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World Journal of Clinical Cases 2022年第6期10卷 1998-2006页

作者： tian-fu liu Jing-Jing He Liang Wang Ling-Yi Zhang Department of Hepatology Lanzhou University Second HospitalLanzhou 730030Gansu ProvinceChina

BACKGROUND Mutations that occur in the ABCB4 gene,which encodes multidrug-resistant protein 3,underlie the occurrence of progressive familial intrahepatic cholestasis type 3(PFIC3).Clinical signs of intrahepatic cholestasis due to gene mutations typically first appear during infancy or childhood.Reports of PFIC3 occurring in adults are rare.CASE SUMMARY This is a case study of a 32-year-old infertile female Chinese patient with a 15-year history of recurrent abnormal liver function.Her primary clinical signs were elevated levels of alkaline phosphatase andγ-glutamyl transpeptidase.Other possible reasons for liver dysfunction were eliminated in this patient,resulting in a diagnosis of PFIC3.The diagnosis was confirmed using gene detection and histological analyses.Assessments using genetic sequencing analysis indicated the presence of two novel heterozygous mutations in the ABCB4 gene,namely,a 2950C>T;p.A984V mutation(exon 24)and a 667A>G;p.I223V mutation(exon 7).After receiving ursodeoxycholic acid(UDCA)treatment,the patient's liver function indices improved,and she successfully became pregnant by in vitro fertilization.However,the patient developed intrahepatic cholestasis of pregnancy in the first trimester.Fortunately,treatment with UDCA was safe and effective.CONCLUSION These novel ABCB4 heterozygous mutations have a variety of clinical phenotypes.Continued follow-up is essential for a comprehensive understanding of PFIC3.

关键词： Progressive familial intrahepatic cholestasis type 3 ABCB4 gene Infertility Intrahepatic cholestasis of pregnancy Case report

Lithium film with abundant stepped structures: A promising route for homogeneous Li ion deposition to conquer lithium dendrite issue and its action mechanism

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Journal of Energy Chemistry 2022年第9期31卷 166-175,I0006页

作者： Yong Zhang Shu-Qin Song Yong Gao tian-fu liu Hong Zhao Department of Materials Science and Engineering Dalian Jiaotong UniversityDalian 116028LiaoningChina The Key Lab of Low-carbon Chemistry&Energy Conservation of Guangdong Province PCFM LabSchool of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou510275GuangdongChina Institute of Science and Technology for New Energy Xi'an Technological UniversityXian 710021ShaanxiChina Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023LiaoningChina

Lithium is considered to be the ‘‘holy grail” for the application of energy storage due to its highest theoretical capacity and lowest anode potential. However, one of the grand difficulties in the development of lithium-based batteries is the lithium dendrite growth that leads to capacity fading and electrode degradation over long-term cycling. Compared with conventional electrolyte modifications, artificial solid electrolyte interfaces(SEI) synthesis and framework designing approaches, tuning surface morphology of lithium anode is the direct route to induce homogeneous Li ion deposition. Due to the high chemical activity of lithium metal, however, controllable growth of lithium micro/nanostructures by traditionally chemical approaches is still a big challenge. Herein, we have developed a facile compression route to fabricate lithium anode with abundant stepped lithium structures. The electrochemical results demonstrate that the dendritic growth issue is effectively suppressed by orderly arranged stepped lithium structures. After 90 cycles, a high discharge capacity of 954 mAh g^(-1) is achieved, which is 2.7times that of the uncompressed lithium anode(342 mAh g). First-principles calculations reveal that the orderly arranged stepped lithium structures are lithiophilic active sites to adsorb Li ion, which contributes to homogeneous deposition of Li ion on lithium anode, eventually solving the lithium dendrite issue. This work paves a new road to suppress dendritic growth, which will provide some new ideas to design long recycling sodium, potassium and zinc, and other metal anode batteries.

关键词： Lithium dendrite Steps/edges Active sites Compression

Post-modification of metal-organic framework for improved CO_(2) photoreduction efficiency

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Chinese Chemical Letters 2023年第3期34卷 490-493页

作者： An-An Zhang Rui Wang Hai-Bo Huang tian-fu liu Rong Cao Department of Chemistry School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350002China

Utilizing metal-organic frameworks(MOFs) to design photocatalysts for CO_(2) reduction catalysts is an excellent idea but currently restricted by the relatively low activity. Enhancing CO_(2) affinity and tuning the oxidation state of metal clusters in MOFs might be a solution to improve the catalytic performance.Herein, the Cl-bridge atoms in the metal clusters of a cobalt MOF were easily exchanged with OH-,which simultaneously oxidized a portion of Co(Ⅱ) to Co(Ⅲ) and resulted in a much enhanced photocatalytic activity for CO_(2) reduction. In contrast, the original framework does not exhibit such superior activity. Comprehensive characterizations on their physicochemical properties revealed that the introduction of hydroxyl group not only greatly increases the CO_(2) affinity but also alters the oxidation state of metal clusters, resulting in significantly improved photocatalytic activities for CO_(2) reduction. This work provides important insight into the design of efficient photocatalysts.

