchase of agricultural insurance, while education, years involved in swine production and scale of swine production positively impacted farmers joining agricultural cooperatives.

关键词： agricultural insurance agricultural cooperatives simultaneous decisions Bivariate Probit China

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Preparation of Polyimide/BaTiO_3/Ag Nanocomposite Films via in situ Technique and Study of Their Dielectric Behavior

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Chinese Journal of Polymer Science 2014年第4期32卷 424-431页

作者： Jia-yu zhan Guo-feng tian zhan-peng Wu Sheng-li Qi 武德珍 State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing Building Materials Academy of Science Research/State Key Laboratory of Solid Waste Reuse for Building Materials

Triphase polyimide nanocomposite films were fabricated using barium titanate （BaTiO3） with high dielectric constant and silver （Ag） with high conductivity as fillers. In situ method was utilized to obtain the homogeneous dispersion of nanoparticles. The in situ polymerization of polyimide precursor-poly（amic acid） was performed in the presence of BaTiO3 particles. Silver compound 1,1,1-trifluoro-2,4-pentadionato silver（I） was added into the BaTiO3 containing poly（amic acid） solution to achieve silver nanoparticles via in situ self metallization technique. The thermally induced reduction converted silver （I） to metallic silver with concomitant imidization of poly（amic acid） to polyimide. Both BaTiO3 and silver nanoparticles were uniformly dispersed in the polyimide substrate. The dependence of dielectric behavior on the BaTiO3 and Ag contents was studied. The incorporation of small amount of silver nanoparticles greatly increased dielectric constant of composite films.

关键词： Polyimide Silver Barium titanate Nanocomposites Dielectrics.

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Superconducting Correlations in Small Metallic Grains

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Communications in Theoretical Physics 2001年第12期36卷 705-714页

作者： WANG Jing JI An-Chun tian guang-Shan Department of Physics Peking University Beijing 100871 China Department of Physics Peking University Beijing 100871 China Department of Physics Peking University Beijing 100871 China

By applying the path-integral formulation and the Feynman theorem, we calculate the off-diagonal superconducting correlation in an ultrasmall metallic grain. Unlike its behavior in the bulk limit, we find that this correlation function is an intensive quantity in this case. Therefore, superconductivity is indeed completely suppressed by quantum fluctuations as the diameter of the grain shrinks to the nanometer scale. This conclusion confirms the previous results by numerical calculations. Furthermore, it also imposes a strong constraint on the delocalizing amplitude of the pair-mixing function, which was recently proposed to characterize superconductivity in the canonical *** numbers: ***, ***, 74.80.

关键词： ultrasmall superconducting grain, the off-diagonal correlation function, path integral formulation and resolvent expansion method

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Application of response surface methodology in optimizaing thesulfation-roasting-leaching process of nickel laterite

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International Journal of Minerals,Metallurgy and Materials 2012年第3期19卷 199-204页

作者： Xue-yi Guo Dong Li zhan Wu Qing-hua tian School of Metallurgical Science and Engineering Central South UniversityChangsha 410083China

Nickel was recovered from nickel laterite using a sulfation-roasting-leaching process and the effects of operation parameters in- cluding acid addition, roasting temperature, and roasting time on nickel extraction and iron dissolution were investigated using response sur- face methodology （RSM）. Two second-order polynomial models of high significance were presented to show the relationship between the responses and the variables. The analysis of variance （ANOVA） showed high coefficients of determination （R2） of 0.894 and 0.980 for the two models, respectively. Optimum areas of 〉-80% Ni extraction and 〈5% Fe dissolution were obtained by the overlaid contours. Verification experiments in the optimum areas were conducted and the results indicate a close agreement with the predicted values obtained from the models.

关键词： nickel laterite sulfation roasting leaching optimization response surface methodology

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Microstructural evolution and aging behavior of Mg-4.5Y-2.5Nd-1.0Gd-0.5Zr alloys with different Zn additions

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Rare Metals 2021年第8期40卷 2188-2196页

作者： Zheng tian Qiang Yang Kai Guan zhan-Yi Cao Jian Meng Key Laboratory of Automobile Materials of Ministry of Education Department of Materials Science and EngineeringJilin UniversityChangchun130025China State Key Laboratory of Rare Earth Resources Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China

Microstructures and mechanical properties of Mg-4.5 Y-2.5 Nd-1.0 Gd-0.5 Zr-xZn(x=0,0.5,1.0,and 1.5;wt%)alloys under as-cast and peak-aged states were investigated in this *** results indicate that the intermetallic phase components are closely dependent on Zn *** as-cast state,the dominant eutectic phase is Mg5 RE in the alloys with 0 wt%and 0.5 wt%Zn additions while Mg5 RE,18 R-and 14 H-LPSO(long period stacking ordered)phases in the alloys with 1.0 wt%and1.5 wt%Zn *** solution and peak-aging,the highest strength and hardness were obtained on the alloy with 0.5 wt%Zn *** electron microscopy(TEM)characterizations revealed that there are denser and finer precipitates on basal(β’)and prismatic(γ’)planes,***,the excellent mechanical performance of the alloy with 0.5 wt%Zn addition is mainly due to precipitation strengthening and grain boundary strengthening.

关键词： Magnesium alloy Intermetallic phase Precipitates Mechanical property

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