关键词： Metal-organic framework Post-modification Hydroxyl group Ion exchange CO_(2)photoreduction

Precise Construction of Stable Bimetallic Metal–Organic Frameworks with Single-Site Ti(IV) Incorporation in Nodes for Efficient Photocatalytic Oxygen Evolution

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CCS Chemistry 2022年第8期4卷 2782-2792页

作者： Lan Li Zhi-Bin Fang Wenzhuo Deng Jun-Dong Yi Rui Wang tian-fu liu State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002 University of Chinese Academy of Sciences Beijing 100049 CAS Key Laboratory of Design and Assembly of functional Nanostructures and fujian Key Laboratory of Nanomaterials Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002

Assembling the reactive low-cost Co clusters and photoresponsive ligands in the form of metal–organic frameworks(MOFs)is a promising strategy to construct efficient water-oxidizing photocatalysts,but it is restricted by poor water stability.Introducing high valent cations in the clusters to build heterometallic Co-MOFs might be a solution,yet a precise fabrication strategy is still challenging.

关键词： cobalt catalyst metal–organic frameworks single-site Ti incorporation stability photocatalytic O_(2)evolution

Harnessing Electrostatic Interactions for Enhanced Conductivity in Metal-Organic Frameworks

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Research 2021年第1期2021卷 1543-1553页

作者： An-An Zhang Xiyue Cheng Xu He Wei liu Shuiquan Deng Rong Cao tian-fu liu Department of Chemistry School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefeiAnhui 230026China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China University of the Chinese Academy of Sciences Beijing 100049China

The poor electrical conductivity of metal-organic frameworks(MOFs)has been a stumbling block for its applications in many important fields.Therefore,exploring a simple and effective strategy to regulate the conductivity of MOFs is highly desired.Herein,anionic guest molecules are incorporated inside the pores of a cationic MOF(PFC-8),which increases its conductivity by five orders of magnitude while maintaining the original porosity.In contrast,the same operation in an isoreticular neutral framework(PFC-9)does not bring such a significant change.Theoretical studies reveal that the guest molecules,stabilized inside pores through electrostatic interaction,play the role of electron donors as do in semiconductors,bringing in an analogous n-type semiconductor mechanism for electron conduction.Therefore,we demonstrate that harnessing electrostatic interaction provides a new way to regulate the conductivity of MOFs without necessarily altering the original porous structure.This strategy would greatly broaden MOFs’application potential in electronic and optoelectronic technologies.

关键词： structure conductivity electrostatic

Structure and magnetic property of bimetallic hexanuclear cluster based on 5-chlorosalicylaldehyde oxime

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Chinese Chemical Letters 2014年第6期25卷 937-940页

作者： Yuan Zhang Chen-Yan Wei tian-fu liu School of Chemistry Beijing Institute of Technology

The bimetallic hexanuclear cluster [Mn4Ni2O2（Cl-Sao）6.（CH3OH）8].10CH3OH （1） was synthesized. Single-crystal X-ray analysis reveals that 1 consists of two [Mn2Ni（μ3-O）（Cl-Sao）3] subunits linked together via two pairs of long Ni-O bonds involving two oximate oxygen atoms and two phenolate oxygen atoms. Each Mn and Ni center achieves six-coordination with axial methanol molecules. The spin centers of the Mnm and Niu ions exchange magnetic coupling through O2-, O-phenolate and -N-O- bridges. The magnetic properties of the cluster have been investigated.

关键词： Cluster Crystal structure Magnetic property Manganese complex Nickel complex

Building Block Symmetry Relegation Induces Mesopore and Abundant Open-Metal Sites in Metal-Organic Frameworks for Cancer Therapy

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CCS Chemistry 2022年第3期4卷 996-1006页

作者： Jing Sun Xuan Zhang Dong Zhang Ying-Pin Chen Fei Wang Lan Li tian-fu liu Huanghao Yang Jibin Song Rong Cao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002 School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210 MOE Key Laboratory for Analytical Science of Food Safety and Biology College of ChemistryFuzhou UniversityFuzhou 350116 NSF’s ChemMatCARS The University of ChicagoArgonneIL 60439 University of Chinese Academy of Sciences Beijing 100049

The judicious choice of metal clusters and organic building blocks leads to a wide variety of structures for metal–organic frameworks(MOFs).In this work,we demonstrated that relegating the symmetry of a building block can also lead to the proliferation of new MOF structures.Herein,a triangle building block was elongated with reduced symmetry for MOF construction,which gave rise to a novel(3,4,6)-connected idp(based on the definition of Reticular Chemistry Structure Resource,http://***/)network(PFC-16)with mesopores and abundant open-metal sites.The framework is composed of the rarely observed tetrakis hexahedral cages,surrounding which are small cages arranged in sodalite topology.The relegated symmetry was required for this novel self-assembly.The obtained MOF with mesopores,a robust backbone,and abundant open-metal sites can incorporate functional species in the structure,which is representatively demonstrated by internalizing the photosensitizer zinc(II)phthalocyanine(ZnPc)and the modifying tumor-targeting molecule folic acid(FA)in PFC-16.The obtained composite FA-ZnPc@nano-PFC-16 shows excellent photodynamic therapy(PDT)efficiency for both in vitro and in vivo experiments,representing a promising candidate for cancer therapy.

关键词： metal-organic frameworks Catalan solids photodynamic therapy cancer imaging

Designing a Bifunctional Brønsted Acid-Base Heterogeneous Catalyst Through Precise Installation of Ligands on Metal-Organic Frameworks

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CCS Chemistry 2020年第1期2卷 616-622页

作者： Xiao-Jing Hu Zi-Xuan Li Huan Xue Xinsong Huang Rong Cao tian-fu liu State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFujianFuzhou 350002(China) University of the Chinese Academy of Sciences Beijing 100049(China) Simon Fraser University Vancouver(Canada)

A Brønsted acid-base bifunctional metal-organic framework(MOF)catalyst,PCN-700-AB[A=Brønsted acid site,TPDC-(COOH)_(2)[(1,1′∶4′,1″-terphenyl)-2,2″,4,4″-tetracarboxylic acid]and B=Brønsted basic site,BDC-NH_(2)],was designed precisely and synthesized successfully through sequential installation of Brønsted acid and base functionalities in a crystalline zirconium(Zr)-MOF.The installation underwent single-crystal-to-singlecrystal transformation throughout the process;hence,the structure of the bifunctional catalyst could be characterized accurately via single-crystal X-ray crystallography.The bifunctional MOF catalyst obtained exhibited excellent acid-base catalytic activity for a cascade of one-pot deacetalization-Knoevenagel condensation reaction.The work presented here could be considered as a promising solution to incorporate multifunctional components readily,especially the hostile aspects,into one MOF structure.

关键词： Brønsted acid-base catalyst linker installation single-crystal transformation metal-organic frameworks

分割氢键有机框架的孔道空间提升光催化CO_(2)还原效率

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Science China Materials 2024年第6期67卷 1846-1850页

作者：王子祥邹莹方志斌李金林李亚峰张安安刘天赋 College of Chemistry Fuzhou UniversityFuzhou 350002China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350002China

氢键有机框架材料(HOFs)在催化领域具有巨大的潜力,但其孔道空间在去除溶剂后易塌陷,限制了其在光催化能源转换和存储方面的应用.本研究采用孔道分割策略成功设计并合成了一种稳定孔道结构、高效光催化CO_(2)还原活性的HOF催化剂.H4TBAP... 详细信息

氢键有机框架材料(HOFs)在催化领域具有巨大的潜力,但其孔道空间在去除溶剂后易塌陷,限制了其在光催化能源转换和存储方面的应用.本研究采用孔道分割策略成功设计并合成了一种稳定孔道结构、高效光催化CO_(2)还原活性的HOF催化剂.H4TBAPy分子通过与HOF孔道中大量的CH…π相互作用锚定自身,并将HOF的大孔道分隔成多个小空间,显著增加了HOF框架的稳定性.同时,富电子属性的H4TBAPy分子提升了HOF体系中电子的传输速率,从而提高了催化活性.这项研究为设计稳定、高性能的HOFs光催化剂提供了新策略.

关键词： hydrogen-bonded organic frameworks CO_(2)photo-reduction pore space partitioning strategy

Efficient CO_(2) photoreduction enabled by the energy transfer pathway in metal-organic framework

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Aggregate 2023年第6期4卷 130-136页

作者： Hai-Xiong liu Duan-Hui Si Mallory F.Smith Ren-fu Li Xi-Ya Li Lan Li Hai-Bo Huang Zhi-Bin Fang Hong-Cai Zhou tian-fu liu State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouP.R.China Department of Chemistry Texas A&M UniversityCollege StationTexasUSA University of Chinese Academy of Sciences BeijingP.R.China

Many studies in metal-organic frameworks(MOFs)aiming for high photocatalytic activity resort to self-assembling both energy donor and acceptor building units in skeleton to achieve effective energy transfer,which,however,usually needs tedious synthetic procedure and design of a new MOF.In this work,we demonstrated that building a Förster resonance energy transfer(FRET)pathway can be realized through suitable molecular doping in a given MOF structure without altering the original porous structure,presenting an alternative strategy to design efficient photocatalysts for CO_(2)reduction.In situ electron spin resonance,ultrafast transient absorption spectroscopy,and computational studies reveal that the FRET-induced excitation has dramatically altered the exciton transfer pathway in structure and facilitated electron-hole separation.As a result,the molecular doped MOFs synthesized through one-pot reaction show outstanding selectivity(96%)and activity(1314μmol⋅g^(−1)⋅h^(−1))for CO production versus almost no activity for the pristine MOFs,and this result stands out from existing competitors.furthermore,the reaction mechanism was proposed and the intermediate signals were detected by in situ diffuse reflectance infrared Fourier transform spectroscopies.This study presents a clear picture of building FRET process in MOFs through molecular doping and provides a new design strategy for MOF-based photocatalysts.

关键词： CO_(2) photoreduction energy transfer molecular doping